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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLR2B-CEP135 (FusionGDB2 ID:67011)

Fusion Gene Summary for POLR2B-CEP135

check button Fusion gene summary
Fusion gene informationFusion gene name: POLR2B-CEP135
Fusion gene ID: 67011
HgeneTgene
Gene symbol

POLR2B

CEP135

Gene ID

5431

9662

Gene nameRNA polymerase II subunit Bcentrosomal protein 135
SynonymsPOL2RB|RPB2|hRPB140CEP4|KIAA0635|MCPH8
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
DescriptionDNA-directed RNA polymerase II subunit RPB2DNA-directed RNA polymerase II 140 kDa polypeptideDNA-directed RNA polymerase II subunit BRNA polymerase II second largest subunitRNA polymerase II subunit 2RNA polymerase II subunit B2polymerase (RNA) II (centrosomal protein of 135 kDacentrosomal protein 135kDacentrosomal protein 4centrosome protein cep135
Modification date2020031320200328
UniProtAcc.

Q66GS9

Ensembl transtripts involved in fusion geneENST00000314595, ENST00000381227, 
ENST00000431623, ENST00000441246, 
ENST00000510355, 		ENST00000422247, 
ENST00000257287, 
Fusion gene scores* DoF score7 X 7 X 4=1962 X 2 X 2=8
# samples 72
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: POLR2B [Title/Abstract] AND CEP135 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLR2B(57861575)-CEP135(56851447), # samples:2
CEP135(56847545)-POLR2B(57865783), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLR2B

GO:0006366

transcription by RNA polymerase II

9852112


check buttonFusion gene breakpoints across POLR2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP135 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-S9-A89Z-01APOLR2Bchr4

57861575

-CEP135chr4

56851447

+
ChimerDB4LGGTCGA-S9-A89Z-01APOLR2Bchr4

57861575

+CEP135chr4

56851447

+


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Fusion Gene ORF analysis for POLR2B-CEP135

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314595ENST00000422247POLR2Bchr4

57861575

+CEP135chr4

56851447

+
5CDS-intronENST00000381227ENST00000422247POLR2Bchr4

57861575

+CEP135chr4

56851447

+
5CDS-intronENST00000431623ENST00000422247POLR2Bchr4

57861575

+CEP135chr4

56851447

+
5CDS-intronENST00000441246ENST00000422247POLR2Bchr4

57861575

+CEP135chr4

56851447

+
In-frameENST00000314595ENST00000257287POLR2Bchr4

57861575

+CEP135chr4

56851447

+
In-frameENST00000381227ENST00000257287POLR2Bchr4

57861575

+CEP135chr4

56851447

+
In-frameENST00000431623ENST00000257287POLR2Bchr4

57861575

+CEP135chr4

56851447

+
In-frameENST00000441246ENST00000257287POLR2Bchr4

57861575

+CEP135chr4

56851447

+
intron-3CDSENST00000510355ENST00000257287POLR2Bchr4

57861575

+CEP135chr4

56851447

+
intron-intronENST00000510355ENST00000422247POLR2Bchr4

57861575

+CEP135chr4

56851447

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381227POLR2Bchr457861575+ENST00000257287CEP135chr456851447+480711484132791792
ENST00000431623POLR2Bchr457861575+ENST00000257287CEP135chr456851447+43657061962349717
ENST00000441246POLR2Bchr457861575+ENST00000257287CEP135chr456851447+468910302502673807
ENST00000314595POLR2Bchr457861575+ENST00000257287CEP135chr456851447+4437778432421792

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381227ENST00000257287POLR2Bchr457861575+CEP135chr456851447+0.000305510.99969447
ENST00000431623ENST00000257287POLR2Bchr457861575+CEP135chr456851447+0.0001047040.99989533
ENST00000441246ENST00000257287POLR2Bchr457861575+CEP135chr456851447+0.0004489710.999551
ENST00000314595ENST00000257287POLR2Bchr457861575+CEP135chr456851447+0.0002757150.9997242

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Fusion Genomic Features for POLR2B-CEP135


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLR2Bchr457861575+CEP135chr456851446+0.0117468590.9882532
POLR2Bchr457861575+CEP135chr456851446+0.0117468590.9882532

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLR2B-CEP135


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:57861575/chr4:56851447)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP135

Q66GS9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP135chr4:57861575chr4:56851447ENST0000025728712261069_11165931782.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCEP135chr4:57861575chr4:56851447ENST00000422247061069_11160250.0Coiled coilOntology_term=ECO:0000255
TgeneCEP135chr4:57861575chr4:56851447ENST0000042224706195_4200250.0Coiled coilOntology_term=ECO:0000255
TgeneCEP135chr4:57861575chr4:56851447ENST0000042224706447_10390250.0Coiled coilOntology_term=ECO:0000255
TgeneCEP135chr4:57861575chr4:56851447ENST000004222470671_1520250.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLR2Bchr4:57861575chr4:56851447ENST00000314595+6251119_11402451175.0Zinc fingerNote=C4-type
HgenePOLR2Bchr4:57861575chr4:56851447ENST00000381227+7261119_11402451175.0Zinc fingerNote=C4-type
TgeneCEP135chr4:57861575chr4:56851447ENST000002572871226195_4205931782.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCEP135chr4:57861575chr4:56851447ENST000002572871226447_10395931782.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCEP135chr4:57861575chr4:56851447ENST00000257287122671_1525931782.6666666666667Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for POLR2B-CEP135


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67011_67011_1_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000314595_CEP135_chr4_56851447_ENST00000257287_length(transcript)=4437nt_BP=778nt
CTTTTGATTTCAAGAGTTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGA
AATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAACAGCTGGATTC
TTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGG
AGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCTTC
ACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGG
TGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGCTT
GACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGC
CCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTTGA
GAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAATC
AGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATAAT
GAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAAAC
AGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAACT
TGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCATGT
AATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTGCA
AGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAAAC
ATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGAGA
AATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCAGC
AGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAAAA
AGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAAAG
CAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAAGA
GCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAAGA
AGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAGCA
ATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTTTC
AAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAGAA
GGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGAGC
TAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAGAT
GCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAGAAATGTGTAATTATCAGA
AAGAATAATGGCTTTCAATGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGTACTTGTTGCTGAAAATCA
TGAACATGGACACAAATTCTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTAAAAGAACTATATCTATAT
GTATATTTTCATATATATGACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATTCATGAATTAAATTACTAA
AAGTATGTTTATACTGTGAATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCATGATATGTGTATGTAAAT
ATTCTTACAGTACTTGTTTTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTATCAACTTTGATGCTATGC
TGTCATGCTTAACTTTTTCTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAGGTCTAGTCTTCTTATAAT
AGCAGAGGTCTTGGTAAAATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAGATACATTTATATATTATG
TAAAATGTTAACTATCATCATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGAGTTTTGTATAAAACAATA
GAACAGAAATTTGGGACATTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAAAAGTATATGGGGTAGGCC
GGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGAGTTTGAGACCAGCCTGAG
CAATGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCCCAGCCACTTGGGAGGCTG
AGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGTAACAC
TCTGTCTCAGAAAAAAAAAAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATATACATTCAGTGATACCAC
TCTTTTTCTTCTAAGCCTGTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGTAATATACATGGAAAACAG
CTTTTTACAATTAATTTTCAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAGAAGTACAAAAAAGAATAT
CAGATACAAAAATCAATCGTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACTAACATAGGAAAGTGAATG
ATCAGTTACTTATGATATATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTGTGTATACCTGGGGGTGGG
CAGTGCTCTTTTTCTAAAACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGTGGGCTGGTTTGCTTTTCT
ACCACCTTTGTAATTTTATGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACATGGGACTGTTTGCAATAC
CATATGGAAATCTTTTAATAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGCAACAGCAAGACATATTTT
GTTAGATATTTTATTTTTAATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACCATGATATTGTTTTGAAAA
AATTTTATCTTAAAATACTGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAATTATGGAGCTTGACCTAG

>67011_67011_1_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000314595_CEP135_chr4_56851447_ENST00000257287_length(amino acids)=792AA_BP=244
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQ
IYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGKSELEKTIEHLTCVNH
QLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI
DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ
LDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHN
RAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR
ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLS

--------------------------------------------------------------
>67011_67011_2_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000381227_CEP135_chr4_56851447_ENST00000257287_length(transcript)=4807nt_BP=1148nt
ACTGAGAACCTACTTAAAGCTATGGCAAAGGCACTGGAGGATTGAGCTAGGTGGGCAGAAAAGAGCAGTGTCGTTATTTGTGCAACAACA
TTGAAAAACAAGCAGAAATAAAACATTGACGGAACGGATACGACCGCAGATTGCGGGAGCTGTCCTCTCAATCAGCCCGGCAGCGGCGGC
CCACAATTTACGCGTGTGCAACCCTAACCCCGGCCCAAGCTTGACCTACAATTTGCGCAGGCGCAGATCCTAACTTTGGCGTCCCTGTGG
GCGGCCTTTGGTGTGAGACGCGTGGTATTCTGGGAACGTCGGAGACGGAAGTTACTTCGTCTTTAGCTCCTGGCGCTGCTGGCTTCTGGG
CGGTTTTTGTCTTTTGATTTCAAGAGTTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGATATGCAATATGATGAGG
ATGATGATGAAATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAAC
AGCTGGATTCTTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGC
ATGCTAGTGGAGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATG
GTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCA
TTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTT
TGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGG
TTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGAT
CATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTT
TTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAG
TGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTC
ATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAA
GAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGG
AGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTG
CAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGC
TGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAA
GATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAAT
TGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTG
CCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTG
AGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAG
AAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGA
GACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTA
TGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAA
AACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCT
CCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCA
TGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAA
TCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAGAAATGTGT
AATTATCAGAAAGAATAATGGCTTTCAATGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGTACTTGTTG
CTGAAAATCATGAACATGGACACAAATTCTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTAAAAGAACT
ATATCTATATGTATATTTTCATATATATGACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATTCATGAATT
AAATTACTAAAAGTATGTTTATACTGTGAATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCATGATATGT
GTATGTAAATATTCTTACAGTACTTGTTTTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTATCAACTTT
GATGCTATGCTGTCATGCTTAACTTTTTCTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAGGTCTAGTC
TTCTTATAATAGCAGAGGTCTTGGTAAAATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAGATACATTT
ATATATTATGTAAAATGTTAACTATCATCATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGAGTTTTGTA
TAAAACAATAGAACAGAAATTTGGGACATTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAAAAGTATAT
GGGGTAGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGAGTTTGAGA
CCAGCCTGAGCAATGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCCCAGCCACT
TGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGTGAC
AGAGTAACACTCTGTCTCAGAAAAAAAAAAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATATACATTCA
GTGATACCACTCTTTTTCTTCTAAGCCTGTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGTAATATACA
TGGAAAACAGCTTTTTACAATTAATTTTCAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAGAAGTACAA
AAAAGAATATCAGATACAAAAATCAATCGTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACTAACATAGG
AAAGTGAATGATCAGTTACTTATGATATATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTGTGTATACC
TGGGGGTGGGCAGTGCTCTTTTTCTAAAACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGTGGGCTGGT
TTGCTTTTCTACCACCTTTGTAATTTTATGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACATGGGACTG
TTTGCAATACCATATGGAAATCTTTTAATAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGCAACAGCAA
GACATATTTTGTTAGATATTTTATTTTTAATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACCATGATATT
GTTTTGAAAAAATTTTATCTTAAAATACTGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAATTATGGAG

>67011_67011_2_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000381227_CEP135_chr4_56851447_ENST00000257287_length(amino acids)=792AA_BP=244
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQ
IYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGKSELEKTIEHLTCVNH
QLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI
DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ
LDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHN
RAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR
ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLS

--------------------------------------------------------------
>67011_67011_3_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000431623_CEP135_chr4_56851447_ENST00000257287_length(transcript)=4365nt_BP=706nt
GTGGTATTCTGGGAACGTCGGAGACGGAAGTTACTTCGTCTTTAGCTCCTGGCGCTGCTGGCTTCTGGGCGGTTTTTGTCTTTTGATTTC
AAGAGTTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGAAATCACCCCGG
ATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGA
AAGAGATGGTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAA
AACAGTCATTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTA
CTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATC
AGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGA
GTGTAGATCATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGT
GAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAA
GTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGA
CTCATCTCATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTC
CATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACA
GGATGAGGAGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGA
AAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGT
GAACCAGCTGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGA
AGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTC
ATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTT
AATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCA
TCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATT
AGAAAAAGAAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGA
AGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAA
AGATATTATGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCT
ACTGAAAAAACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCA
CTTAACCTCCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGA
AAACACCATGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGA
ACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAG
AAATGTGTAATTATCAGAAAGAATAATGGCTTTCAATGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGT
ACTTGTTGCTGAAAATCATGAACATGGACACAAATTCTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTA
AAAGAACTATATCTATATGTATATTTTCATATATATGACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATT
CATGAATTAAATTACTAAAAGTATGTTTATACTGTGAATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCA
TGATATGTGTATGTAAATATTCTTACAGTACTTGTTTTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTA
TCAACTTTGATGCTATGCTGTCATGCTTAACTTTTTCTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAG
GTCTAGTCTTCTTATAATAGCAGAGGTCTTGGTAAAATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAG
ATACATTTATATATTATGTAAAATGTTAACTATCATCATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGA
GTTTTGTATAAAACAATAGAACAGAAATTTGGGACATTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAA
AAGTATATGGGGTAGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGA
GTTTGAGACCAGCCTGAGCAATGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCC
CAGCCACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCC
TGGGTGACAGAGTAACACTCTGTCTCAGAAAAAAAAAAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATA
TACATTCAGTGATACCACTCTTTTTCTTCTAAGCCTGTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGT
AATATACATGGAAAACAGCTTTTTACAATTAATTTTCAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAG
AAGTACAAAAAAGAATATCAGATACAAAAATCAATCGTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACT
AACATAGGAAAGTGAATGATCAGTTACTTATGATATATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTG
TGTATACCTGGGGGTGGGCAGTGCTCTTTTTCTAAAACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGT
GGGCTGGTTTGCTTTTCTACCACCTTTGTAATTTTATGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACA
TGGGACTGTTTGCAATACCATATGGAAATCTTTTAATAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGC
AACAGCAAGACATATTTTGTTAGATATTTTATTTTTAATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACC
ATGATATTGTTTTGAAAAAATTTTATCTTAAAATACTGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAA

>67011_67011_3_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000431623_CEP135_chr4_56851447_ENST00000257287_length(amino acids)=717AA_BP=169
MLDCNQPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNG
LTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGK
SELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGE
LESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKE
TLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKE
KENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQ
EDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE

--------------------------------------------------------------
>67011_67011_4_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000441246_CEP135_chr4_56851447_ENST00000257287_length(transcript)=4689nt_BP=1030nt
ATTCTGGGAACGTCGGAGACGGAAGTTACTTCGTCTTTAGCTCCTGGCGCTGCTGGCTTCTGGGCGGTTTTTGTCTTTTGATTTCAAGAG
TTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGGCTGGAGTGCAGTGGCGCGATCTCAGCTCCTGCGAGGAGGCGGA
CCGCCCATTCCGTGCCCGGTAGCCGCGAGGGACCGGTGGTAGCCGCGAGGGACGGGCGGCGGGCTCGGTGCTGTGGCGAGGCGGGGATGG
CACTCCCCCCCGCCGCCCCGTGGGGCGGCCCCGACTTTCGGGCGATATGCAATATGATGAGGATGATGATGAAATCACCCCGGATTTGTG
GCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAACAGCTGGATTCTTTTGATGAGTTTATTCA
GATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGGAGAAGTTGAAGAACCGCC
ACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCTTCACCAATGATGCCCAATGA
AGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGGTGAAGAACAACTTCAGAC
TCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTG
TGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAAC
AAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTTGAGAATTCTTCCCGACCCAC
CAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTAT
TGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTC
GTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAAACAGAGGTGAACTCACTTAG
GATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACA
AATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCATGTAATGAAAAAGACCATTGG
TGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAA
AGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAAACATTGGTTAATCGAGATCG
TGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAA
CAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGA
AATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTT
AGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGA
ACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAAGAGCACATAAATGCCCATCA
TGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGT
ATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAGCAATTGAATTCGAAAAACCT
TGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTTTCAAATGAGAGACATACAGT
TAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAGAAGGATACAGAAATCCAGCT
ACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGAGCTAAAGTGGCACAGTTACA
AACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGC
TACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAGAAATGTGTAATTATCAGAAAGAATAATGGCTTTCAA
TGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGTACTTGTTGCTGAAAATCATGAACATGGACACAAATT
CTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTAAAAGAACTATATCTATATGTATATTTTCATATATAT
GACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATTCATGAATTAAATTACTAAAAGTATGTTTATACTGTG
AATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCATGATATGTGTATGTAAATATTCTTACAGTACTTGTT
TTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTATCAACTTTGATGCTATGCTGTCATGCTTAACTTTTT
CTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAGGTCTAGTCTTCTTATAATAGCAGAGGTCTTGGTAAA
ATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAGATACATTTATATATTATGTAAAATGTTAACTATCAT
CATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGAGTTTTGTATAAAACAATAGAACAGAAATTTGGGACA
TTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAAAAGTATATGGGGTAGGCCGGGTGCAGTGGCTCACGC
CTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGAGTTTGAGACCAGCCTGAGCAATGTGGTGAAACCCCA
TCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCCCAGCCACTTGGGAGGCTGAGGCAGGAGAATTGCTTG
AACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGTAACACTCTGTCTCAGAAAAAAAA
AAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATATACATTCAGTGATACCACTCTTTTTCTTCTAAGCCT
GTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGTAATATACATGGAAAACAGCTTTTTACAATTAATTTT
CAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAGAAGTACAAAAAAGAATATCAGATACAAAAATCAATC
GTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACTAACATAGGAAAGTGAATGATCAGTTACTTATGATAT
ATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTGTGTATACCTGGGGGTGGGCAGTGCTCTTTTTCTAAA
ACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGTGGGCTGGTTTGCTTTTCTACCACCTTTGTAATTTTA
TGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACATGGGACTGTTTGCAATACCATATGGAAATCTTTTAA
TAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGCAACAGCAAGACATATTTTGTTAGATATTTTATTTTT
AATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACCATGATATTGTTTTGAAAAAATTTTATCTTAAAATAC
TGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAATTATGGAGCTTGACCTAGATTTGCCAATAAACTTTC

>67011_67011_4_POLR2B-CEP135_POLR2B_chr4_57861575_ENST00000441246_CEP135_chr4_56851447_ENST00000257287_length(amino acids)=807AA_BP=259
MWRGGDGTPPRRPVGRPRLSGDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHAS
GEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNG
LTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGK
SELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGE
LESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKE
TLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKE
KENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQ
EDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POLR2B-CEP135


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLR2B-CEP135


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLR2B-CEP135


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource