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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLDIP3-MED15 (FusionGDB2 ID:66917)

Fusion Gene Summary for POLDIP3-MED15

check button Fusion gene summary
Fusion gene informationFusion gene name: POLDIP3-MED15
Fusion gene ID: 66917
HgeneTgene
Gene symbol

POLDIP3

MED15

Gene ID

84271

51586

Gene nameDNA polymerase delta interacting protein 3mediator complex subunit 15
SynonymsPDIP3|PDIP46|SKARARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
Cytomap

22q13.2

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionpolymerase delta-interacting protein 346 kDa DNA polymerase delta interaction proteinRNA-binding protein P46S6K1 Aly/REF-like targetpolymerase (DNA) delta interacting protein 3polymerase (DNA-directed), delta interacting protein 3mediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
Modification date2020031320200313
UniProtAcc.

Q96RN5

Ensembl transtripts involved in fusion geneENST00000252115, ENST00000339677, 
ENST00000348657, ENST00000451060, 
ENST00000491021, 		ENST00000263205, 
ENST00000382974, ENST00000406969, 
ENST00000478831, ENST00000541476, 
ENST00000542773, ENST00000292733, 
ENST00000425759, 
Fusion gene scores* DoF score15 X 26 X 8=312022 X 18 X 9=3564
# samples 2924
** MAII scorelog2(29/3120*10)=-3.42742122373468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3564*10)=-3.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLDIP3 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLDIP3(42998776)-MED15(20905723), # samples:2
Anticipated loss of major functional domain due to fusion event.POLDIP3-MED15 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLDIP3

GO:0016973

poly(A)+ mRNA export from nucleus

22928037


check buttonFusion gene breakpoints across POLDIP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MED15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A4F4-06APOLDIP3chr22

42997976

-MED15chr22

20905723

+
ChimerDB4SKCMTCGA-FS-A4F4-06APOLDIP3chr22

42998776

-MED15chr22

20905723

+


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Fusion Gene ORF analysis for POLDIP3-MED15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252115ENST00000263205POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000382974POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000406969POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000478831POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000541476POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000542773POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000451060ENST00000263205POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000451060ENST00000382974POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000451060ENST00000406969POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000451060ENST00000478831POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000451060ENST00000541476POLDIP3chr22

42997976

-MED15chr22

20905723

+
5CDS-intronENST00000451060ENST00000542773POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-3CDSENST00000451060ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000451060ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000491021ENST00000292733POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-3CDSENST00000491021ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000491021ENST00000425759POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-3CDSENST00000491021ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000263205POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000382974POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000406969POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000478831POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000541476POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000542773POLDIP3chr22

42997976

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
Frame-shiftENST00000451060ENST00000292733POLDIP3chr22

42997976

-MED15chr22

20905723

+
Frame-shiftENST00000451060ENST00000425759POLDIP3chr22

42997976

-MED15chr22

20905723

+
In-frameENST00000252115ENST00000292733POLDIP3chr22

42997976

-MED15chr22

20905723

+
In-frameENST00000252115ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000252115ENST00000425759POLDIP3chr22

42997976

-MED15chr22

20905723

+
In-frameENST00000252115ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000339677ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000339677ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000348657ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000348657ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
intron-3CDSENST00000339677ENST00000292733POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-3CDSENST00000339677ENST00000425759POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-3CDSENST00000348657ENST00000292733POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-3CDSENST00000348657ENST00000425759POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000339677ENST00000263205POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000339677ENST00000382974POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000339677ENST00000406969POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000339677ENST00000478831POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000339677ENST00000541476POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000339677ENST00000542773POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000348657ENST00000263205POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000348657ENST00000382974POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000348657ENST00000406969POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000348657ENST00000478831POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000348657ENST00000541476POLDIP3chr22

42997976

-MED15chr22

20905723

+
intron-intronENST00000348657ENST00000542773POLDIP3chr22

42997976

-MED15chr22

20905723

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348657POLDIP3chr2242998776-ENST00000425759MED15chr2220905723+3329524742401775
ENST00000348657POLDIP3chr2242998776-ENST00000292733MED15chr2220905723+3543524742614846
ENST00000252115POLDIP3chr2242998776-ENST00000425759MED15chr2220905723+33605551052432775
ENST00000252115POLDIP3chr2242998776-ENST00000292733MED15chr2220905723+35745551052645846
ENST00000339677POLDIP3chr2242998776-ENST00000425759MED15chr2220905723+325545002327775
ENST00000339677POLDIP3chr2242998776-ENST00000292733MED15chr2220905723+346945002540846
ENST00000252115POLDIP3chr2242997976-ENST00000425759MED15chr2220905723+34476421052519804
ENST00000252115POLDIP3chr2242997976-ENST00000292733MED15chr2220905723+36616421052732875

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348657ENST00000425759POLDIP3chr2242998776-MED15chr2220905723+0.0262747520.97372526
ENST00000348657ENST00000292733POLDIP3chr2242998776-MED15chr2220905723+0.0285124690.9714875
ENST00000252115ENST00000425759POLDIP3chr2242998776-MED15chr2220905723+0.0243413880.9756586
ENST00000252115ENST00000292733POLDIP3chr2242998776-MED15chr2220905723+0.0267529640.97324705
ENST00000339677ENST00000425759POLDIP3chr2242998776-MED15chr2220905723+0.0277114340.97228855
ENST00000339677ENST00000292733POLDIP3chr2242998776-MED15chr2220905723+0.0294630340.97053695
ENST00000252115ENST00000425759POLDIP3chr2242997976-MED15chr2220905723+0.024757510.9752425
ENST00000252115ENST00000292733POLDIP3chr2242997976-MED15chr2220905723+0.0234339220.9765661

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Fusion Genomic Features for POLDIP3-MED15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLDIP3chr2242997975-MED15chr2220905722+2.11E-060.99999785
POLDIP3chr2242998775-MED15chr2220905722+1.02E-060.9999989
POLDIP3chr2242997975-MED15chr2220905722+2.11E-060.99999785
POLDIP3chr2242998775-MED15chr2220905722+1.02E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLDIP3-MED15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:42998776/chr22:20905723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MED15

Q96RN5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118161_17452789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118178_19352789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118205_21852789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118226_23952789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118243_26252789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118266_51552789.0Compositional biasNote=Pro-rich
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118360_36752789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118449_45652789.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118602_61152789.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117161_17452749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117178_19352749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117205_21852749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117226_23952749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117243_26252749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117266_51552749.0Compositional biasNote=Pro-rich
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117360_36752749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117449_45652749.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117602_61152749.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116161_17452678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116178_19352678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116205_21852678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116226_23952678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116243_26252678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116266_51552678.0Compositional biasNote=Pro-rich
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116360_36752678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116449_45652678.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116602_61152678.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118161_17452789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118178_19352789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118205_21852789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118226_23952789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118243_26252789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118266_51552789.0Compositional biasNote=Pro-rich
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118360_36752789.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118449_45652789.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118602_61152789.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117161_17452749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117178_19352749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117205_21852749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117226_23952749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117243_26252749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117266_51552749.0Compositional biasNote=Pro-rich
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117360_36752749.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117449_45652749.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117602_61152749.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116161_17452678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116178_19352678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116205_21852678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116226_23952678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116243_26252678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116266_51552678.0Compositional biasNote=Pro-rich
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116360_36752678.0Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116449_45652678.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116602_61152678.0Compositional biasNote=Poly-Pro
TgeneMED15chr22:42997976chr22:20905723ENST00000263205118547_56452789.0MotifNuclear localization signal
TgeneMED15chr22:42997976chr22:20905723ENST00000292733117547_56452749.0MotifNuclear localization signal
TgeneMED15chr22:42997976chr22:20905723ENST00000382974116547_56452678.0MotifNuclear localization signal
TgeneMED15chr22:42998776chr22:20905723ENST00000263205118547_56452789.0MotifNuclear localization signal
TgeneMED15chr22:42998776chr22:20905723ENST00000292733117547_56452749.0MotifNuclear localization signal
TgeneMED15chr22:42998776chr22:20905723ENST00000382974116547_56452678.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLDIP3chr22:42997976chr22:20905723ENST00000252115-39280_351179422.0DomainRRM
HgenePOLDIP3chr22:42997976chr22:20905723ENST00000348657-18280_3510393.0DomainRRM
HgenePOLDIP3chr22:42998776chr22:20905723ENST00000252115-29280_351150422.0DomainRRM
HgenePOLDIP3chr22:42998776chr22:20905723ENST00000348657-28280_351150393.0DomainRRM


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Fusion Gene Sequence for POLDIP3-MED15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66917_66917_1_POLDIP3-MED15_POLDIP3_chr22_42997976_ENST00000252115_MED15_chr22_20905723_ENST00000292733_length(transcript)=3661nt_BP=642nt
GCGAGAGTTGGTCCGCGGACGCCGGAAGTAGTTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTT
GCTCGGCGGAGCAAGATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCG
GGAGTTGGAGGTGTCCGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGAT
GCCCGGCAGAAGATTGGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTT
CGAATCAAAGGGAAAGTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCT
GATGCCCGGGAGAAGATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTC
ACCAAAACCATCCAGGTTCCACAGCAGAAAGCCATGGCACCACTTCATCCCCATCCTGCCGGAATGAGAATCAATGTTGTCAATAACCAC
CAGGCCAAACAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTC
AGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAG
TCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCT
CACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAG
TTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAG
CAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAG
CAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAG
CAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTC
CCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTC
CGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATG
GTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATG
CCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGT
AGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCT
TTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAG
CTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGC
CTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGAC
ATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAAC
ATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTG
GTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAG
TTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTG
CCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTC
CTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAG
AGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGT
CAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACG
AAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATG
TGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTG
CACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAA
CACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAG
GGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTG
CTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCAC
TGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCC
GGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGT

>66917_66917_1_POLDIP3-MED15_POLDIP3_chr22_42997976_ENST00000252115_MED15_chr22_20905723_ENST00000292733_length(amino acids)=875AA_BP=179
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQVPQQKAMAPLHPHPAGMRINVVNNHQAKQD
EYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAV
VSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQ
QQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQ
TQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQ
PSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYI
EPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPV
FNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLEL

--------------------------------------------------------------
>66917_66917_2_POLDIP3-MED15_POLDIP3_chr22_42997976_ENST00000252115_MED15_chr22_20905723_ENST00000425759_length(transcript)=3447nt_BP=642nt
GCGAGAGTTGGTCCGCGGACGCCGGAAGTAGTTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTT
GCTCGGCGGAGCAAGATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCG
GGAGTTGGAGGTGTCCGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGAT
GCCCGGCAGAAGATTGGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTT
CGAATCAAAGGGAAAGTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCT
GATGCCCGGGAGAAGATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTC
ACCAAAACCATCCAGGTTCCACAGCAGAAAGCCATGGCACCACTTCATCCCCATCCTGCCGGAATGAGAATCAATGTTGTCAATAACCAC
CAGGCCAAACAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTC
AGTGCCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAG
CAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAG
CTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAG
CGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCA
ATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCAC
CAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCA
CAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTG
CAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGC
CTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGC
CAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCC
CAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATG
AGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATG
ATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGG
TGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTG
CCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTAC
CGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGAT
GAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGC
AACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTAT
CCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGG
CTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAG
CCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAG
CCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCG
CAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCA
GGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTG
CTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGT
TCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCC
CATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGC
GTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCC
GTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCT
GCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATT

>66917_66917_2_POLDIP3-MED15_POLDIP3_chr22_42997976_ENST00000252115_MED15_chr22_20905723_ENST00000425759_length(amino acids)=804AA_BP=179
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQVPQQKAMAPLHPHPAGMRINVVNNHQAKQD
EYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQ
QQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQ
PQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLS
SPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGS
SQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQ
QYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTV

--------------------------------------------------------------
>66917_66917_3_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000252115_MED15_chr22_20905723_ENST00000292733_length(transcript)=3574nt_BP=555nt
GCGAGAGTTGGTCCGCGGACGCCGGAAGTAGTTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTT
GCTCGGCGGAGCAAGATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCG
GGAGTTGGAGGTGTCCGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGAT
GCCCGGCAGAAGATTGGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTT
CGAATCAAAGGGAAAGTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCT
GATGCCCGGGAGAAGATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTC
ACCAAAACCATCCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCC
GTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGA
CAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCC
CCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAG
CAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAG
CAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAAT
CAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCC
CAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAA
CTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTT
GTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAG
ATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCG
ATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCC
AGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGA
CCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAG
CAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAG
AGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAAT
GACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCC
AACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCA
GTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCC
AAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGT
GTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCC
TTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCC
CAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCC
TGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAA
ACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCC
ATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGG
GTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTA
AAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTC
CAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTC
CTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCC
CACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGG
GCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTA

>66917_66917_3_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000252115_MED15_chr22_20905723_ENST00000292733_length(amino acids)=846AA_BP=150
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSDPM
NALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQ
QQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQ
ALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM
VVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP
SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDI
LTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTR
KRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSV

--------------------------------------------------------------
>66917_66917_4_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000252115_MED15_chr22_20905723_ENST00000425759_length(transcript)=3360nt_BP=555nt
GCGAGAGTTGGTCCGCGGACGCCGGAAGTAGTTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTT
GCTCGGCGGAGCAAGATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCG
GGAGTTGGAGGTGTCCGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGAT
GCCCGGCAGAAGATTGGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTT
CGAATCAAAGGGAAAGTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCT
GATGCCCGGGAGAAGATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTC
ACCAAAACCATCCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCC
GTCAGTGCCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAG
CAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAG
CAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTG
CAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCA
CCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCAC
CACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTG
TCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCA
GTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGC
AGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCC
GGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCC
TCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTC
ATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGC
ATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAG
CGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCG
GTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTG
TACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGAT
GATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGC
AGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGAC
TATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCC
AGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCC
TAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGA
GAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAG
GCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCC
TCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGT
GTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTG
GGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTG
GCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGG
GGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGA
CCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTG
CCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAA

>66917_66917_4_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000252115_MED15_chr22_20905723_ENST00000425759_length(amino acids)=775AA_BP=150
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSAQL
QLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ
LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA
LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSS
QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKI
DKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFV
PAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQS

--------------------------------------------------------------
>66917_66917_5_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000339677_MED15_chr22_20905723_ENST00000292733_length(transcript)=3469nt_BP=450nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATG
AATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGG
ATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCT
GTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAG
CAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCA
GTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAG
CAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
GCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAG
ATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCG
CAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATG
GTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGA
GTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCC
CAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCC
AGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCT
GTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTAC
ATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATT
CTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCC
ACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCT
GTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGG
AAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAAC
CTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAG
CTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTG
CACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAG
GCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTA
GGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACC
TGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCC
AGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGT
TGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGAT
TCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGC
CTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTG
GGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGA
AGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGG
GAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCAC

>66917_66917_5_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000339677_MED15_chr22_20905723_ENST00000292733_length(amino acids)=846AA_BP=150
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSDPM
NALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQ
QQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQ
ALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM
VVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP
SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDI
LTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTR
KRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSV

--------------------------------------------------------------
>66917_66917_6_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000339677_MED15_chr22_20905723_ENST00000425759_length(transcript)=3255nt_BP=450nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTG
CAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAG
CAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAG
CAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAG
CTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCA
CCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCA
CAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCT
CTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTG
CAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTG
TCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCA
CAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTG
ACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGC
TCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATC
GACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAG
ACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAA
CAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTT
CCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGC
ATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACT
GTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGC
CCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTC
CCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAG
GGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGG
TTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGG
TTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCAC
CGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCC
CTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCT
GCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGC
TGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCT
GCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAG
CACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGC
ACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATTTATTATTCCTGT

>66917_66917_6_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000339677_MED15_chr22_20905723_ENST00000425759_length(amino acids)=775AA_BP=150
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSAQL
QLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ
LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA
LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSS
QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKI
DKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFV
PAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQS

--------------------------------------------------------------
>66917_66917_7_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000348657_MED15_chr22_20905723_ENST00000292733_length(transcript)=3543nt_BP=524nt
TTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTTGCTCGGCGGAGCAAGATGGCGGACATCTCCC
TGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTCCGATCTCGAGTTGGGA
TCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATTGGCCTCTCAGATGCCC
GGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAAGTGCAGGATGCCAGAG
AGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAGATCAGCTTGAAGAGGA
GTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAGGACGAATACCTTTCTC
TCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCC
TGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTG
CCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAA
CTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTAC
AGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGC
AGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGC
TGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGC
CACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGC
ACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGG
TGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCC
CAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGA
GCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGC
CCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGC
CCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTG
TCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCC
GCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGA
AGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCC
CGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCC
TGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGG
ATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACT
GCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTG
ACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCT
CCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCG
CCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTA
GAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGAT
AGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGAT
CCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGT
GTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTT
TGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGC
TGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCA
GGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAG
GACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGT
TGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAAT

>66917_66917_7_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000348657_MED15_chr22_20905723_ENST00000292733_length(amino acids)=846AA_BP=150
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSDPM
NALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQ
QQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQ
ALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM
VVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP
SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDI
LTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTR
KRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSV

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>66917_66917_8_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000348657_MED15_chr22_20905723_ENST00000425759_length(transcript)=3329nt_BP=524nt
TTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTTGCTCGGCGGAGCAAGATGGCGGACATCTCCC
TGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTCCGATCTCGAGTTGGGA
TCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATTGGCCTCTCAGATGCCC
GGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAAGTGCAGGATGCCAGAG
AGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAGATCAGCTTGAAGAGGA
GTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAGGACGAATACCTTTCTC
TCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTGCAGCTCCAGCAGGTGG
CGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGT
TCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGC
ATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAAC
AGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCAC
AGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTC
CAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGT
TGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAG
CAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGG
GCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACG
TCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCAC
AGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGG
AGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACA
GAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTG
AGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCC
AGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCA
TTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCC
AGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCA
AGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACC
GGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGG
TCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCT
CATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTT
TATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTT
GGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGG
TCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAG
AACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGA
GCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCA
GCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTG
TGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCA
CCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTC

>66917_66917_8_POLDIP3-MED15_POLDIP3_chr22_42998776_ENST00000348657_MED15_chr22_20905723_ENST00000425759_length(amino acids)=775AA_BP=150
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSAQL
QLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ
LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA
LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSS
QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKI
DKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFV
PAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQS

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Fusion Gene PPI Analysis for POLDIP3-MED15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMED15chr22:42997976chr22:20905723ENST000002632051189_7352.0789.0SREBF1
TgeneMED15chr22:42997976chr22:20905723ENST000002927331179_7352.0749.0SREBF1
TgeneMED15chr22:42997976chr22:20905723ENST000003829741169_7352.0678.0SREBF1
TgeneMED15chr22:42998776chr22:20905723ENST000002632051189_7352.0789.0SREBF1
TgeneMED15chr22:42998776chr22:20905723ENST000002927331179_7352.0749.0SREBF1
TgeneMED15chr22:42998776chr22:20905723ENST000003829741169_7352.0678.0SREBF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLDIP3-MED15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLDIP3-MED15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource