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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POLR3E-C16orf52 (FusionGDB2 ID:67102)

Fusion Gene Summary for POLR3E-C16orf52

check button Fusion gene summary
Fusion gene informationFusion gene name: POLR3E-C16orf52
Fusion gene ID: 67102
HgeneTgene
Gene symbol

POLR3E

C16orf52

Gene ID

55718

730094

Gene nameRNA polymerase III subunit Emodulator of smoothened
SynonymsC37|RPC5|SINATTHOG|BC030336|C16orf52
Cytomap

16p12.2

16p12.2

Type of geneprotein-codingprotein-coding
DescriptionDNA-directed RNA polymerase III subunit RPC5DNA-directed RNA polymerase III 80 kDa polypeptideRNA polymerase III 80 kDa subunit RPC5RNA polymerase III subunit C5polymerase (RNA) III (DNA directed) polypeptide E (80kD)polymerase (RNA) III subunit Emodulator of smoothened proteinAttenuator of Hedgehoguncharacterized protein C16orf52
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299853, ENST00000359210, 
ENST00000418581, ENST00000564209, 
ENST00000564256, 		ENST00000569656, 
ENST00000542527, ENST00000562695, 
ENST00000567004, 
Fusion gene scores* DoF score5 X 7 X 5=1751 X 2 X 3=6
# samples 83
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context

PubMed: POLR3E [Title/Abstract] AND C16orf52 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOLR3E(22337116)-C16orf52(22098614), # samples:2
Anticipated loss of major functional domain due to fusion event.POLR3E-C16orf52 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across POLR3E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C16orf52 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GM-A2DB-01APOLR3Echr16

22337116

+C16orf52chr16

22098614

+
ChimerDB4LUADTCGA-NJ-A4YF-01APOLR3Echr16

22330267

+C16orf52chr16

22086808

+
ChimerDB4LUSCTCGA-43-6143-01APOLR3Echr16

22308858

+C16orf52chr16

22086808

+


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Fusion Gene ORF analysis for POLR3E-C16orf52

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000299853ENST00000569656POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-3UTRENST00000359210ENST00000569656POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-3UTRENST00000418581ENST00000569656POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-3UTRENST00000564209ENST00000569656POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000299853ENST00000542527POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000299853ENST00000562695POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000299853ENST00000567004POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000359210ENST00000542527POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000359210ENST00000562695POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000359210ENST00000567004POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000418581ENST00000542527POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000418581ENST00000562695POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000418581ENST00000567004POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000564209ENST00000542527POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000564209ENST00000562695POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5CDS-intronENST00000564209ENST00000567004POLR3Echr16

22337116

+C16orf52chr16

22098614

+
5UTR-3CDSENST00000299853ENST00000542527POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000299853ENST00000562695POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000299853ENST00000567004POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000299853ENST00000569656POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000359210ENST00000542527POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000359210ENST00000562695POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000359210ENST00000567004POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000359210ENST00000569656POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000418581ENST00000542527POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000418581ENST00000562695POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000418581ENST00000567004POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000418581ENST00000569656POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000564209ENST00000542527POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000564209ENST00000562695POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000564209ENST00000567004POLR3Echr16

22308858

+C16orf52chr16

22086808

+
5UTR-3CDSENST00000564209ENST00000569656POLR3Echr16

22308858

+C16orf52chr16

22086808

+
Frame-shiftENST00000299853ENST00000542527POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000299853ENST00000567004POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000299853ENST00000569656POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000359210ENST00000542527POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000359210ENST00000567004POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000359210ENST00000569656POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000418581ENST00000542527POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000418581ENST00000567004POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000418581ENST00000569656POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000564209ENST00000542527POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000564209ENST00000567004POLR3Echr16

22330267

+C16orf52chr16

22086808

+
Frame-shiftENST00000564209ENST00000569656POLR3Echr16

22330267

+C16orf52chr16

22086808

+
In-frameENST00000299853ENST00000562695POLR3Echr16

22330267

+C16orf52chr16

22086808

+
In-frameENST00000359210ENST00000562695POLR3Echr16

22330267

+C16orf52chr16

22086808

+
In-frameENST00000418581ENST00000562695POLR3Echr16

22330267

+C16orf52chr16

22086808

+
In-frameENST00000564209ENST00000562695POLR3Echr16

22330267

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000542527POLR3Echr16

22330267

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000542527POLR3Echr16

22308858

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000562695POLR3Echr16

22330267

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000562695POLR3Echr16

22308858

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000567004POLR3Echr16

22330267

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000567004POLR3Echr16

22308858

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000569656POLR3Echr16

22330267

+C16orf52chr16

22086808

+
intron-3CDSENST00000564256ENST00000569656POLR3Echr16

22308858

+C16orf52chr16

22086808

+
intron-3UTRENST00000564256ENST00000569656POLR3Echr16

22337116

+C16orf52chr16

22098614

+
intron-intronENST00000564256ENST00000542527POLR3Echr16

22337116

+C16orf52chr16

22098614

+
intron-intronENST00000564256ENST00000562695POLR3Echr16

22337116

+C16orf52chr16

22098614

+
intron-intronENST00000564256ENST00000567004POLR3Echr16

22337116

+C16orf52chr16

22098614

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299853POLR3Echr1622330267+ENST00000562695C16orf52chr1622086808+17231153711369432
ENST00000564209POLR3Echr1622330267+ENST00000562695C16orf52chr1622086808+17211151691367432
ENST00000418581POLR3Echr1622330267+ENST00000562695C16orf52chr1622086808+15971027531243396
ENST00000359210POLR3Echr1622330267+ENST00000562695C16orf52chr1622086808+16991129471345432

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299853ENST00000562695POLR3Echr1622330267+C16orf52chr1622086808+0.0041789480.995821
ENST00000564209ENST00000562695POLR3Echr1622330267+C16orf52chr1622086808+0.0042029680.99579704
ENST00000418581ENST00000562695POLR3Echr1622330267+C16orf52chr1622086808+0.0063445740.99365544
ENST00000359210ENST00000562695POLR3Echr1622330267+C16orf52chr1622086808+0.0047765920.99522346

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Fusion Genomic Features for POLR3E-C16orf52


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
POLR3Echr1622308858+C16orf52chr1622086807+0.0007208170.9992792
POLR3Echr1622330267+C16orf52chr1622086807+0.0001264530.9998735
POLR3Echr1622308858+C16orf52chr1622086807+0.0007208170.9992792
POLR3Echr1622330267+C16orf52chr1622086807+0.0001264530.9998735

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for POLR3E-C16orf52


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:22337116/chr16:22098614)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC16orf52chr16:22330267chr16:22086808ENST0000056965617101_12112138.33333333333334TransmembraneHelical
TgeneC16orf52chr16:22330267chr16:22086808ENST0000056965617139_15912138.33333333333334TransmembraneHelical
TgeneC16orf52chr16:22330267chr16:22086808ENST000005696561768_8812138.33333333333334TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC16orf52chr16:22330267chr16:22086808ENST00000569656177_2912138.33333333333334TransmembraneHelical


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Fusion Gene Sequence for POLR3E-C16orf52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67102_67102_1_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000299853_C16orf52_chr16_22086808_ENST00000562695_length(transcript)=1723nt_BP=1153nt
ACGTGTCCGCCGGAGTTTCTCCACCAGCAACATGGCCGCCGCCTGAGAGGAGAGCCGGGCCGCCGCCGTCTCTGCAGCCCGCGGGTAACT
GGGCCGTTGCCGCCGTCCGCGCTCGGCCCCCGCGGAGAGATCGAGCTGAAGGACTGCGCGGCTGGCTCTCCTCTAGTATGGCCAATGAAG
AGGATGACCCAGTTGTACAGGAGATCGATGTGTACTTGGCCAAGAGTCTGGCGGAAAAGCTGTATCTATTTCAGTACCCTGTGCGTCCAG
CCTCGATGACCTACGATGACATTCCGCACCTCTCAGCCAAGATCAAGCCCAAGCAGCAGAAGGTAGAGCTTGAGATGGCCATCGACACCC
TGAACCCCAACTATTGCCGCAGCAAAGGGGAGCAGATTGCGCTGAACGTGGACGGGGCCTGCGCCGACGAGACCAGCACGTATTCCTCGA
AGCTGATGGACAAGCAGACCTTCTGCTCTTCCCAGACCACCAGTAACACATCCCGTTATGCCGCTGCACTCTACAGGCAAGGTGAGCTCC
ACCTGACACCTTTACATGGCATCCTGCAGCTGCGGCCCAGCTTCTCCTACCTGGATAAGGCTGACGCCAAGCACCGGGAGAGGGAGGCGG
CCAACGAGGCAGGGGACTCTTCACAGGATGAGGCGGAAGACGATGTTAAGCAGATCACGGTGCGGTTCTCCCGGCCGGAGTCAGAGCAGG
CCCGCCAGCGCCGTGTGCAGTCCTATGAGTTCCTGCAGAAGAAGCACGCAGAGGAGCCCTGGGTCCACCTGCATTACTATGGCCTGAGGG
ACAGTCGCTCTGAGCATGAGCGTCAGTACCTGCTGTGCCCCGGCTCAAGCGGGGTGGAGAACACGGAGCTCGTCAAGTCACCCAGTGAGT
ACCTGATGATGCTGATGCCACCCAGCCAGGAGGAGGAGAAAGACAAGCCTGTGGCCCCCAGCAACGTCCTGTCGATGGCCCAGCTGCGCA
CGCTGCCCCTGGCCGATCAGATCAAGATCCTGATGAAGAATGTGAAGGTCATGCCTTTTGCCAACTTGATGAGCCTCCTGGGCCCCTCCA
TCGATTCCGTGGCTGTTCTGCGGGGCATCCAGAAGGTGGCGATGTTGGTCCAAGGGAACTGGGTGGTGAAGAGGAGCACTCACTGTGGGC
CTCGTGCGACAGTGTCAAACAATCCATGGACGAGACCGGACGTGCATCCCTCCCCGGCTTCCCCCGGAGTGGGTCACCACACTGTTTTTT
ATCATCATGGGAATCATTTCATTGACTGTCACATGTGGTTTGCTGGTGGCTTCCCACTGGCGAAGAGAAGCTACAAAATATGCTCGATGG
ATAGCATTCACTGGAAGTAAGTAACCTGTGCTTACTAAATTTGTCTAGAAGGCACCCACCCACACTGGTATTTTTATGAAGATAATCAAG
AATCAGTAATAAGGACTTCATAATCATCAAAGAGCACCACTTGTGTATGGCCGTGAGATAGACTCTACACAGTCCCATCATTTCTTCAAA
ACTCTTTCTGCAAGACCAGGACATCCACAACTTTAATCACTTTGTATGAAATGCTATTTTAATGAATTTTATTTTTGCTCAGATTGTGAC
ATAAGTGTTCCAGGTTTGTGACTCAGAGTTACCAGTAGCCTGAGTCTTTTCCTCTTCTTGAAGCTATTGGTATCATCTATCAAAATAAAG

>67102_67102_1_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000299853_C16orf52_chr16_22086808_ENST00000562695_length(amino acids)=432AA_BP=360
MQPAGNWAVAAVRARPPRRDRAEGLRGWLSSSMANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVEL
EMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAK
HREREAANEAGDSSQDEAEDDVKQITVRFSRPESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTEL
VKSPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSLLGPSIDSVAVLRGIQKVAMLVQGNWVVK

--------------------------------------------------------------
>67102_67102_2_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000359210_C16orf52_chr16_22086808_ENST00000562695_length(transcript)=1699nt_BP=1129nt
CAGCAACATGGCCGCCGCCTGAGAGGAGAGCCGGGCCGCCGCCGTCTCTGCAGCCCGCGGGTAACTGGGCCGTTGCCGCCGTCCGCGCTC
GGCCCCCGCGGAGAGATCGAGCTGAAGGACTGCGCGGCTGGCTCTCCTCTAGTATGGCCAATGAAGAGGATGACCCAGTTGTACAGGAGA
TCGATGTGTACTTGGCCAAGAGTCTGGCGGAAAAGCTGTATCTATTTCAGTACCCTGTGCGTCCAGCCTCGATGACCTACGATGACATTC
CGCACCTCTCAGCCAAGATCAAGCCCAAGCAGCAGAAGGTAGAGCTTGAGATGGCCATCGACACCCTGAACCCCAACTATTGCCGCAGCA
AAGGGGAGCAGATTGCGCTGAACGTGGACGGGGCCTGCGCCGACGAGACCAGCACGTATTCCTCGAAGCTGATGGACAAGCAGACCTTCT
GCTCTTCCCAGACCACCAGTAACACATCCCGTTATGCCGCTGCACTCTACAGGCAAGGTGAGCTCCACCTGACACCTTTACATGGCATCC
TGCAGCTGCGGCCCAGCTTCTCCTACCTGGATAAGGCTGACGCCAAGCACCGGGAGAGGGAGGCGGCCAACGAGGCAGGGGACTCTTCAC
AGGATGAGGCGGAAGACGATGTTAAGCAGATCACGGTGCGGTTCTCCCGGCCGGAGTCAGAGCAGGCCCGCCAGCGCCGTGTGCAGTCCT
ATGAGTTCCTGCAGAAGAAGCACGCAGAGGAGCCCTGGGTCCACCTGCATTACTATGGCCTGAGGGACAGTCGCTCTGAGCATGAGCGTC
AGTACCTGCTGTGCCCCGGCTCAAGCGGGGTGGAGAACACGGAGCTCGTCAAGTCACCCAGTGAGTACCTGATGATGCTGATGCCACCCA
GCCAGGAGGAGGAGAAAGACAAGCCTGTGGCCCCCAGCAACGTCCTGTCGATGGCCCAGCTGCGCACGCTGCCCCTGGCCGATCAGATCA
AGATCCTGATGAAGAATGTGAAGGTCATGCCTTTTGCCAACTTGATGAGCCTCCTGGGCCCCTCCATCGATTCCGTGGCTGTTCTGCGGG
GCATCCAGAAGGTGGCGATGTTGGTCCAAGGGAACTGGGTGGTGAAGAGGAGCACTCACTGTGGGCCTCGTGCGACAGTGTCAAACAATC
CATGGACGAGACCGGACGTGCATCCCTCCCCGGCTTCCCCCGGAGTGGGTCACCACACTGTTTTTTATCATCATGGGAATCATTTCATTG
ACTGTCACATGTGGTTTGCTGGTGGCTTCCCACTGGCGAAGAGAAGCTACAAAATATGCTCGATGGATAGCATTCACTGGAAGTAAGTAA
CCTGTGCTTACTAAATTTGTCTAGAAGGCACCCACCCACACTGGTATTTTTATGAAGATAATCAAGAATCAGTAATAAGGACTTCATAAT
CATCAAAGAGCACCACTTGTGTATGGCCGTGAGATAGACTCTACACAGTCCCATCATTTCTTCAAAACTCTTTCTGCAAGACCAGGACAT
CCACAACTTTAATCACTTTGTATGAAATGCTATTTTAATGAATTTTATTTTTGCTCAGATTGTGACATAAGTGTTCCAGGTTTGTGACTC

>67102_67102_2_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000359210_C16orf52_chr16_22086808_ENST00000562695_length(amino acids)=432AA_BP=360
MQPAGNWAVAAVRARPPRRDRAEGLRGWLSSSMANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVEL
EMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAK
HREREAANEAGDSSQDEAEDDVKQITVRFSRPESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTEL
VKSPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSLLGPSIDSVAVLRGIQKVAMLVQGNWVVK

--------------------------------------------------------------
>67102_67102_3_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000418581_C16orf52_chr16_22086808_ENST00000562695_length(transcript)=1597nt_BP=1027nt
CTCCACCAGCAACATGGCCGCCGCCTGAGAGGAGAGCCGGGCCGCCGCCGTCTCTGCAGCCCGCGGGTAACTGGGCCGTTGCCGCCGTCC
GCGCTCGGCCCCCGCGGAGAGATCGAGCTGAAGGACTGCGCGGCTGGCTCTCCTCTAGTATGGCCAATGAAGAGGATGACCCAGTTGTAC
AGGAGATCAAGCCCAAGCAGCAGAAGGTAGAGCTTGAGATGGCCATCGACACCCTGAACCCCAACTATTGCCGCAGCAAAGGGGAGCAGA
TTGCGCTGAACGTGGACGGGGCCTGCGCCGACGAGACCAGCACGTATTCCTCGAAGCTGATGGACAAGCAGACCTTCTGCTCTTCCCAGA
CCACCAGTAACACATCCCGTTATGCCGCTGCACTCTACAGGCAAGGTGAGCTCCACCTGACACCTTTACATGGCATCCTGCAGCTGCGGC
CCAGCTTCTCCTACCTGGATAAGGCTGACGCCAAGCACCGGGAGAGGGAGGCGGCCAACGAGGCAGGGGACTCTTCACAGGATGAGGCGG
AAGACGATGTTAAGCAGATCACGGTGCGGTTCTCCCGGCCGGAGTCAGAGCAGGCCCGCCAGCGCCGTGTGCAGTCCTATGAGTTCCTGC
AGAAGAAGCACGCAGAGGAGCCCTGGGTCCACCTGCATTACTATGGCCTGAGGGACAGTCGCTCTGAGCATGAGCGTCAGTACCTGCTGT
GCCCCGGCTCAAGCGGGGTGGAGAACACGGAGCTCGTCAAGTCACCCAGTGAGTACCTGATGATGCTGATGCCACCCAGCCAGGAGGAGG
AGAAAGACAAGCCTGTGGCCCCCAGCAACGTCCTGTCGATGGCCCAGCTGCGCACGCTGCCCCTGGCCGATCAGATCAAGATCCTGATGA
AGAATGTGAAGGTCATGCCTTTTGCCAACTTGATGAGCCTCCTGGGCCCCTCCATCGATTCCGTGGCTGTTCTGCGGGGCATCCAGAAGG
TGGCGATGTTGGTCCAAGGGAACTGGGTGGTGAAGAGGAGCACTCACTGTGGGCCTCGTGCGACAGTGTCAAACAATCCATGGACGAGAC
CGGACGTGCATCCCTCCCCGGCTTCCCCCGGAGTGGGTCACCACACTGTTTTTTATCATCATGGGAATCATTTCATTGACTGTCACATGT
GGTTTGCTGGTGGCTTCCCACTGGCGAAGAGAAGCTACAAAATATGCTCGATGGATAGCATTCACTGGAAGTAAGTAACCTGTGCTTACT
AAATTTGTCTAGAAGGCACCCACCCACACTGGTATTTTTATGAAGATAATCAAGAATCAGTAATAAGGACTTCATAATCATCAAAGAGCA
CCACTTGTGTATGGCCGTGAGATAGACTCTACACAGTCCCATCATTTCTTCAAAACTCTTTCTGCAAGACCAGGACATCCACAACTTTAA
TCACTTTGTATGAAATGCTATTTTAATGAATTTTATTTTTGCTCAGATTGTGACATAAGTGTTCCAGGTTTGTGACTCAGAGTTACCAGT

>67102_67102_3_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000418581_C16orf52_chr16_22086808_ENST00000562695_length(amino acids)=396AA_BP=324
MQPAGNWAVAAVRARPPRRDRAEGLRGWLSSSMANEEDDPVVQEIKPKQQKVELEMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSS
KLMDKQTFCSSQTTSNTSRYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRPESEQ
ARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVKSPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLR
TLPLADQIKILMKNVKVMPFANLMSLLGPSIDSVAVLRGIQKVAMLVQGNWVVKRSTHCGPRATVSNNPWTRPDVHPSPASPGVGHHTVF

--------------------------------------------------------------
>67102_67102_4_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000564209_C16orf52_chr16_22086808_ENST00000562695_length(transcript)=1721nt_BP=1151nt
GTGTCCGCCGGAGTTTCTCCACCAGCAACATGGCCGCCGCCTGAGAGGAGAGCCGGGCCGCCGCCGTCTCTGCAGCCCGCGGGTAACTGG
GCCGTTGCCGCCGTCCGCGCTCGGCCCCCGCGGAGAGATCGAGCTGAAGGACTGCGCGGCTGGCTCTCCTCTAGTATGGCCAATGAAGAG
GATGACCCAGTTGTACAGGAGATCGATGTGTACTTGGCCAAGAGTCTGGCGGAAAAGCTGTATCTATTTCAGTACCCTGTGCGTCCAGCC
TCGATGACCTACGATGACATTCCGCACCTCTCAGCCAAGATCAAGCCCAAGCAGCAGAAGGTAGAGCTTGAGATGGCCATCGACACCCTG
AACCCCAACTATTGCCGCAGCAAAGGGGAGCAGATTGCGCTGAACGTGGACGGGGCCTGCGCCGACGAGACCAGCACGTATTCCTCGAAG
CTGATGGACAAGCAGACCTTCTGCTCTTCCCAGACCACCAGTAACACATCCCGTTATGCCGCTGCACTCTACAGGCAAGGTGAGCTCCAC
CTGACACCTTTACATGGCATCCTGCAGCTGCGGCCCAGCTTCTCCTACCTGGATAAGGCTGACGCCAAGCACCGGGAGAGGGAGGCGGCC
AACGAGGCAGGGGACTCTTCACAGGATGAGGCGGAAGACGATGTTAAGCAGATCACGGTGCGGTTCTCCCGGCCGGAGTCAGAGCAGGCC
CGCCAGCGCCGTGTGCAGTCCTATGAGTTCCTGCAGAAGAAGCACGCAGAGGAGCCCTGGGTCCACCTGCATTACTATGGCCTGAGGGAC
AGTCGCTCTGAGCATGAGCGTCAGTACCTGCTGTGCCCCGGCTCAAGCGGGGTGGAGAACACGGAGCTCGTCAAGTCACCCAGTGAGTAC
CTGATGATGCTGATGCCACCCAGCCAGGAGGAGGAGAAAGACAAGCCTGTGGCCCCCAGCAACGTCCTGTCGATGGCCCAGCTGCGCACG
CTGCCCCTGGCCGATCAGATCAAGATCCTGATGAAGAATGTGAAGGTCATGCCTTTTGCCAACTTGATGAGCCTCCTGGGCCCCTCCATC
GATTCCGTGGCTGTTCTGCGGGGCATCCAGAAGGTGGCGATGTTGGTCCAAGGGAACTGGGTGGTGAAGAGGAGCACTCACTGTGGGCCT
CGTGCGACAGTGTCAAACAATCCATGGACGAGACCGGACGTGCATCCCTCCCCGGCTTCCCCCGGAGTGGGTCACCACACTGTTTTTTAT
CATCATGGGAATCATTTCATTGACTGTCACATGTGGTTTGCTGGTGGCTTCCCACTGGCGAAGAGAAGCTACAAAATATGCTCGATGGAT
AGCATTCACTGGAAGTAAGTAACCTGTGCTTACTAAATTTGTCTAGAAGGCACCCACCCACACTGGTATTTTTATGAAGATAATCAAGAA
TCAGTAATAAGGACTTCATAATCATCAAAGAGCACCACTTGTGTATGGCCGTGAGATAGACTCTACACAGTCCCATCATTTCTTCAAAAC
TCTTTCTGCAAGACCAGGACATCCACAACTTTAATCACTTTGTATGAAATGCTATTTTAATGAATTTTATTTTTGCTCAGATTGTGACAT
AAGTGTTCCAGGTTTGTGACTCAGAGTTACCAGTAGCCTGAGTCTTTTCCTCTTCTTGAAGCTATTGGTATCATCTATCAAAATAAAGAT

>67102_67102_4_POLR3E-C16orf52_POLR3E_chr16_22330267_ENST00000564209_C16orf52_chr16_22086808_ENST00000562695_length(amino acids)=432AA_BP=360
MQPAGNWAVAAVRARPPRRDRAEGLRGWLSSSMANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVEL
EMAIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYRQGELHLTPLHGILQLRPSFSYLDKADAK
HREREAANEAGDSSQDEAEDDVKQITVRFSRPESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTEL
VKSPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSLLGPSIDSVAVLRGIQKVAMLVQGNWVVK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POLR3E-C16orf52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POLR3E-C16orf52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POLR3E-C16orf52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource