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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:POP1-TRPS1 (FusionGDB2 ID:67182)

Fusion Gene Summary for POP1-TRPS1

check button Fusion gene summary
Fusion gene informationFusion gene name: POP1-TRPS1
Fusion gene ID: 67182
HgeneTgene
Gene symbol

POP1

TRPS1

Gene ID

260434

7227

Gene namepyrin domain containing 1transcriptional repressor GATA binding 1
SynonymsASC2|POP1|PYC1|cPOP1GC79|LGCR
Cytomap

16p11.2

8q23.3

Type of geneprotein-codingprotein-coding
Descriptionpyrin domain-containing protein 1PAAD-only protein 1PYD (pyrin domain) containing 1cellular POP1pyrin-only protein 1zinc finger transcription factor Trps1tricho-rhino-phalangeal syndrome type I proteintrichorhinophalangeal syndrome Izinc finger protein GC79
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000349693, ENST00000401707, 
ENST00000395715, ENST00000220888, 
ENST00000519076, ENST00000519674, 
ENST00000520276, 
Fusion gene scores* DoF score6 X 6 X 6=21614 X 16 X 3=672
# samples 614
** MAII scorelog2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/672*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POP1 [Title/Abstract] AND TRPS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPOP1(99135706)-TRPS1(116421433), # samples:1
POP1(99135706)-TRPS1(116423784), # samples:1
POP1(99135706)-TRPS1(116426301), # samples:1
Anticipated loss of major functional domain due to fusion event.POP1-TRPS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
POP1-TRPS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
POP1-TRPS1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOP1

GO:0006469

negative regulation of protein kinase activity

12656673

HgenePOP1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

12656673

HgenePOP1

GO:0033209

tumor necrosis factor-mediated signaling pathway

12656673

HgenePOP1

GO:0045087

innate immune response

12656673

HgenePOP1

GO:0050718

positive regulation of interleukin-1 beta secretion

12656673

TgeneTRPS1

GO:0000122

negative regulation of transcription by RNA polymerase II

12885770|21673316


check buttonFusion gene breakpoints across POP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRPS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A5XU-01APOP1chr8

99135706

+TRPS1chr8

116421433

+
ChimerDB4BRCATCGA-AC-A5XU-01APOP1chr8

99135706

+TRPS1chr8

116423784

+
ChimerDB4BRCATCGA-AC-A5XU-01APOP1chr8

99135706

+TRPS1chr8

116426301

+


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Fusion Gene ORF analysis for POP1-TRPS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000349693ENST00000395715POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-3UTRENST00000349693ENST00000395715POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-3UTRENST00000401707ENST00000395715POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-3UTRENST00000401707ENST00000395715POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000349693ENST00000220888POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000349693ENST00000220888POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000349693ENST00000519076POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000349693ENST00000519076POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000349693ENST00000519674POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000349693ENST00000519674POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000349693ENST00000519674POP1chr8

99135706

+TRPS1chr8

116426301

+
5CDS-intronENST00000349693ENST00000520276POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000349693ENST00000520276POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000401707ENST00000220888POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000401707ENST00000220888POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000401707ENST00000519076POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000401707ENST00000519076POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000401707ENST00000519674POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000401707ENST00000519674POP1chr8

99135706

+TRPS1chr8

116423784

+
5CDS-intronENST00000401707ENST00000519674POP1chr8

99135706

+TRPS1chr8

116426301

+
5CDS-intronENST00000401707ENST00000520276POP1chr8

99135706

+TRPS1chr8

116421433

+
5CDS-intronENST00000401707ENST00000520276POP1chr8

99135706

+TRPS1chr8

116423784

+
Frame-shiftENST00000349693ENST00000220888POP1chr8

99135706

+TRPS1chr8

116426301

+
Frame-shiftENST00000349693ENST00000519076POP1chr8

99135706

+TRPS1chr8

116426301

+
Frame-shiftENST00000349693ENST00000520276POP1chr8

99135706

+TRPS1chr8

116426301

+
Frame-shiftENST00000401707ENST00000220888POP1chr8

99135706

+TRPS1chr8

116426301

+
Frame-shiftENST00000401707ENST00000519076POP1chr8

99135706

+TRPS1chr8

116426301

+
Frame-shiftENST00000401707ENST00000520276POP1chr8

99135706

+TRPS1chr8

116426301

+
In-frameENST00000349693ENST00000395715POP1chr8

99135706

+TRPS1chr8

116426301

+
In-frameENST00000401707ENST00000395715POP1chr8

99135706

+TRPS1chr8

116426301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401707POP1chr899135706+ENST00000395715TRPS1chr8116426301+580122310871404105
ENST00000349693POP1chr899135706+ENST00000395715TRPS1chr8116426301+574817010341351105

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401707ENST00000395715POP1chr899135706+TRPS1chr8116426301+0.72024670.27975333
ENST00000349693ENST00000395715POP1chr899135706+TRPS1chr8116426301+0.71598690.28401306

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Fusion Genomic Features for POP1-TRPS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POP1-TRPS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:99135706/chr8:116421433)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRPS1chr8:99135706chr8:116426301ENST00000220888061163_128101282.0RegionTranscriptional repressor domain
TgeneTRPS1chr8:99135706chr8:116426301ENST00000395715071163_128101295.0RegionTranscriptional repressor domain
TgeneTRPS1chr8:99135706chr8:116426301ENST00000520276061163_128101286.0RegionTranscriptional repressor domain
TgeneTRPS1chr8:99135706chr8:116426301ENST00000220888061215_123701282.0Zinc fingerC2H2-type 6
TgeneTRPS1chr8:99135706chr8:116426301ENST00000220888061243_126701282.0Zinc fingerC2H2-type 7
TgeneTRPS1chr8:99135706chr8:116426301ENST0000022088806222_24701282.0Zinc fingerC2H2-type 1%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000022088806333_35801282.0Zinc fingerC2H2-type 2%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000022088806614_63701282.0Zinc fingerC2H2-type 3%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000022088806666_68901282.0Zinc fingerC2H2-type 4
TgeneTRPS1chr8:99135706chr8:116426301ENST0000022088806692_71501282.0Zinc fingerC2H2-type 5
TgeneTRPS1chr8:99135706chr8:116426301ENST0000022088806896_92001282.0Zinc fingerGATA-type
TgeneTRPS1chr8:99135706chr8:116426301ENST00000395715071215_123701295.0Zinc fingerC2H2-type 6
TgeneTRPS1chr8:99135706chr8:116426301ENST00000395715071243_126701295.0Zinc fingerC2H2-type 7
TgeneTRPS1chr8:99135706chr8:116426301ENST0000039571507222_24701295.0Zinc fingerC2H2-type 1%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000039571507333_35801295.0Zinc fingerC2H2-type 2%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000039571507614_63701295.0Zinc fingerC2H2-type 3%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000039571507666_68901295.0Zinc fingerC2H2-type 4
TgeneTRPS1chr8:99135706chr8:116426301ENST0000039571507692_71501295.0Zinc fingerC2H2-type 5
TgeneTRPS1chr8:99135706chr8:116426301ENST0000039571507896_92001295.0Zinc fingerGATA-type
TgeneTRPS1chr8:99135706chr8:116426301ENST00000520276061215_123701286.0Zinc fingerC2H2-type 6
TgeneTRPS1chr8:99135706chr8:116426301ENST00000520276061243_126701286.0Zinc fingerC2H2-type 7
TgeneTRPS1chr8:99135706chr8:116426301ENST0000052027606222_24701286.0Zinc fingerC2H2-type 1%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000052027606333_35801286.0Zinc fingerC2H2-type 2%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000052027606614_63701286.0Zinc fingerC2H2-type 3%3B atypical
TgeneTRPS1chr8:99135706chr8:116426301ENST0000052027606666_68901286.0Zinc fingerC2H2-type 4
TgeneTRPS1chr8:99135706chr8:116426301ENST0000052027606692_71501286.0Zinc fingerC2H2-type 5
TgeneTRPS1chr8:99135706chr8:116426301ENST0000052027606896_92001286.0Zinc fingerGATA-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for POP1-TRPS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67182_67182_1_POP1-TRPS1_POP1_chr8_99135706_ENST00000349693_TRPS1_chr8_116426301_ENST00000395715_length(transcript)=5748nt_BP=170nt
GTGATCTGGAATGGCCCAGATCCCTTAAATGTCAAATGCAAAAGAAAGAAAACACGCCAAGAAAATGAGAAACCAGCCTACCAATGTGAC
TCTGTCCTCTGGCTTTGTGGCTGACAGAGGTGTAAAGCACCACAGTGGAGGTGAAAAACCTTTCCAAGCTCAAAAACAAGCTGCATAGGA
ACAATGCACAAGTGGAAAAAAATGGAAAACCTAAAGAGTAAAACCTTAGCACTTAGCACAATTAAATAGAAATAGGTTTTCTTGATGGGA
ATTCAATAGCTTGTAATGTCTTATGAAGACCTATTAAAAAAATACTTCATAGAGCCTGCCTTATCCAACATGAAATTCCCTTCTTTTGTT
ATTCTTTCTTTTGATGAGTAGGTTACCAAGATTAAAAAGTGAGATAAATGGTCAATGAGAAAGAATGGAAGATGGTAAACAATCACTTTT
TAAAACCTGTTAAGTCAAAACCATCTTGGCTAATATGTACTGGGGAAATAATCCATAAGAGATATCACCAGACTAGAATTAATATATTTA
TAAAGAAAGAGACCAAAACTGTCTAGAATTTGAAAGGGTTTACATATTATTATACTAAAGCAGTACTGGACTGGCCATTGGACCATTTGT
TCCAAAACCCATAAATTGTTGCCTAAATTTATAATGATCATGAAACCCTAGGCAGAGGAGGAGAAATTGAAGGTCCAGGGCAATGAAAGA
AAAATGGCGCCCTCTCAATTTAGTCTTCTCTCATTGGCCATGTTTCAGATTTTGACCTAGAAATGCGAGCTGTGGTTAGGCTTGGTTAGA
GTGCAGCAAGCAACATGACAGATGGTGGCACGCTGTTTTTACCCAGCCCTGCCTGTACATACACATGCACACCCTCTCTGATATTTTTGT
CCTTTAGATGTTCAAATACTCAGTAGTCCTTTTGTTTGCGGTTTAGATTCATTTTGTCCACACATGTACCCATTTTAAAAAACAATGTCC
TCGATGCTTCTGTAGTGATTTCATTTTAGCCAGGTATTTCTTTCTTGTGTGTGATGAACCAGTATGGATTTGCTTTTCTAAGCCTCCTGT
TGGTTACTAATCTCACTTGGCACATTATAACTAAAGGAATCCCCTCAATTCAAAAGCATAGATGGATACAAATGTCAGACCGTGGGTTTA
ATTTGTTTAGAACACATGGCATTTCTTCACAAGGTAACCTGCTGTATTTATTTATTTTCTTTTGGTTAAATATAATTTCCAAACTTTGTG
GTCAGGCAGCGTCTAAGGTTACGTTACCACAGACTGACAGTTGGTATATGTACCAGCCAATCCCTTCATTAAATGTATACAGATTTAGTT
AAGTAGCATTAAATAGGATTCTTAGAAGTATGTCCTCATAGAACTTTTAATACTTAAGGCTTTGTAAAAACTATCCATGAAGGGAAAGCT
CCTCAGCATAACTGCTCAGGGAAATAGGGCTAAATAACTGAACATTAAATAATTGGTTAAAGGTGCTGTTAGTCGAGCCTCAATGCTTGC
TACAAGGATGTATGTACAAGGACTGACTTTAATAATTTGCATTATATTGTCCCAACCAGTAGTTTATTTTTTGCCACGGAGATGTAGAAG
ATATTACAAGCTACTGGATGCACTGTCAGATTAACTTATTTCATTAAAGAAGTTGGGAGAACAAATAGGAAAAAAAAAACTTATTTTTCT
AGTAAATATTAATGTATTACATTTCAAATAATGGTGCCTGACATATTGAATAATTATTTTCTACAGTGTACGTATGCAACAAAGATATTC
CATCATGCATTAGAGTCAGTTCTGGCTCTGCCTAGCTGTTTACATTTGCAAATGTAGCAAACAAGGTAATGAAGCAACTATTTCTATTGC
AGTAGATATCCTTTTGTGTGTGTGTGTGTGCATTAAAGTTGTAAACGGTAACATGAAACAAATGAAAGTTCTTGCTATAATGGTATGGAA
AACAAGAAGGAAATGAAAATATTTTTATGCCTACTTAGGAAAAAAAGGGTAGCACTTATTCATTCCAAGTACTTTTTTTTTTTTAATTTT
TAAGCTCTTAACTCACATTGTTATGCTTAAGATGATAAACATATATCCTCTTTTTATTGCTTTGTCTATGTTTCATATGAAACATTTCAG
AAATTATTTTGATAAGTGTTGCTGGAATCTGCAACGCTGATTTTTTTTTGCATTCTGTAGTCGCATTTGCACTCCATTTTTACATTAATT
CGCAGTTGCTTTGTATCATTGTTTTGTTTGGGTTTTGTTTCTTTTTCACAGTGCCGGGTCTTCGTTTCTTAAAGTTGGATGGCAGGTAGA
GTTCAACCAGTTCGTGACTGTTGTAGCGAATGAAGTTAAAAAAATGTCTTTCTGATGTTGTGTTGTCATTTTCATTTTTGCATTTTTTTG
TTTGCATATTAAAAAAAGAGAAAAGAGAAAGCAAGAGACAGAAATCAGGACTAAGTCCTCTGCTTCAGTTTCATTGTTAACGGGCCTTAT
TCTGATCTCACCTGTCGCGTAGCTCTAATATTCACATAAACTGAAATAAAGAAGTGGAATGAGGAGCTTTGACATTCAAATTATGTGATG
TAATTTATCTTCCTTAGGAATTTTGATGGATGCATCTCAAAATGTATAGCCAGACTTGAGAGGTGACAATTAAAGATCTAAAAAAGAGAG
GAGATTCCCCCAAACAACAATATTTAATTTTCTTAGTAAAAAGAATAACAGAATGCATCGTGGCAATCCTTAAGCAACATTATCTATGTG
GACTGCTTAAATCAGCAAAACACCAGAAGTTTGGTTAACTTGGGCAATATGACAAGTATTACTTTTTGGGCAAAACTACTCATTAAGCAA
TTTCTCTAGTGTGTCGGACACAAATAGGTTCTTTATTTTTGGCATGTATGCCTTTTTATTTTCATTCAATTTTTTTTTTTTCTCAGACAG
ACATAGTAGTATCGACTAGCATTGGAAAATACATATCACTATTCTTGGAATATTTATGGTCAGTCTACTTTTTAGTAAAATATTTTTGGA
TAGCGTTGACACGATAGATCTTATTCCATACTTCTTTATTATTGATAATTTTATTTTCATTTTTTGCTTTCATTATTATACATATTTTGG
TGGAGAAGAGGTTGGGCTTTTTTGAAAGAGACAAAAATTTATTATAACACTAAACACTCCTTTTTTGACATATTAAAGCCTTTATTCCAT
CTCTCAAGATATATTATAAAATTTATTTTTTTAATTTAAGATTTCTGAATTATTTTATCTTAAATTGTGATTTTAAACGAGCTATTATGG
TACGGAACTTTTTTTAATGAGGAATTTCATGATGATTTAGGAATTTTCTCTCTTGGAAAAGGCTTCCCCTGTGATGAAAATGATGTGCCA
GCTAAAATTGTGTGCCATTTAAAAACTGAAAATATTTTAAAATTATTTGTCTATATTCTAAATTGAGCTTTGGATCAAACTTTAGGCCAG
GACCAGCTCATGCGTTCTCATTCTTCCTTTTCTCACTCTTTCTCTCATCACTCACCTCTGTATTCATTCTGTTGTTTGGGATAGAAAAAT
CATAAAGAGCCAACCCATCTCAGAACGTTGTGGATTGAGAGAGACACTACATGACTCCAAGTATATGAGAAAAGGACAGAGCTCTAATTG
ATAACTCTGTAGTTCAAAAGGAAAAGAGTATGCCCAATTCTCTCTACATGACATATTGAGATTTTTTTTAATCAACTTTTAAGATAGTGA
TGTTCTGTTCTAAACTGTTCTGTTTTAGTGAAGGTAGATTTTTATAAAACAAGCATGGGGATTCTTTTCTAAGGTAATATTAATGAGAAG
GGAAAAAAGTATCTTTAACAGCTCTTTGTTGAAGCCTGTGGTAGCACATTATGTTTATAATTGCACATGTGCACATAATCTATTATGATC
CAATGCAAATACAGCTCCAAAAATATTAAATGTATATATATTTTAAAATGCCTGAGGAAATACATTTTTCTTAATAAACTGAAGAGTCTC
AGTATGGCTATTAAAATAATTATTAGCCTCCTGTTGTGTGGCTGCAAAACATCACAAAGTGACCGGTCTTGAGACCTGTGAACTGCTGCC
CTGTTTAGTAAATAAAATTAATGCATTTCTAGAGGGGGAATATCTGCCATCCAGTGGTGGAAATGTGGAGTAAAGAAGCTGGTGGTCTGC
TTCTGTGCTGTATGCCAGCCTTTTGCCTTAAGTTGAGAGGAGGTCAACTTTAGCTACTGTCTTTGGTTTGAGAGCCATGGCAAAAAAAAA
AAAAGAAAAAAAGATCAAGTCGTCTTTGGTGAGCCAGTAAGGTGAAAGCTTGCTGACTGTCCAAGGCACAAGAGAAAATTGAGGAATTGA
AATGCAACCTGAGTATCAAACTAAATATTCTAATCAAAGGTAGGTACTGTTAGGTGGAATTCTATCAGCAGGCAACTGCAAATGAGAAGA
AGATAGAAGGACGCCCGTCGGGACTTTGGAGGGCATTGTTATTTTCCCAAAGAAAGACGGCCAAGGGCAGAGGCATGGATTCTTTGCAGA
GCACTTCCTTTTGGTTTTTCAGTACTGTTTCATAGACAGTGGGCTCACATGTTCCTGATAGTGCTGCAGTTGCTTAGAAAGCATCCCAGT
TAATTGCAGTAATTAGAACTTCTGGAATATGCTAGGGCAGAAGTATGTCAAGTATGTCACATGAAGAAAATGTGAAATTCAAGAGTAATC
CACACGTGAGAAACTAGACAATGTACATTCATGTGTTCTCTTGAAAGGAAAGGGAGAGCTGTAAGCTTCACTCTGTCCTACACCGGAGAA
AAGCAGGAATAACTTTACCGTGGAAATAATGTTTAGCTTTTATCAGAGAAAATTGTCCTTCTAGAGCATAGAGTCCCAAAACTCAATTCT
GGTTTTCCCCTGTTTTTTTTTTTTTTTTTTTTCCCAACATATAAACTGCAGCATATCACTTTTTCTTTTTGTGCCTCAGGTTCCTCACCT
GTAAAATTGAAAAATATATGTATTAATAATATTATTAATAATAATAATGGTAATGTAGTACTTGTTTGTAAAGCACTTTGAGATCCTTGG
TTGAAAGGCACCATAGGAGTGCCAAGTATTATTATGTGGCCAAGGGGGTTATTTAAACTGTCAGTTCCCAAAGGCCAGGAAAGGTTGGGG
TCATTTTTCTTAAAGACGAGCTGTAAATATCAACTAGGCAGCCAATAGTGTTGACTATGAAGATGCAAAACTATTACTAGGCTGATAAAA
TCATAGTTTCTTAATGGCTACCAATAAGGCAAATATCACAATAATAAACGCCAAATTCCTTAGGGCGGACTATTTGACAACCACATGGAA
AACTTTGGGGGAGGCATGAGGGGGGAACATCTCAAAATGCCAATGTAAAATTTAACTTACAGCAATATTCACCAGCAGAAAATGTCTTTC
ATATGGAATGATTTCATGTTGCTAAGAAAAAGAATTCAATTTGTAGTCCTGATTTGAATACTAGAATGTTGGCTATAATAGTTCTGTTCT
TACAACACATGAAATTTTTTCGTTTTATTTTATTTTGTTTTCATAGTGCATGTTCATTTCTACTCACAAACATGTTCTTGGTGTATTTCT

>67182_67182_1_POP1-TRPS1_POP1_chr8_99135706_ENST00000349693_TRPS1_chr8_116426301_ENST00000395715_length(amino acids)=105AA_BP=
MCVMNQYGFAFLSLLLVTNLTWHIITKGIPSIQKHRWIQMSDRGFNLFRTHGISSQGNLLYLFIFFWLNIISKLCGQAASKVTLPQTDSW

--------------------------------------------------------------
>67182_67182_2_POP1-TRPS1_POP1_chr8_99135706_ENST00000401707_TRPS1_chr8_116426301_ENST00000395715_length(transcript)=5801nt_BP=223nt
CTCCAGGAGCTTTGGCTCGGTGGGTACTGTCGCGGAGGCTTGTCATTCTGACCCGGGGATTCCTCACAGCGTCTGGCAGAAATGTCAAAT
GCAAAAGAAAGAAAACACGCCAAGAAAATGAGAAACCAGCCTACCAATGTGACTCTGTCCTCTGGCTTTGTGGCTGACAGAGGTGTAAAG
CACCACAGTGGAGGTGAAAAACCTTTCCAAGCTCAAAAACAAGCTGCATAGGAACAATGCACAAGTGGAAAAAAATGGAAAACCTAAAGA
GTAAAACCTTAGCACTTAGCACAATTAAATAGAAATAGGTTTTCTTGATGGGAATTCAATAGCTTGTAATGTCTTATGAAGACCTATTAA
AAAAATACTTCATAGAGCCTGCCTTATCCAACATGAAATTCCCTTCTTTTGTTATTCTTTCTTTTGATGAGTAGGTTACCAAGATTAAAA
AGTGAGATAAATGGTCAATGAGAAAGAATGGAAGATGGTAAACAATCACTTTTTAAAACCTGTTAAGTCAAAACCATCTTGGCTAATATG
TACTGGGGAAATAATCCATAAGAGATATCACCAGACTAGAATTAATATATTTATAAAGAAAGAGACCAAAACTGTCTAGAATTTGAAAGG
GTTTACATATTATTATACTAAAGCAGTACTGGACTGGCCATTGGACCATTTGTTCCAAAACCCATAAATTGTTGCCTAAATTTATAATGA
TCATGAAACCCTAGGCAGAGGAGGAGAAATTGAAGGTCCAGGGCAATGAAAGAAAAATGGCGCCCTCTCAATTTAGTCTTCTCTCATTGG
CCATGTTTCAGATTTTGACCTAGAAATGCGAGCTGTGGTTAGGCTTGGTTAGAGTGCAGCAAGCAACATGACAGATGGTGGCACGCTGTT
TTTACCCAGCCCTGCCTGTACATACACATGCACACCCTCTCTGATATTTTTGTCCTTTAGATGTTCAAATACTCAGTAGTCCTTTTGTTT
GCGGTTTAGATTCATTTTGTCCACACATGTACCCATTTTAAAAAACAATGTCCTCGATGCTTCTGTAGTGATTTCATTTTAGCCAGGTAT
TTCTTTCTTGTGTGTGATGAACCAGTATGGATTTGCTTTTCTAAGCCTCCTGTTGGTTACTAATCTCACTTGGCACATTATAACTAAAGG
AATCCCCTCAATTCAAAAGCATAGATGGATACAAATGTCAGACCGTGGGTTTAATTTGTTTAGAACACATGGCATTTCTTCACAAGGTAA
CCTGCTGTATTTATTTATTTTCTTTTGGTTAAATATAATTTCCAAACTTTGTGGTCAGGCAGCGTCTAAGGTTACGTTACCACAGACTGA
CAGTTGGTATATGTACCAGCCAATCCCTTCATTAAATGTATACAGATTTAGTTAAGTAGCATTAAATAGGATTCTTAGAAGTATGTCCTC
ATAGAACTTTTAATACTTAAGGCTTTGTAAAAACTATCCATGAAGGGAAAGCTCCTCAGCATAACTGCTCAGGGAAATAGGGCTAAATAA
CTGAACATTAAATAATTGGTTAAAGGTGCTGTTAGTCGAGCCTCAATGCTTGCTACAAGGATGTATGTACAAGGACTGACTTTAATAATT
TGCATTATATTGTCCCAACCAGTAGTTTATTTTTTGCCACGGAGATGTAGAAGATATTACAAGCTACTGGATGCACTGTCAGATTAACTT
ATTTCATTAAAGAAGTTGGGAGAACAAATAGGAAAAAAAAAACTTATTTTTCTAGTAAATATTAATGTATTACATTTCAAATAATGGTGC
CTGACATATTGAATAATTATTTTCTACAGTGTACGTATGCAACAAAGATATTCCATCATGCATTAGAGTCAGTTCTGGCTCTGCCTAGCT
GTTTACATTTGCAAATGTAGCAAACAAGGTAATGAAGCAACTATTTCTATTGCAGTAGATATCCTTTTGTGTGTGTGTGTGTGCATTAAA
GTTGTAAACGGTAACATGAAACAAATGAAAGTTCTTGCTATAATGGTATGGAAAACAAGAAGGAAATGAAAATATTTTTATGCCTACTTA
GGAAAAAAAGGGTAGCACTTATTCATTCCAAGTACTTTTTTTTTTTTAATTTTTAAGCTCTTAACTCACATTGTTATGCTTAAGATGATA
AACATATATCCTCTTTTTATTGCTTTGTCTATGTTTCATATGAAACATTTCAGAAATTATTTTGATAAGTGTTGCTGGAATCTGCAACGC
TGATTTTTTTTTGCATTCTGTAGTCGCATTTGCACTCCATTTTTACATTAATTCGCAGTTGCTTTGTATCATTGTTTTGTTTGGGTTTTG
TTTCTTTTTCACAGTGCCGGGTCTTCGTTTCTTAAAGTTGGATGGCAGGTAGAGTTCAACCAGTTCGTGACTGTTGTAGCGAATGAAGTT
AAAAAAATGTCTTTCTGATGTTGTGTTGTCATTTTCATTTTTGCATTTTTTTGTTTGCATATTAAAAAAAGAGAAAAGAGAAAGCAAGAG
ACAGAAATCAGGACTAAGTCCTCTGCTTCAGTTTCATTGTTAACGGGCCTTATTCTGATCTCACCTGTCGCGTAGCTCTAATATTCACAT
AAACTGAAATAAAGAAGTGGAATGAGGAGCTTTGACATTCAAATTATGTGATGTAATTTATCTTCCTTAGGAATTTTGATGGATGCATCT
CAAAATGTATAGCCAGACTTGAGAGGTGACAATTAAAGATCTAAAAAAGAGAGGAGATTCCCCCAAACAACAATATTTAATTTTCTTAGT
AAAAAGAATAACAGAATGCATCGTGGCAATCCTTAAGCAACATTATCTATGTGGACTGCTTAAATCAGCAAAACACCAGAAGTTTGGTTA
ACTTGGGCAATATGACAAGTATTACTTTTTGGGCAAAACTACTCATTAAGCAATTTCTCTAGTGTGTCGGACACAAATAGGTTCTTTATT
TTTGGCATGTATGCCTTTTTATTTTCATTCAATTTTTTTTTTTTCTCAGACAGACATAGTAGTATCGACTAGCATTGGAAAATACATATC
ACTATTCTTGGAATATTTATGGTCAGTCTACTTTTTAGTAAAATATTTTTGGATAGCGTTGACACGATAGATCTTATTCCATACTTCTTT
ATTATTGATAATTTTATTTTCATTTTTTGCTTTCATTATTATACATATTTTGGTGGAGAAGAGGTTGGGCTTTTTTGAAAGAGACAAAAA
TTTATTATAACACTAAACACTCCTTTTTTGACATATTAAAGCCTTTATTCCATCTCTCAAGATATATTATAAAATTTATTTTTTTAATTT
AAGATTTCTGAATTATTTTATCTTAAATTGTGATTTTAAACGAGCTATTATGGTACGGAACTTTTTTTAATGAGGAATTTCATGATGATT
TAGGAATTTTCTCTCTTGGAAAAGGCTTCCCCTGTGATGAAAATGATGTGCCAGCTAAAATTGTGTGCCATTTAAAAACTGAAAATATTT
TAAAATTATTTGTCTATATTCTAAATTGAGCTTTGGATCAAACTTTAGGCCAGGACCAGCTCATGCGTTCTCATTCTTCCTTTTCTCACT
CTTTCTCTCATCACTCACCTCTGTATTCATTCTGTTGTTTGGGATAGAAAAATCATAAAGAGCCAACCCATCTCAGAACGTTGTGGATTG
AGAGAGACACTACATGACTCCAAGTATATGAGAAAAGGACAGAGCTCTAATTGATAACTCTGTAGTTCAAAAGGAAAAGAGTATGCCCAA
TTCTCTCTACATGACATATTGAGATTTTTTTTAATCAACTTTTAAGATAGTGATGTTCTGTTCTAAACTGTTCTGTTTTAGTGAAGGTAG
ATTTTTATAAAACAAGCATGGGGATTCTTTTCTAAGGTAATATTAATGAGAAGGGAAAAAAGTATCTTTAACAGCTCTTTGTTGAAGCCT
GTGGTAGCACATTATGTTTATAATTGCACATGTGCACATAATCTATTATGATCCAATGCAAATACAGCTCCAAAAATATTAAATGTATAT
ATATTTTAAAATGCCTGAGGAAATACATTTTTCTTAATAAACTGAAGAGTCTCAGTATGGCTATTAAAATAATTATTAGCCTCCTGTTGT
GTGGCTGCAAAACATCACAAAGTGACCGGTCTTGAGACCTGTGAACTGCTGCCCTGTTTAGTAAATAAAATTAATGCATTTCTAGAGGGG
GAATATCTGCCATCCAGTGGTGGAAATGTGGAGTAAAGAAGCTGGTGGTCTGCTTCTGTGCTGTATGCCAGCCTTTTGCCTTAAGTTGAG
AGGAGGTCAACTTTAGCTACTGTCTTTGGTTTGAGAGCCATGGCAAAAAAAAAAAAAGAAAAAAAGATCAAGTCGTCTTTGGTGAGCCAG
TAAGGTGAAAGCTTGCTGACTGTCCAAGGCACAAGAGAAAATTGAGGAATTGAAATGCAACCTGAGTATCAAACTAAATATTCTAATCAA
AGGTAGGTACTGTTAGGTGGAATTCTATCAGCAGGCAACTGCAAATGAGAAGAAGATAGAAGGACGCCCGTCGGGACTTTGGAGGGCATT
GTTATTTTCCCAAAGAAAGACGGCCAAGGGCAGAGGCATGGATTCTTTGCAGAGCACTTCCTTTTGGTTTTTCAGTACTGTTTCATAGAC
AGTGGGCTCACATGTTCCTGATAGTGCTGCAGTTGCTTAGAAAGCATCCCAGTTAATTGCAGTAATTAGAACTTCTGGAATATGCTAGGG
CAGAAGTATGTCAAGTATGTCACATGAAGAAAATGTGAAATTCAAGAGTAATCCACACGTGAGAAACTAGACAATGTACATTCATGTGTT
CTCTTGAAAGGAAAGGGAGAGCTGTAAGCTTCACTCTGTCCTACACCGGAGAAAAGCAGGAATAACTTTACCGTGGAAATAATGTTTAGC
TTTTATCAGAGAAAATTGTCCTTCTAGAGCATAGAGTCCCAAAACTCAATTCTGGTTTTCCCCTGTTTTTTTTTTTTTTTTTTTTCCCAA
CATATAAACTGCAGCATATCACTTTTTCTTTTTGTGCCTCAGGTTCCTCACCTGTAAAATTGAAAAATATATGTATTAATAATATTATTA
ATAATAATAATGGTAATGTAGTACTTGTTTGTAAAGCACTTTGAGATCCTTGGTTGAAAGGCACCATAGGAGTGCCAAGTATTATTATGT
GGCCAAGGGGGTTATTTAAACTGTCAGTTCCCAAAGGCCAGGAAAGGTTGGGGTCATTTTTCTTAAAGACGAGCTGTAAATATCAACTAG
GCAGCCAATAGTGTTGACTATGAAGATGCAAAACTATTACTAGGCTGATAAAATCATAGTTTCTTAATGGCTACCAATAAGGCAAATATC
ACAATAATAAACGCCAAATTCCTTAGGGCGGACTATTTGACAACCACATGGAAAACTTTGGGGGAGGCATGAGGGGGGAACATCTCAAAA
TGCCAATGTAAAATTTAACTTACAGCAATATTCACCAGCAGAAAATGTCTTTCATATGGAATGATTTCATGTTGCTAAGAAAAAGAATTC
AATTTGTAGTCCTGATTTGAATACTAGAATGTTGGCTATAATAGTTCTGTTCTTACAACACATGAAATTTTTTCGTTTTATTTTATTTTG
TTTTCATAGTGCATGTTCATTTCTACTCACAAACATGTTCTTGGTGTATTTCTTATGCAAACAATCTTCAGGCAGCAAAGATGTCTGTTA

>67182_67182_2_POP1-TRPS1_POP1_chr8_99135706_ENST00000401707_TRPS1_chr8_116426301_ENST00000395715_length(amino acids)=105AA_BP=
MCVMNQYGFAFLSLLLVTNLTWHIITKGIPSIQKHRWIQMSDRGFNLFRTHGISSQGNLLYLFIFFWLNIISKLCGQAASKVTLPQTDSW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for POP1-TRPS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for POP1-TRPS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for POP1-TRPS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource