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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLR3B-RBM19 (FusionGDB2 ID:67097)

Fusion Gene Summary for POLR3B-RBM19

check button Fusion gene summary
Fusion gene informationFusion gene name: POLR3B-RBM19
Fusion gene ID: 67097
HgeneTgene
Gene symbol

POLR3B

RBM19

Gene ID

55703

9904

Gene nameRNA polymerase III subunit BRNA binding motif protein 19
SynonymsC128|HLD8|INMAP|RPC2Mrd1
Cytomap

12q23.3

12q24.13-q24.21

Type of geneprotein-codingprotein-coding
DescriptionDNA-directed RNA polymerase III subunit RPC2DNA-directed RNA polymerase III 127.6 kDa polypeptideDNA-directed RNA polymerase III subunit BRNA polymerase III subunit C2interphase nucleus and mitotic apparatus associated proteinpolymerase (RNA) III (DNprobable RNA-binding protein 19
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000228347, ENST00000539066, 
ENST00000549195, 		ENST00000553232, 
ENST00000261741, ENST00000392561, 
ENST00000545145, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 3 X 2=30
# samples 33
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/30*10)=0
Context

PubMed: POLR3B [Title/Abstract] AND RBM19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLR3B(106799754)-RBM19(114282593), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across POLR3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBM19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HO-01APOLR3Bchr12

106799754

-RBM19chr12

114282593

-


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Fusion Gene ORF analysis for POLR3B-RBM19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000228347ENST00000553232POLR3Bchr12

106799754

-RBM19chr12

114282593

-
5CDS-intronENST00000539066ENST00000553232POLR3Bchr12

106799754

-RBM19chr12

114282593

-
In-frameENST00000228347ENST00000261741POLR3Bchr12

106799754

-RBM19chr12

114282593

-
In-frameENST00000228347ENST00000392561POLR3Bchr12

106799754

-RBM19chr12

114282593

-
In-frameENST00000228347ENST00000545145POLR3Bchr12

106799754

-RBM19chr12

114282593

-
In-frameENST00000539066ENST00000261741POLR3Bchr12

106799754

-RBM19chr12

114282593

-
In-frameENST00000539066ENST00000392561POLR3Bchr12

106799754

-RBM19chr12

114282593

-
In-frameENST00000539066ENST00000545145POLR3Bchr12

106799754

-RBM19chr12

114282593

-
intron-3CDSENST00000549195ENST00000261741POLR3Bchr12

106799754

-RBM19chr12

114282593

-
intron-3CDSENST00000549195ENST00000392561POLR3Bchr12

106799754

-RBM19chr12

114282593

-
intron-3CDSENST00000549195ENST00000545145POLR3Bchr12

106799754

-RBM19chr12

114282593

-
intron-intronENST00000549195ENST00000553232POLR3Bchr12

106799754

-RBM19chr12

114282593

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000228347POLR3Bchr12106799754-ENST00000545145RBM19chr12114282593-286711881591406415
ENST00000228347POLR3Bchr12106799754-ENST00000392561RBM19chr12114282593-201211881591406415
ENST00000228347POLR3Bchr12106799754-ENST00000261741RBM19chr12114282593-257411881591406415
ENST00000539066POLR3Bchr12106799754-ENST00000545145RBM19chr12114282593-271410351531253366
ENST00000539066POLR3Bchr12106799754-ENST00000392561RBM19chr12114282593-185910351531253366
ENST00000539066POLR3Bchr12106799754-ENST00000261741RBM19chr12114282593-242110351531253366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000228347ENST00000545145POLR3Bchr12106799754-RBM19chr12114282593-0.0010402550.9989598
ENST00000228347ENST00000392561POLR3Bchr12106799754-RBM19chr12114282593-0.0026148020.9973852
ENST00000228347ENST00000261741POLR3Bchr12106799754-RBM19chr12114282593-0.0032227660.99677724
ENST00000539066ENST00000545145POLR3Bchr12106799754-RBM19chr12114282593-0.0016018640.9983981
ENST00000539066ENST00000392561POLR3Bchr12106799754-RBM19chr12114282593-0.0038847270.9961152
ENST00000539066ENST00000261741POLR3Bchr12106799754-RBM19chr12114282593-0.0045285110.9954715

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Fusion Genomic Features for POLR3B-RBM19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POLR3B-RBM19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:106799754/chr12:114282593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLR3Bchr12:106799754chr12:114282593ENST00000228347-11281080_10953221134.0Zinc fingerNote=C4-type
HgenePOLR3Bchr12:106799754chr12:114282593ENST00000539066-11281080_10952641076.0Zinc fingerNote=C4-type
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124225_232888961.0Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124391_396888961.0Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124714_725888961.0Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125225_2328881094.6666666666667Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125391_3968881094.6666666666667Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125714_7258881094.6666666666667Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125225_2328881381.0Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125391_3968881381.0Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125714_7258881381.0Compositional biasNote=Poly-Glu
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124294_369888961.0DomainRRM 2
TgeneRBM19chr12:106799754chr12:114282593ENST0000026174121242_79888961.0DomainRRM 1
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124402_480888961.0DomainRRM 3
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124587_659888961.0DomainRRM 4
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124730_811888961.0DomainRRM 5
TgeneRBM19chr12:106799754chr12:114282593ENST000002617412124832_912888961.0DomainRRM 6
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125294_3698881094.6666666666667DomainRRM 2
TgeneRBM19chr12:106799754chr12:114282593ENST0000039256121252_798881094.6666666666667DomainRRM 1
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125402_4808881094.6666666666667DomainRRM 3
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125587_6598881094.6666666666667DomainRRM 4
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125730_8118881094.6666666666667DomainRRM 5
TgeneRBM19chr12:106799754chr12:114282593ENST000003925612125832_9128881094.6666666666667DomainRRM 6
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125294_3698881381.0DomainRRM 2
TgeneRBM19chr12:106799754chr12:114282593ENST0000054514521252_798881381.0DomainRRM 1
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125402_4808881381.0DomainRRM 3
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125587_6598881381.0DomainRRM 4
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125730_8118881381.0DomainRRM 5
TgeneRBM19chr12:106799754chr12:114282593ENST000005451452125832_9128881381.0DomainRRM 6


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Fusion Gene Sequence for POLR3B-RBM19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67097_67097_1_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000228347_RBM19_chr12_114282593_ENST00000261741_length(transcript)=2574nt_BP=1188nt
ACCAGAGGGCGTACTTTCCTTACTCGGCCTCGGCCACATCCGGGTTCCACCGCAGATTCGGGCAGGGAGCGGGCGGAACCTTTCTACCGC
GTCTCTAGCTAACACGCACGGCGGGGACAGTTTAGGCCTCCGCGCACCGTTCGCCGGGAGTCTTGCAGTTTGCTTGGTGCAGGGAAGGCG
GGCGCGGAGGTTCTATCTGTTTCTTCCTCCTTCGTGAGCAGCATGGACGTGCTAGCGGAGGAGTTTGGGAACCTGACTCCGGAGCAGCTG
GCGGCGCCGATCCCGACTGTAGAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAAGGCCTTGTGAAACAGCATATAGATTCA
TTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAATGAAAAGGTTACAAGTGACGCTGACCCTATGTGGTACTTAAAA
TATCTTAATATCTATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTGTCCCCTCATGAGTGCCGTTTGAGAGAC
ATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACCCGAGGCAGCCAGAGGATCATCCGCAATGCCTTACCTATCGGCAGAATG
CCCATAATGCTACGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAACTGAACGAATGTCCCTTAGATCCAGGT
GGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATCCAAGAGCAGCTGTCTAAGAACAGGATCATCGTGGAGGCTGATAGAAAA
GGGGCTGTTGGAGCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCTGTGAAACAAGGACGATTTTATTTGAGG
CATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTTAAGGCCATGGGTGTTGAGAGTGACCAGGAAATTGTGCAGATGATTGGA
ACAGAGGAGCACGTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATTTTCACACAGATGCAGGCATTAAAATAT
ATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGACCAAAGAAAACCAAAATAGAAGAAGCAAGAGAGCTCCTGGCTTCCACC
ATTCTGACCCATGTCCCAAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC
GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC
CTGGAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGTGTGTGGCTCCGGGGCC
CTGGGGACCGGGACAGCCGCTCCAGCTTCTGCACTCACCACCATGTGGGCTGGGGGGCGGGGCGGGGAGCGGCAGGCGGCCCCACCCTGC
ACTGGTCCAAGGTCGGAGGAGACAGGGGATGAGGAAGGCCTCAGGCCACTGCCCAGCGGCCCAGGCATCCTGGGTTTCACCAGTGACGCG
TTCTAGCAGACACTGACTGCGCACCTGCTCTGTAGCAGACACGGAAGAGTCCAAGGGAGCAGCCACGTTAGGAAGAGAGACTTGGGAACA
GCTACACAGGGAGCTAGAACCCCTGCTCCCCCTGTCCCCACCCCAGGAGAGTAAGGGGACGAGGGCCAGCTCTCTGGCATCAGGCTGCTT
GGACATGAAACCCCGTCTCCAAGCTCAAGCTGGGAGACCCTGGCCCAGTTTCCTTATCTCCTTGGGCCCAGCCTTCCCCTTGCTAGCTAG
TTCTTACTTCATAAGGTTTTAGAGAGAAATAAACGCAGTAATGCATGAAGAGTGCCGGGCATGGTGCTGAGCCCTGTTCCTGCTCTCCCT
CCAGGGCTGCTGAGCTAGAATTCCCACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATCCTCGT
CACTTGGGACCACGAGCCCTGGTTCAGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCAAGCTC
CCTGGCTGAGCTGAATGATGTCACTCATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTCCGCTG
GCCAGCAGCATCCCCAGGCTTCTCTCAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCTGTGCC
AGCACCAGGCAGAGGGCAAGACGGAGAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTCCCCGA
GGTGCGACCTCAGACTAATGACATCCTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGATAGAC

>67097_67097_1_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000228347_RBM19_chr12_114282593_ENST00000261741_length(amino acids)=415AA_BP=343
MLGAGKAGAEVLSVSSSFVSSMDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDA
DPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLN
ECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQ
EIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPRAFNALCHSTHLYGRRL

--------------------------------------------------------------
>67097_67097_2_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000228347_RBM19_chr12_114282593_ENST00000392561_length(transcript)=2012nt_BP=1188nt
ACCAGAGGGCGTACTTTCCTTACTCGGCCTCGGCCACATCCGGGTTCCACCGCAGATTCGGGCAGGGAGCGGGCGGAACCTTTCTACCGC
GTCTCTAGCTAACACGCACGGCGGGGACAGTTTAGGCCTCCGCGCACCGTTCGCCGGGAGTCTTGCAGTTTGCTTGGTGCAGGGAAGGCG
GGCGCGGAGGTTCTATCTGTTTCTTCCTCCTTCGTGAGCAGCATGGACGTGCTAGCGGAGGAGTTTGGGAACCTGACTCCGGAGCAGCTG
GCGGCGCCGATCCCGACTGTAGAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAAGGCCTTGTGAAACAGCATATAGATTCA
TTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAATGAAAAGGTTACAAGTGACGCTGACCCTATGTGGTACTTAAAA
TATCTTAATATCTATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTGTCCCCTCATGAGTGCCGTTTGAGAGAC
ATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACCCGAGGCAGCCAGAGGATCATCCGCAATGCCTTACCTATCGGCAGAATG
CCCATAATGCTACGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAACTGAACGAATGTCCCTTAGATCCAGGT
GGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATCCAAGAGCAGCTGTCTAAGAACAGGATCATCGTGGAGGCTGATAGAAAA
GGGGCTGTTGGAGCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCTGTGAAACAAGGACGATTTTATTTGAGG
CATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTTAAGGCCATGGGTGTTGAGAGTGACCAGGAAATTGTGCAGATGATTGGA
ACAGAGGAGCACGTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATTTTCACACAGATGCAGGCATTAAAATAT
ATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGACCAAAGAAAACCAAAATAGAAGAAGCAAGAGAGCTCCTGGCTTCCACC
ATTCTGACCCATGTCCCAAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC
GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC
CTGGAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGGCTGCTGAGCTAGAATT
CCCACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATCCTCGTCACTTGGGACCACGAGCCCTGG
TTCAGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCAAGCTCCCTGGCTGAGCTGAATGATGTC
ACTCATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTCCGCTGGCCAGCAGCATCCCCAGGCTTC
TCTCAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCTGTGCCAGCACCAGGCAGAGGGCAAGAC
GGAGAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTCCCCGAGGTGCGACCTCAGACTAATGAC
ATCCTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGATAGACAGTGCCAGAATTAAGTGAGTCA

>67097_67097_2_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000228347_RBM19_chr12_114282593_ENST00000392561_length(amino acids)=415AA_BP=343
MLGAGKAGAEVLSVSSSFVSSMDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDA
DPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLN
ECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQ
EIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPRAFNALCHSTHLYGRRL

--------------------------------------------------------------
>67097_67097_3_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000228347_RBM19_chr12_114282593_ENST00000545145_length(transcript)=2867nt_BP=1188nt
ACCAGAGGGCGTACTTTCCTTACTCGGCCTCGGCCACATCCGGGTTCCACCGCAGATTCGGGCAGGGAGCGGGCGGAACCTTTCTACCGC
GTCTCTAGCTAACACGCACGGCGGGGACAGTTTAGGCCTCCGCGCACCGTTCGCCGGGAGTCTTGCAGTTTGCTTGGTGCAGGGAAGGCG
GGCGCGGAGGTTCTATCTGTTTCTTCCTCCTTCGTGAGCAGCATGGACGTGCTAGCGGAGGAGTTTGGGAACCTGACTCCGGAGCAGCTG
GCGGCGCCGATCCCGACTGTAGAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAAGGCCTTGTGAAACAGCATATAGATTCA
TTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAATGAAAAGGTTACAAGTGACGCTGACCCTATGTGGTACTTAAAA
TATCTTAATATCTATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTGTCCCCTCATGAGTGCCGTTTGAGAGAC
ATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACCCGAGGCAGCCAGAGGATCATCCGCAATGCCTTACCTATCGGCAGAATG
CCCATAATGCTACGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAACTGAACGAATGTCCCTTAGATCCAGGT
GGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATCCAAGAGCAGCTGTCTAAGAACAGGATCATCGTGGAGGCTGATAGAAAA
GGGGCTGTTGGAGCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCTGTGAAACAAGGACGATTTTATTTGAGG
CATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTTAAGGCCATGGGTGTTGAGAGTGACCAGGAAATTGTGCAGATGATTGGA
ACAGAGGAGCACGTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATTTTCACACAGATGCAGGCATTAAAATAT
ATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGACCAAAGAAAACCAAAATAGAAGAAGCAAGAGAGCTCCTGGCTTCCACC
ATTCTGACCCATGTCCCAAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC
GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC
CTGGAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGCTGGAGTGCAGTGGCGT
GATCTGGGCTCACCTCCCTGGTTCAAGCGATTGTCCCGCCTCAGCCTCCCAAGGCTGGGATTACAGGTATGCACCACCACGCCCGGCTAA
TTTTGTATTTTTCATAGAGACTGGGTTTCACCATGTAGACCAGGCTGGTCTCGAATTCCTGACCTCAAGTGATCCACCTACCTCGGCCTC
CCAAAGTGTGGGGATTACGGGTGTGAGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGACAGGGTTTCACCATGTGGGCCAGGCT
GGTCTTGAACTCCCAACCTCAAGTGATCCACCCACCTTGTTCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACCATGCCCAGCCTGTT
CCTAACCCTTTCAACTGGGGGGTCTCAAGTGGGTGAGGACTCCATGGCCACGGCAGCAGAACTGTCTCTTCTGAAAACCAGACTCCGGGG
CCCCTGGGTCAGCACCTCTAGGTCATTCCACAGACTTACACAGTTTAAAGAAAGAGCCAGCGAACATGGGGTGATCCTGGGGTGCCACTG
GGATCCCAAGCCAGGCCCGGAGGTCTGCCTGTTTCGTCCCCAGAAACTTGAGCTGGCATCCTCCGCTGGTTTGCACTGGGCACGGGGACT
GGAGAGCCACCAGGCCACTGAGCGCAGCATGCTATCACTTCTCAGGAAGTTGTGAGGGTGAGGAGAATAGCCGGGCCCACTCTGCAGAGG
GGAGGAACAGGCACAGGCTAGAGGCACGGGCTGATAGAGTGAGTCCTCTCCCTCATTCATTCATTCATTCATTCATTCATCCATCAGACA
CCTGCTGGGCATCTGCTGTGTGCGAGACACTGTGCTGGGTGCCCCAGACACAAGACAGAAACTCGGGTCGCTCTGTGTGCCTCCACACTG
GCCTTCCCTGCTGCGTGGACGCAGGCTCTGTCTCCTAGGCTTTAAGCCCCATGCATCAGGTGGAAGACAATTTCCAGCAGCCTCTGCCCG
CTTGTTTTTCCTCCTCTCCTTTTCCTGCCGCCTTGGTCTTTTTTGTCTTTTGTGCAGGGCCGTCTCTCGCAGCGCCCGTCTGTGCTCCGC
AGCGTCTAGGAAAGGATTAGTGTGAGCAGAGCACGCAGGCTTTGGTGAACAGAGCCGAGCTTGGTTTCAACATCTAATTCAATTTGTTCT
GCCGAGATTGAAATATGAAATGGTTGCCAGTCAAACGTTCAAAGGACGGGGAAGGGAGAGTGAGCGCATGCTGAAATTTAAATTTTAATG
AAAATGACTTTAACCCTTTGGTACACCTTGCAAAATGTAACCCATCCTCCCATCCTGTGAAAGCGGCCTCTCGGGTTAGAGCTTTTCCAC

>67097_67097_3_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000228347_RBM19_chr12_114282593_ENST00000545145_length(amino acids)=415AA_BP=343
MLGAGKAGAEVLSVSSSFVSSMDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDA
DPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLN
ECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQ
EIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPRAFNALCHSTHLYGRRL

--------------------------------------------------------------
>67097_67097_4_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000539066_RBM19_chr12_114282593_ENST00000261741_length(transcript)=2421nt_BP=1035nt
AGAGCGTCGCGCTTGCGAGTCTTTTTTCCAGAGCCGGCCTCCGCGTGCGCGAGTGAAGGCTGATCCCAGAGGAGCTGTCAGCCGCTGCGG
GGGCCGAGAAGCCCCGCTGCTGGCTCTAGGGTTGGAGCTCTTCCAGCATAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAA
GGCCTTGTGAAACAGCATATAGATTCATTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAATGAAAAGGTTACAAGT
GACGCTGACCCTATGTGGTACTTAAAATATCTTAATATCTATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTG
TCCCCTCATGAGTGCCGTTTGAGAGACATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACCCGAGGCAGCCAGAGGATCATC
CGCAATGCCTTACCTATCGGCAGAATGCCCATAATGCTACGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAA
CTGAACGAATGTCCCTTAGATCCAGGTGGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATCCAAGAGCAGCTGTCTAAGAAC
AGGATCATCGTGGAGGCTGATAGAAAAGGGGCTGTTGGAGCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCT
GTGAAACAAGGACGATTTTATTTGAGGCATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTTAAGGCCATGGGTGTTGAGAGT
GACCAGGAAATTGTGCAGATGATTGGAACAGAGGAGCACGTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATT
TTCACACAGATGCAGGCATTAAAATATATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGACCAAAGAAAACCAAAATAGAA
GAAGCAAGAGAGCTCCTGGCTTCCACCATTCTGACCCATGTCCCAAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGG
AGGCTGGTGCTGGAGTGGGCCGACTCCGAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAA
AAGCGGTCTGTGGTGTTGGACGAGATCCTGGAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGC
ACCGAGAGGGTGTGTGGCTCCGGGGCCCTGGGGACCGGGACAGCCGCTCCAGCTTCTGCACTCACCACCATGTGGGCTGGGGGGCGGGGC
GGGGAGCGGCAGGCGGCCCCACCCTGCACTGGTCCAAGGTCGGAGGAGACAGGGGATGAGGAAGGCCTCAGGCCACTGCCCAGCGGCCCA
GGCATCCTGGGTTTCACCAGTGACGCGTTCTAGCAGACACTGACTGCGCACCTGCTCTGTAGCAGACACGGAAGAGTCCAAGGGAGCAGC
CACGTTAGGAAGAGAGACTTGGGAACAGCTACACAGGGAGCTAGAACCCCTGCTCCCCCTGTCCCCACCCCAGGAGAGTAAGGGGACGAG
GGCCAGCTCTCTGGCATCAGGCTGCTTGGACATGAAACCCCGTCTCCAAGCTCAAGCTGGGAGACCCTGGCCCAGTTTCCTTATCTCCTT
GGGCCCAGCCTTCCCCTTGCTAGCTAGTTCTTACTTCATAAGGTTTTAGAGAGAAATAAACGCAGTAATGCATGAAGAGTGCCGGGCATG
GTGCTGAGCCCTGTTCCTGCTCTCCCTCCAGGGCTGCTGAGCTAGAATTCCCACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGAC
TTGGTCTCTGTCCTGCCCCATCCTCGTCACTTGGGACCACGAGCCCTGGTTCAGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCAT
CGAGCTCCAAGCCCAGATGCCAAGCTCCCTGGCTGAGCTGAATGATGTCACTCATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTG
TGAAATGCATCAAGGTCCTCTCCGCTGGCCAGCAGCATCCCCAGGCTTCTCTCAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGC
AGCCTCCCGCCTGGAAGGGCCTGTGCCAGCACCAGGCAGAGGGCAAGACGGAGAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGT
CTGAATCTAGACATCGCCATTCCCCGAGGTGCGACCTCAGACTAATGACATCCTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGG

>67097_67097_4_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000539066_RBM19_chr12_114282593_ENST00000261741_length(amino acids)=366AA_BP=294
MLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIE
YTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTH
EKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWG
GGPKKTKIEEARELLASTILTHVPRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQLEGSDSDSE

--------------------------------------------------------------
>67097_67097_5_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000539066_RBM19_chr12_114282593_ENST00000392561_length(transcript)=1859nt_BP=1035nt
AGAGCGTCGCGCTTGCGAGTCTTTTTTCCAGAGCCGGCCTCCGCGTGCGCGAGTGAAGGCTGATCCCAGAGGAGCTGTCAGCCGCTGCGG
GGGCCGAGAAGCCCCGCTGCTGGCTCTAGGGTTGGAGCTCTTCCAGCATAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAA
GGCCTTGTGAAACAGCATATAGATTCATTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAATGAAAAGGTTACAAGT
GACGCTGACCCTATGTGGTACTTAAAATATCTTAATATCTATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTG
TCCCCTCATGAGTGCCGTTTGAGAGACATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACCCGAGGCAGCCAGAGGATCATC
CGCAATGCCTTACCTATCGGCAGAATGCCCATAATGCTACGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAA
CTGAACGAATGTCCCTTAGATCCAGGTGGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATCCAAGAGCAGCTGTCTAAGAAC
AGGATCATCGTGGAGGCTGATAGAAAAGGGGCTGTTGGAGCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCT
GTGAAACAAGGACGATTTTATTTGAGGCATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTTAAGGCCATGGGTGTTGAGAGT
GACCAGGAAATTGTGCAGATGATTGGAACAGAGGAGCACGTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATT
TTCACACAGATGCAGGCATTAAAATATATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGACCAAAGAAAACCAAAATAGAA
GAAGCAAGAGAGCTCCTGGCTTCCACCATTCTGACCCATGTCCCAAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGG
AGGCTGGTGCTGGAGTGGGCCGACTCCGAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAA
AAGCGGTCTGTGGTGTTGGACGAGATCCTGGAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGC
ACCGAGAGGGGCTGCTGAGCTAGAATTCCCACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATC
CTCGTCACTTGGGACCACGAGCCCTGGTTCAGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCA
AGCTCCCTGGCTGAGCTGAATGATGTCACTCATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTC
CGCTGGCCAGCAGCATCCCCAGGCTTCTCTCAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCT
GTGCCAGCACCAGGCAGAGGGCAAGACGGAGAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTC
CCCGAGGTGCGACCTCAGACTAATGACATCCTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGA

>67097_67097_5_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000539066_RBM19_chr12_114282593_ENST00000392561_length(amino acids)=366AA_BP=294
MLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIE
YTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTH
EKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWG
GGPKKTKIEEARELLASTILTHVPRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQLEGSDSDSE

--------------------------------------------------------------
>67097_67097_6_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000539066_RBM19_chr12_114282593_ENST00000545145_length(transcript)=2714nt_BP=1035nt
AGAGCGTCGCGCTTGCGAGTCTTTTTTCCAGAGCCGGCCTCCGCGTGCGCGAGTGAAGGCTGATCCCAGAGGAGCTGTCAGCCGCTGCGG
GGGCCGAGAAGCCCCGCTGCTGGCTCTAGGGTTGGAGCTCTTCCAGCATAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAA
GGCCTTGTGAAACAGCATATAGATTCATTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAATGAAAAGGTTACAAGT
GACGCTGACCCTATGTGGTACTTAAAATATCTTAATATCTATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTG
TCCCCTCATGAGTGCCGTTTGAGAGACATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACCCGAGGCAGCCAGAGGATCATC
CGCAATGCCTTACCTATCGGCAGAATGCCCATAATGCTACGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAA
CTGAACGAATGTCCCTTAGATCCAGGTGGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATCCAAGAGCAGCTGTCTAAGAAC
AGGATCATCGTGGAGGCTGATAGAAAAGGGGCTGTTGGAGCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCT
GTGAAACAAGGACGATTTTATTTGAGGCATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTTAAGGCCATGGGTGTTGAGAGT
GACCAGGAAATTGTGCAGATGATTGGAACAGAGGAGCACGTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATT
TTCACACAGATGCAGGCATTAAAATATATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGACCAAAGAAAACCAAAATAGAA
GAAGCAAGAGAGCTCCTGGCTTCCACCATTCTGACCCATGTCCCAAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGG
AGGCTGGTGCTGGAGTGGGCCGACTCCGAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAA
AAGCGGTCTGTGGTGTTGGACGAGATCCTGGAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGC
ACCGAGAGGGCTGGAGTGCAGTGGCGTGATCTGGGCTCACCTCCCTGGTTCAAGCGATTGTCCCGCCTCAGCCTCCCAAGGCTGGGATTA
CAGGTATGCACCACCACGCCCGGCTAATTTTGTATTTTTCATAGAGACTGGGTTTCACCATGTAGACCAGGCTGGTCTCGAATTCCTGAC
CTCAAGTGATCCACCTACCTCGGCCTCCCAAAGTGTGGGGATTACGGGTGTGAGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAG
ACAGGGTTTCACCATGTGGGCCAGGCTGGTCTTGAACTCCCAACCTCAAGTGATCCACCCACCTTGTTCTCCCAAAGTGCTGAGATTACA
GGTGTGAGCCACCATGCCCAGCCTGTTCCTAACCCTTTCAACTGGGGGGTCTCAAGTGGGTGAGGACTCCATGGCCACGGCAGCAGAACT
GTCTCTTCTGAAAACCAGACTCCGGGGCCCCTGGGTCAGCACCTCTAGGTCATTCCACAGACTTACACAGTTTAAAGAAAGAGCCAGCGA
ACATGGGGTGATCCTGGGGTGCCACTGGGATCCCAAGCCAGGCCCGGAGGTCTGCCTGTTTCGTCCCCAGAAACTTGAGCTGGCATCCTC
CGCTGGTTTGCACTGGGCACGGGGACTGGAGAGCCACCAGGCCACTGAGCGCAGCATGCTATCACTTCTCAGGAAGTTGTGAGGGTGAGG
AGAATAGCCGGGCCCACTCTGCAGAGGGGAGGAACAGGCACAGGCTAGAGGCACGGGCTGATAGAGTGAGTCCTCTCCCTCATTCATTCA
TTCATTCATTCATTCATCCATCAGACACCTGCTGGGCATCTGCTGTGTGCGAGACACTGTGCTGGGTGCCCCAGACACAAGACAGAAACT
CGGGTCGCTCTGTGTGCCTCCACACTGGCCTTCCCTGCTGCGTGGACGCAGGCTCTGTCTCCTAGGCTTTAAGCCCCATGCATCAGGTGG
AAGACAATTTCCAGCAGCCTCTGCCCGCTTGTTTTTCCTCCTCTCCTTTTCCTGCCGCCTTGGTCTTTTTTGTCTTTTGTGCAGGGCCGT
CTCTCGCAGCGCCCGTCTGTGCTCCGCAGCGTCTAGGAAAGGATTAGTGTGAGCAGAGCACGCAGGCTTTGGTGAACAGAGCCGAGCTTG
GTTTCAACATCTAATTCAATTTGTTCTGCCGAGATTGAAATATGAAATGGTTGCCAGTCAAACGTTCAAAGGACGGGGAAGGGAGAGTGA
GCGCATGCTGAAATTTAAATTTTAATGAAAATGACTTTAACCCTTTGGTACACCTTGCAAAATGTAACCCATCCTCCCATCCTGTGAAAG
CGGCCTCTCGGGTTAGAGCTTTTCCACCCACTTCTCTTCCACTGAGCTTCACTAATAATATGTAATCATTTTTTTCAGCCGTCTTAATAA

>67097_67097_6_POLR3B-RBM19_POLR3B_chr12_106799754_ENST00000539066_RBM19_chr12_114282593_ENST00000545145_length(amino acids)=366AA_BP=294
MLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIE
YTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTH
EKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWG
GGPKKTKIEEARELLASTILTHVPRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQLEGSDSDSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POLR3B-RBM19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLR3B-RBM19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLR3B-RBM19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource