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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PON2-LRRFIP1 (FusionGDB2 ID:67167)

Fusion Gene Summary for PON2-LRRFIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PON2-LRRFIP1
Fusion gene ID: 67167
HgeneTgene
Gene symbol

PON2

LRRFIP1

Gene ID

5445

9208

Gene nameparaoxonase 2LRR binding FLII interacting protein 1
Synonyms-FLAP-1|FLAP1|FLIIAP1|GCF-2|GCF2|HUFI-1|TRIP
Cytomap

7q21.3

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionserum paraoxonase/arylesterase 2A-esterase 2PON 2aromatic esterase 2arylesterase 2paraoxonase nirsserum aryldialkylphosphatase 2leucine-rich repeat flightless-interacting protein 1GC-binding factor 2LRR FLII-interacting protein 1NEDD8-conjugating enzymeTAR RNA-interacting proteinleucine rich repeat (in FLII) interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q32MZ4

Ensembl transtripts involved in fusion geneENST00000222572, ENST00000433091, 
ENST00000536183, ENST00000483292, 
ENST00000244815, ENST00000289175, 
ENST00000392000, ENST00000468950, 
ENST00000308482, 
Fusion gene scores* DoF score7 X 4 X 6=16814 X 13 X 6=1092
# samples 715
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PON2 [Title/Abstract] AND LRRFIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPON2(95045554)-LRRFIP1(238617187), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePON2

GO:0019439

aromatic compound catabolic process

15772423

TgeneLRRFIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

14522076


check buttonFusion gene breakpoints across PON2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRFIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01APON2chr7

95045554

-LRRFIP1chr2

238617187

+


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Fusion Gene ORF analysis for PON2-LRRFIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000222572ENST00000244815PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000222572ENST00000289175PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000222572ENST00000392000PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000222572ENST00000468950PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000433091ENST00000244815PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000433091ENST00000289175PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000433091ENST00000392000PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000433091ENST00000468950PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000536183ENST00000244815PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000536183ENST00000289175PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000536183ENST00000392000PON2chr7

95045554

-LRRFIP1chr2

238617187

+
5CDS-intronENST00000536183ENST00000468950PON2chr7

95045554

-LRRFIP1chr2

238617187

+
In-frameENST00000222572ENST00000308482PON2chr7

95045554

-LRRFIP1chr2

238617187

+
In-frameENST00000433091ENST00000308482PON2chr7

95045554

-LRRFIP1chr2

238617187

+
In-frameENST00000536183ENST00000308482PON2chr7

95045554

-LRRFIP1chr2

238617187

+
intron-3CDSENST00000483292ENST00000308482PON2chr7

95045554

-LRRFIP1chr2

238617187

+
intron-intronENST00000483292ENST00000244815PON2chr7

95045554

-LRRFIP1chr2

238617187

+
intron-intronENST00000483292ENST00000289175PON2chr7

95045554

-LRRFIP1chr2

238617187

+
intron-intronENST00000483292ENST00000392000PON2chr7

95045554

-LRRFIP1chr2

238617187

+
intron-intronENST00000483292ENST00000468950PON2chr7

95045554

-LRRFIP1chr2

238617187

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000536183PON2chr795045554-ENST00000308482LRRFIP1chr2238617187+30584481842274696
ENST00000433091PON2chr795045554-ENST00000308482LRRFIP1chr2238617187+30584481842274696
ENST00000222572PON2chr795045554-ENST00000308482LRRFIP1chr2238617187+30584481842274696

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536183ENST00000308482PON2chr795045554-LRRFIP1chr2238617187+0.0049869880.99501294
ENST00000433091ENST00000308482PON2chr795045554-LRRFIP1chr2238617187+0.0049869880.99501294
ENST00000222572ENST00000308482PON2chr795045554-LRRFIP1chr2238617187+0.0049869880.99501294

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Fusion Genomic Features for PON2-LRRFIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PON2chr795045553-LRRFIP1chr2238617186+1.76E-050.99998236
PON2chr795045553-LRRFIP1chr2238617186+1.76E-050.99998236

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PON2-LRRFIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:95045554/chr2:238617187)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRFIP1

Q32MZ4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000244815010128_25022785.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr7:95045554chr2:238617187ENST0000028917508128_25022753.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000308482024128_25032641.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000392000011128_25022809.0Coiled coilOntology_term=ECO:0000269
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000244815010567_59322785.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr7:95045554chr2:238617187ENST0000028917508567_59322753.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000308482024567_59332641.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000392000011567_59322809.0Compositional biasNote=Lys-rich
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000244815010485_58422785.0RegionNote=DNA-binding
TgeneLRRFIP1chr7:95045554chr2:238617187ENST0000028917508485_58422753.0RegionNote=DNA-binding
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000308482024485_58432641.0RegionNote=DNA-binding
TgeneLRRFIP1chr7:95045554chr2:238617187ENST00000392000011485_58422809.0RegionNote=DNA-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PON2-LRRFIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67167_67167_1_PON2-LRRFIP1_PON2_chr7_95045554_ENST00000222572_LRRFIP1_chr2_238617187_ENST00000308482_length(transcript)=3058nt_BP=448nt
AAGTTTCACATCATGAGCCTAATGTAAGGCGTGTCCGGGCCGTCCCGAAGGTATCTGGGGAAATAGGTTTGTGAGGACAAAGACCAGGGC
CAGGCCCAGGGCGGAGCCTCCGCGGCCCCGACGCAGGGACTCGGCCTAGGCGGAGGACGGGGCGGAGCGCGGCCGGCACCATCGAGCCGG
GAAGATGGCACCGCCCACGGAGCTGCTGGCCAGGCCGGAGCGAGGCAGCGCGCCCGGCTCCCGCGCCATGGGGCGGCTGGTGGCTGTGGG
CTTGCTGGGGATCGCGCTGGCGCTCCTGGGCGAGAGGCTTCTGGCACTCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGA
CCTTCCACACTGCCACCTGATTAAAGGAATTGAAGCTGGCTCTGAAGATATTGACATACTTCCCAATGGTCTGGCTTTTTTTAGTGTGGC
GGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTA
TCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATC
CAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGG
GGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTA
CAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTC
CCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGA
AGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTC
CTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCA
GATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTAT
GGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACA
GCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGC
TGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGAT
TTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGA
ACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGG
AGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGA
TGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGA
GAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAG
GGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTT
AGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAG
AGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCG
GAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGT
CCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCA
CCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCA
TAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCA
GTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAA
TCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAA
CTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGA
TTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATT

>67167_67167_1_PON2-LRRFIP1_PON2_chr7_95045554_ENST00000222572_LRRFIP1_chr2_238617187_ENST00000308482_length(amino acids)=696AA_BP=88
MAPPTELLARPERGSAPGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVAE
ARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGG
PYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEE
RPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMV
SNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREIS
DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDG
TLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLE

--------------------------------------------------------------
>67167_67167_2_PON2-LRRFIP1_PON2_chr7_95045554_ENST00000433091_LRRFIP1_chr2_238617187_ENST00000308482_length(transcript)=3058nt_BP=448nt
AAGTTTCACATCATGAGCCTAATGTAAGGCGTGTCCGGGCCGTCCCGAAGGTATCTGGGGAAATAGGTTTGTGAGGACAAAGACCAGGGC
CAGGCCCAGGGCGGAGCCTCCGCGGCCCCGACGCAGGGACTCGGCCTAGGCGGAGGACGGGGCGGAGCGCGGCCGGCACCATCGAGCCGG
GAAGATGGCACCGCCCACGGAGCTGCTGGCCAGGCCGGAGCGAGGCAGCGCGCCCGGCTCCCGCGCCATGGGGCGGCTGGTGGCTGTGGG
CTTGCTGGGGATCGCGCTGGCGCTCCTGGGCGAGAGGCTTCTGGCACTCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGA
CCTTCCACACTGCCACCTGATTAAAGGAATTGAAGCTGGCTCTGAAGATATTGACATACTTCCCAATGGTCTGGCTTTTTTTAGTGTGGC
GGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTA
TCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATC
CAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGG
GGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTA
CAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTC
CCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGA
AGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTC
CTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCA
GATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTAT
GGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACA
GCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGC
TGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGAT
TTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGA
ACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGG
AGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGA
TGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGA
GAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAG
GGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTT
AGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAG
AGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCG
GAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGT
CCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCA
CCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCA
TAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCA
GTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAA
TCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAA
CTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGA
TTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATT

>67167_67167_2_PON2-LRRFIP1_PON2_chr7_95045554_ENST00000433091_LRRFIP1_chr2_238617187_ENST00000308482_length(amino acids)=696AA_BP=88
MAPPTELLARPERGSAPGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVAE
ARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGG
PYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEE
RPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMV
SNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREIS
DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDG
TLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLE

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>67167_67167_3_PON2-LRRFIP1_PON2_chr7_95045554_ENST00000536183_LRRFIP1_chr2_238617187_ENST00000308482_length(transcript)=3058nt_BP=448nt
AAGTTTCACATCATGAGCCTAATGTAAGGCGTGTCCGGGCCGTCCCGAAGGTATCTGGGGAAATAGGTTTGTGAGGACAAAGACCAGGGC
CAGGCCCAGGGCGGAGCCTCCGCGGCCCCGACGCAGGGACTCGGCCTAGGCGGAGGACGGGGCGGAGCGCGGCCGGCACCATCGAGCCGG
GAAGATGGCACCGCCCACGGAGCTGCTGGCCAGGCCGGAGCGAGGCAGCGCGCCCGGCTCCCGCGCCATGGGGCGGCTGGTGGCTGTGGG
CTTGCTGGGGATCGCGCTGGCGCTCCTGGGCGAGAGGCTTCTGGCACTCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGA
CCTTCCACACTGCCACCTGATTAAAGGAATTGAAGCTGGCTCTGAAGATATTGACATACTTCCCAATGGTCTGGCTTTTTTTAGTGTGGC
GGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTA
TCAGGTCCAAAAGAAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATC
CAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGG
GGGTCCTTACGCCTGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTA
CAGCGCTGCCCGGCCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTC
CCGTGCTCCCTCGGAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGA
AGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTC
CTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCA
GATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTAT
GGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACA
GCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGC
TGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGAT
TTCTGATCTTCAGGAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGA
ACGGGATGATCTTAGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGG
AGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGA
TGGGACCCTAGATATTAGGTTGAAAAAGCTGGTTGATGAACGGGAATGCTTATTGGAACAGATTAAGAAACTCAAAGGGCAGCTGGAGGA
GAGACAGAAGATTGGCAAACTAGACAATCTTCGATCTGAAGATGATGTCTTGGAAAACGGGACAGACATGCATGTAATGGACCTACAAAG
GGATGCCAACAGACAGATCAGCGACCTCAAATTTAAACTTGCAAAATCTGAGCAAGAGATAACTGCATTAGAACAAAATGTAATAAGGTT
AGAGAGTCAAGTATCACGTTACAAATCAGCGGCTGAAAATGCAGAAAAAATAGAAGATGAACTTAAGGCAGAAAAACGGAAACTCCAAAG
AGAGCTCCGCTCTGCATTGGATAAAACAGAAGAGCTCGAGGTGAGCAACGGCCACTTAGTGAAGCGTCTGGAAAAAATGAAAGCAAATCG
GAGTGCACTCTTGTCCCAGCAGTAAATTCCAGCTCTGATCAGGCAACTGGTTGGTGACTGGAGAGCATTGTTTCATAGGCTTTTCTCTGT
CCTATCTGGGAGCGCTGCTTCTTCCCCTGCCTTCCGAGAGACGAAGACCGTGGCGAGCTTGGCGCTTAGGGGCTCCCGTGCCATGGCTCA
CCCCAGGGAGCCCCAGCAGCCACCAGGTGCCTCTGTCTGCAGACCCCTGGCCCGGGCTGGCGCCGACGCTCAGAACCTGCAGGTACTTCA
TAAGCACACAGGGGCCTCGAGGGAGCTCTGTGTCTGACCGCACAGCAGCCTCTGAATGCCGCTGGAAGTGATGATCAAAGTAAAGATTCA
GTTGGGACTTGAGTTTTTTTTTTTTTTCATGTGTCTTGCTGAAGATTAAGGGGAAATGTTACAGTGTTGGGACTTCCTTTCATGGCAGAA
TCTACAATTTGAGCGACTTCAGTAGTATCTCTTAGTCTACGCTTTTCATACACAAAACACTGTGGAACCACAAGCCATTACCAAGCAAAA
CTCTTTCACTGGAAACAAGGGGGCAGTCTAGAAGTAAAAGTGACCTTAAGAAGACTCTTTACAGGCAACAAATGAAGCTTTTCTAAGGGA
TTTTTGCATCAGTTCAGTCATAAGAATACTTTTTTCCAGGGTAATTAGGCAATAGCTTCACTGAAAATGACAGCTTTTCATTGCATTATT

>67167_67167_3_PON2-LRRFIP1_PON2_chr7_95045554_ENST00000536183_LRRFIP1_chr2_238617187_ENST00000308482_length(amino acids)=696AA_BP=88
MAPPTELLARPERGSAPGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVAE
ARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGG
PYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEE
RPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMV
SNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREIS
DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDG
TLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLE

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Fusion Gene PPI Analysis for PON2-LRRFIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PON2-LRRFIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PON2-LRRFIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource