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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPA1-LRRC20 (FusionGDB2 ID:67268)

Fusion Gene Summary for PPA1-LRRC20

check button Fusion gene summary
Fusion gene informationFusion gene name: PPA1-LRRC20
Fusion gene ID: 67268
HgeneTgene
Gene symbol

PPA1

LRRC20

Gene ID

5464

55222

Gene nameinorganic pyrophosphatase 1leucine rich repeat containing 20
SynonymsHEL-S-66p|IOPPP|PP|PP1|SID6-8061-
Cytomap

10q22.1

10q22.1

Type of geneprotein-codingprotein-coding
Descriptioninorganic pyrophosphatasePPasecytosolic inorganic pyrophosphatasediphosphate phosphohydrolaseepididymis secretory sperm binding protein Li 66pinorganic diphosphatase 1pyrophosphatase (inorganic) 1pyrophosphatase 1pyrophosphate phospho-hydrolaseleucine-rich repeat-containing protein 20
Modification date2020031320200313
UniProtAcc.

Q8TCA0

Ensembl transtripts involved in fusion geneENST00000373232, ENST00000608321, 
ENST00000495346, 		ENST00000355790, 
ENST00000358141, ENST00000373224, 
ENST00000395010, ENST00000395011, 
Fusion gene scores* DoF score9 X 8 X 5=3602 X 2 X 4=16
# samples 115
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPA1 [Title/Abstract] AND LRRC20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPA1(71977568)-LRRC20(72083786), # samples:1
PPA1(71973219)-LRRC20(72083786), # samples:1
PPA1(71973219)-LRRC20(72100458), # samples:1
Anticipated loss of major functional domain due to fusion event.PPA1-LRRC20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-JL-A3YW-01APPA1chr10

71977568

-LRRC20chr10

72083786

-
ChimerDB4OVTCGA-13-0888-01APPA1chr10

71973219

-LRRC20chr10

72083786

-
ChimerDB4UCECTCGA-B5-A1N2-01APPA1chr10

71973219

-LRRC20chr10

72100458

-


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Fusion Gene ORF analysis for PPA1-LRRC20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373232ENST00000355790PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000355790PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000355790PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000373232ENST00000358141PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000358141PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000358141PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000373232ENST00000373224PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000373224PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000373224PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000373232ENST00000395010PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000395010PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000373232ENST00000395010PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000373232ENST00000395011PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000608321ENST00000355790PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000355790PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000355790PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000608321ENST00000358141PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000358141PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000358141PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000608321ENST00000373224PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000373224PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000373224PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000608321ENST00000395010PPA1chr10

71977568

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000395010PPA1chr10

71973219

-LRRC20chr10

72083786

-
5CDS-intronENST00000608321ENST00000395010PPA1chr10

71973219

-LRRC20chr10

72100458

-
5CDS-intronENST00000608321ENST00000395011PPA1chr10

71973219

-LRRC20chr10

72100458

-
Frame-shiftENST00000373232ENST00000395011PPA1chr10

71977568

-LRRC20chr10

72083786

-
Frame-shiftENST00000608321ENST00000395011PPA1chr10

71977568

-LRRC20chr10

72083786

-
In-frameENST00000373232ENST00000395011PPA1chr10

71973219

-LRRC20chr10

72083786

-
In-frameENST00000608321ENST00000395011PPA1chr10

71973219

-LRRC20chr10

72083786

-
intron-3CDSENST00000495346ENST00000395011PPA1chr10

71977568

-LRRC20chr10

72083786

-
intron-3CDSENST00000495346ENST00000395011PPA1chr10

71973219

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000355790PPA1chr10

71977568

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000355790PPA1chr10

71973219

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000355790PPA1chr10

71973219

-LRRC20chr10

72100458

-
intron-intronENST00000495346ENST00000358141PPA1chr10

71977568

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000358141PPA1chr10

71973219

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000358141PPA1chr10

71973219

-LRRC20chr10

72100458

-
intron-intronENST00000495346ENST00000373224PPA1chr10

71977568

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000373224PPA1chr10

71973219

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000373224PPA1chr10

71973219

-LRRC20chr10

72100458

-
intron-intronENST00000495346ENST00000395010PPA1chr10

71977568

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000395010PPA1chr10

71973219

-LRRC20chr10

72083786

-
intron-intronENST00000495346ENST00000395010PPA1chr10

71973219

-LRRC20chr10

72100458

-
intron-intronENST00000495346ENST00000395011PPA1chr10

71973219

-LRRC20chr10

72100458

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373232PPA1chr1071973219-ENST00000395011LRRC20chr1072083786-331561134933299
ENST00000608321PPA1chr1071973219-ENST00000395011LRRC20chr1072083786-329258811910299

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373232ENST00000395011PPA1chr1071973219-LRRC20chr1072083786-0.0039543760.99604565
ENST00000608321ENST00000395011PPA1chr1071973219-LRRC20chr1072083786-0.0038479540.996152

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Fusion Genomic Features for PPA1-LRRC20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPA1-LRRC20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71977568/chr10:72083786)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRRC20

Q8TCA0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC20chr10:71973219chr10:72083786ENST0000035579025121_14177185.0RepeatNote=LRR 4
TgeneLRRC20chr10:71973219chr10:72083786ENST0000035579025145_16777185.0RepeatNote=LRR 5
TgeneLRRC20chr10:71973219chr10:72083786ENST000003557902575_9677185.0RepeatNote=LRR 2
TgeneLRRC20chr10:71973219chr10:72083786ENST000003557902598_12077185.0RepeatNote=LRR 3
TgeneLRRC20chr10:71973219chr10:72083786ENST0000035814114121_14127135.0RepeatNote=LRR 4
TgeneLRRC20chr10:71973219chr10:72083786ENST0000035814114145_16727135.0RepeatNote=LRR 5
TgeneLRRC20chr10:71973219chr10:72083786ENST000003581411451_7227135.0RepeatNote=LRR 1
TgeneLRRC20chr10:71973219chr10:72083786ENST000003581411475_9627135.0RepeatNote=LRR 2
TgeneLRRC20chr10:71973219chr10:72083786ENST000003581411498_12027135.0RepeatNote=LRR 3
TgeneLRRC20chr10:71973219chr10:72083786ENST0000037322425121_14177185.0RepeatNote=LRR 4
TgeneLRRC20chr10:71973219chr10:72083786ENST0000037322425145_16777185.0RepeatNote=LRR 5
TgeneLRRC20chr10:71973219chr10:72083786ENST000003732242575_9677185.0RepeatNote=LRR 2
TgeneLRRC20chr10:71973219chr10:72083786ENST000003732242598_12077185.0RepeatNote=LRR 3
TgeneLRRC20chr10:71973219chr10:72083786ENST0000039501004121_1410129.0RepeatNote=LRR 4
TgeneLRRC20chr10:71973219chr10:72083786ENST0000039501004145_1670129.0RepeatNote=LRR 5
TgeneLRRC20chr10:71973219chr10:72083786ENST000003950100451_720129.0RepeatNote=LRR 1
TgeneLRRC20chr10:71973219chr10:72083786ENST000003950100475_960129.0RepeatNote=LRR 2
TgeneLRRC20chr10:71973219chr10:72083786ENST000003950100498_1200129.0RepeatNote=LRR 3
TgeneLRRC20chr10:71973219chr10:72083786ENST0000039501114121_14127135.0RepeatNote=LRR 4
TgeneLRRC20chr10:71973219chr10:72083786ENST0000039501114145_16727135.0RepeatNote=LRR 5
TgeneLRRC20chr10:71973219chr10:72083786ENST000003950111451_7227135.0RepeatNote=LRR 1
TgeneLRRC20chr10:71973219chr10:72083786ENST000003950111475_9627135.0RepeatNote=LRR 2
TgeneLRRC20chr10:71973219chr10:72083786ENST000003950111498_12027135.0RepeatNote=LRR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC20chr10:71973219chr10:72083786ENST000003557902551_7277185.0RepeatNote=LRR 1
TgeneLRRC20chr10:71973219chr10:72083786ENST000003732242551_7277185.0RepeatNote=LRR 1


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Fusion Gene Sequence for PPA1-LRRC20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67268_67268_1_PPA1-LRRC20_PPA1_chr10_71973219_ENST00000373232_LRRC20_chr10_72083786_ENST00000395011_length(transcript)=3315nt_BP=611nt
AGTGCTCGCAGTGCGCAGGCGTGGGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGA
CTCCGGCACTATGAGCGGCTTCAGCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATGAGAAAGGACA
ATATATATCTCCATTTCATGATATTCCAATTTATGCAGATAAGGATGTGTTTCACATGGTAGTTGAAGTACCACGCTGGTCTAATGCAAA
AATGGAGATTGCTACAAAGGACCCTTTAAACCCTATTAAACAAGATGTGAAAAAAGGAAAACTTCGCTATGTTGCGAATTTGTTCCCGTA
TAAAGGATATATCTGGAACTATGGTGCCATCCCTCAGACTTGGGAAGACCCAGGGCACAATGATAAACATACTGGCTGTTGTGGTGACAA
TGACCCAATTGATGTGTGTGAAATTGGAAGCAAGGTATGTGCAAGAGGTGAAATAATTGGCGTGAAAGTTCTAGGCATATTGGCTATGAT
TGACGAAGGGGAAACCGACTGGAAAGTCATTGCCATTAATGTGGATGATCCTGATGCAGCCAATTATAATGAGCTCCACCTGGAGGGGAA
CTTCCTACACCGCCTCCCCAGCGAGGTCAGTGCCCTGCAGCACCTCAAGGCCATTGACCTGTCCCGGAACCAGTTCCAGGACTTCCCTGA
GCAGCTTACCGCCCTGCCGGCGCTGGAGACCATCAACCTGGAGGAGAACGAGATCGTAGATGTGCCCGTGGAGAAGCTGGCCGCCATGCC
AGCCTTGCGCAGCATCAACCTCCGCTTCAACCCACTCAACGCCGAGGTGCGCGTGATCGCCCCGCCGCTCATCAAGTTTGACATGCTCAT
GTCTCCGGAAGGCGCAAGAGCCCCCCTACCTTAGGCCACCCTCCTCATGCCCACCCAGCAAGGGGCAGAGGCCACAGGCCTGGAACCCTG
GAAGGGAGGGAGGCCCATGGGAGGCCAAGCCTGGGGGCTGGGGGCGGGTGGGCCGAGCAGCACGTGGTGGGTGGGGTGCAGCTGGTCTGG
ATAGATAGCTTACAGCAGTAGTGGGCTCTGGAATGCCCAAGGGAAGAGGCAAGGTGGGGCCTGCAGCCTGGACTCGGCACTCACAGCTGC
TGTGCAAACTCAGGCAGATCTCCTGCCCTCTCTGAGCCTTGTCACTTGAAAAAAACAGGACCCTTTCCCTCCTTTGGGCTCCCTGGAGGT
TTTTAAGCAGTACGTGCCTCCAAGTTACCTCCAGATCAGCAGGCACAGGTGGGCATTGCCAGGTATTTTCTGAGCCCCTGCGGGTTTGAG
GCCTTGTTTTTAGTGCTGAGAGCCAGTTGCTGCCCTGAGAAGAGAAGACAACCTCCATCTATTTATTGCTTCCTGAGAACTGACCTGGAT
GCGGCCCTCTGCAGGGCCCAGTCTTCAGTCCTGTGGTCCCTGGACTGGTGGGAACCTGAACTAGGAGTCCTGGGAGAGCTGTGGTGGGAA
TATGGGCTGGCACTGCTGCAGGGCAAGAACATTCATGTAGGAGCCCGAGGACCAGCAGGCTGGGAATGGGGAGCAAGTCACGTCAGCTCT
GTCATTCCCCACAGTTAACAAATTGGCGGGGTGGGAAGTCCTGAGTGCTCCGTCCCTCTAGCATCACTCCTGAGCTGCGGGAGAGGTGGC
CCAGAGAACAGCAGAGTCAGTTACACCTGCAGCTCTTGTCTAAAGTGATTAGATGGCCACCCTCACCACTGTCCAGTCCAGCAGCAGCCT
GGCTGCCTTGTCATGGCCTCCTGGGGGCAGAAGGCGATGTGGACCACGGGATTTGTAGCCAGCCAGCTCCCAGGCCAACGCCCAAAGCCC
TGATGACCTGGTTCTTCTGAGGCCCTCAACCTGGCATCTTAGGGTATGGTCAGGCAACAGGGTGACCAGCTGTCCTGGTTTCCCAGGACA
TGGAACTTTCAATGCTAAAACTGGGACAGTACCCAGCAAGTGGGGATGGTTGGTCCCCTACCAGGAGAGGGCCTGGGGCTCTTGCTTCCC
GAGAACGCCTGTGGCTTGAAGAACCTTGACTGCTTGGTCCTCAGGTATCTACCTCCCACCTTCTCCTCATCTGTGGAGCAAGCCAACTCA
GTGCCCCAGACCCCACCTGATCTGCATCTTTGTTTGCATCTCCAGAGACACCTGAGGCCCCAGAGCTTGAGGCAAAGCCAGGCCGTCCAA
ATCCTGTGTGCCGTGGACGAGTGGCCACTTTACTACTCCTAAGGCTAAGATGTTGAGAGCTCAGACCACTGCTCAGAGCAGTAATCCCTG
CTCAGAATGCTCCCAGTTCCCTCGTCCCTGCCCAGGTCTCTTGTCTCTTGGGAAGGAACTGATAGGTCGGGCCATTGTTGGGCCATCACT
GAGCGCTCAGTATCTCAAGAGACTCTGTTCATTCTGCTCGTATCCCAAGGCCTGGTTGGTCAAACTCTGGGCAAAGGGTTTTCAGGATGA
GGAGGTCAAGACAGGATCTCCAGAGCTACCGAGTTCATCTGTGGGTGTTGGGGGCAAGTGGGGGCTGAAGTCCTGTGCAGGCTGCGCTGG
CCCCACCTGCCTTGTGCCCTGGAGTGGGGTTTCTCCTTGTTGAAGAAGAGGCATCCTTCTCTGATGTGCACAAACACAATGTATGACCAG
AGCCTTGCAACTCAAAGTGTGGTCTGTGGACCAGCAGCGGCAGTGACACCTGGGAGCTTGTTAGGAATGCAGAGTCTAGGCCTCACCCTA
TACCTCCCGACTCAGACCCTGCATTTTAGCAAGACCCCCAGCTGATTCCTATAAGCACTTTAGAGTTTGAGAAGCAAGGACCTAGGCTGG
GGATGTCCTCCGAGCAGAGGGTGAAGTTTCTCTCAGTTCTCTCCCTGCCACTTCCAGGGATCTGAGCCTGTGCTCAGCCTCCTCCCTAAC
CCACCCTGGGAGACACTTGGCCTGTTAGATTGTTCCAGAGTCTGCATGGCACTCCTGAAGAAGGGAGTGTGACCTGCAGTCACCAGGAGA
TGAGGGTTAGGTGTGCCCAGCCCTCCAGACCCGGCCTTTCTGGTTAACCCCTGCATGCCAAGCTGCCTGCTGCCCCAGGTCCTCACCTCA
GGCCTTTGAAGGGGCAGCTTCTGGAAGTTGTTTTCTCCTCTGCTTGGAGAGTTTGCCCTTGTCTGTCTTGGAAAGTGTGGGCAGCCACAG

>67268_67268_1_PPA1-LRRC20_PPA1_chr10_71973219_ENST00000373232_LRRC20_chr10_72083786_ENST00000395011_length(amino acids)=299AA_BP=192
MSVGAACGLVALWQRRRQDSGTMSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNP
IKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIA
INVDDPDAANYNELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP

--------------------------------------------------------------
>67268_67268_2_PPA1-LRRC20_PPA1_chr10_71973219_ENST00000608321_LRRC20_chr10_72083786_ENST00000395011_length(transcript)=3292nt_BP=588nt
GGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGACTCCGGCACTATGAGCGGCTTCA
GCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATGAGAAAGGACAATATATATCTCCATTTCATGATA
TTCCAATTTATGCAGATAAGGATGTGTTTCACATGGTAGTTGAAGTACCACGCTGGTCTAATGCAAAAATGGAGATTGCTACAAAGGACC
CTTTAAACCCTATTAAACAAGATGTGAAAAAAGGAAAACTTCGCTATGTTGCGAATTTGTTCCCGTATAAAGGATATATCTGGAACTATG
GTGCCATCCCTCAGACTTGGGAAGACCCAGGGCACAATGATAAACATACTGGCTGTTGTGGTGACAATGACCCAATTGATGTGTGTGAAA
TTGGAAGCAAGGTATGTGCAAGAGGTGAAATAATTGGCGTGAAAGTTCTAGGCATATTGGCTATGATTGACGAAGGGGAAACCGACTGGA
AAGTCATTGCCATTAATGTGGATGATCCTGATGCAGCCAATTATAATGAGCTCCACCTGGAGGGGAACTTCCTACACCGCCTCCCCAGCG
AGGTCAGTGCCCTGCAGCACCTCAAGGCCATTGACCTGTCCCGGAACCAGTTCCAGGACTTCCCTGAGCAGCTTACCGCCCTGCCGGCGC
TGGAGACCATCAACCTGGAGGAGAACGAGATCGTAGATGTGCCCGTGGAGAAGCTGGCCGCCATGCCAGCCTTGCGCAGCATCAACCTCC
GCTTCAACCCACTCAACGCCGAGGTGCGCGTGATCGCCCCGCCGCTCATCAAGTTTGACATGCTCATGTCTCCGGAAGGCGCAAGAGCCC
CCCTACCTTAGGCCACCCTCCTCATGCCCACCCAGCAAGGGGCAGAGGCCACAGGCCTGGAACCCTGGAAGGGAGGGAGGCCCATGGGAG
GCCAAGCCTGGGGGCTGGGGGCGGGTGGGCCGAGCAGCACGTGGTGGGTGGGGTGCAGCTGGTCTGGATAGATAGCTTACAGCAGTAGTG
GGCTCTGGAATGCCCAAGGGAAGAGGCAAGGTGGGGCCTGCAGCCTGGACTCGGCACTCACAGCTGCTGTGCAAACTCAGGCAGATCTCC
TGCCCTCTCTGAGCCTTGTCACTTGAAAAAAACAGGACCCTTTCCCTCCTTTGGGCTCCCTGGAGGTTTTTAAGCAGTACGTGCCTCCAA
GTTACCTCCAGATCAGCAGGCACAGGTGGGCATTGCCAGGTATTTTCTGAGCCCCTGCGGGTTTGAGGCCTTGTTTTTAGTGCTGAGAGC
CAGTTGCTGCCCTGAGAAGAGAAGACAACCTCCATCTATTTATTGCTTCCTGAGAACTGACCTGGATGCGGCCCTCTGCAGGGCCCAGTC
TTCAGTCCTGTGGTCCCTGGACTGGTGGGAACCTGAACTAGGAGTCCTGGGAGAGCTGTGGTGGGAATATGGGCTGGCACTGCTGCAGGG
CAAGAACATTCATGTAGGAGCCCGAGGACCAGCAGGCTGGGAATGGGGAGCAAGTCACGTCAGCTCTGTCATTCCCCACAGTTAACAAAT
TGGCGGGGTGGGAAGTCCTGAGTGCTCCGTCCCTCTAGCATCACTCCTGAGCTGCGGGAGAGGTGGCCCAGAGAACAGCAGAGTCAGTTA
CACCTGCAGCTCTTGTCTAAAGTGATTAGATGGCCACCCTCACCACTGTCCAGTCCAGCAGCAGCCTGGCTGCCTTGTCATGGCCTCCTG
GGGGCAGAAGGCGATGTGGACCACGGGATTTGTAGCCAGCCAGCTCCCAGGCCAACGCCCAAAGCCCTGATGACCTGGTTCTTCTGAGGC
CCTCAACCTGGCATCTTAGGGTATGGTCAGGCAACAGGGTGACCAGCTGTCCTGGTTTCCCAGGACATGGAACTTTCAATGCTAAAACTG
GGACAGTACCCAGCAAGTGGGGATGGTTGGTCCCCTACCAGGAGAGGGCCTGGGGCTCTTGCTTCCCGAGAACGCCTGTGGCTTGAAGAA
CCTTGACTGCTTGGTCCTCAGGTATCTACCTCCCACCTTCTCCTCATCTGTGGAGCAAGCCAACTCAGTGCCCCAGACCCCACCTGATCT
GCATCTTTGTTTGCATCTCCAGAGACACCTGAGGCCCCAGAGCTTGAGGCAAAGCCAGGCCGTCCAAATCCTGTGTGCCGTGGACGAGTG
GCCACTTTACTACTCCTAAGGCTAAGATGTTGAGAGCTCAGACCACTGCTCAGAGCAGTAATCCCTGCTCAGAATGCTCCCAGTTCCCTC
GTCCCTGCCCAGGTCTCTTGTCTCTTGGGAAGGAACTGATAGGTCGGGCCATTGTTGGGCCATCACTGAGCGCTCAGTATCTCAAGAGAC
TCTGTTCATTCTGCTCGTATCCCAAGGCCTGGTTGGTCAAACTCTGGGCAAAGGGTTTTCAGGATGAGGAGGTCAAGACAGGATCTCCAG
AGCTACCGAGTTCATCTGTGGGTGTTGGGGGCAAGTGGGGGCTGAAGTCCTGTGCAGGCTGCGCTGGCCCCACCTGCCTTGTGCCCTGGA
GTGGGGTTTCTCCTTGTTGAAGAAGAGGCATCCTTCTCTGATGTGCACAAACACAATGTATGACCAGAGCCTTGCAACTCAAAGTGTGGT
CTGTGGACCAGCAGCGGCAGTGACACCTGGGAGCTTGTTAGGAATGCAGAGTCTAGGCCTCACCCTATACCTCCCGACTCAGACCCTGCA
TTTTAGCAAGACCCCCAGCTGATTCCTATAAGCACTTTAGAGTTTGAGAAGCAAGGACCTAGGCTGGGGATGTCCTCCGAGCAGAGGGTG
AAGTTTCTCTCAGTTCTCTCCCTGCCACTTCCAGGGATCTGAGCCTGTGCTCAGCCTCCTCCCTAACCCACCCTGGGAGACACTTGGCCT
GTTAGATTGTTCCAGAGTCTGCATGGCACTCCTGAAGAAGGGAGTGTGACCTGCAGTCACCAGGAGATGAGGGTTAGGTGTGCCCAGCCC
TCCAGACCCGGCCTTTCTGGTTAACCCCTGCATGCCAAGCTGCCTGCTGCCCCAGGTCCTCACCTCAGGCCTTTGAAGGGGCAGCTTCTG
GAAGTTGTTTTCTCCTCTGCTTGGAGAGTTTGCCCTTGTCTGTCTTGGAAAGTGTGGGCAGCCACAGATGCCCCCAAATCAGAGCTCACA

>67268_67268_2_PPA1-LRRC20_PPA1_chr10_71973219_ENST00000608321_LRRC20_chr10_72083786_ENST00000395011_length(amino acids)=299AA_BP=192
MSVGAACGLVALWQRRRQDSGTMSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNP
IKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIA
INVDDPDAANYNELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP

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Fusion Gene PPI Analysis for PPA1-LRRC20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPA1-LRRC20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPA1-LRRC20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource