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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLM-OGDH (FusionGDB2 ID:66962)

Fusion Gene Summary for POLM-OGDH

check button Fusion gene summary
Fusion gene informationFusion gene name: POLM-OGDH
Fusion gene ID: 66962
HgeneTgene
Gene symbol

POLM

OGDH

Gene ID

27434

4967

Gene nameDNA polymerase muoxoglutarate dehydrogenase
SynonymsPol Mu|Tdt-NAKGDH|E1k|OGDC
Cytomap

7p13

7p13

Type of geneprotein-codingprotein-coding
DescriptionDNA-directed DNA/RNA polymerase muPol iotapolymerase (DNA) mupolymerase (DNA-directed), muterminal transferase2-oxoglutarate dehydrogenase, mitochondrial2-oxoglutarate dehydrogenase complex component E1OGDC-E1oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)oxoglutarate decarboxylaseoxoglutarate dehydrogenase (succinyl-transferring)testicular tis
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000242248, ENST00000335195, 
ENST00000395831, ENST00000492971, 
ENST00000222673, ENST00000443864, 
ENST00000444676, ENST00000447398, 
ENST00000449767, ENST00000459672, 
ENST00000543843, ENST00000439616, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 11 X 4=440
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLM [Title/Abstract] AND OGDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLM(44113224)-OGDH(44739740), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOGDH

GO:0006103

2-oxoglutarate metabolic process

24495017|29211711

TgeneOGDH

GO:0006104

succinyl-CoA metabolic process

24495017|29211711

TgeneOGDH

GO:0106077

histone succinylation

29211711


check buttonFusion gene breakpoints across POLM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OGDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FV-01APOLMchr7

44113224

-OGDHchr7

44739740

+


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Fusion Gene ORF analysis for POLM-OGDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000242248ENST00000222673POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000242248ENST00000443864POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000242248ENST00000444676POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000242248ENST00000447398POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000242248ENST00000449767POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000242248ENST00000459672POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000242248ENST00000543843POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000222673POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000443864POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000444676POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000447398POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000449767POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000459672POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000335195ENST00000543843POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000222673POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000443864POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000444676POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000447398POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000449767POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000459672POLMchr7

44113224

-OGDHchr7

44739740

+
5CDS-intronENST00000395831ENST00000543843POLMchr7

44113224

-OGDHchr7

44739740

+
In-frameENST00000242248ENST00000439616POLMchr7

44113224

-OGDHchr7

44739740

+
In-frameENST00000335195ENST00000439616POLMchr7

44113224

-OGDHchr7

44739740

+
In-frameENST00000395831ENST00000439616POLMchr7

44113224

-OGDHchr7

44739740

+
intron-3CDSENST00000492971ENST00000439616POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000222673POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000443864POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000444676POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000447398POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000449767POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000459672POLMchr7

44113224

-OGDHchr7

44739740

+
intron-intronENST00000492971ENST00000543843POLMchr7

44113224

-OGDHchr7

44739740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335195POLMchr744113224-ENST00000439616OGDHchr744739740+2186131351954649
ENST00000242248POLMchr744113224-ENST00000439616OGDHchr744739740+23731500302141703
ENST00000395831POLMchr744113224-ENST00000439616OGDHchr744739740+20781205261846606

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335195ENST00000439616POLMchr744113224-OGDHchr744739740+0.1030093060.89699066
ENST00000242248ENST00000439616POLMchr744113224-OGDHchr744739740+0.0728476940.92715234
ENST00000395831ENST00000439616POLMchr744113224-OGDHchr744739740+0.126668020.873332

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Fusion Genomic Features for POLM-OGDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLMchr744113223-OGDHchr744739739+8.18E-060.9999918
POLMchr744113223-OGDHchr744739739+8.18E-060.9999918

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLM-OGDH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:44113224/chr7:44739740)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLMchr7:44113224chr7:44739740ENST00000242248-101122_122466495.0DomainBRCT
HgenePOLMchr7:44113224chr7:44739740ENST00000242248-1011323_332466495.0RegionInvolved in ssDNA binding
TgeneOGDHchr7:44113224chr7:44739740ENST0000044386409154_1580428.0Calcium bindingOntology_term=ECO:0000269

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneOGDHchr7:44113224chr7:44739740ENST000002226731723154_1588101024.0Calcium bindingOntology_term=ECO:0000269
TgeneOGDHchr7:44113224chr7:44739740ENST000004497671723154_1588061020.0Calcium bindingOntology_term=ECO:0000269


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Fusion Gene Sequence for POLM-OGDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>66962_66962_1_POLM-OGDH_POLM_chr7_44113224_ENST00000242248_OGDH_chr7_44739740_ENST00000439616_length(transcript)=2373nt_BP=1500nt
CCGCCCGCCCACCCGCTTCCGTCAGCCTCACTGGGGCTTCCTTCCGTCTCGCTCGGAGTTTCCCTCTGCGTTCGCTCCGCGCTGCTGGAG
GCTGTCGTCCCAATGCTCCCCAAACGGCGGCGAGCGCGGGTCGGGTCCCCTAGCGGCGATGCCGCTTCCTCCACGCCGCCCTCGACGCGC
TTCCCGGGAGTCGCCATCTACCTGGTCGAGCCTCGCATGGGTCGCAGCCGCCGGGCCTTCCTCACAGGCCTGGCGCGCTCCAAAGGCTTC
CGCGTCCTTGACGCCTGCAGCTCCGAAGCGACACATGTTGTGATGGAAGAGACCTCAGCAGAGGAGGCCGTCAGCTGGCAGGAGCGCAGG
ATGGCAGCTGCTCCCCCGGGTTGCACCCCCCCAGCTCTGCTGGACATAAGCTGGTTAACAGAGAGCCTGGGAGCTGGGCAGCCTGTACCT
GTGGAGTGCCGGCACCGCCTGGAGGTGGCTGGGCCAAGGAAGGGGCCTCTGAGCCCAGCATGGATGCCTGCCTATGCCTGCCAGCGCCCT
ACGCCCCTCACACACCACAACACTGGCCTCTCCGAGGCTCTGGAGATACTGGCCGAGGCAGCAGGCTTTGAAGGCAGTGAGGGCCGCCTC
CTCACCTTCTGCAGAGCAGCCTCGGTGCTCAAGGCCCTTCCCAGCCCTGTCACAACCCTGAGCCAGCTGCAGGGGCTTCCCCACTTTGGA
GAACACTCCTCTAGGGTTGTCCAGGAGCTGCTGGAGCATGGAGTGTGTGAGGAGGTGGAGAGAGTTCGGCGCTCAGAGAGGTACCAGACC
ATGAAGCTCTTCACCCAGATCTTCGGGGTCGGTGTGAAGACTGCTGACCGGTGGTACCGGGAAGGACTGCGAACCTTAGATGACCTCCGA
GAGCAGCCCCAGAAACTAACCCAACAGCAGAAAGCGGGGCTCCAGCACCACCAGGACCTGAGCACCCCAGTCCTGCGGTCCGATGTAGAT
GCCCTGCAGCAGGTGGTGGAGGAAGCTGTGGGGCAGGCCCTGCCTGGGGCCACCGTCACGCTGACCGGCGGCTTCCGCAGGGGGAAGTTG
CAGGGCCATGACGTGGACTTCCTCATCACCCACCCCAAGGAGGGTCAGGAGGCGGGGCTGCTGCCTAGAGTGATGTGCCGCCTGCAGGAC
CAGGGCCTCATCCTGTACCACCAGCACCAGCACAGCTGCTGTGAGTCCCCTACCCGCCTGGCCCAACAGAGCCACATGGACGCTTTTGAG
AGAAGTTTCTGCATTTTCCGCCTACCACAACCTCCAGGGGCTGCTGTGGGGGGATCCACGAGGCCCTGCCCATCCTGGAAGGCCGTGAGA
GTGGACTTGGTAGTTGCACCCGTCAGCCAGTTCCCTTTCGCCCTGCTCGGTTGGACTGGCTCCAAGCTTTTCCAGCGGGAGCTGCGCCGC
TTCAGCCGGAAGGAGAAGGGCCTGTGGCTGAACAGCCATGGGCTGTTTGACCCGGAGCAGGACCTTAAAGAAGCCAACTTCGACATCAAT
CAGCTATATGACTGCAATTGGGTTGTTGTCAACTGCTCCACTCCTGGCAACTTCTTCCACGTGCTACGACGCCAGATCCTGCTGCCATTC
CGGAAGCCGTTAATTATCTTCACCCCCAAATCCCTGTTGCGCCACCCCGAGGCCAGATCCAGCTTTGATGAGATGCTTCCAGGAACCCAC
TTCCAGCGGGTGATCCCAGAAGATGGCCCTGCAGCTCAGAACCCAGAAAATGTCAAAAGGCTTCTCTTCTGCACCGGCAAAGTGTATTAT
GACCTCACCCGGGAGCGCAAAGCACGCGACATGGTGGGGCAGGTGGCCATCACAAGGATTGAGCAGCTGTCGCCATTCCCCTTTGACCTC
CTGCTGAAGGAGGTGCAGAAGTACCCCAATGCTGAGCTGGCCTGGTGCCAGGAGGAGCACAAGAACCAAGGCTACTATGACTACGTGAAG
CCAAGACTTCGGACCACCATCAGCCGCGCCAAGCCCGTCTGGTATGCCGGCCGGGACCCAGCGGCTGCTCCAGCCACCGGCAACAAGAAG
ACCCACCTGACGGAGCTGCAGCGCCTCCTGGACACGGCCTTCGACCTGGACGTCTTCAAGAACTTCTCGTAGATGCTGCCTAGGGTTGCT
TGGGCCACTGCCCTCTCCACACCCATGACTGCCCCTTGCTTCTCAACTAAAGAATAGTGCCTCAGCGCTGCCCACACCACCGCCCTCCTC
GCTGTGCCACCACCCCTCCCTCTGCTCTCATAGGAGTTAGGCTGTCGTCCCCCTCCAGTGCTTGGCTGCCCCACAGGCCACACGCTGCCC

>66962_66962_1_POLM-OGDH_POLM_chr7_44113224_ENST00000242248_OGDH_chr7_44739740_ENST00000439616_length(amino acids)=703AA_BP=489
MGLPSVSLGVSLCVRSALLEAVVPMLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLDACSSEA
THVVMEETSAEEAVSWQERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECRHRLEVAGPRKGPLSPAWMPAYACQRPTPLTHHNTGL
SEALEILAEAAGFEGSEGRLLTFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTMKLFTQIFGV
GVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLSTPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLIT
HPKEGQEAGLLPRVMCRLQDQGLILYHQHQHSCCESPTRLAQQSHMDAFERSFCIFRLPQPPGAAVGGSTRPCPSWKAVRVDLVVAPVSQ
FPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPK
SLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPN

--------------------------------------------------------------
>66962_66962_2_POLM-OGDH_POLM_chr7_44113224_ENST00000335195_OGDH_chr7_44739740_ENST00000439616_length(transcript)=2186nt_BP=1313nt
CCGCGCTGCTGGAGGCTGTCGTCCCAATGCTCCCCAAACGGCGGCGAGCGCGGGTCGGGTCCCCTAGCGGCGATGCCGCTTCCTCCACGC
CGCCCTCGACGCGCTTCCCGGGAGTCGCCATCTACCTGGTCGAGCCTCGCATGGGTCGCAGCCGCCGGGCCTTCCTCACAGGCCTGGCGC
GCTCCAAAGGCTTCCGCGTCCTTGACGCCTGCAGCTCCGAAGCGACACATGTTGTGATGGAAGAGACCTCAGCAGAGGAGGCCGTCAGCT
GGCAGGAGCGCAGGATGGCAGCTGCTCCCCCGGGTTGCACCCCCCCAGCTCTGCTGGACATAAGCTGGTTAACAGAGAGCCTGGGAGCTG
GGCAGCCTGTACCTGTGGAGTGCCGGCACCGCCTGGAGGTGGCTGGGCCAAGGAAGGGGCCTCTGAGCCCAGCATGGATGCCTGCCTATG
CCTGCCAGCGCCCTACGCCCCTCACACACCACAACACTGGCCTCTCCGAGGCTCTGGAGATACTGGCCGAGGCAGCAGGCTTTGAAGGCA
GTGAGGGCCGCCTCCTCACCTTCTGCAGAGCAGCCTCGGTGCTCAAGGCCCTTCCCAGCCCTGTCACAACCCTGAGCCAGCTGCAGGGGC
TTCCCCACTTTGGAGAACACTCCTCTAGGGTTGTCCAGGAGCTGCTGGAGCATGGAGTGTGTGAGGAGGTGGAGAGAGTTCGGCGCTCAG
AGAGGTACCAGACCATGAAGCTCTTCACCCAGATCTTCGGGGTCGGTGTGAAGACTGCTGACCGGTGGTACCGGGAAGGACTGCGAACCT
TAGATGACCTCCGAGAGCAGCCCCAGAAACTAACCCAACAGCAGAAAGCGGCACCACCAGGACCTGAGCACCCCAGTCCTGCGGTCCGAT
GTAGATGCCCTGCAGCAGGTGGTGGAGGAAGCTGTGGGGCAGGCCCTGCCTGGGGCCACCGTCACGCTGACCGGCGGCTTCCGCAGGGCC
TCATCCTGTACCACCAGCACCAGCACAGCTGCTGTGAGTCCCCTACCCGCCTGGCCCAACAGAGCCACATGGACGCTTTTGAGAGAAGTT
TCTGCATTTTCCGCCTACCACAACCTCCAGGGGCTGCTGTGGGGGGATCCACGAGGCCCTGCCCATCCTGGAAGGCCGTGAGAGTGGACT
TGGTAGTTGCACCCGTCAGCCAGTTCCCTTTCGCCCTGCTCGGTTGGACTGGCTCCAAGCTTTTCCAGCGGGAGCTGCGCCGCTTCAGCC
GGAAGGAGAAGGGCCTGTGGCTGAACAGCCATGGGCTGTTTGACCCGGAGCAGGACCTTAAAGAAGCCAACTTCGACATCAATCAGCTAT
ATGACTGCAATTGGGTTGTTGTCAACTGCTCCACTCCTGGCAACTTCTTCCACGTGCTACGACGCCAGATCCTGCTGCCATTCCGGAAGC
CGTTAATTATCTTCACCCCCAAATCCCTGTTGCGCCACCCCGAGGCCAGATCCAGCTTTGATGAGATGCTTCCAGGAACCCACTTCCAGC
GGGTGATCCCAGAAGATGGCCCTGCAGCTCAGAACCCAGAAAATGTCAAAAGGCTTCTCTTCTGCACCGGCAAAGTGTATTATGACCTCA
CCCGGGAGCGCAAAGCACGCGACATGGTGGGGCAGGTGGCCATCACAAGGATTGAGCAGCTGTCGCCATTCCCCTTTGACCTCCTGCTGA
AGGAGGTGCAGAAGTACCCCAATGCTGAGCTGGCCTGGTGCCAGGAGGAGCACAAGAACCAAGGCTACTATGACTACGTGAAGCCAAGAC
TTCGGACCACCATCAGCCGCGCCAAGCCCGTCTGGTATGCCGGCCGGGACCCAGCGGCTGCTCCAGCCACCGGCAACAAGAAGACCCACC
TGACGGAGCTGCAGCGCCTCCTGGACACGGCCTTCGACCTGGACGTCTTCAAGAACTTCTCGTAGATGCTGCCTAGGGTTGCTTGGGCCA
CTGCCCTCTCCACACCCATGACTGCCCCTTGCTTCTCAACTAAAGAATAGTGCCTCAGCGCTGCCCACACCACCGCCCTCCTCGCTGTGC
CACCACCCCTCCCTCTGCTCTCATAGGAGTTAGGCTGTCGTCCCCCTCCAGTGCTTGGCTGCCCCACAGGCCACACGCTGCCCAGGCTCT

>66962_66962_2_POLM-OGDH_POLM_chr7_44113224_ENST00000335195_OGDH_chr7_44739740_ENST00000439616_length(amino acids)=649AA_BP=435
MLEAVVPMLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLDACSSEATHVVMEETSAEEAVSWQ
ERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECRHRLEVAGPRKGPLSPAWMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSE
GRLLTFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTMKLFTQIFGVGVKTADRWYREGLRTLD
DLREQPQKLTQQQKAAPPGPEHPSPAVRCRCPAAGGGGSCGAGPAWGHRHADRRLPQGLILYHQHQHSCCESPTRLAQQSHMDAFERSFC
IFRLPQPPGAAVGGSTRPCPSWKAVRVDLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQDLKEANFDINQLYD
CNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTR
ERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLT

--------------------------------------------------------------
>66962_66962_3_POLM-OGDH_POLM_chr7_44113224_ENST00000395831_OGDH_chr7_44739740_ENST00000439616_length(transcript)=2078nt_BP=1205nt
GAGTTTCCCTCTGCGTTCGCTCCGCGCTGCTGGAGGCTGTCGTCCCAATGCTCCCCAAACGGCGGCGAGCGCGGGTCGGGTCCCCTAGCG
GCGATGCCGCTTCCTCCACGCCGCCCTCGACGCGCTTCCCGGGAGTCGCCATCTACCTGGTCGAGCCTCGCATGGGTCGCAGCCGCCGGG
CCTTCCTCACAGGCCTGGCGCGCTCCAAAGGCTTCCGCGTCCTTGACGCCTGCAGCTCCGAAGCGACACATGTTGTGATGGAAGAGACCT
CAGCAGAGGAGGCCGTCAGCTGGCAGGAGCGCAGGATGGCAGCTGCTCCCCCGGGTTGCACCCCCCCAGCTCTGCTGGACATAAGCTGGT
TAACAGAGAGCCTGGGAGCTGGGCAGCCTGTACCTGTGGAGTGCCGGCACCGCCTGGAGGTGGCTGGGCCAAGGAAGGGGCCTCTGAGCC
CAGCATGGATGCCTGCCTATGCCTGCCAGCGCCCTACGCCCCTCACACACCACAACACTGGCCTCTCCGAGGCTCTGGAGATACTGGCCG
AGGCAGCAGGCTTTGAAGGCAGTGAGGGCCGCCTCCTCACCTTCTGCAGAGCAGCCTCGGTGCTCAAGGCCCTTCCCAGCCCTGTCACAA
CCCTGAGCCAGCTGCAGGGGCTTCCCCACTTTGGAGAACACTCCTCTAGGGTTGTCCAGGAGCTGCTGGAGCATGGAGTGTGTGAGGAGG
TGGAGAGAGTTCGGCGCTCAGAGAGGGCTCCAGCACCACCAGGACCTGAGCACCCCAGTCCTGCGGTCCGATGTAGATGCCCTGCAGCAG
GTGGTGGAGGAAGCTGTGGGGCAGGCCCTGCCTGGGGCCACCGTCACGCTGACCGGCGGCTTCCGCAGGGCCTCATCCTGTACCACCAGC
ACCAGCACAGCTGCTGTGAGTCCCCTACCCGCCTGGCCCAACAGAGCCACATGGACGCTTTTGAGAGAAGTTTCTGCATTTTCCGCCTAC
CACAACCTCCAGGGGCTGCTGTGGGGGGATCCACGAGGCCCTGCCCATCCTGGAAGGCCGTGAGAGTGGACTTGGTAGTTGCACCCGTCA
GCCAGTTCCCTTTCGCCCTGCTCGGTTGGACTGGCTCCAAGCTTTTCCAGCGGGAGCTGCGCCGCTTCAGCCGGAAGGAGAAGGGCCTGT
GGCTGAACAGCCATGGGCTGTTTGACCCGGAGCAGGACCTTAAAGAAGCCAACTTCGACATCAATCAGCTATATGACTGCAATTGGGTTG
TTGTCAACTGCTCCACTCCTGGCAACTTCTTCCACGTGCTACGACGCCAGATCCTGCTGCCATTCCGGAAGCCGTTAATTATCTTCACCC
CCAAATCCCTGTTGCGCCACCCCGAGGCCAGATCCAGCTTTGATGAGATGCTTCCAGGAACCCACTTCCAGCGGGTGATCCCAGAAGATG
GCCCTGCAGCTCAGAACCCAGAAAATGTCAAAAGGCTTCTCTTCTGCACCGGCAAAGTGTATTATGACCTCACCCGGGAGCGCAAAGCAC
GCGACATGGTGGGGCAGGTGGCCATCACAAGGATTGAGCAGCTGTCGCCATTCCCCTTTGACCTCCTGCTGAAGGAGGTGCAGAAGTACC
CCAATGCTGAGCTGGCCTGGTGCCAGGAGGAGCACAAGAACCAAGGCTACTATGACTACGTGAAGCCAAGACTTCGGACCACCATCAGCC
GCGCCAAGCCCGTCTGGTATGCCGGCCGGGACCCAGCGGCTGCTCCAGCCACCGGCAACAAGAAGACCCACCTGACGGAGCTGCAGCGCC
TCCTGGACACGGCCTTCGACCTGGACGTCTTCAAGAACTTCTCGTAGATGCTGCCTAGGGTTGCTTGGGCCACTGCCCTCTCCACACCCA
TGACTGCCCCTTGCTTCTCAACTAAAGAATAGTGCCTCAGCGCTGCCCACACCACCGCCCTCCTCGCTGTGCCACCACCCCTCCCTCTGC
TCTCATAGGAGTTAGGCTGTCGTCCCCCTCCAGTGCTTGGCTGCCCCACAGGCCACACGCTGCCCAGGCTCTGCTGACTTCTGAGCAGTT

>66962_66962_3_POLM-OGDH_POLM_chr7_44113224_ENST00000395831_OGDH_chr7_44739740_ENST00000439616_length(amino acids)=606AA_BP=392
MLEAVVPMLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLDACSSEATHVVMEETSAEEAVSWQ
ERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECRHRLEVAGPRKGPLSPAWMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSE
GRLLTFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERAPAPPGPEHPSPAVRCRCPAAGGGGSCGAG
PAWGHRHADRRLPQGLILYHQHQHSCCESPTRLAQQSHMDAFERSFCIFRLPQPPGAAVGGSTRPCPSWKAVRVDLVVAPVSQFPFALLG
WTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPE
ARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQ

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Fusion Gene PPI Analysis for POLM-OGDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLM-OGDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLM-OGDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource