FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:POLK-TBCA (FusionGDB2 ID:66961)

Fusion Gene Summary for POLK-TBCA

check button Fusion gene summary
Fusion gene informationFusion gene name: POLK-TBCA
Fusion gene ID: 66961
HgeneTgene
Gene symbol

POLK

TBCA

Gene ID

51426

6902

Gene nameDNA polymerase kappatubulin folding cofactor A
SynonymsDINB1|DINP|POLQ-
Cytomap

5q13.3

5q14.1

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase kappapolymerase (DNA directed) kappatubulin-specific chaperone ACFATCP1-chaperonin cofactor Achaperonin cofactor Aepididymis secretory sperm binding protein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000506928, ENST00000241436, 
ENST00000352007, ENST00000504026, 
ENST00000508526, ENST00000515295, 
ENST00000380481, 		ENST00000306388, 
ENST00000380377, ENST00000517881, 
ENST00000517679, ENST00000518338, 
ENST00000520039, ENST00000520361, 
ENST00000522370, 
Fusion gene scores* DoF score7 X 6 X 4=16811 X 5 X 6=330
# samples 712
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/330*10)=-1.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLK [Title/Abstract] AND TBCA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLK(74848416)-TBCA(76989177), # samples:1
Anticipated loss of major functional domain due to fusion event.POLK-TBCA seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
POLK-TBCA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLK

GO:0006281

DNA repair

28297716

HgenePOLK

GO:0006974

cellular response to DNA damage stimulus

28297716

HgenePOLK

GO:0034644

cellular response to UV

28297716

HgenePOLK

GO:0042276

error-prone translesion synthesis

28297716


check buttonFusion gene breakpoints across POLK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBCA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8678-01APOLKchr5

74848416

+TBCAchr5

76989177

-


Top

Fusion Gene ORF analysis for POLK-TBCA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000506928ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-3CDSENST00000506928ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-5UTRENST00000506928ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-intronENST00000506928ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-intronENST00000506928ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-intronENST00000506928ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-intronENST00000506928ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
3UTR-intronENST00000506928ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-5UTRENST00000241436ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-5UTRENST00000352007ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-5UTRENST00000504026ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-5UTRENST00000508526ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-5UTRENST00000515295ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000241436ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000241436ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000241436ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000241436ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000241436ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000352007ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000352007ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000352007ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000352007ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000352007ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000504026ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000504026ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000504026ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000504026ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000504026ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000508526ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000508526ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000508526ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000508526ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000508526ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000515295ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000515295ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000515295ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000515295ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
5CDS-intronENST00000515295ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-3CDSENST00000380481ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-3CDSENST00000380481ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-5UTRENST00000380481ENST00000517881POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-intronENST00000380481ENST00000517679POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-intronENST00000380481ENST00000518338POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-intronENST00000380481ENST00000520039POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-intronENST00000380481ENST00000520361POLKchr5

74848416

+TBCAchr5

76989177

-
5UTR-intronENST00000380481ENST00000522370POLKchr5

74848416

+TBCAchr5

76989177

-
Frame-shiftENST00000241436ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
Frame-shiftENST00000352007ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
Frame-shiftENST00000504026ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
Frame-shiftENST00000508526ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
Frame-shiftENST00000515295ENST00000306388POLKchr5

74848416

+TBCAchr5

76989177

-
In-frameENST00000241436ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-
In-frameENST00000352007ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-
In-frameENST00000504026ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-
In-frameENST00000508526ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-
In-frameENST00000515295ENST00000380377POLKchr5

74848416

+TBCAchr5

76989177

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000241436POLKchr574848416+ENST00000380377TBCAchr576989177-847427172594140
ENST00000352007POLKchr574848416+ENST00000380377TBCAchr576989177-77135196518140
ENST00000515295POLKchr574848416+ENST00000380377TBCAchr576989177-68826813435140
ENST00000508526POLKchr574848416+ENST00000380377TBCAchr576989177-6752550422140
ENST00000504026POLKchr574848416+ENST00000380377TBCAchr576989177-6752550422140

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000241436ENST00000380377POLKchr574848416+TBCAchr576989177-0.0024073480.9975926
ENST00000352007ENST00000380377POLKchr574848416+TBCAchr576989177-0.0021788330.9978212
ENST00000515295ENST00000380377POLKchr574848416+TBCAchr576989177-0.0026226550.9973774
ENST00000508526ENST00000380377POLKchr574848416+TBCAchr576989177-0.0028186320.9971814
ENST00000504026ENST00000380377POLKchr574848416+TBCAchr576989177-0.0028186320.9971814

Top

Fusion Genomic Features for POLK-TBCA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for POLK-TBCA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:74848416/chr5:76989177)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLKchr5:74848416chr5:76989177ENST00000241436+315103_35885871.0DomainNote=UmuC
HgenePOLKchr5:74848416chr5:76989177ENST00000352007+310103_35885673.0DomainNote=UmuC
HgenePOLKchr5:74848416chr5:76989177ENST00000380481+215103_3580781.0DomainNote=UmuC
HgenePOLKchr5:74848416chr5:76989177ENST00000504026+212103_35885445.3333333333333DomainNote=UmuC
HgenePOLKchr5:74848416chr5:76989177ENST00000508526+29103_35885673.0DomainNote=UmuC
HgenePOLKchr5:74848416chr5:76989177ENST00000515295+210103_35885473.0DomainNote=UmuC
HgenePOLKchr5:74848416chr5:76989177ENST00000241436+315621_65185871.0Zinc fingerUBZ4-type 1
HgenePOLKchr5:74848416chr5:76989177ENST00000241436+315776_80685871.0Zinc fingerUBZ4-type 2
HgenePOLKchr5:74848416chr5:76989177ENST00000352007+310621_65185673.0Zinc fingerUBZ4-type 1
HgenePOLKchr5:74848416chr5:76989177ENST00000352007+310776_80685673.0Zinc fingerUBZ4-type 2
HgenePOLKchr5:74848416chr5:76989177ENST00000380481+215621_6510781.0Zinc fingerUBZ4-type 1
HgenePOLKchr5:74848416chr5:76989177ENST00000380481+215776_8060781.0Zinc fingerUBZ4-type 2
HgenePOLKchr5:74848416chr5:76989177ENST00000504026+212621_65185445.3333333333333Zinc fingerUBZ4-type 1
HgenePOLKchr5:74848416chr5:76989177ENST00000504026+212776_80685445.3333333333333Zinc fingerUBZ4-type 2
HgenePOLKchr5:74848416chr5:76989177ENST00000508526+29621_65185673.0Zinc fingerUBZ4-type 1
HgenePOLKchr5:74848416chr5:76989177ENST00000508526+29776_80685673.0Zinc fingerUBZ4-type 2
HgenePOLKchr5:74848416chr5:76989177ENST00000515295+210621_65185473.0Zinc fingerUBZ4-type 1
HgenePOLKchr5:74848416chr5:76989177ENST00000515295+210776_80685473.0Zinc fingerUBZ4-type 2


Top

Fusion Gene Sequence for POLK-TBCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66961_66961_1_POLK-TBCA_POLK_chr5_74848416_ENST00000241436_TBCA_chr5_76989177_ENST00000380377_length(transcript)=847nt_BP=427nt
TACCTCCGGCTCTCCCGGGTGACGACGGGTAGAAAAGCAGGAGGAGCGGAGAAAGGAGAGGGCGGGGTAGGGATGCAGCTGTGCTGCATT
CTGGGAAGGGCGTTGGTCCGTCGCTCGCGCAGCCTCCTGGGAGTTGTAGTCGCGATCCTGAGGTAACGGATAAGTTTATACCATGGATAG
CACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGATTAGATAA
AGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTCAACCAACG
AATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGGCAGAGATCCTACAAGAATCCAG
GATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAATGAAAAAGACTTGGAAGAAGC
TGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTGCATTAAAT
CCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGGTTACATAT
ATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTTTACAAAATTTTTAAATTAACC

>66961_66961_1_POLK-TBCA_POLK_chr5_74848416_ENST00000241436_TBCA_chr5_76989177_ENST00000380377_length(amino acids)=140AA_BP=85
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQAEILQ

--------------------------------------------------------------
>66961_66961_2_POLK-TBCA_POLK_chr5_74848416_ENST00000352007_TBCA_chr5_76989177_ENST00000380377_length(transcript)=771nt_BP=351nt
AGCTGTGCTGCATTCTGGGAAGGGCGTTGGTCCGTCGCTCGCGCAGCCTCCTGGGAGTTGTAGTCGCGATCCTGAGGTAACGGATAAGTT
TATACCATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATG
GAAGGATTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAG
CAAGTCAACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGGCAGAGATC
CTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAATGAAAAA
GACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGG
TTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTT
ATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTTTACAAAA

>66961_66961_2_POLK-TBCA_POLK_chr5_74848416_ENST00000352007_TBCA_chr5_76989177_ENST00000380377_length(amino acids)=140AA_BP=85
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQAEILQ

--------------------------------------------------------------
>66961_66961_3_POLK-TBCA_POLK_chr5_74848416_ENST00000504026_TBCA_chr5_76989177_ENST00000380377_length(transcript)=675nt_BP=255nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGGCAGAGATCCTACAA
GAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAATGAAAAAGACTTG
GAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTG
CATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGG
TTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTTTACAAAATTTTTA

>66961_66961_3_POLK-TBCA_POLK_chr5_74848416_ENST00000504026_TBCA_chr5_76989177_ENST00000380377_length(amino acids)=140AA_BP=85
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQAEILQ

--------------------------------------------------------------
>66961_66961_4_POLK-TBCA_POLK_chr5_74848416_ENST00000508526_TBCA_chr5_76989177_ENST00000380377_length(transcript)=675nt_BP=255nt
ATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGCAGGAATGGAAGGA
TTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAAAGAAAAGCAAGTC
AACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGGCAGAGATCCTACAA
GAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAATGAAAAAGACTTG
GAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTATGGGGTGGTTTTTG
CATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGATTGTTTTTATCTGG
TTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTTTACAAAATTTTTA

>66961_66961_4_POLK-TBCA_POLK_chr5_74848416_ENST00000508526_TBCA_chr5_76989177_ENST00000380377_length(amino acids)=140AA_BP=85
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQAEILQ

--------------------------------------------------------------
>66961_66961_5_POLK-TBCA_POLK_chr5_74848416_ENST00000515295_TBCA_chr5_76989177_ENST00000380377_length(transcript)=688nt_BP=268nt
ATAAGTTTATACCATGGATAGCACAAAGGAGAAGTGTGACAGTTACAAAGATGATCTTCTGCTTAGGATGGGACTTAATGATAATAAAGC
AGGAATGGAAGGATTAGATAAAGAGAAAATTAACAAAATTATAATGGAAGCCACGAAGGGGTCCAGATTTTATGGAAATGAGCTCAAGAA
AGAAAAGCAAGTCAACCAACGAATTGAAAATATGATGCAACAAAAAGCTCAAATCACCAGCCAACAGCTAAGAAAAGCACAATTACAGGC
AGAGATCCTACAAGAATCCAGGATGATGATCCCAGATTGCCAGCGCAGGTTGGAAGCCGCATATTTGGATCTTCAACGGATACTAGAAAA
TGAAAAAGACTTGGAAGAAGCTGAGGAATATAAAGAAGCACGTTTAGTACTGGATTCAGTGAAGTTAGAAGCCTGAAACTTTTCTCGTAT
GGGGTGGTTTTTGCATTAAATCCTGGGGTCCATTTTACAATCCATTATTTTTGACCACTGCTATGTGTTCAAGTAGTATGAGAATGTGAT
TGTTTTTATCTGGTTACATATATATTTCTTTGTCTAATTTAATATGTCAAATAAATGAGTTCATCTAATAAAATTGTTTATTTTATACTT

>66961_66961_5_POLK-TBCA_POLK_chr5_74848416_ENST00000515295_TBCA_chr5_76989177_ENST00000380377_length(amino acids)=140AA_BP=85
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQAEILQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for POLK-TBCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for POLK-TBCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for POLK-TBCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource