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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:POLR3H-ENTHD1 (FusionGDB2 ID:67112) |
Fusion Gene Summary for POLR3H-ENTHD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR3H-ENTHD1 | Fusion gene ID: 67112 | Hgene | Tgene | Gene symbol | POLR3H | ENTHD1 | Gene ID | 171568 | 150350 |
| Gene name | RNA polymerase III subunit H | ENTH domain containing 1 | |
| Synonyms | C25|RPC22.9|RPC8 | CACNA1I|dJ370M22.3 | |
| Cytomap | 22q13.2 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase III subunit RPC8DNA-directed RNA polymerase III subunit 22.9 kDa polypeptideDNA-directed RNA polymerase III subunit HRNA nucleotidyltransferase (DNA-directed)RNA polymerase III subunit C8polymerase (RNA) III (DNA directed) | ENTH domain-containing protein 1dJ370M22.3 (EPSIN 2B)epsin-2B | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q8IYW4 | |
| Ensembl transtripts involved in fusion gene | ENST00000337566, ENST00000355209, ENST00000396504, ENST00000407461, ENST00000420561, | ENST00000325157, ENST00000490326, | |
| Fusion gene scores | * DoF score | 4 X 3 X 5=60 | 5 X 6 X 6=180 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLR3H [Title/Abstract] AND ENTHD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | POLR3H(41936703)-ENTHD1(40258012), # samples:1 POLR3H(41936703)-ENTHD1(40283907), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | POLR3H-ENTHD1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. POLR3H-ENTHD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLR3H | GO:0006139 | nucleobase-containing compound metabolic process | 12391170 |
| Hgene | POLR3H | GO:0006383 | transcription by RNA polymerase III | 12391170 |
| Fusion gene breakpoints across POLR3H (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ENTHD1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-AO-A03V-01A | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| ChimerDB4 | BRCA | TCGA-AO-A03V-01A | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
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Fusion Gene ORF analysis for POLR3H-ENTHD1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000337566 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-5UTR | ENST00000355209 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-5UTR | ENST00000396504 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-5UTR | ENST00000407461 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-intron | ENST00000337566 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| 5CDS-intron | ENST00000337566 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-intron | ENST00000355209 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| 5CDS-intron | ENST00000355209 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-intron | ENST00000396504 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| 5CDS-intron | ENST00000396504 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| 5CDS-intron | ENST00000407461 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| 5CDS-intron | ENST00000407461 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| Frame-shift | ENST00000407461 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| In-frame | ENST00000337566 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| In-frame | ENST00000355209 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| In-frame | ENST00000396504 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| intron-3CDS | ENST00000420561 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| intron-5UTR | ENST00000420561 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| intron-intron | ENST00000420561 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - |
| intron-intron | ENST00000420561 | ENST00000490326 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40283907 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000396504 | POLR3H | chr22 | 41936703 | - | ENST00000325157 | ENTHD1 | chr22 | 40258012 | - | 2383 | 273 | 65 | 1747 | 560 |
| ENST00000355209 | POLR3H | chr22 | 41936703 | - | ENST00000325157 | ENTHD1 | chr22 | 40258012 | - | 2662 | 552 | 305 | 2026 | 573 |
| ENST00000337566 | POLR3H | chr22 | 41936703 | - | ENST00000325157 | ENTHD1 | chr22 | 40258012 | - | 2679 | 569 | 322 | 2043 | 573 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000396504 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - | 0.00072396 | 0.9992761 |
| ENST00000355209 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - | 0.000767635 | 0.9992324 |
| ENST00000337566 | ENST00000325157 | POLR3H | chr22 | 41936703 | - | ENTHD1 | chr22 | 40258012 | - | 0.000782947 | 0.99921703 |
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Fusion Genomic Features for POLR3H-ENTHD1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for POLR3H-ENTHD1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41936703/chr22:40258012) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ENTHD1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ENTHD1 | chr22:41936703 | chr22:40258012 | ENST00000325157 | 1 | 7 | 543_574 | 116 | 608.0 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ENTHD1 | chr22:41936703 | chr22:40258012 | ENST00000325157 | 1 | 7 | 9_141 | 116 | 608.0 | Domain | ENTH |
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Fusion Gene Sequence for POLR3H-ENTHD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >67112_67112_1_POLR3H-ENTHD1_POLR3H_chr22_41936703_ENST00000337566_ENTHD1_chr22_40258012_ENST00000325157_length(transcript)=2679nt_BP=569nt AAGCGCGAGCGGCTGTGCGCGGTGCGTGGTGCGTGGTGCGTGATACGAGCGGCGGCACGTGGCGCGGGTGCGGGGCGTGGAGTGGCGTGG CGTGGAGTGGCGTGGCGTGGCGGGGTCTCGCGGCGCGGGCGCGCACCCGGAGCTGTGGACGGAGAGTGCCTCCCTCTGGCCTCAGTTTCC TCATGTTGTAGTAGCGGAGCATGGCCCGGACCGGGCCCCCGAGACCGCCCCGTGCAACCTCACCGCCAGCCTGGGGGCCTCAGCGACTGG GACGGGACCAAGGGGCTCGGGGATTCTCCCTGCCCCCGGCCCTGGTGCGTGACTGACCCTCCTGTTCCCAGAGCCCCCAGCGCAGGCCGG GATGTTCGTCCTGGTGGAAATGGTGGACACCGTCCGGATCCCCCCTTGGCAGTTTGAGAGGAAGCTCAACGACTCCATTGCCGAGGAGCT GAACAAGAAGTTGGCCAACAAGGTCGTGTACAACGTGGGACTCTGCATTTGTCTGTTTGATATCACCAAACTGGAGGATGCCTATGTATT CCCTGGGGATGGCGCATCACACACCAAAGGTTATTATATCCGGGAAAAATCTAAGCAAGTCATCACATTGCTGATGGATGAACCATTGCT GTGTAAAGAGAGGGAAGTGGCATGTCGGACTAGACAGCGTACCTCCCACTCTATATTGTTTTCTAAAAGACAACTTGGTTCAAGTAACTC ACTGACAGCGTGCACTTCTGCCCCCACACCGGATATTTCTGCTTCAGAGAAGAAGTATAAGCTTCCTAAGTTTGGAAGGTTACATAATAA AAGAAATGTGTGCAAGGCAGGATTGAAACAAGAGCATTGCCAAGATGTTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACTTCC ACTCAAGATTCATGGTTGGAAATCAACAGAGGACCTGATGACATTTTTGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCCTTC CATTGTCTCTCCAATCACTTGCTTGTCAGAAGCAGAAGAAGTTTGTAATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAATAG TCCTTCTGGGCAGAGAGATGTGAGTTTGGACAAGAGATCAGATGGTATCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACCTTT AGAAAAGCAATCAGCTGCAGAAGGTCTTAAAACATTGACAATTTTACCAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGACTT AAGGGTATCAAAGTCAGATTCTACTTTCCATAACCAGGCCTCTGTAGAAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCGAGT GAAGGAGATTGTAATCAACAAGGCCTACCAGAAACCAGCACAATCCAGCATTCAGATGGATGATAAAATCCTCAAGACAACCACACGGGT TTCAACTGCTTCTGAGGGAGCATCTTCCTTTTCTCCTTTATCCATGTCATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCTCTT ATCACCAATTCTGGCCGGACCTTCCTTCTGGACTCTGTCCCATCAACAGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGCCAA GCTGCATCACTCCTTTGCTTCTAGGGGCCCAGTGTCTTCTGATGTAGAGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAATAA CTCTGATTCTGCTAAAAAGAATATAAGTCACATTTCTAGTAGTCACTGGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCCTCT GTCCTGTTCTGGTTTTCAGTCAACCAAAGACTTCCCCCAGGAACCTGAAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAAACG TGCGATCGCTAGATTACATGAAGATCTGAGCACAGTGATCCAAGAACTTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAATAG TTCACAAATAAGCCAGTCTTCCCAGGTCCCCCAGTCTTCTGAGGGGAGCTCAGATCAGATCTAATCATCACAATATCTATTTTTGATAGA ACTCGTGTGGTTCCACTTCCCCAAGACTTACGTTAGCATTGTATAAATTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCT TGTCAGGTTTATTAGCAAGTATCTTTCAAACTAATACTTTCATTTGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATT TCAGATTTAGATATTAGTTCATTTGAAACAGAAGAGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATT GTGGTAAGACCTCAAACTGCAAATGACTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCT TGTTAACAAGCCTCTGAGGTGACCTAGGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCA AGGGCCAGAAATCTTTTCTTTCTTCCAGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGTCAA >67112_67112_1_POLR3H-ENTHD1_POLR3H_chr22_41936703_ENST00000337566_ENTHD1_chr22_40258012_ENST00000325157_length(amino acids)=573AA_BP=82 MTLLFPEPPAQAGMFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKGYYIREKS KQVITLLMDEPLLCKEREVACRTRQRTSHSILFSKRQLGSSNSLTACTSAPTPDISASEKKYKLPKFGRLHNKRNVCKAGLKQEHCQDVH LPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVSPITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIF TNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVSKSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSI QMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPILAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEE NDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCSGFQSTKDFPQEPEAKNSISVLLREVKRAIARLHEDLSTVIQELN -------------------------------------------------------------- >67112_67112_2_POLR3H-ENTHD1_POLR3H_chr22_41936703_ENST00000355209_ENTHD1_chr22_40258012_ENST00000325157_length(transcript)=2662nt_BP=552nt CGCGGTGCGTGGTGCGTGGTGCGTGATACGAGCGGCGGCACGTGGCGCGGGTGCGGGGCGTGGAGTGGCGTGGCGTGGAGTGGCGTGGCG TGGCGGGGTCTCGCGGCGCGGGCGCGCACCCGGAGCTGTGGACGGAGAGTGCCTCCCTCTGGCCTCAGTTTCCTCATGTTGTAGTAGCGG AGCATGGCCCGGACCGGGCCCCCGAGACCGCCCCGTGCAACCTCACCGCCAGCCTGGGGGCCTCAGCGACTGGGACGGGACCAAGGGGCT CGGGGATTCTCCCTGCCCCCGGCCCTGGTGCGTGACTGACCCTCCTGTTCCCAGAGCCCCCAGCGCAGGCCGGGATGTTCGTCCTGGTGG AAATGGTGGACACCGTCCGGATCCCCCCTTGGCAGTTTGAGAGGAAGCTCAACGACTCCATTGCCGAGGAGCTGAACAAGAAGTTGGCCA ACAAGGTCGTGTACAACGTGGGACTCTGCATTTGTCTGTTTGATATCACCAAACTGGAGGATGCCTATGTATTCCCTGGGGATGGCGCAT CACACACCAAAGGTTATTATATCCGGGAAAAATCTAAGCAAGTCATCACATTGCTGATGGATGAACCATTGCTGTGTAAAGAGAGGGAAG TGGCATGTCGGACTAGACAGCGTACCTCCCACTCTATATTGTTTTCTAAAAGACAACTTGGTTCAAGTAACTCACTGACAGCGTGCACTT CTGCCCCCACACCGGATATTTCTGCTTCAGAGAAGAAGTATAAGCTTCCTAAGTTTGGAAGGTTACATAATAAAAGAAATGTGTGCAAGG CAGGATTGAAACAAGAGCATTGCCAAGATGTTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACTTCCACTCAAGATTCATGGTT GGAAATCAACAGAGGACCTGATGACATTTTTGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCCTTCCATTGTCTCTCCAATCA CTTGCTTGTCAGAAGCAGAAGAAGTTTGTAATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAATAGTCCTTCTGGGCAGAGAG ATGTGAGTTTGGACAAGAGATCAGATGGTATCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACCTTTAGAAAAGCAATCAGCTG CAGAAGGTCTTAAAACATTGACAATTTTACCAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGACTTAAGGGTATCAAAGTCAG ATTCTACTTTCCATAACCAGGCCTCTGTAGAAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCGAGTGAAGGAGATTGTAATCA ACAAGGCCTACCAGAAACCAGCACAATCCAGCATTCAGATGGATGATAAAATCCTCAAGACAACCACACGGGTTTCAACTGCTTCTGAGG GAGCATCTTCCTTTTCTCCTTTATCCATGTCATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCTCTTATCACCAATTCTGGCCG GACCTTCCTTCTGGACTCTGTCCCATCAACAGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGCCAAGCTGCATCACTCCTTTG CTTCTAGGGGCCCAGTGTCTTCTGATGTAGAGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAATAACTCTGATTCTGCTAAAA AGAATATAAGTCACATTTCTAGTAGTCACTGGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCCTCTGTCCTGTTCTGGTTTTC AGTCAACCAAAGACTTCCCCCAGGAACCTGAAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAAACGTGCGATCGCTAGATTAC ATGAAGATCTGAGCACAGTGATCCAAGAACTTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAATAGTTCACAAATAAGCCAGT CTTCCCAGGTCCCCCAGTCTTCTGAGGGGAGCTCAGATCAGATCTAATCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCACT TCCCCAAGACTTACGTTAGCATTGTATAAATTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGCA AGTATCTTTCAAACTAATACTTTCATTTGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTAG TTCATTTGAAACAGAAGAGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAAC TGCAAATGACTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTCTGA GGTGACCTAGGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGGCCAGAAATCTTTT CTTTCTTCCAGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGTCAATGTATATTGCAAGGTGA >67112_67112_2_POLR3H-ENTHD1_POLR3H_chr22_41936703_ENST00000355209_ENTHD1_chr22_40258012_ENST00000325157_length(amino acids)=573AA_BP=82 MTLLFPEPPAQAGMFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKGYYIREKS KQVITLLMDEPLLCKEREVACRTRQRTSHSILFSKRQLGSSNSLTACTSAPTPDISASEKKYKLPKFGRLHNKRNVCKAGLKQEHCQDVH LPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVSPITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIF TNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVSKSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSI QMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPILAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEE NDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCSGFQSTKDFPQEPEAKNSISVLLREVKRAIARLHEDLSTVIQELN -------------------------------------------------------------- >67112_67112_3_POLR3H-ENTHD1_POLR3H_chr22_41936703_ENST00000396504_ENTHD1_chr22_40258012_ENST00000325157_length(transcript)=2383nt_BP=273nt GCAGTCGCGCAAGCGCGAGCGGCTGTGCGCGGTGCGTGGTGCGTGAGCCCCCAGCGCAGGCCGGGATGTTCGTCCTGGTGGAAATGGTGG ACACCGTCCGGATCCCCCCTTGGCAGTTTGAGAGGAAGCTCAACGACTCCATTGCCGAGGAGCTGAACAAGAAGTTGGCCAACAAGGTCG TGTACAACGTGGGACTCTGCATTTGTCTGTTTGATATCACCAAACTGGAGGATGCCTATGTATTCCCTGGGGATGGCGCATCACACACCA AAGGTTATTATATCCGGGAAAAATCTAAGCAAGTCATCACATTGCTGATGGATGAACCATTGCTGTGTAAAGAGAGGGAAGTGGCATGTC GGACTAGACAGCGTACCTCCCACTCTATATTGTTTTCTAAAAGACAACTTGGTTCAAGTAACTCACTGACAGCGTGCACTTCTGCCCCCA CACCGGATATTTCTGCTTCAGAGAAGAAGTATAAGCTTCCTAAGTTTGGAAGGTTACATAATAAAAGAAATGTGTGCAAGGCAGGATTGA AACAAGAGCATTGCCAAGATGTTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACTTCCACTCAAGATTCATGGTTGGAAATCAA CAGAGGACCTGATGACATTTTTGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCCTTCCATTGTCTCTCCAATCACTTGCTTGT CAGAAGCAGAAGAAGTTTGTAATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAATAGTCCTTCTGGGCAGAGAGATGTGAGTT TGGACAAGAGATCAGATGGTATCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACCTTTAGAAAAGCAATCAGCTGCAGAAGGTC TTAAAACATTGACAATTTTACCAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGACTTAAGGGTATCAAAGTCAGATTCTACTT TCCATAACCAGGCCTCTGTAGAAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCGAGTGAAGGAGATTGTAATCAACAAGGCCT ACCAGAAACCAGCACAATCCAGCATTCAGATGGATGATAAAATCCTCAAGACAACCACACGGGTTTCAACTGCTTCTGAGGGAGCATCTT CCTTTTCTCCTTTATCCATGTCATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCTCTTATCACCAATTCTGGCCGGACCTTCCT TCTGGACTCTGTCCCATCAACAGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGCCAAGCTGCATCACTCCTTTGCTTCTAGGG GCCCAGTGTCTTCTGATGTAGAGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAATAACTCTGATTCTGCTAAAAAGAATATAA GTCACATTTCTAGTAGTCACTGGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCCTCTGTCCTGTTCTGGTTTTCAGTCAACCA AAGACTTCCCCCAGGAACCTGAAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAAACGTGCGATCGCTAGATTACATGAAGATC TGAGCACAGTGATCCAAGAACTTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAATAGTTCACAAATAAGCCAGTCTTCCCAGG TCCCCCAGTCTTCTGAGGGGAGCTCAGATCAGATCTAATCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCACTTCCCCAAGA CTTACGTTAGCATTGTATAAATTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGCAAGTATCTTT CAAACTAATACTTTCATTTGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTAGTTCATTTGA AACAGAAGAGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAACTGCAAATGA CTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTCTGAGGTGACCTA GGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGGCCAGAAATCTTTTCTTTCTTCC AGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGTCAATGTATATTGCAAGGTGAATTCAAATG >67112_67112_3_POLR3H-ENTHD1_POLR3H_chr22_41936703_ENST00000396504_ENTHD1_chr22_40258012_ENST00000325157_length(amino acids)=560AA_BP=69 MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKGYYIREKSKQVITLLMDEPLL CKEREVACRTRQRTSHSILFSKRQLGSSNSLTACTSAPTPDISASEKKYKLPKFGRLHNKRNVCKAGLKQEHCQDVHLPTETMLSQETLP LKIHGWKSTEDLMTFLDDDPELPLLATPPSIVSPITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPL EKQSAAEGLKTLTILPACWSSKEEFISPDLRVSKSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRV STASEGASSFSPLSMSSPDLASPEKSAHLLSPILAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNN SDSAKKNISHISSSHWGEFSTQNVDQFIPLSCSGFQSTKDFPQEPEAKNSISVLLREVKRAIARLHEDLSTVIQELNVINNILMSMSLNS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for POLR3H-ENTHD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for POLR3H-ENTHD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for POLR3H-ENTHD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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