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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POMT1-IVNS1ABP (FusionGDB2 ID:67157)

Fusion Gene Summary for POMT1-IVNS1ABP

check button Fusion gene summary
Fusion gene informationFusion gene name: POMT1-IVNS1ABP
Fusion gene ID: 67157
HgeneTgene
Gene symbol

POMT1

IVNS1ABP

Gene ID

10585

10625

Gene nameprotein O-mannosyltransferase 1influenza virus NS1A binding protein
SynonymsLGMD2K|LGMDR11|MDDGA1|MDDGB1|MDDGC1|RTARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP
Cytomap

9q34.13

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionprotein O-mannosyl-transferase 1dolichyl-phosphate-mannose--protein mannosyltransferase 1testis tissue sperm-binding protein Li 57ptruncated O-mannosyl-transferase 1 variant SV3DELinfluenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39
Modification date2020032820200320
UniProtAcc.

Q9Y6Y0

Ensembl transtripts involved in fusion geneENST00000341012, ENST00000354713, 
ENST00000372228, ENST00000402686, 
ENST00000423007, ENST00000541219, 
ENST00000404875, ENST00000419118, 
ENST00000485278, 		ENST00000392007, 
ENST00000459929, ENST00000367497, 
ENST00000367498, 
Fusion gene scores* DoF score5 X 4 X 5=10017 X 9 X 9=1377
# samples 518
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POMT1 [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOMT1(134381840)-IVNS1ABP(185274775), # samples:1
Anticipated loss of major functional domain due to fusion event.POMT1-IVNS1ABP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across POMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IVNS1ABP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CJ-5677-11APOMT1chr9

134381840

+IVNS1ABPchr1

185274775

-


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Fusion Gene ORF analysis for POMT1-IVNS1ABP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000341012ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000341012ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000354713ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000354713ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000372228ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000372228ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000402686ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000402686ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000423007ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000423007ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000541219ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000541219ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000341012ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000354713ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000372228ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000402686ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000423007ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000541219ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-3CDSENST00000404875ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-3CDSENST00000419118ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-5UTRENST00000404875ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-5UTRENST00000404875ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-5UTRENST00000419118ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-5UTRENST00000419118ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-intronENST00000404875ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
5UTR-intronENST00000419118ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
Frame-shiftENST00000341012ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
Frame-shiftENST00000354713ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
Frame-shiftENST00000372228ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
Frame-shiftENST00000402686ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
Frame-shiftENST00000423007ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
In-frameENST00000541219ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
intron-3CDSENST00000485278ENST00000367498POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
intron-5UTRENST00000485278ENST00000392007POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
intron-5UTRENST00000485278ENST00000459929POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-
intron-intronENST00000485278ENST00000367497POMT1chr9

134381840

+IVNS1ABPchr1

185274775

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541219POMT1chr9134381840+ENST00000367498IVNS1ABPchr1185274775-30991801471451434

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541219ENST00000367498POMT1chr9134381840+IVNS1ABPchr1185274775-0.0004292150.9995708

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Fusion Genomic Features for POMT1-IVNS1ABP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POMT1-IVNS1ABP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:134381840/chr1:185274775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IVNS1ABP

Q9Y6Y0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:9696811}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+3198_2839672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+42040_6093748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+42068_8893748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+4208_2893748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+42040_6093726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+42068_8893726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+4208_2893726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+42040_6093726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+42068_8893726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+4208_2893726.0TransmembraneHelical
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615369_415219643.0RepeatNote=Kelch 1
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615416_463219643.0RepeatNote=Kelch 2
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615465_512219643.0RepeatNote=Kelch 3
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615513_559219643.0RepeatNote=Kelch 4
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615560_606219643.0RepeatNote=Kelch 5
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615608_642219643.0RepeatNote=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319318_38139672.0DomainMIR 1
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319392_44939672.0DomainMIR 2
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319453_51339672.0DomainMIR 3
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420318_38193748.0DomainMIR 1
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420392_44993748.0DomainMIR 2
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420453_51393748.0DomainMIR 3
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420318_38193726.0DomainMIR 1
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420392_44993726.0DomainMIR 2
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420453_51393726.0DomainMIR 3
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218318_3810609.0DomainMIR 1
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218392_4490609.0DomainMIR 2
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218453_5130609.0DomainMIR 3
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420318_38193726.0DomainMIR 1
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420392_44993726.0DomainMIR 2
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420453_51393726.0DomainMIR 3
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319122_14239672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319154_17439672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319183_20339672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319206_22639672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319269_28939672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+31940_6039672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319597_61739672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319636_65639672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+319661_68139672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+31968_8839672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000341012+31999_11939672.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420122_14293748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420154_17493748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420183_20393748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420206_22693748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420269_28993748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420597_61793748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420636_65693748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+420661_68193748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000372228+42099_11993748.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420122_14293726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420154_17493726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420183_20393726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420206_22693726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420269_28993726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420597_61793726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420636_65693726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+420661_68193726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000402686+42099_11993726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218122_1420609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218154_1740609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218183_2030609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218206_2260609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218269_2890609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+21840_600609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218597_6170609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218636_6560609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+218661_6810609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+21868_880609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+2188_280609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000404875+21899_1190609.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420122_14293726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420154_17493726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420183_20393726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420206_22693726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420269_28993726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420597_61793726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420636_65693726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+420661_68193726.0TransmembraneHelical
HgenePOMT1chr9:134381840chr1:185274775ENST00000423007+42099_11993726.0TransmembraneHelical
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST00000367498615134_233219643.0DomainNote=BACK
TgeneIVNS1ABPchr9:134381840chr1:185274775ENST0000036749861532_99219643.0DomainBTB


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Fusion Gene Sequence for POMT1-IVNS1ABP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67157_67157_1_POMT1-IVNS1ABP_POMT1_chr9_134381840_ENST00000541219_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=3099nt_BP=180nt
AACGTTGAGCAGGGCGGTGGGTGGTGCGGAGTGCCGAGCGGCCTCACCCCCAACCGTCGGCCCAGTCGGACGGTTCCGAGGCGTTGCCGG
GAGCCGGGCGCGGCTCTGTGTGGACTCGGAGAAACGCGGGTTATTTAGGAGGATTCGATGGCAATTTTTTGTGGAACAGAATTGGAGCAG
GTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGAC
CACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAAT
GCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGAT
GGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTT
GAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAA
CTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCT
CCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGAC
CTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGT
GCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACA
AAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGT
GCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGG
CGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTAT
GATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTAT
GCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATT
TTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGG
GTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATT
TGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGA
TTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTAT
GGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATA
CTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTT
TTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCA
GTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAG
TACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGT
TGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAA
ACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTT
GTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAA
ATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCT
GCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGC
ATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAG
GTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGC
CACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGT
TTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCA

>67157_67157_1_POMT1-IVNS1ABP_POMT1_chr9_134381840_ENST00000541219_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=434AA_BP=3
MAIFCGTELEQVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTS
NNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECY
NPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKG
LKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFD

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Fusion Gene PPI Analysis for POMT1-IVNS1ABP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POMT1-IVNS1ABP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POMT1-IVNS1ABP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource