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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:POU2F1-MAEL (FusionGDB2 ID:67237)

Fusion Gene Summary for POU2F1-MAEL

Fusion gene summary

Fusion gene information	Fusion gene name: POU2F1-MAEL
	Fusion gene ID: 67237
		Hgene	Tgene
	Gene symbol	POU2F1	MAEL
	Gene ID	5451	84944
	Gene name	POU class 2 homeobox 1	maelstrom spermatogenic transposon silencer
	Synonyms	OCT1\|OTF1\|oct-1B	CT128\|SPATA35
	Cytomap	1q24.2	1q24.1
	Type of gene	protein-coding	protein-coding
	Description	POU domain, class 2, transcription factor 1NF-A1OTF-1Octamer-binding transcription factor-1POU class 2 homeobox 1 isoform Oct-1Roct-1octamer-binding protein 1octamer-binding transcription factor 1	protein maelstrom homologcancer/testis antigen 128maelstrom homologspermatogenesis associated 35testicular tissue protein Li 116
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000367865, ENST00000367866, ENST00000429375, ENST00000420254, ENST00000452019, ENST00000541643, ENST00000367862,	ENST00000367870, ENST00000367872, ENST00000491055,
Fusion gene scores	* DoF score	15 X 7 X 11=1155	3 X 7 X 4=84
	# samples	17	5
	** MAII score	log2(17/1155*10)=-2.76428620016572 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/84*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: POU2F1 [Title/Abstract] AND MAEL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	POU2F1(167190195)-MAEL(166973417), # samples:2 POU2F1(167190195)-MAEL(166960615), # samples:2 POU2F1(167190195)-MAEL(166973416), # samples:2
Anticipated loss of major functional domain due to fusion event.	POU2F1-MAEL seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	POU2F1	GO:0045892	negative regulation of transcription, DNA-templated	11891224\|11997177
Hgene	POU2F1	GO:0045944	positive regulation of transcription by RNA polymerase II	15252056

Fusion gene breakpoints across POU2F1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAEL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-2H-A9GG-01A	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
ChimerDB4	ESCA	TCGA-2H-A9GG	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
ChimerDB4	ESCA	TCGA-2H-A9GG	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
ChimerDB4	OV	TCGA-13-1405-01A	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
ChimerDB4	OV	TCGA-13-1405-01A	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+

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Fusion Gene ORF analysis for POU2F1-MAEL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000367865	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
3UTR-3CDS	ENST00000367865	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
3UTR-3CDS	ENST00000367865	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
3UTR-3CDS	ENST00000367865	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
3UTR-3CDS	ENST00000367865	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
3UTR-3CDS	ENST00000367865	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
3UTR-3CDS	ENST00000367865	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
3UTR-3CDS	ENST00000367865	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
3UTR-3UTR	ENST00000367865	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
3UTR-3UTR	ENST00000367865	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
3UTR-3UTR	ENST00000367865	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
3UTR-intron	ENST00000367865	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5CDS-3UTR	ENST00000367866	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5CDS-3UTR	ENST00000367866	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5CDS-3UTR	ENST00000367866	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5CDS-3UTR	ENST00000429375	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5CDS-3UTR	ENST00000429375	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5CDS-3UTR	ENST00000429375	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5CDS-intron	ENST00000367866	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5CDS-intron	ENST00000429375	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000420254	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3CDS	ENST00000420254	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3CDS	ENST00000420254	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000420254	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3CDS	ENST00000420254	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3CDS	ENST00000420254	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3CDS	ENST00000420254	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000420254	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3CDS	ENST00000452019	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3CDS	ENST00000452019	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3CDS	ENST00000452019	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000452019	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3CDS	ENST00000452019	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3CDS	ENST00000452019	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3CDS	ENST00000452019	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000452019	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3CDS	ENST00000541643	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3CDS	ENST00000541643	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3CDS	ENST00000541643	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000541643	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3CDS	ENST00000541643	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3CDS	ENST00000541643	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3CDS	ENST00000541643	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-3CDS	ENST00000541643	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3UTR	ENST00000420254	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3UTR	ENST00000420254	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3UTR	ENST00000420254	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3UTR	ENST00000452019	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3UTR	ENST00000452019	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3UTR	ENST00000452019	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-3UTR	ENST00000541643	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
5UTR-3UTR	ENST00000541643	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
5UTR-3UTR	ENST00000541643	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
5UTR-intron	ENST00000420254	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-intron	ENST00000452019	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
5UTR-intron	ENST00000541643	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
Frame-shift	ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
Frame-shift	ENST00000367866	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
Frame-shift	ENST00000367866	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
Frame-shift	ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
Frame-shift	ENST00000429375	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
Frame-shift	ENST00000429375	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
In-frame	ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
In-frame	ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
In-frame	ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
In-frame	ENST00000367866	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
In-frame	ENST00000367866	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
In-frame	ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
In-frame	ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
In-frame	ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
In-frame	ENST00000429375	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
In-frame	ENST00000429375	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
intron-3CDS	ENST00000367862	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
intron-3CDS	ENST00000367862	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
intron-3CDS	ENST00000367862	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
intron-3CDS	ENST00000367862	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
intron-3CDS	ENST00000367862	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
intron-3CDS	ENST00000367862	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
intron-3CDS	ENST00000367862	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+
intron-3CDS	ENST00000367862	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
intron-3UTR	ENST00000367862	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+
intron-3UTR	ENST00000367862	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+
intron-3UTR	ENST00000367862	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166960615	+
intron-intron	ENST00000367862	ENST00000491055	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367866	POU2F1	chr1	167190195	+	ENST00000367872	MAEL	chr1	166973417	+	1271	130	51	911	286
ENST00000367866	POU2F1	chr1	167190195	+	ENST00000367870	MAEL	chr1	166973417	+	1234	130	51	911	286
ENST00000429375	POU2F1	chr1	167190195	+	ENST00000367872	MAEL	chr1	166973417	+	1209	68	7	849	280
ENST00000429375	POU2F1	chr1	167190195	+	ENST00000367870	MAEL	chr1	166973417	+	1172	68	7	849	280
ENST00000367866	POU2F1	chr1	167190195	+	ENST00000367872	MAEL	chr1	166973416	+	1271	130	51	911	286
ENST00000367866	POU2F1	chr1	167190195	+	ENST00000367870	MAEL	chr1	166973416	+	1234	130	51	911	286
ENST00000429375	POU2F1	chr1	167190195	+	ENST00000367872	MAEL	chr1	166973416	+	1209	68	7	849	280
ENST00000429375	POU2F1	chr1	167190195	+	ENST00000367870	MAEL	chr1	166973416	+	1172	68	7	849	280
ENST00000367866	POU2F1	chr1	167190195	+	ENST00000367870	MAEL	chr1	166958638	+	1615	130	51	1292	413
ENST00000429375	POU2F1	chr1	167190195	+	ENST00000367870	MAEL	chr1	166958638	+	1553	68	7	1230	407

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367866	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+	0.000798284	0.9992017
ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+	0.0008876	0.9991124
ENST00000429375	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+	0.00073695	0.999263
ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973417	+	0.000805849	0.9991942
ENST00000367866	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	0.000798284	0.9992017
ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	0.0008876	0.9991124
ENST00000429375	ENST00000367872	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	0.00073695	0.999263
ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	0.000805849	0.9991942
ENST00000367866	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+	0.001486985	0.99851304
ENST00000429375	ENST00000367870	POU2F1	chr1	167190195	+	MAEL	chr1	166958638	+	0.00154668	0.99845326

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Fusion Genomic Features for POU2F1-MAEL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
POU2F1	chr1	167190195	+	MAEL	chr1	166960614	+	0.035949863	0.9640501
POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	6.43E-06	0.99999356
POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	6.43E-06	0.99999356
POU2F1	chr1	167190195	+	MAEL	chr1	166960614	+	0.035949863	0.9640501
POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	6.43E-06	0.99999356
POU2F1	chr1	167190195	+	MAEL	chr1	166973416	+	6.43E-06	0.99999356

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for POU2F1-MAEL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:167190195/chr1:166973417)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MAEL

chr1:167190195

chr1:166958638

ENST00000367870

4_73

404.0

DNA binding

Note=HMG box

Tgene

MAEL

chr1:167190195

chr1:166958638

ENST00000367872

4_73

435.0

DNA binding

Note=HMG box

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000367862

379_438

756.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000420254

379_438

654.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000429375

379_438

704.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000541643

379_438

744.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000367862

379_438

756.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000420254

379_438

654.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000429375

379_438

704.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000541643

379_438

744.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000367862

379_438

756.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000420254

379_438

654.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000429375

379_438

704.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000541643

379_438

744.0

DNA binding

Homeobox

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000367862

280_354

756.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000420254

280_354

654.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000429375

280_354

704.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166958638

ENST00000541643

280_354

744.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000367862

280_354

756.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000420254

280_354

654.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000429375

280_354

704.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973416

ENST00000541643

280_354

744.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000367862

280_354

756.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000420254

280_354

654.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000429375

280_354

704.0

Domain

POU-specific

Hgene

POU2F1

chr1:167190195

chr1:166973417

ENST00000541643

280_354

744.0

Domain

POU-specific

Tgene

MAEL

chr1:167190195

chr1:166973416

ENST00000367870

4_73

143

404.0

DNA binding

Note=HMG box

Tgene

MAEL

chr1:167190195

chr1:166973416

ENST00000367872

4_73

174

435.0

DNA binding

Note=HMG box

Tgene

MAEL

chr1:167190195

chr1:166973417

ENST00000367870

4_73

143

404.0

DNA binding

Note=HMG box

Tgene

MAEL

chr1:167190195

chr1:166973417

ENST00000367872

4_73

174

435.0

DNA binding

Note=HMG box

Top

Fusion Gene Sequence for POU2F1-MAEL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>67237_67237_1_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166958638_ENST00000367870_length(transcript)=1615nt_BP=130nt
GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG
AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGAGAAGATCCCCGAACTACGGCGACGAGGCCTGCCTGTGGCTCGCGTTGCT
GATGCCATCCCTTACTGCTCCTCAGACTGGGCGAAACCTGTTTTCACACCACTGAGGAGGCCAGGCATGCTTGTACCAAAGCAGAATGTT
TCACCTCCAGATATGTCAGCTTTGTCTTTAAAAGGTGATCAAGCTCTCCTTGGAGGCATTTTTTATTTTTTGAACATTTTTAGCCATGGC
GAGCTACCTCCTCATTGTGAACAGCGCTTCCTCCCTTGTGAAATTGGCTGTGTTAAGTATTCTCTCCAAGAAGGTATTATGGCAGATTTC
CACAGTTTTATAAATCCTGGTGAAATTCCACGAGGATTTCGATTTCATTGTCAGGCTGCAAGTGATTCTAGTCACAAGATTCCTATTTCA
AATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTAC
TGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACT
GTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATG
TGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTAC
TGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTG
ACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAG
GAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACC
CGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAA
GATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTA
CAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAA
AATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAG

>67237_67237_1_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166958638_ENST00000367870_length(amino acids)=413AA_BP=26
MVKIFKMADGGAASQDESSAAAAAAAEKIPELRRRGLPVARVADAIPYCSSDWAKPVFTPLRRPGMLVPKQNVSPPDMSALSLKGDQALL
GGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNFERGHNQATVLQNLYR
FIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDI
LFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKI

--------------------------------------------------------------
>67237_67237_2_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973416_ENST00000367870_length(transcript)=1234nt_BP=130nt
GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG
AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAAC
CAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACC
AGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGG
ATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACA
AGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCC
ACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTG
GATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCC
ATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCC
AATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCT
TCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCAC
ATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCT
TGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAA

>67237_67237_2_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973416_ENST00000367870_length(amino acids)=286AA_BP=26
MVKIFKMADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQ
DLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDY
EASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLS

--------------------------------------------------------------
>67237_67237_3_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973416_ENST00000367872_length(transcript)=1271nt_BP=130nt
GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG
AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAAC
CAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACC
AGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGG
ATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACA
AGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCC
ACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTG
GATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCC
ATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCC
AATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCT
TCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCAC
ATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCT
TGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAA
AACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGATAATAAAGGTATTGAATATCTGTTATGAA

>67237_67237_3_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973416_ENST00000367872_length(amino acids)=286AA_BP=26
MVKIFKMADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQ
DLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDY
EASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLS

--------------------------------------------------------------
>67237_67237_4_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973417_ENST00000367870_length(transcript)=1234nt_BP=130nt
GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG
AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAAC
CAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACC
AGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGG
ATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACA
AGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCC
ACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTG
GATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCC
ATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCC
AATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCT
TCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCAC
ATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCT
TGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAA

>67237_67237_4_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973417_ENST00000367870_length(amino acids)=286AA_BP=26
MVKIFKMADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQ
DLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDY
EASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLS

--------------------------------------------------------------
>67237_67237_5_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973417_ENST00000367872_length(transcript)=1271nt_BP=130nt
GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG
AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAAC
CAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACC
AGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGG
ATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACA
AGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCC
ACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTG
GATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCC
ATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCC
AATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCT
TCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCAC
ATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCT
TGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAA
AACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGATAATAAAGGTATTGAATATCTGTTATGAA

>67237_67237_5_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000367866_MAEL_chr1_166973417_ENST00000367872_length(amino acids)=286AA_BP=26
MVKIFKMADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQ
DLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDY
EASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLS

--------------------------------------------------------------
>67237_67237_6_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166958638_ENST00000367870_length(transcript)=1553nt_BP=68nt
ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGAGAAGATCCCCGAACTACGGCG
ACGAGGCCTGCCTGTGGCTCGCGTTGCTGATGCCATCCCTTACTGCTCCTCAGACTGGGCGAAACCTGTTTTCACACCACTGAGGAGGCC
AGGCATGCTTGTACCAAAGCAGAATGTTTCACCTCCAGATATGTCAGCTTTGTCTTTAAAAGGTGATCAAGCTCTCCTTGGAGGCATTTT
TTATTTTTTGAACATTTTTAGCCATGGCGAGCTACCTCCTCATTGTGAACAGCGCTTCCTCCCTTGTGAAATTGGCTGTGTTAAGTATTC
TCTCCAAGAAGGTATTATGGCAGATTTCCACAGTTTTATAAATCCTGGTGAAATTCCACGAGGATTTCGATTTCATTGTCAGGCTGCAAG
TGATTCTAGTCACAAGATTCCTATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCC
CAACCCAGGGAACTGGCCACCTATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGA
AATCAGGCAAGATCTACAACTTCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTG
GATTCGAAGCCTCCTAGATGTGGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGC
TTTAGCTGTTTGCAAGAAGATTGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACT
ACAAGATTATGAGGCCAGCAATAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGG
ATTCTCTCATTTCAACTCTTCTAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAA
CAGCAGCGTTCGGGGAAGAGGAATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACAC
TTCACTCTCACCTTACATGTCCCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAAC
AGTAACAGGCCCAACTTCCTTCTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTG
TAAGGAAATTGTTTCATAGATTTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCC
TGGCTGTATGATGGGTATATCATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGA

>67237_67237_6_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166958638_ENST00000367870_length(amino acids)=407AA_BP=20
MADGGAASQDESSAAAAAAAEKIPELRRRGLPVARVADAIPYCSSDWAKPVFTPLRRPGMLVPKQNVSPPDMSALSLKGDQALLGGIFYF
LNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNFERGHNQATVLQNLYRFIHPNP
GNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALA
VCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSS

--------------------------------------------------------------
>67237_67237_7_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973416_ENST00000367870_length(transcript)=1172nt_BP=68nt
ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCC
TATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACC
TATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACT
TCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGT
GGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGAT
TGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAA
TAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTC
TAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGG
AATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTC
CCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTT
CTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGAT
TTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATC
ATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGAT

>67237_67237_7_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973416_ENST00000367870_length(amino acids)=280AA_BP=20
MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT
VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV
TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK

--------------------------------------------------------------
>67237_67237_8_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973416_ENST00000367872_length(transcript)=1209nt_BP=68nt
ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCC
TATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACC
TATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACT
TCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGT
GGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGAT
TGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAA
TAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTC
TAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGG
AATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTC
CCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTT
CTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGAT
TTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATC
ATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGAT

>67237_67237_8_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973416_ENST00000367872_length(amino acids)=280AA_BP=20
MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT
VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV
TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK

--------------------------------------------------------------
>67237_67237_9_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973417_ENST00000367870_length(transcript)=1172nt_BP=68nt
ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCC
TATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACC
TATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACT
TCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGT
GGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGAT
TGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAA
TAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTC
TAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGG
AATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTC
CCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTT
CTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGAT
TTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATC
ATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGAT

>67237_67237_9_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973417_ENST00000367870_length(amino acids)=280AA_BP=20
MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT
VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV
TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK

--------------------------------------------------------------
>67237_67237_10_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973417_ENST00000367872_length(transcript)=1209nt_BP=68nt
ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGTGATTCTAGTCACAAGATTCC
TATTTCAAATTTTGAACGTGGGCATAACCAAGCAACTGTGTTACAAAACCTTTATAGATTTATTCATCCCAACCCAGGGAACTGGCCACC
TATCTACTGCAAGTCTGATGATAGAACCAGAGTCAACTGGTGTTTGAAGCATATGGCAAAGGCATCAGAAATCAGGCAAGATCTACAACT
TCTCACTGTAGAGGACCTTGTAGTGGGGATCTACCAACAAAAATTTCTCAAGGAGCCCTCTAAGACTTGGATTCGAAGCCTCCTAGATGT
GGCCATGTGGGATTATTCTAGCAACACAAGGTGCAAGTGGCATGAAGAAAATGATATTCTCTTCTGTGCTTTAGCTGTTTGCAAGAAGAT
TGCGTACTGCATCAGTAATTCTCTGGCCACTCTCTTTGGAATCCAGCTCACAGAGGCTCATGTACCACTACAAGATTATGAGGCCAGCAA
TAGTGTGACACCCAAAATGGTTGTATTGGATGCAGGGCGTTACCAGAAGCTAAGGGTTGGGAGTTCAGGATTCTCTCATTTCAACTCTTC
TAATGAGGAACAAAGATCAAACACACCCATTGGTGACTACCCATCTAGGGCAAAAATTTCTGGCCAAAACAGCAGCGTTCGGGGAAGAGG
AATTACCCGCTTACTAGAGAGCATTTCCAATTCTTCCAGCAATATCCACAAATTCTCCAACTGTGACACTTCACTCTCACCTTACATGTC
CCAAAAAGATGGATACAAATCTTTCTCTTCCTTATCTTAATGATGGTACTCTTTTCAATTTCTGAAAACAGTAACAGGCCCAACTTCCTT
CTTACTACAGTCATATTAAACAGATCACATCAATGACAAATGTCACTACTATAAAAACTACTTAATTTGTAAGGAAATTGTTTCATAGAT
TTAAAAAAATTGTGGTTGGAGAGCATCTTGGCATTTGTGCTTTTTTTCTTGAGGGATTGTTCTGCTTCCTGGCTGTATGATGGGTATATC
ATTAAAGTTTGGAGTCCTATATGAACAAAACTGACATTTTTAGAGTTGTACTTTTGGGAATGTTATAGATTGATCATTCTTTCTCCTGAT

>67237_67237_10_POU2F1-MAEL_POU2F1_chr1_167190195_ENST00000429375_MAEL_chr1_166973417_ENST00000367872_length(amino acids)=280AA_BP=20
MADGGAASQDESSAAAAAAAGDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLT
VEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSV
TPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for POU2F1-MAEL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for POU2F1-MAEL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for POU2F1-MAEL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source