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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:POLE-GOLGA3 (FusionGDB2 ID:66933) |
Fusion Gene Summary for POLE-GOLGA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLE-GOLGA3 | Fusion gene ID: 66933 | Hgene | Tgene | Gene symbol | POLE | GOLGA3 | Gene ID | 5426 | 2802 |
| Gene name | DNA polymerase epsilon, catalytic subunit | golgin A3 | |
| Synonyms | CRCS12|FILS|IMAGEI|POLE1 | GCP170|MEA-2 | |
| Cytomap | 12q24.33 | 12q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA polymerase epsilon catalytic subunit ADNA polymerase II subunit ADNA polymerase epsilon catalytic subunit proteinpolymerase (DNA directed), epsilon, catalytic subunitpolymerase (DNA) epsilon, catalytic subunit | golgin subfamily A member 3Golgi membrane associated proteinGolgi peripheral membrane proteinSY2/SY10 proteingolgi autoantigen, golgin subfamily a, 3golgi complex-associated protein of 170 kDagolgin-160golgin-165male enhanced antigen-2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q08378 | |
| Ensembl transtripts involved in fusion gene | ENST00000320574, ENST00000535270, ENST00000434528, | ENST00000534967, ENST00000537452, ENST00000545875, ENST00000204726, ENST00000450791, ENST00000456883, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 7 X 15 X 7=735 |
| # samples | 6 | 15 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/735*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLE [Title/Abstract] AND GOLGA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | POLE(133248801)-GOLGA3(133360893), # samples:2 GOLGA3(133398582)-POLE(133257865), # samples:1 GOLGA3(133374926)-POLE(133257865), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | GOLGA3-POLE seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GOLGA3-POLE seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GOLGA3-POLE seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. GOLGA3-POLE seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLE | GO:0006287 | base-excision repair, gap-filling | 10559260 |
| Fusion gene breakpoints across POLE (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GOLGA3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A0BZ-01A | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
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Fusion Gene ORF analysis for POLE-GOLGA3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000320574 | ENST00000534967 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| 5CDS-intron | ENST00000535270 | ENST00000534967 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| Frame-shift | ENST00000320574 | ENST00000537452 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| Frame-shift | ENST00000320574 | ENST00000545875 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| Frame-shift | ENST00000535270 | ENST00000537452 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| Frame-shift | ENST00000535270 | ENST00000545875 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| In-frame | ENST00000320574 | ENST00000204726 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| In-frame | ENST00000320574 | ENST00000450791 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| In-frame | ENST00000320574 | ENST00000456883 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| In-frame | ENST00000535270 | ENST00000204726 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| In-frame | ENST00000535270 | ENST00000450791 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| In-frame | ENST00000535270 | ENST00000456883 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| intron-3CDS | ENST00000434528 | ENST00000204726 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| intron-3CDS | ENST00000434528 | ENST00000450791 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| intron-3CDS | ENST00000434528 | ENST00000456883 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| intron-3CDS | ENST00000434528 | ENST00000537452 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| intron-3CDS | ENST00000434528 | ENST00000545875 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| intron-intron | ENST00000434528 | ENST00000534967 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000320574 | POLE | chr12 | 133248801 | - | ENST00000204726 | GOLGA3 | chr12 | 133360893 | - | 7408 | 1838 | 44 | 3211 | 1055 |
| ENST00000320574 | POLE | chr12 | 133248801 | - | ENST00000450791 | GOLGA3 | chr12 | 133360893 | - | 7402 | 1838 | 44 | 3211 | 1055 |
| ENST00000320574 | POLE | chr12 | 133248801 | - | ENST00000456883 | GOLGA3 | chr12 | 133360893 | - | 3501 | 1838 | 44 | 2887 | 947 |
| ENST00000535270 | POLE | chr12 | 133248801 | - | ENST00000204726 | GOLGA3 | chr12 | 133360893 | - | 7296 | 1726 | 13 | 3099 | 1028 |
| ENST00000535270 | POLE | chr12 | 133248801 | - | ENST00000450791 | GOLGA3 | chr12 | 133360893 | - | 7290 | 1726 | 13 | 3099 | 1028 |
| ENST00000535270 | POLE | chr12 | 133248801 | - | ENST00000456883 | GOLGA3 | chr12 | 133360893 | - | 3389 | 1726 | 13 | 2775 | 920 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000320574 | ENST00000204726 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - | 0.000260064 | 0.99973994 |
| ENST00000320574 | ENST00000450791 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - | 0.000259617 | 0.9997404 |
| ENST00000320574 | ENST00000456883 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - | 0.004440758 | 0.9955592 |
| ENST00000535270 | ENST00000204726 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - | 0.000155296 | 0.9998447 |
| ENST00000535270 | ENST00000450791 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - | 0.000154926 | 0.999845 |
| ENST00000535270 | ENST00000456883 | POLE | chr12 | 133248801 | - | GOLGA3 | chr12 | 133360893 | - | 0.002987865 | 0.99701214 |
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Fusion Genomic Features for POLE-GOLGA3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for POLE-GOLGA3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133248801/chr12:133360893) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GOLGA3 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000204726 | 14 | 24 | 1231_1369 | 1041 | 1499.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000450791 | 13 | 23 | 1231_1369 | 1041 | 1499.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000456883 | 14 | 22 | 1231_1369 | 1041 | 1391.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000537452 | 13 | 15 | 1231_1369 | 1041 | 1135.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000545875 | 14 | 16 | 1231_1369 | 1041 | 1135.0 | Compositional bias | Note=Gln-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | POLE | chr12:133248801 | chr12:133360893 | ENST00000320574 | - | 16 | 49 | 2221_2238 | 598 | 2287.0 | Motif | CysB motif |
| Hgene | POLE | chr12:133248801 | chr12:133360893 | ENST00000320574 | - | 16 | 49 | 2158_2190 | 598 | 2287.0 | Zinc finger | CysA-type |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000204726 | 14 | 24 | 394_1459 | 1041 | 1499.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000450791 | 13 | 23 | 394_1459 | 1041 | 1499.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000456883 | 14 | 22 | 394_1459 | 1041 | 1391.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000537452 | 13 | 15 | 394_1459 | 1041 | 1135.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000545875 | 14 | 16 | 394_1459 | 1041 | 1135.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000204726 | 14 | 24 | 20_95 | 1041 | 1499.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000204726 | 14 | 24 | 538_744 | 1041 | 1499.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000450791 | 13 | 23 | 20_95 | 1041 | 1499.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000450791 | 13 | 23 | 538_744 | 1041 | 1499.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000456883 | 14 | 22 | 20_95 | 1041 | 1391.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000456883 | 14 | 22 | 538_744 | 1041 | 1391.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000537452 | 13 | 15 | 20_95 | 1041 | 1135.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000537452 | 13 | 15 | 538_744 | 1041 | 1135.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000545875 | 14 | 16 | 20_95 | 1041 | 1135.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000545875 | 14 | 16 | 538_744 | 1041 | 1135.0 | Compositional bias | Note=Gln-rich | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000204726 | 14 | 24 | 172_257 | 1041 | 1499.0 | Region | Note=Golgi-targeting domain | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000450791 | 13 | 23 | 172_257 | 1041 | 1499.0 | Region | Note=Golgi-targeting domain | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000456883 | 14 | 22 | 172_257 | 1041 | 1391.0 | Region | Note=Golgi-targeting domain | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000537452 | 13 | 15 | 172_257 | 1041 | 1135.0 | Region | Note=Golgi-targeting domain | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000545875 | 14 | 16 | 172_257 | 1041 | 1135.0 | Region | Note=Golgi-targeting domain |
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Fusion Gene Sequence for POLE-GOLGA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >66933_66933_1_POLE-GOLGA3_POLE_chr12_133248801_ENST00000320574_GOLGA3_chr12_133360893_ENST00000204726_length(transcript)=7408nt_BP=1838nt CGCCAAATTTCTCCCCTGAAGCAGAGGTGGTAGCCAACGGCTCCATGTCTCTGAGGAGCGGCGGGCGGCGGCGCGCGGACCCAGGCGCGG ATGGCGAGGCCAGCAGGGATGATGGCGCCACTTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATT TGCGGTTTGGTTTTGAGCGGCTGAAGGAGCCTGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTACCGAGATTTTAGATGAAGATA AGCGCTTAGGCAGTGCAGTGGATTACTACTTTATTCAAGATGACGGAAGCAGATTTAAGGTGGCTTTGCCCTATAAACCGTATTTCTACA TTGCGACCAGAAAGGGTTGTGAGCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCA AAGAGGATCTGGACTTGCCAAATCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAG TGAGGAAGGAGATCTCCCCTGCCGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGC AGAGGGGCGGTGTCATTACTGATGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATG TTCCCTACCACATCCGCCTCTCCATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAG AAATCACCCGCCGAGATGACCTTGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTC CTGATGCTGAGACAGACCAGATTATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAG ATATTGAAGATTTTGAGTTCACCCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAA GGTGGTTTGAACACGTCCAGGAGACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGG CAGCAGTCCACGGTCTGAGCATGCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGG ACTGCCTCAGGTGGGTGAAGAGGGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATC CCGTGGAGCTAGACCCGGAGGACATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCA CTTACTACCTGTACATGAAGTACGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGG GCTCTGGCACTCTGTGTGAGGCCTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATA AGCTGACGGACGACGGACACGTGCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATA TCCCTTGCCGGTTTAGGATGAATCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGG AGAAAGTGCCTGTGGAGCAAGTCACCAACTTTGAAGAGGAAAGGATCCAGGCCCTGGAGGCGGAGCTGCAGGCTGTCAGTCATAGCAAGA CGCTGCTGGAAAAGGAACTGCAGGAGGTCATAGCGCTGACCAGCCAGGAGCTGGAGGAGTCCCGGGAGAAGGTGCTGGAGCTGGAGGACG AGCTTCAAGAATCCAGAGGCTTTAGGAAGAAGATAAAACGCCTTGAGGAGTCAAACAAGAAGTTGGCTCTTGAATTAGAGCACGAGAAAG GGAAGCTTACGGGCCTCGGTCAGTCCAACGCAGCTCTGCGGGAACACAACAGCATCCTAGAAACAGCTTTGGCCAAGAGGGAGGCAGACC TAGTCCAGTTGAACCTTCAGGTGCAGGCAGTTTTGCAGCGCAAAGAAGAGGAGGATCGCCAGATGAAGCATCTTGTCCAGGCCCTGCAGG CCTCACTAGAGAAGGAGAAGGAGAAGGTGAACAGCCTCAAGGAGCAGGTGGCTGCTGCCAAGGTGGAAGCCGGGCATAACCGCCGCCACT TCAAGGCGGCCTCCTTGGAGCTGAGTGAGGTGAAGAAGGAGCTGCAGGCCAAGGAACACCTGGTGCAGAAGCTGCAGGCCGAGGCCGACG ACCTTCAGATTCGGGAGGGGAAACATTCCCAGGAGATAGCACAGTTCCAAGCAGAGCTGGCCGAGGCCCGGGCACAGCTCCAGCTCCTGC AGAAGCAGCTGGACGAGCAGCTCAGCAAACAGCCCGTGGGAAACCAAGAGATGGAAAATCTCAAATGGGAGGTGGATCAGAAAGAAAGAG AAATCCAGTCCTTGAAGCAGCAGCTGGACTTGACGGAGCAGCAGGGCAGGAAGGAACTGGAAGGGCTACAGCAGCTGCTGCAGAACGTCA AGTCTGAGTTGGAGATGGCCCAGGAAGACCTGTCCATGACCCAGAAGGATAAATTTATGCTCCAGGCAAAAGTGTCGGAGCTGAAGAACA ACATGAAGACCCTGCTCCAGCAGAACCAGCAGCTCAAGCTGGACCTACGCCGCGGCGCGGCCAAGACGAGAAAGGAGCCGAAAGGCGAGG CCAGCTCTTCCAACCCTGCCACGCCCATCAAGATCCCGGACTGCCCAGTTCCCGCCTCGCTGCTGGAGGAGCTGCTGAGACCACCGCCCG CCGTGAGCAAGGAGCCCCTCAAGAACCTGAACAGCTGCCTCCAGCAGCTCAAGCAGGAGATGGACAGCCTGCAGCGCCAGATGGAGGAGC ACGCCCTGACGGTGCACGAGTCTCTGTCCTCGTGGACGCCGCTGGAGCCAGCCACTGCCAGCCCTGTGCCCCCGGGGGGTCACGCCGGCC CACGCGGCGACCCACAGAGACACAGTCAGAGCAGGGCTTCCAAAGAAGGGCCGGGAGAGTGACTGCTGTGGACTCGCCTCCGTGCGCCGC TGCCCCAGAAGGCTCTTATCAATGTTATTTATTTGATTGTGTGGTCGATGTTTTTCTAAGACATGAAATTTAAGTTTTGTTTTGCCTTTA ACAAGAAGTAAAATATATAGCAGAATGAGAGCCAAGGACTAGAAAAACATTCGAAGATCACAATTAGCTTTTCACATGGAATGACCAACT CTTAAAAGCCTGATAGGCTCTCGGCGAGGAGCTTTGAACGTGTCTGAAGGGTTACTTGTAGGTCGTGGCTTCTGAGCGGCCACCGATGCT GCTCTCTGCGGGTGACAGGGAGAGGCTGCGTAACTGGGAGCAGCTGTGTGACAGGGTCTGCGGCACCGCGCCTGGCCAGGCCGGCTGCAG TTTCTCACTTCCCTGTTCCATTCAGTAAGAGCTTTACTTTTCCGCAGAAATGAAATTTTATCTGTACCTTTGGCTTTTTACTTGTTTTTT TGGATAGCCATCCCACCATAGGATGTGTACATAGATACTGAATATCATAATCCAATCTTTGTTTTTTTTTTTTTTTTTTTTTTGAGACAG AGTCTCGCTTTGTTGCCCAGGCTGGAGTGCAGTGGCACACTCTCCGCTCACTGCAAGCTCCGCCTCCCAGGTTCATGCGATTCTCCTGCC TCAGCCTCTCGAGTAGCTGGGATTACAGGCGTGCGCCACTATGCCAGGCTAATGTTTGTATTTTTAGTAGCAATGGGGTTTCACCATGTT GGCCAGGATGGTCTCGATCTCCTGACCTCAAGTGATCTGCCCATCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCTGCGCC CGGCCTGTCACCCAGTCTTTAAGAAGCATATGCTCATGTTATTGAAGAAGAACCTACTTATTATTGATTGCCTTTTGAAAATTTGTTGGG AATAATTTACCTGCAGGATTTAGGGATAGTCAGAAAATTCTAAGAAATATAATTATTTTATTTACCTTCTAAAGCCAAATATTCTTACAC AGAAAGGTCCTCTGTTGTTCTGGTTTTACTTTGTTGCTGAGGATCTTTCCTTCCTGCTGGTCTCTTCCTCTCAGGCCACTGGCCCTGTGT GATTCCACCGTGGCTGGCCACTGGGAAGGGGCAGCTTGGACCCTTGGTCAGGCCTGACGGCCATCAGGAGGCACAAGGACACTGAGGCCC CATATCTGATCTGACCTTTGGGGGGGCACAGGGAGAGGCCGGTGGAGGAGGAGGAGGAGAGCAGACCAGGGGCTCCCTGCAGCGACTCCC GCGGTTTCCCCTGGAGTCAGCCAGGTGTAGGTCGCAGGCGGTAACAAACCTCACACTCCTGTTCCCCAAGTGAAAATCTTTACCATTGTC TGTGGGAGCGCCTGTACTCGTGTGTAGGAGCACCTGTACTTCTGCAGTCATCGAGAAGTCCTGGATCTTTTGTGGTTACACCAGCATCAT GTGGCAAGCAGAGGCGACTTCCGGAAGAGACAGGCAGGCACCGTGAGGAAGGTGGCTGTGCTCTCCCAGGTGTCTCAGAGACAGATGCCT TATTTAAAATCAGCACGACATGTGTGAGATCTTCTGTTTCCTACCCCAAATCCTGAAACCCTGCAGACACTGGCTGACTGGGAGAGGTGG GGTCTGTAAGTTGTCCCCTAGTTTGCTAAGAAAATCTAAAATAATATTTATTATATGAGTTAGGAGAGAGAGAATGGGTCCGCGTGGCCT CCTCTGCAGATGTACTGGTCTGAAATGAGGTTCTGAGTCACTGGCCAGGCCAGATGTGCTCATGTCGGTGTCTGGTGTCTGTTTTGTGGA GAAAACAGTATGGTGTGTTTTAAGCTATTTGTGTTCTGTTGTAATATACTTTTAGAAGGTTAATTGGTAAGGTTAAGGTAGCATTAACCA CAAAGATGTTTGGTATTTAAAAAATATTCTCTAGCAAATATTGGAATTTCCAAAATATATCATTTGTACAGGGTTAATTTTGAAATAATA CTTGAAAATTTCATTATAAATATATCCTACTTTTTATCTTAAGTTGAAGATGTTATTTACTAAATTGTTCTTGTACCATTAGAAAAAAAA ATACGGCAATTTACGTTCTTATTTATTTTGGCTGTACTACCCCTTTGTTTTAATTTTAAAATCAAGAAATCGGGCCGGGCGCGGTGGCTC ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAAGAGGTCCAGACCATCCTGGCCAACATGGCAAAAC CCCGTCTTTACTAAACATACAAAAATTAGCCGGGTGTCGTAGTGCGCACCTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCA CTTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAT AAATAAATGATTTTAAAAAATCTAAAATCGAGAAATCACACATTCAGTGGGGAGCGACTTCTCCTTGCTTATGGGAAGTCCTCAAGTGAG TGATGTTCACCATGTATTTTTTTTTCTCTTAGGACAGACTAATTCTGAAAATACCGAAGGAAAAGTAGCTCTATGTTCTCACCCCGGTTT TCCTGCGTGTGTGCCCTTGGGTGCGATGCCTCCCCCAGCGCTCTGTGGTCGCCGGTGCCAGGGCCCCCTCTGGTTTGGCAGGGCCTGGCT GCCTTTGCTCCCTGCAGTGAGTCTTTTGGTGTTTTCATGCACGGCTTGTGCTTCTGGATCTGAGGCCTCTCGTGTTCACGCGGACACTTC CTTCCTTAAGAAGACGCCTAAAAGAGGAAGTTGGAATTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTG CAGTGGCGTGATCTCTGCTCACTGCAAGCTCCGCCATCTGGGTTCAAGCGATTCTCCTGCCTCATTCTCCCCAGTAGCTGGGATTACAGG TGCCCGCCACCACACCAGCCTAATTTTTGTATTTTTAGAGGGGTGGAGTTCCACCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCA GGTGATCCTGAGCCTCAGCCTCCCAAAGTGCTGGAATTATAGGCGTGAACCACCGCCCCCGGCTGCAGTTGGATTTTTAAATTGCTTTTT TTTATTGTTGAGGTTTTTTTATCTCCAAGGGACTCTCCCGGCACTTCTACCTTCCAGAGTTACTTCAGTGCATAAAGTTTGAATTATTTT GTTCTTGTGGGCAGAAGTGGGAATGATGGAATATCCTCACGGAAAAGGCAGTGAAGTTGGGAGTACTGCTTACAAAACAGGGTCACCAGT GCATTATGTGGCGTGTTCATCCCCACGCCGTGTGTCACGGGCTAGGGCGGCGTGTTCATCCCCACACCGTGTGTCACAACAGGCTAGGGC ACTTCACGATGTCACTACTTGTTTTTCTGATGTTCCAAAAACAACGTAACTTGGTTTTCATGTGTTTTTCCGTGGTATATGTGAGATTGA TGCTACGGGTCTTACGGACTCACACCCGTTCCCACTCTCTGCAATATGGATCAGGCAGTGTTTCTGATAGGATGTGAAATGGACTCTCCT CGGGTGGGTCCAGCAGGGGCCCTGCCCACCAGAACACAGTCCGTGCTGTGCTGCGCTAAGGAGCTGGCCCTCAACTCTCCTTGGTGCAGG GTTCCCACAACCGAGTTCTAGTTCCCTGAGGTCTTTAAAAACAAAAACAGAATGTTGTACGTGAAGATTCTAGGAGGGGAGGGACCAGCA AATCTGAGAGAACCGTCCTGGGGCCTCCCTTCGAGGAGCCCTCTGATGTGAGGAGGGACTTGAGTTGAGTGACGCTGTGGTGTGAGGTGT TCTGAGCTCACTGACCGGAAGGTCCAGGTGAATCTCGTCATAAGTGATCTCAGGCTCTCACAGGATCCGGAGGGAAATGTGTTAGAGGGT CTGGAAAATTCAGTGCTTTTGAGTTACTTGTTTTTATTAAAAATTTCCTCACAAAAGAGAGTCCTCAAGTTGTGGCTGTTCTTGGGAAAG GGGTCACCGTGTCTGACAAAGTGTAACTTTAAAAAGCACGTTGATTTTTTACAAATGTAAGTGTGCTTGGGAATTCCTTAAATTTTGTGC >66933_66933_1_POLE-GOLGA3_POLE_chr12_133248801_ENST00000320574_GOLGA3_chr12_133360893_ENST00000204726_length(amino acids)=1055AA_BP=598 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDD GSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPV VLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATE QPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEERIQALEAELQAVSHSKTLLEKELQEVIALTS QELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRK EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQ FQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQ KDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQ -------------------------------------------------------------- >66933_66933_2_POLE-GOLGA3_POLE_chr12_133248801_ENST00000320574_GOLGA3_chr12_133360893_ENST00000450791_length(transcript)=7402nt_BP=1838nt CGCCAAATTTCTCCCCTGAAGCAGAGGTGGTAGCCAACGGCTCCATGTCTCTGAGGAGCGGCGGGCGGCGGCGCGCGGACCCAGGCGCGG ATGGCGAGGCCAGCAGGGATGATGGCGCCACTTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATT TGCGGTTTGGTTTTGAGCGGCTGAAGGAGCCTGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTACCGAGATTTTAGATGAAGATA AGCGCTTAGGCAGTGCAGTGGATTACTACTTTATTCAAGATGACGGAAGCAGATTTAAGGTGGCTTTGCCCTATAAACCGTATTTCTACA TTGCGACCAGAAAGGGTTGTGAGCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCA AAGAGGATCTGGACTTGCCAAATCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAG TGAGGAAGGAGATCTCCCCTGCCGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGC AGAGGGGCGGTGTCATTACTGATGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATG TTCCCTACCACATCCGCCTCTCCATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAG AAATCACCCGCCGAGATGACCTTGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTC CTGATGCTGAGACAGACCAGATTATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAG ATATTGAAGATTTTGAGTTCACCCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAA GGTGGTTTGAACACGTCCAGGAGACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGG CAGCAGTCCACGGTCTGAGCATGCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGG ACTGCCTCAGGTGGGTGAAGAGGGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATC CCGTGGAGCTAGACCCGGAGGACATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCA CTTACTACCTGTACATGAAGTACGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGG GCTCTGGCACTCTGTGTGAGGCCTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATA AGCTGACGGACGACGGACACGTGCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATA TCCCTTGCCGGTTTAGGATGAATCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGG AGAAAGTGCCTGTGGAGCAAGTCACCAACTTTGAAGAGGAAAGGATCCAGGCCCTGGAGGCGGAGCTGCAGGCTGTCAGTCATAGCAAGA CGCTGCTGGAAAAGGAACTGCAGGAGGTCATAGCGCTGACCAGCCAGGAGCTGGAGGAGTCCCGGGAGAAGGTGCTGGAGCTGGAGGACG AGCTTCAAGAATCCAGAGGCTTTAGGAAGAAGATAAAACGCCTTGAGGAGTCAAACAAGAAGTTGGCTCTTGAATTAGAGCACGAGAAAG GGAAGCTTACGGGCCTCGGTCAGTCCAACGCAGCTCTGCGGGAACACAACAGCATCCTAGAAACAGCTTTGGCCAAGAGGGAGGCAGACC TAGTCCAGTTGAACCTTCAGGTGCAGGCAGTTTTGCAGCGCAAAGAAGAGGAGGATCGCCAGATGAAGCATCTTGTCCAGGCCCTGCAGG CCTCACTAGAGAAGGAGAAGGAGAAGGTGAACAGCCTCAAGGAGCAGGTGGCTGCTGCCAAGGTGGAAGCCGGGCATAACCGCCGCCACT TCAAGGCGGCCTCCTTGGAGCTGAGTGAGGTGAAGAAGGAGCTGCAGGCCAAGGAACACCTGGTGCAGAAGCTGCAGGCCGAGGCCGACG ACCTTCAGATTCGGGAGGGGAAACATTCCCAGGAGATAGCACAGTTCCAAGCAGAGCTGGCCGAGGCCCGGGCACAGCTCCAGCTCCTGC AGAAGCAGCTGGACGAGCAGCTCAGCAAACAGCCCGTGGGAAACCAAGAGATGGAAAATCTCAAATGGGAGGTGGATCAGAAAGAAAGAG AAATCCAGTCCTTGAAGCAGCAGCTGGACTTGACGGAGCAGCAGGGCAGGAAGGAACTGGAAGGGCTACAGCAGCTGCTGCAGAACGTCA AGTCTGAGTTGGAGATGGCCCAGGAAGACCTGTCCATGACCCAGAAGGATAAATTTATGCTCCAGGCAAAAGTGTCGGAGCTGAAGAACA ACATGAAGACCCTGCTCCAGCAGAACCAGCAGCTCAAGCTGGACCTACGCCGCGGCGCGGCCAAGACGAGAAAGGAGCCGAAAGGCGAGG CCAGCTCTTCCAACCCTGCCACGCCCATCAAGATCCCGGACTGCCCAGTTCCCGCCTCGCTGCTGGAGGAGCTGCTGAGACCACCGCCCG CCGTGAGCAAGGAGCCCCTCAAGAACCTGAACAGCTGCCTCCAGCAGCTCAAGCAGGAGATGGACAGCCTGCAGCGCCAGATGGAGGAGC ACGCCCTGACGGTGCACGAGTCTCTGTCCTCGTGGACGCCGCTGGAGCCAGCCACTGCCAGCCCTGTGCCCCCGGGGGGTCACGCCGGCC CACGCGGCGACCCACAGAGACACAGTCAGAGCAGGGCTTCCAAAGAAGGGCCGGGAGAGTGACTGCTGTGGACTCGCCTCCGTGCGCCGC TGCCCCAGAAGGCTCTTATCAATGTTATTTATTTGATTGTGTGGTCGATGTTTTTCTAAGACATGAAATTTAAGTTTTGTTTTGCCTTTA ACAAGAAGTAAAATATATAGCAGAATGAGAGCCAAGGACTAGAAAAACATTCGAAGATCACAATTAGCTTTTCACATGGAATGACCAACT CTTAAAAGCCTGATAGGCTCTCGGCGAGGAGCTTTGAACGTGTCTGAAGGGTTACTTGTAGGTCGTGGCTTCTGAGCGGCCACCGATGCT GCTCTCTGCGGGTGACAGGGAGAGGCTGCGTAACTGGGAGCAGCTGTGTGACAGGGTCTGCGGCACCGCGCCTGGCCAGGCCGGCTGCAG TTTCTCACTTCCCTGTTCCATTCAGTAAGAGCTTTACTTTTCCGCAGAAATGAAATTTTATCTGTACCTTTGGCTTTTTACTTGTTTTTT TGGATAGCCATCCCACCATAGGATGTGTACATAGATACTGAATATCATAATCCAATCTTTGTTTTTTTTTTTTTTTTTTTTTTGAGACAG AGTCTCGCTTTGTTGCCCAGGCTGGAGTGCAGTGGCACACTCTCCGCTCACTGCAAGCTCCGCCTCCCAGGTTCATGCGATTCTCCTGCC TCAGCCTCTCGAGTAGCTGGGATTACAGGCGTGCGCCACTATGCCAGGCTAATGTTTGTATTTTTAGTAGCAATGGGGTTTCACCATGTT GGCCAGGATGGTCTCGATCTCCTGACCTCAAGTGATCTGCCCATCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCTGCGCC CGGCCTGTCACCCAGTCTTTAAGAAGCATATGCTCATGTTATTGAAGAAGAACCTACTTATTATTGATTGCCTTTTGAAAATTTGTTGGG AATAATTTACCTGCAGGATTTAGGGATAGTCAGAAAATTCTAAGAAATATAATTATTTTATTTACCTTCTAAAGCCAAATATTCTTACAC AGAAAGGTCCTCTGTTGTTCTGGTTTTACTTTGTTGCTGAGGATCTTTCCTTCCTGCTGGTCTCTTCCTCTCAGGCCACTGGCCCTGTGT GATTCCACCGTGGCTGGCCACTGGGAAGGGGCAGCTTGGACCCTTGGTCAGGCCTGACGGCCATCAGGAGGCACAAGGACACTGAGGCCC CATATCTGATCTGACCTTTGGGGGGGCACAGGGAGAGGCCGGTGGAGGAGGAGGAGGAGAGCAGACCAGGGGCTCCCTGCAGCGACTCCC GCGGTTTCCCCTGGAGTCAGCCAGGTGTAGGTCGCAGGCGGTAACAAACCTCACACTCCTGTTCCCCAAGTGAAAATCTTTACCATTGTC TGTGGGAGCGCCTGTACTCGTGTGTAGGAGCACCTGTACTTCTGCAGTCATCGAGAAGTCCTGGATCTTTTGTGGTTACACCAGCATCAT GTGGCAAGCAGAGGCGACTTCCGGAAGAGACAGGCAGGCACCGTGAGGAAGGTGGCTGTGCTCTCCCAGGTGTCTCAGAGACAGATGCCT TATTTAAAATCAGCACGACATGTGTGAGATCTTCTGTTTCCTACCCCAAATCCTGAAACCCTGCAGACACTGGCTGACTGGGAGAGGTGG GGTCTGTAAGTTGTCCCCTAGTTTGCTAAGAAAATCTAAAATAATATTTATTATATGAGTTAGGAGAGAGAGAATGGGTCCGCGTGGCCT CCTCTGCAGATGTACTGGTCTGAAATGAGGTTCTGAGTCACTGGCCAGGCCAGATGTGCTCATGTCGGTGTCTGGTGTCTGTTTTGTGGA GAAAACAGTATGGTGTGTTTTAAGCTATTTGTGTTCTGTTGTAATATACTTTTAGAAGGTTAATTGGTAAGGTTAAGGTAGCATTAACCA CAAAGATGTTTGGTATTTAAAAAATATTCTCTAGCAAATATTGGAATTTCCAAAATATATCATTTGTACAGGGTTAATTTTGAAATAATA CTTGAAAATTTCATTATAAATATATCCTACTTTTTATCTTAAGTTGAAGATGTTATTTACTAAATTGTTCTTGTACCATTAGAAAAAAAA ATACGGCAATTTACGTTCTTATTTATTTTGGCTGTACTACCCCTTTGTTTTAATTTTAAAATCAAGAAATCGGGCCGGGCGCGGTGGCTC ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAAGAGGTCCAGACCATCCTGGCCAACATGGCAAAAC CCCGTCTTTACTAAACATACAAAAATTAGCCGGGTGTCGTAGTGCGCACCTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCA CTTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAT AAATAAATGATTTTAAAAAATCTAAAATCGAGAAATCACACATTCAGTGGGGAGCGACTTCTCCTTGCTTATGGGAAGTCCTCAAGTGAG TGATGTTCACCATGTATTTTTTTTTCTCTTAGGACAGACTAATTCTGAAAATACCGAAGGAAAAGTAGCTCTATGTTCTCACCCCGGTTT TCCTGCGTGTGTGCCCTTGGGTGCGATGCCTCCCCCAGCGCTCTGTGGTCGCCGGTGCCAGGGCCCCCTCTGGTTTGGCAGGGCCTGGCT GCCTTTGCTCCCTGCAGTGAGTCTTTTGGTGTTTTCATGCACGGCTTGTGCTTCTGGATCTGAGGCCTCTCGTGTTCACGCGGACACTTC CTTCCTTAAGAAGACGCCTAAAAGAGGAAGTTGGAATTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTG CAGTGGCGTGATCTCTGCTCACTGCAAGCTCCGCCATCTGGGTTCAAGCGATTCTCCTGCCTCATTCTCCCCAGTAGCTGGGATTACAGG TGCCCGCCACCACACCAGCCTAATTTTTGTATTTTTAGAGGGGTGGAGTTCCACCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCA GGTGATCCTGAGCCTCAGCCTCCCAAAGTGCTGGAATTATAGGCGTGAACCACCGCCCCCGGCTGCAGTTGGATTTTTAAATTGCTTTTT TTTATTGTTGAGGTTTTTTTATCTCCAAGGGACTCTCCCGGCACTTCTACCTTCCAGAGTTACTTCAGTGCATAAAGTTTGAATTATTTT GTTCTTGTGGGCAGAAGTGGGAATGATGGAATATCCTCACGGAAAAGGCAGTGAAGTTGGGAGTACTGCTTACAAAACAGGGTCACCAGT GCATTATGTGGCGTGTTCATCCCCACGCCGTGTGTCACGGGCTAGGGCGGCGTGTTCATCCCCACACCGTGTGTCACAACAGGCTAGGGC ACTTCACGATGTCACTACTTGTTTTTCTGATGTTCCAAAAACAACGTAACTTGGTTTTCATGTGTTTTTCCGTGGTATATGTGAGATTGA TGCTACGGGTCTTACGGACTCACACCCGTTCCCACTCTCTGCAATATGGATCAGGCAGTGTTTCTGATAGGATGTGAAATGGACTCTCCT CGGGTGGGTCCAGCAGGGGCCCTGCCCACCAGAACACAGTCCGTGCTGTGCTGCGCTAAGGAGCTGGCCCTCAACTCTCCTTGGTGCAGG GTTCCCACAACCGAGTTCTAGTTCCCTGAGGTCTTTAAAAACAAAAACAGAATGTTGTACGTGAAGATTCTAGGAGGGGAGGGACCAGCA AATCTGAGAGAACCGTCCTGGGGCCTCCCTTCGAGGAGCCCTCTGATGTGAGGAGGGACTTGAGTTGAGTGACGCTGTGGTGTGAGGTGT TCTGAGCTCACTGACCGGAAGGTCCAGGTGAATCTCGTCATAAGTGATCTCAGGCTCTCACAGGATCCGGAGGGAAATGTGTTAGAGGGT CTGGAAAATTCAGTGCTTTTGAGTTACTTGTTTTTATTAAAAATTTCCTCACAAAAGAGAGTCCTCAAGTTGTGGCTGTTCTTGGGAAAG GGGTCACCGTGTCTGACAAAGTGTAACTTTAAAAAGCACGTTGATTTTTTACAAATGTAAGTGTGCTTGGGAATTCCTTAAATTTTGTGC >66933_66933_2_POLE-GOLGA3_POLE_chr12_133248801_ENST00000320574_GOLGA3_chr12_133360893_ENST00000450791_length(amino acids)=1055AA_BP=598 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDD GSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPV VLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATE QPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEERIQALEAELQAVSHSKTLLEKELQEVIALTS QELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRK EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQ FQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQ KDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQ -------------------------------------------------------------- >66933_66933_3_POLE-GOLGA3_POLE_chr12_133248801_ENST00000320574_GOLGA3_chr12_133360893_ENST00000456883_length(transcript)=3501nt_BP=1838nt CGCCAAATTTCTCCCCTGAAGCAGAGGTGGTAGCCAACGGCTCCATGTCTCTGAGGAGCGGCGGGCGGCGGCGCGCGGACCCAGGCGCGG ATGGCGAGGCCAGCAGGGATGATGGCGCCACTTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATT TGCGGTTTGGTTTTGAGCGGCTGAAGGAGCCTGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTACCGAGATTTTAGATGAAGATA AGCGCTTAGGCAGTGCAGTGGATTACTACTTTATTCAAGATGACGGAAGCAGATTTAAGGTGGCTTTGCCCTATAAACCGTATTTCTACA TTGCGACCAGAAAGGGTTGTGAGCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCA AAGAGGATCTGGACTTGCCAAATCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAG TGAGGAAGGAGATCTCCCCTGCCGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGC AGAGGGGCGGTGTCATTACTGATGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATG TTCCCTACCACATCCGCCTCTCCATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAG AAATCACCCGCCGAGATGACCTTGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTC CTGATGCTGAGACAGACCAGATTATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAG ATATTGAAGATTTTGAGTTCACCCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAA GGTGGTTTGAACACGTCCAGGAGACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGG CAGCAGTCCACGGTCTGAGCATGCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGG ACTGCCTCAGGTGGGTGAAGAGGGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATC CCGTGGAGCTAGACCCGGAGGACATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCA CTTACTACCTGTACATGAAGTACGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGG GCTCTGGCACTCTGTGTGAGGCCTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATA AGCTGACGGACGACGGACACGTGCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATA TCCCTTGCCGGTTTAGGATGAATCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGG AGAAAGTGCCTGTGGAGCAAGTCACCAACTTTGAAGAGGAAAGGATCCAGGCCCTGGAGGCGGAGCTGCAGGCTGTCAGTCATAGCAAGA CGCTGCTGGAAAAGGAACTGCAGGAGGTCATAGCGCTGACCAGCCAGGAGCTGGAGGAGTCCCGGGAGAAGGTGCTGGAGCTGGAGGACG AGCTTCAAGAATCCAGAGGCTTTAGGAAGAAGATAAAACGCCTTGAGGAGTCAAACAAGAAGTTGGCTCTTGAATTAGAGCACGAGAAAG GGAAGCTTACGGGCCTCGGTCAGTCCAACGCAGCTCTGCGGGAACACAACAGCATCCTAGAAACAGCTTTGGCCAAGAGGGAGGCAGACC TAGTCCAGTTGAACCTTCAGGTGCAGGCAGTTTTGCAGCGCAAAGAAGAGGAGGATCGCCAGATGAAGCATCTTGTCCAGGCCCTGCAGG CCTCACTAGAGAAGGAGAAGGAGAAGGTGAACAGCCTCAAGGAGCAGGTGGCTGCTGCCAAGGTGGAAGCCGGGCATAACCGCCGCCACT TCAAGGCGGCCTCCTTGGAGCTGAGTGAGGTGAAGAAGGAGCTGCAGGCCAAGGAACACCTGGTGCAGAAGCTGCAGGCCGAGGCCGACG ACCTTCAGATTCGGGAGGGGAAACATTCCCAGGAGATAGCACAGTTCCAAGCAGAGCTGGCCGAGGCCCGGGCACAGCTCCAGCTCCTGC AGAAGCAGCTGGACGAGCAGCTCAGCAAACAGCCCGTGGGAAACCAAGAGATGGAAAATCTCAAATGGGAGGTGGATCAGAAAGAAAGAG AAATCCAGTCCTTGAAGCAGCAGCTGGACTTGACGGAGCAGCAGGGCAGGAAGGAACTGGAAGGGCTACAGCAGCTGCTGCAGAACGTCA AGTCTGAGTTGGAGATGGCCCAGGAAGACCTGTCCATGACCCAGAAGGATAAATTTATGCTCCAGGCAAAAGTGTCGGAGCTGAAGAACA ACATGAAGACCCTGCTCCAGCAGAACCAGCAGCTCAAGCTGGACCTACGCCGCGGCGCGGCCAAGACGGTACTCAGGCCCGCGTCCCTCC CGGGGTAGCCGACGTGCGCTGTAGATGCTCTCGGACAGGAGGCTGGCAGACGTGTTAGTCATTCAGACATAAACGGATTTGTTGAGCCCA CACTGAGCAGCTGCTGTGTAGTCAGTGGTAATGGGGTGACAGATGAAATCATTTCATTCTGGTTTCATTCATCCAACAGTGTTTTCCTCG TTCTGTGAATTCAAATACCACTTTGTTGTAATGTGCTTTGTAAAGCAGATGAGCGGTGGTCTGTGACTCGGCAGTCCCTGCTGTGTGTGA AGGGCTGGGGCCCGGGAGCTGTGCCCAGGCGCCCGGCGGTTTTCTGTGCTCGGTCCACATCCATGTTTTCCAGGAGGCAGGTGGGAGGGC AGCGCTCGGATTGAGAGGCCGTTTAGCGTCGTGTGCTTATCTGTGGAAAAAGTTTGAAGTCCCAGAAAAGGGAGCCTAAGCTGGAAAACT TACTTAATTTCTTACGGAAATTCCACATCAAGGTCTTGAGTATCTGATGGGAGAAGCGTCTGGGAGAGCTGTAGTCTGTGGCTCGGCCCC >66933_66933_3_POLE-GOLGA3_POLE_chr12_133248801_ENST00000320574_GOLGA3_chr12_133360893_ENST00000456883_length(amino acids)=947AA_BP=598 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDD GSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPV VLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATE QPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEERIQALEAELQAVSHSKTLLEKELQEVIALTS QELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRK EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQ FQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQ -------------------------------------------------------------- >66933_66933_4_POLE-GOLGA3_POLE_chr12_133248801_ENST00000535270_GOLGA3_chr12_133360893_ENST00000204726_length(transcript)=7296nt_BP=1726nt AGCCAACGGCTCCATGTCTCTGAGGAGCGGCGGGCGGCGGCGCGCGGACCCAGGCGCGGATGGCGAGGCCAGCAGGGATGATGGCGCCAC TTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATTTGCGGTTTGGTTTTGAGCGGCTGAAGGAGCC TGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTGTGGCTTTGCCCTATAAACCGTATTTCTACATTGCGACCAGAAAGGGTTGTGA GCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCAAAGAGGATCTGGACTTGCCAAA TCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAGTGAGGAAGGAGATCTCCCCTGC CGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGCAGAGGGGCGGTGTCATTACTGA TGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATGTTCCCTACCACATCCGCCTCTC CATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAGAAATCACCCGCCGAGATGACCT TGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTCCTGATGCTGAGACAGACCAGAT TATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAGATATTGAAGATTTTGAGTTCAC CCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAAGGTGGTTTGAACACGTCCAGGA GACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGGCAGCAGTCCACGGTCTGAGCAT GCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGGACTGCCTCAGGTGGGTGAAGAG GGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATCCCGTGGAGCTAGACCCGGAGGA CATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCACTTACTACCTGTACATGAAGTA CGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGGGCTCTGGCACTCTGTGTGAGGC CTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATAAGCTGACGGACGACGGACACGT GCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATATCCCTTGCCGGTTTAGGATGAA TCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGGAGAAAGTGCCTGTGGAGCAAGT CACCAACTTTGAAGAGGAAAGGATCCAGGCCCTGGAGGCGGAGCTGCAGGCTGTCAGTCATAGCAAGACGCTGCTGGAAAAGGAACTGCA GGAGGTCATAGCGCTGACCAGCCAGGAGCTGGAGGAGTCCCGGGAGAAGGTGCTGGAGCTGGAGGACGAGCTTCAAGAATCCAGAGGCTT TAGGAAGAAGATAAAACGCCTTGAGGAGTCAAACAAGAAGTTGGCTCTTGAATTAGAGCACGAGAAAGGGAAGCTTACGGGCCTCGGTCA GTCCAACGCAGCTCTGCGGGAACACAACAGCATCCTAGAAACAGCTTTGGCCAAGAGGGAGGCAGACCTAGTCCAGTTGAACCTTCAGGT GCAGGCAGTTTTGCAGCGCAAAGAAGAGGAGGATCGCCAGATGAAGCATCTTGTCCAGGCCCTGCAGGCCTCACTAGAGAAGGAGAAGGA GAAGGTGAACAGCCTCAAGGAGCAGGTGGCTGCTGCCAAGGTGGAAGCCGGGCATAACCGCCGCCACTTCAAGGCGGCCTCCTTGGAGCT GAGTGAGGTGAAGAAGGAGCTGCAGGCCAAGGAACACCTGGTGCAGAAGCTGCAGGCCGAGGCCGACGACCTTCAGATTCGGGAGGGGAA ACATTCCCAGGAGATAGCACAGTTCCAAGCAGAGCTGGCCGAGGCCCGGGCACAGCTCCAGCTCCTGCAGAAGCAGCTGGACGAGCAGCT CAGCAAACAGCCCGTGGGAAACCAAGAGATGGAAAATCTCAAATGGGAGGTGGATCAGAAAGAAAGAGAAATCCAGTCCTTGAAGCAGCA GCTGGACTTGACGGAGCAGCAGGGCAGGAAGGAACTGGAAGGGCTACAGCAGCTGCTGCAGAACGTCAAGTCTGAGTTGGAGATGGCCCA GGAAGACCTGTCCATGACCCAGAAGGATAAATTTATGCTCCAGGCAAAAGTGTCGGAGCTGAAGAACAACATGAAGACCCTGCTCCAGCA GAACCAGCAGCTCAAGCTGGACCTACGCCGCGGCGCGGCCAAGACGAGAAAGGAGCCGAAAGGCGAGGCCAGCTCTTCCAACCCTGCCAC GCCCATCAAGATCCCGGACTGCCCAGTTCCCGCCTCGCTGCTGGAGGAGCTGCTGAGACCACCGCCCGCCGTGAGCAAGGAGCCCCTCAA GAACCTGAACAGCTGCCTCCAGCAGCTCAAGCAGGAGATGGACAGCCTGCAGCGCCAGATGGAGGAGCACGCCCTGACGGTGCACGAGTC TCTGTCCTCGTGGACGCCGCTGGAGCCAGCCACTGCCAGCCCTGTGCCCCCGGGGGGTCACGCCGGCCCACGCGGCGACCCACAGAGACA CAGTCAGAGCAGGGCTTCCAAAGAAGGGCCGGGAGAGTGACTGCTGTGGACTCGCCTCCGTGCGCCGCTGCCCCAGAAGGCTCTTATCAA TGTTATTTATTTGATTGTGTGGTCGATGTTTTTCTAAGACATGAAATTTAAGTTTTGTTTTGCCTTTAACAAGAAGTAAAATATATAGCA GAATGAGAGCCAAGGACTAGAAAAACATTCGAAGATCACAATTAGCTTTTCACATGGAATGACCAACTCTTAAAAGCCTGATAGGCTCTC GGCGAGGAGCTTTGAACGTGTCTGAAGGGTTACTTGTAGGTCGTGGCTTCTGAGCGGCCACCGATGCTGCTCTCTGCGGGTGACAGGGAG AGGCTGCGTAACTGGGAGCAGCTGTGTGACAGGGTCTGCGGCACCGCGCCTGGCCAGGCCGGCTGCAGTTTCTCACTTCCCTGTTCCATT CAGTAAGAGCTTTACTTTTCCGCAGAAATGAAATTTTATCTGTACCTTTGGCTTTTTACTTGTTTTTTTGGATAGCCATCCCACCATAGG ATGTGTACATAGATACTGAATATCATAATCCAATCTTTGTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTTTGTTGCCCAGGC TGGAGTGCAGTGGCACACTCTCCGCTCACTGCAAGCTCCGCCTCCCAGGTTCATGCGATTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGA TTACAGGCGTGCGCCACTATGCCAGGCTAATGTTTGTATTTTTAGTAGCAATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCC TGACCTCAAGTGATCTGCCCATCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCTGCGCCCGGCCTGTCACCCAGTCTTTAA GAAGCATATGCTCATGTTATTGAAGAAGAACCTACTTATTATTGATTGCCTTTTGAAAATTTGTTGGGAATAATTTACCTGCAGGATTTA GGGATAGTCAGAAAATTCTAAGAAATATAATTATTTTATTTACCTTCTAAAGCCAAATATTCTTACACAGAAAGGTCCTCTGTTGTTCTG GTTTTACTTTGTTGCTGAGGATCTTTCCTTCCTGCTGGTCTCTTCCTCTCAGGCCACTGGCCCTGTGTGATTCCACCGTGGCTGGCCACT GGGAAGGGGCAGCTTGGACCCTTGGTCAGGCCTGACGGCCATCAGGAGGCACAAGGACACTGAGGCCCCATATCTGATCTGACCTTTGGG GGGGCACAGGGAGAGGCCGGTGGAGGAGGAGGAGGAGAGCAGACCAGGGGCTCCCTGCAGCGACTCCCGCGGTTTCCCCTGGAGTCAGCC AGGTGTAGGTCGCAGGCGGTAACAAACCTCACACTCCTGTTCCCCAAGTGAAAATCTTTACCATTGTCTGTGGGAGCGCCTGTACTCGTG TGTAGGAGCACCTGTACTTCTGCAGTCATCGAGAAGTCCTGGATCTTTTGTGGTTACACCAGCATCATGTGGCAAGCAGAGGCGACTTCC GGAAGAGACAGGCAGGCACCGTGAGGAAGGTGGCTGTGCTCTCCCAGGTGTCTCAGAGACAGATGCCTTATTTAAAATCAGCACGACATG TGTGAGATCTTCTGTTTCCTACCCCAAATCCTGAAACCCTGCAGACACTGGCTGACTGGGAGAGGTGGGGTCTGTAAGTTGTCCCCTAGT TTGCTAAGAAAATCTAAAATAATATTTATTATATGAGTTAGGAGAGAGAGAATGGGTCCGCGTGGCCTCCTCTGCAGATGTACTGGTCTG AAATGAGGTTCTGAGTCACTGGCCAGGCCAGATGTGCTCATGTCGGTGTCTGGTGTCTGTTTTGTGGAGAAAACAGTATGGTGTGTTTTA AGCTATTTGTGTTCTGTTGTAATATACTTTTAGAAGGTTAATTGGTAAGGTTAAGGTAGCATTAACCACAAAGATGTTTGGTATTTAAAA AATATTCTCTAGCAAATATTGGAATTTCCAAAATATATCATTTGTACAGGGTTAATTTTGAAATAATACTTGAAAATTTCATTATAAATA TATCCTACTTTTTATCTTAAGTTGAAGATGTTATTTACTAAATTGTTCTTGTACCATTAGAAAAAAAAATACGGCAATTTACGTTCTTAT TTATTTTGGCTGTACTACCCCTTTGTTTTAATTTTAAAATCAAGAAATCGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTT GGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAAGAGGTCCAGACCATCCTGGCCAACATGGCAAAACCCCGTCTTTACTAAACATACAA AAATTAGCCGGGTGTCGTAGTGCGCACCTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGCT TGCAGTGAGCCGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAATAAATAAATGATTTTAAAAAATC TAAAATCGAGAAATCACACATTCAGTGGGGAGCGACTTCTCCTTGCTTATGGGAAGTCCTCAAGTGAGTGATGTTCACCATGTATTTTTT TTTCTCTTAGGACAGACTAATTCTGAAAATACCGAAGGAAAAGTAGCTCTATGTTCTCACCCCGGTTTTCCTGCGTGTGTGCCCTTGGGT GCGATGCCTCCCCCAGCGCTCTGTGGTCGCCGGTGCCAGGGCCCCCTCTGGTTTGGCAGGGCCTGGCTGCCTTTGCTCCCTGCAGTGAGT CTTTTGGTGTTTTCATGCACGGCTTGTGCTTCTGGATCTGAGGCCTCTCGTGTTCACGCGGACACTTCCTTCCTTAAGAAGACGCCTAAA AGAGGAAGTTGGAATTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCTGCTCAC TGCAAGCTCCGCCATCTGGGTTCAAGCGATTCTCCTGCCTCATTCTCCCCAGTAGCTGGGATTACAGGTGCCCGCCACCACACCAGCCTA ATTTTTGTATTTTTAGAGGGGTGGAGTTCCACCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCAGGTGATCCTGAGCCTCAGCCTC CCAAAGTGCTGGAATTATAGGCGTGAACCACCGCCCCCGGCTGCAGTTGGATTTTTAAATTGCTTTTTTTTATTGTTGAGGTTTTTTTAT CTCCAAGGGACTCTCCCGGCACTTCTACCTTCCAGAGTTACTTCAGTGCATAAAGTTTGAATTATTTTGTTCTTGTGGGCAGAAGTGGGA ATGATGGAATATCCTCACGGAAAAGGCAGTGAAGTTGGGAGTACTGCTTACAAAACAGGGTCACCAGTGCATTATGTGGCGTGTTCATCC CCACGCCGTGTGTCACGGGCTAGGGCGGCGTGTTCATCCCCACACCGTGTGTCACAACAGGCTAGGGCACTTCACGATGTCACTACTTGT TTTTCTGATGTTCCAAAAACAACGTAACTTGGTTTTCATGTGTTTTTCCGTGGTATATGTGAGATTGATGCTACGGGTCTTACGGACTCA CACCCGTTCCCACTCTCTGCAATATGGATCAGGCAGTGTTTCTGATAGGATGTGAAATGGACTCTCCTCGGGTGGGTCCAGCAGGGGCCC TGCCCACCAGAACACAGTCCGTGCTGTGCTGCGCTAAGGAGCTGGCCCTCAACTCTCCTTGGTGCAGGGTTCCCACAACCGAGTTCTAGT TCCCTGAGGTCTTTAAAAACAAAAACAGAATGTTGTACGTGAAGATTCTAGGAGGGGAGGGACCAGCAAATCTGAGAGAACCGTCCTGGG GCCTCCCTTCGAGGAGCCCTCTGATGTGAGGAGGGACTTGAGTTGAGTGACGCTGTGGTGTGAGGTGTTCTGAGCTCACTGACCGGAAGG TCCAGGTGAATCTCGTCATAAGTGATCTCAGGCTCTCACAGGATCCGGAGGGAAATGTGTTAGAGGGTCTGGAAAATTCAGTGCTTTTGA GTTACTTGTTTTTATTAAAAATTTCCTCACAAAAGAGAGTCCTCAAGTTGTGGCTGTTCTTGGGAAAGGGGTCACCGTGTCTGACAAAGT GTAACTTTAAAAAGCACGTTGATTTTTTACAAATGTAAGTGTGCTTGGGAATTCCTTAAATTTTGTGCAATAAACTATTTTTTGGTAAAG >66933_66933_4_POLE-GOLGA3_POLE_chr12_133248801_ENST00000535270_GOLGA3_chr12_133360893_ENST00000204726_length(amino acids)=1028AA_BP=571 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPVALPYKPYFYIATRKGCEREVS SFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEET SKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMIS YMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEI GFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPF IFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAF DFLLQRVEKTLRHALEEEEKVPVEQVTNFEEERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKI KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQP VGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL KLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSW -------------------------------------------------------------- >66933_66933_5_POLE-GOLGA3_POLE_chr12_133248801_ENST00000535270_GOLGA3_chr12_133360893_ENST00000450791_length(transcript)=7290nt_BP=1726nt AGCCAACGGCTCCATGTCTCTGAGGAGCGGCGGGCGGCGGCGCGCGGACCCAGGCGCGGATGGCGAGGCCAGCAGGGATGATGGCGCCAC TTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATTTGCGGTTTGGTTTTGAGCGGCTGAAGGAGCC TGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTGTGGCTTTGCCCTATAAACCGTATTTCTACATTGCGACCAGAAAGGGTTGTGA GCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCAAAGAGGATCTGGACTTGCCAAA TCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAGTGAGGAAGGAGATCTCCCCTGC CGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGCAGAGGGGCGGTGTCATTACTGA TGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATGTTCCCTACCACATCCGCCTCTC CATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAGAAATCACCCGCCGAGATGACCT TGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTCCTGATGCTGAGACAGACCAGAT TATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAGATATTGAAGATTTTGAGTTCAC CCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAAGGTGGTTTGAACACGTCCAGGA GACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGGCAGCAGTCCACGGTCTGAGCAT GCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGGACTGCCTCAGGTGGGTGAAGAG GGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATCCCGTGGAGCTAGACCCGGAGGA CATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCACTTACTACCTGTACATGAAGTA CGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGGGCTCTGGCACTCTGTGTGAGGC CTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATAAGCTGACGGACGACGGACACGT GCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATATCCCTTGCCGGTTTAGGATGAA TCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGGAGAAAGTGCCTGTGGAGCAAGT CACCAACTTTGAAGAGGAAAGGATCCAGGCCCTGGAGGCGGAGCTGCAGGCTGTCAGTCATAGCAAGACGCTGCTGGAAAAGGAACTGCA GGAGGTCATAGCGCTGACCAGCCAGGAGCTGGAGGAGTCCCGGGAGAAGGTGCTGGAGCTGGAGGACGAGCTTCAAGAATCCAGAGGCTT TAGGAAGAAGATAAAACGCCTTGAGGAGTCAAACAAGAAGTTGGCTCTTGAATTAGAGCACGAGAAAGGGAAGCTTACGGGCCTCGGTCA GTCCAACGCAGCTCTGCGGGAACACAACAGCATCCTAGAAACAGCTTTGGCCAAGAGGGAGGCAGACCTAGTCCAGTTGAACCTTCAGGT GCAGGCAGTTTTGCAGCGCAAAGAAGAGGAGGATCGCCAGATGAAGCATCTTGTCCAGGCCCTGCAGGCCTCACTAGAGAAGGAGAAGGA GAAGGTGAACAGCCTCAAGGAGCAGGTGGCTGCTGCCAAGGTGGAAGCCGGGCATAACCGCCGCCACTTCAAGGCGGCCTCCTTGGAGCT GAGTGAGGTGAAGAAGGAGCTGCAGGCCAAGGAACACCTGGTGCAGAAGCTGCAGGCCGAGGCCGACGACCTTCAGATTCGGGAGGGGAA ACATTCCCAGGAGATAGCACAGTTCCAAGCAGAGCTGGCCGAGGCCCGGGCACAGCTCCAGCTCCTGCAGAAGCAGCTGGACGAGCAGCT CAGCAAACAGCCCGTGGGAAACCAAGAGATGGAAAATCTCAAATGGGAGGTGGATCAGAAAGAAAGAGAAATCCAGTCCTTGAAGCAGCA GCTGGACTTGACGGAGCAGCAGGGCAGGAAGGAACTGGAAGGGCTACAGCAGCTGCTGCAGAACGTCAAGTCTGAGTTGGAGATGGCCCA GGAAGACCTGTCCATGACCCAGAAGGATAAATTTATGCTCCAGGCAAAAGTGTCGGAGCTGAAGAACAACATGAAGACCCTGCTCCAGCA GAACCAGCAGCTCAAGCTGGACCTACGCCGCGGCGCGGCCAAGACGAGAAAGGAGCCGAAAGGCGAGGCCAGCTCTTCCAACCCTGCCAC GCCCATCAAGATCCCGGACTGCCCAGTTCCCGCCTCGCTGCTGGAGGAGCTGCTGAGACCACCGCCCGCCGTGAGCAAGGAGCCCCTCAA GAACCTGAACAGCTGCCTCCAGCAGCTCAAGCAGGAGATGGACAGCCTGCAGCGCCAGATGGAGGAGCACGCCCTGACGGTGCACGAGTC TCTGTCCTCGTGGACGCCGCTGGAGCCAGCCACTGCCAGCCCTGTGCCCCCGGGGGGTCACGCCGGCCCACGCGGCGACCCACAGAGACA CAGTCAGAGCAGGGCTTCCAAAGAAGGGCCGGGAGAGTGACTGCTGTGGACTCGCCTCCGTGCGCCGCTGCCCCAGAAGGCTCTTATCAA TGTTATTTATTTGATTGTGTGGTCGATGTTTTTCTAAGACATGAAATTTAAGTTTTGTTTTGCCTTTAACAAGAAGTAAAATATATAGCA GAATGAGAGCCAAGGACTAGAAAAACATTCGAAGATCACAATTAGCTTTTCACATGGAATGACCAACTCTTAAAAGCCTGATAGGCTCTC GGCGAGGAGCTTTGAACGTGTCTGAAGGGTTACTTGTAGGTCGTGGCTTCTGAGCGGCCACCGATGCTGCTCTCTGCGGGTGACAGGGAG AGGCTGCGTAACTGGGAGCAGCTGTGTGACAGGGTCTGCGGCACCGCGCCTGGCCAGGCCGGCTGCAGTTTCTCACTTCCCTGTTCCATT CAGTAAGAGCTTTACTTTTCCGCAGAAATGAAATTTTATCTGTACCTTTGGCTTTTTACTTGTTTTTTTGGATAGCCATCCCACCATAGG ATGTGTACATAGATACTGAATATCATAATCCAATCTTTGTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTTTGTTGCCCAGGC TGGAGTGCAGTGGCACACTCTCCGCTCACTGCAAGCTCCGCCTCCCAGGTTCATGCGATTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGA TTACAGGCGTGCGCCACTATGCCAGGCTAATGTTTGTATTTTTAGTAGCAATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCC TGACCTCAAGTGATCTGCCCATCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCTGCGCCCGGCCTGTCACCCAGTCTTTAA GAAGCATATGCTCATGTTATTGAAGAAGAACCTACTTATTATTGATTGCCTTTTGAAAATTTGTTGGGAATAATTTACCTGCAGGATTTA GGGATAGTCAGAAAATTCTAAGAAATATAATTATTTTATTTACCTTCTAAAGCCAAATATTCTTACACAGAAAGGTCCTCTGTTGTTCTG GTTTTACTTTGTTGCTGAGGATCTTTCCTTCCTGCTGGTCTCTTCCTCTCAGGCCACTGGCCCTGTGTGATTCCACCGTGGCTGGCCACT GGGAAGGGGCAGCTTGGACCCTTGGTCAGGCCTGACGGCCATCAGGAGGCACAAGGACACTGAGGCCCCATATCTGATCTGACCTTTGGG GGGGCACAGGGAGAGGCCGGTGGAGGAGGAGGAGGAGAGCAGACCAGGGGCTCCCTGCAGCGACTCCCGCGGTTTCCCCTGGAGTCAGCC AGGTGTAGGTCGCAGGCGGTAACAAACCTCACACTCCTGTTCCCCAAGTGAAAATCTTTACCATTGTCTGTGGGAGCGCCTGTACTCGTG TGTAGGAGCACCTGTACTTCTGCAGTCATCGAGAAGTCCTGGATCTTTTGTGGTTACACCAGCATCATGTGGCAAGCAGAGGCGACTTCC GGAAGAGACAGGCAGGCACCGTGAGGAAGGTGGCTGTGCTCTCCCAGGTGTCTCAGAGACAGATGCCTTATTTAAAATCAGCACGACATG TGTGAGATCTTCTGTTTCCTACCCCAAATCCTGAAACCCTGCAGACACTGGCTGACTGGGAGAGGTGGGGTCTGTAAGTTGTCCCCTAGT TTGCTAAGAAAATCTAAAATAATATTTATTATATGAGTTAGGAGAGAGAGAATGGGTCCGCGTGGCCTCCTCTGCAGATGTACTGGTCTG AAATGAGGTTCTGAGTCACTGGCCAGGCCAGATGTGCTCATGTCGGTGTCTGGTGTCTGTTTTGTGGAGAAAACAGTATGGTGTGTTTTA AGCTATTTGTGTTCTGTTGTAATATACTTTTAGAAGGTTAATTGGTAAGGTTAAGGTAGCATTAACCACAAAGATGTTTGGTATTTAAAA AATATTCTCTAGCAAATATTGGAATTTCCAAAATATATCATTTGTACAGGGTTAATTTTGAAATAATACTTGAAAATTTCATTATAAATA TATCCTACTTTTTATCTTAAGTTGAAGATGTTATTTACTAAATTGTTCTTGTACCATTAGAAAAAAAAATACGGCAATTTACGTTCTTAT TTATTTTGGCTGTACTACCCCTTTGTTTTAATTTTAAAATCAAGAAATCGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTT GGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAAGAGGTCCAGACCATCCTGGCCAACATGGCAAAACCCCGTCTTTACTAAACATACAA AAATTAGCCGGGTGTCGTAGTGCGCACCTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGCT TGCAGTGAGCCGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAATAAATAAATGATTTTAAAAAATC TAAAATCGAGAAATCACACATTCAGTGGGGAGCGACTTCTCCTTGCTTATGGGAAGTCCTCAAGTGAGTGATGTTCACCATGTATTTTTT TTTCTCTTAGGACAGACTAATTCTGAAAATACCGAAGGAAAAGTAGCTCTATGTTCTCACCCCGGTTTTCCTGCGTGTGTGCCCTTGGGT GCGATGCCTCCCCCAGCGCTCTGTGGTCGCCGGTGCCAGGGCCCCCTCTGGTTTGGCAGGGCCTGGCTGCCTTTGCTCCCTGCAGTGAGT CTTTTGGTGTTTTCATGCACGGCTTGTGCTTCTGGATCTGAGGCCTCTCGTGTTCACGCGGACACTTCCTTCCTTAAGAAGACGCCTAAA AGAGGAAGTTGGAATTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCTGCTCAC TGCAAGCTCCGCCATCTGGGTTCAAGCGATTCTCCTGCCTCATTCTCCCCAGTAGCTGGGATTACAGGTGCCCGCCACCACACCAGCCTA ATTTTTGTATTTTTAGAGGGGTGGAGTTCCACCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCAGGTGATCCTGAGCCTCAGCCTC CCAAAGTGCTGGAATTATAGGCGTGAACCACCGCCCCCGGCTGCAGTTGGATTTTTAAATTGCTTTTTTTTATTGTTGAGGTTTTTTTAT CTCCAAGGGACTCTCCCGGCACTTCTACCTTCCAGAGTTACTTCAGTGCATAAAGTTTGAATTATTTTGTTCTTGTGGGCAGAAGTGGGA ATGATGGAATATCCTCACGGAAAAGGCAGTGAAGTTGGGAGTACTGCTTACAAAACAGGGTCACCAGTGCATTATGTGGCGTGTTCATCC CCACGCCGTGTGTCACGGGCTAGGGCGGCGTGTTCATCCCCACACCGTGTGTCACAACAGGCTAGGGCACTTCACGATGTCACTACTTGT TTTTCTGATGTTCCAAAAACAACGTAACTTGGTTTTCATGTGTTTTTCCGTGGTATATGTGAGATTGATGCTACGGGTCTTACGGACTCA CACCCGTTCCCACTCTCTGCAATATGGATCAGGCAGTGTTTCTGATAGGATGTGAAATGGACTCTCCTCGGGTGGGTCCAGCAGGGGCCC TGCCCACCAGAACACAGTCCGTGCTGTGCTGCGCTAAGGAGCTGGCCCTCAACTCTCCTTGGTGCAGGGTTCCCACAACCGAGTTCTAGT TCCCTGAGGTCTTTAAAAACAAAAACAGAATGTTGTACGTGAAGATTCTAGGAGGGGAGGGACCAGCAAATCTGAGAGAACCGTCCTGGG GCCTCCCTTCGAGGAGCCCTCTGATGTGAGGAGGGACTTGAGTTGAGTGACGCTGTGGTGTGAGGTGTTCTGAGCTCACTGACCGGAAGG TCCAGGTGAATCTCGTCATAAGTGATCTCAGGCTCTCACAGGATCCGGAGGGAAATGTGTTAGAGGGTCTGGAAAATTCAGTGCTTTTGA GTTACTTGTTTTTATTAAAAATTTCCTCACAAAAGAGAGTCCTCAAGTTGTGGCTGTTCTTGGGAAAGGGGTCACCGTGTCTGACAAAGT GTAACTTTAAAAAGCACGTTGATTTTTTACAAATGTAAGTGTGCTTGGGAATTCCTTAAATTTTGTGCAATAAACTATTTTTTGGTAAAG >66933_66933_5_POLE-GOLGA3_POLE_chr12_133248801_ENST00000535270_GOLGA3_chr12_133360893_ENST00000450791_length(amino acids)=1028AA_BP=571 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPVALPYKPYFYIATRKGCEREVS SFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEET SKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMIS YMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEI GFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPF IFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAF DFLLQRVEKTLRHALEEEEKVPVEQVTNFEEERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKI KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQP VGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL KLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSW -------------------------------------------------------------- >66933_66933_6_POLE-GOLGA3_POLE_chr12_133248801_ENST00000535270_GOLGA3_chr12_133360893_ENST00000456883_length(transcript)=3389nt_BP=1726nt AGCCAACGGCTCCATGTCTCTGAGGAGCGGCGGGCGGCGGCGCGCGGACCCAGGCGCGGATGGCGAGGCCAGCAGGGATGATGGCGCCAC TTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATTTGCGGTTTGGTTTTGAGCGGCTGAAGGAGCC TGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTGTGGCTTTGCCCTATAAACCGTATTTCTACATTGCGACCAGAAAGGGTTGTGA GCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCAAAGAGGATCTGGACTTGCCAAA TCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAGTGAGGAAGGAGATCTCCCCTGC CGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGCAGAGGGGCGGTGTCATTACTGA TGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATGTTCCCTACCACATCCGCCTCTC CATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAGAAATCACCCGCCGAGATGACCT TGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTCCTGATGCTGAGACAGACCAGAT TATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAGATATTGAAGATTTTGAGTTCAC CCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAAGGTGGTTTGAACACGTCCAGGA GACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGGCAGCAGTCCACGGTCTGAGCAT GCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGGACTGCCTCAGGTGGGTGAAGAG GGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATCCCGTGGAGCTAGACCCGGAGGA CATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCACTTACTACCTGTACATGAAGTA CGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGGGCTCTGGCACTCTGTGTGAGGC CTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATAAGCTGACGGACGACGGACACGT GCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATATCCCTTGCCGGTTTAGGATGAA TCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGGAGAAAGTGCCTGTGGAGCAAGT CACCAACTTTGAAGAGGAAAGGATCCAGGCCCTGGAGGCGGAGCTGCAGGCTGTCAGTCATAGCAAGACGCTGCTGGAAAAGGAACTGCA GGAGGTCATAGCGCTGACCAGCCAGGAGCTGGAGGAGTCCCGGGAGAAGGTGCTGGAGCTGGAGGACGAGCTTCAAGAATCCAGAGGCTT TAGGAAGAAGATAAAACGCCTTGAGGAGTCAAACAAGAAGTTGGCTCTTGAATTAGAGCACGAGAAAGGGAAGCTTACGGGCCTCGGTCA GTCCAACGCAGCTCTGCGGGAACACAACAGCATCCTAGAAACAGCTTTGGCCAAGAGGGAGGCAGACCTAGTCCAGTTGAACCTTCAGGT GCAGGCAGTTTTGCAGCGCAAAGAAGAGGAGGATCGCCAGATGAAGCATCTTGTCCAGGCCCTGCAGGCCTCACTAGAGAAGGAGAAGGA GAAGGTGAACAGCCTCAAGGAGCAGGTGGCTGCTGCCAAGGTGGAAGCCGGGCATAACCGCCGCCACTTCAAGGCGGCCTCCTTGGAGCT GAGTGAGGTGAAGAAGGAGCTGCAGGCCAAGGAACACCTGGTGCAGAAGCTGCAGGCCGAGGCCGACGACCTTCAGATTCGGGAGGGGAA ACATTCCCAGGAGATAGCACAGTTCCAAGCAGAGCTGGCCGAGGCCCGGGCACAGCTCCAGCTCCTGCAGAAGCAGCTGGACGAGCAGCT CAGCAAACAGCCCGTGGGAAACCAAGAGATGGAAAATCTCAAATGGGAGGTGGATCAGAAAGAAAGAGAAATCCAGTCCTTGAAGCAGCA GCTGGACTTGACGGAGCAGCAGGGCAGGAAGGAACTGGAAGGGCTACAGCAGCTGCTGCAGAACGTCAAGTCTGAGTTGGAGATGGCCCA GGAAGACCTGTCCATGACCCAGAAGGATAAATTTATGCTCCAGGCAAAAGTGTCGGAGCTGAAGAACAACATGAAGACCCTGCTCCAGCA GAACCAGCAGCTCAAGCTGGACCTACGCCGCGGCGCGGCCAAGACGGTACTCAGGCCCGCGTCCCTCCCGGGGTAGCCGACGTGCGCTGT AGATGCTCTCGGACAGGAGGCTGGCAGACGTGTTAGTCATTCAGACATAAACGGATTTGTTGAGCCCACACTGAGCAGCTGCTGTGTAGT CAGTGGTAATGGGGTGACAGATGAAATCATTTCATTCTGGTTTCATTCATCCAACAGTGTTTTCCTCGTTCTGTGAATTCAAATACCACT TTGTTGTAATGTGCTTTGTAAAGCAGATGAGCGGTGGTCTGTGACTCGGCAGTCCCTGCTGTGTGTGAAGGGCTGGGGCCCGGGAGCTGT GCCCAGGCGCCCGGCGGTTTTCTGTGCTCGGTCCACATCCATGTTTTCCAGGAGGCAGGTGGGAGGGCAGCGCTCGGATTGAGAGGCCGT TTAGCGTCGTGTGCTTATCTGTGGAAAAAGTTTGAAGTCCCAGAAAAGGGAGCCTAAGCTGGAAAACTTACTTAATTTCTTACGGAAATT CCACATCAAGGTCTTGAGTATCTGATGGGAGAAGCGTCTGGGAGAGCTGTAGTCTGTGGCTCGGCCCCGTCCTGCCGCAGACCCAGGACT >66933_66933_6_POLE-GOLGA3_POLE_chr12_133248801_ENST00000535270_GOLGA3_chr12_133360893_ENST00000456883_length(amino acids)=920AA_BP=571 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPVALPYKPYFYIATRKGCEREVS SFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEET SKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMIS YMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEI GFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPF IFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAF DFLLQRVEKTLRHALEEEEKVPVEQVTNFEEERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKI KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQP VGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for POLE-GOLGA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000204726 | 14 | 24 | 121_141 | 1041.0 | 1499.0 | GOPC | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000450791 | 13 | 23 | 121_141 | 1041.0 | 1499.0 | GOPC | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000456883 | 14 | 22 | 121_141 | 1041.0 | 1391.0 | GOPC | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000537452 | 13 | 15 | 121_141 | 1041.0 | 1135.0 | GOPC | |
| Tgene | GOLGA3 | chr12:133248801 | chr12:133360893 | ENST00000545875 | 14 | 16 | 121_141 | 1041.0 | 1135.0 | GOPC |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for POLE-GOLGA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for POLE-GOLGA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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