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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:PPA1-MICU1 (FusionGDB2 ID:67270)

Fusion Gene Summary for PPA1-MICU1

Fusion gene summary

Fusion gene information	Fusion gene name: PPA1-MICU1
	Fusion gene ID: 67270
		Hgene	Tgene
	Gene symbol	PPA1	MICU1
	Gene ID	5464	10367
	Gene name	inorganic pyrophosphatase 1	mitochondrial calcium uptake 1
	Synonyms	HEL-S-66p\|IOPPP\|PP\|PP1\|SID6-8061	CALC\|CBARA1\|EFHA3\|MPXPS\|ara CALC
	Cytomap	10q22.1	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	inorganic pyrophosphatasePPasecytosolic inorganic pyrophosphatasediphosphate phosphohydrolaseepididymis secretory sperm binding protein Li 66pinorganic diphosphatase 1pyrophosphatase (inorganic) 1pyrophosphatase 1pyrophosphate phospho-hydrolase	calcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q9BPX6
	Ensembl transtripts involved in fusion gene	ENST00000373232, ENST00000608321, ENST00000495346,	ENST00000398763, ENST00000418483, ENST00000604025, ENST00000361114, ENST00000398761, ENST00000401998,
Fusion gene scores	* DoF score	9 X 8 X 5=360	22 X 15 X 11=3630
	# samples	11	30
	** MAII score	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/3630*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPA1 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPA1(71993020)-MICU1(74268027), # samples:1 PPA1(71993020)-MICU1(74237014), # samples:1
Anticipated loss of major functional domain due to fusion event.	PPA1-MICU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PPA1-MICU1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MICU1	GO:0006851	mitochondrial calcium ion transmembrane transport	24560927
Tgene	MICU1	GO:0051260	protein homooligomerization	24514027
Tgene	MICU1	GO:0051561	positive regulation of mitochondrial calcium ion concentration	24560927
Tgene	MICU1	GO:0070509	calcium ion import	20693986

Fusion gene breakpoints across PPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A1EF-01A	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
ChimerDB4	LIHC	TCGA-DD-A1EF-01A	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-

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Fusion Gene ORF analysis for PPA1-MICU1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000373232	ENST00000398763	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
5CDS-5UTR	ENST00000608321	ENST00000398763	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
5CDS-intron	ENST00000373232	ENST00000418483	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
5CDS-intron	ENST00000373232	ENST00000604025	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
5CDS-intron	ENST00000373232	ENST00000604025	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
5CDS-intron	ENST00000608321	ENST00000418483	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
5CDS-intron	ENST00000608321	ENST00000604025	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
5CDS-intron	ENST00000608321	ENST00000604025	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
Frame-shift	ENST00000373232	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000373232	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000373232	ENST00000398763	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000373232	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000373232	ENST00000418483	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000608321	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000608321	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000608321	ENST00000398763	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000608321	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
Frame-shift	ENST00000608321	ENST00000418483	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
In-frame	ENST00000373232	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
In-frame	ENST00000373232	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
In-frame	ENST00000373232	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
In-frame	ENST00000608321	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
In-frame	ENST00000608321	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
In-frame	ENST00000608321	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
intron-3CDS	ENST00000495346	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
intron-3CDS	ENST00000495346	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
intron-3CDS	ENST00000495346	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
intron-3CDS	ENST00000495346	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
intron-3CDS	ENST00000495346	ENST00000398763	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
intron-3CDS	ENST00000495346	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
intron-3CDS	ENST00000495346	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
intron-3CDS	ENST00000495346	ENST00000418483	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
intron-5UTR	ENST00000495346	ENST00000398763	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
intron-intron	ENST00000495346	ENST00000418483	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-
intron-intron	ENST00000495346	ENST00000604025	PPA1	chr10	71993020	-	MICU1	chr10	74237014	-
intron-intron	ENST00000495346	ENST00000604025	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000373232	PPA1	chr10	71993020	-	ENST00000401998	MICU1	chr10	74268027	-	1913	164	311	1057	248
ENST00000373232	PPA1	chr10	71993020	-	ENST00000361114	MICU1	chr10	74268027	-	1913	164	311	1057	248
ENST00000373232	PPA1	chr10	71993020	-	ENST00000398761	MICU1	chr10	74268027	-	1913	164	311	1057	248
ENST00000608321	PPA1	chr10	71993020	-	ENST00000401998	MICU1	chr10	74268027	-	1890	141	288	1034	248
ENST00000608321	PPA1	chr10	71993020	-	ENST00000361114	MICU1	chr10	74268027	-	1890	141	288	1034	248
ENST00000608321	PPA1	chr10	71993020	-	ENST00000398761	MICU1	chr10	74268027	-	1890	141	288	1034	248

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373232	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-	0.004875013	0.995125
ENST00000373232	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-	0.005184258	0.99481577
ENST00000373232	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-	0.004875013	0.995125
ENST00000608321	ENST00000401998	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-	0.004422712	0.99557734
ENST00000608321	ENST00000361114	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-	0.004773573	0.9952264
ENST00000608321	ENST00000398761	PPA1	chr10	71993020	-	MICU1	chr10	74268027	-	0.004422712	0.99557734

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Fusion Genomic Features for PPA1-MICU1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPA1-MICU1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71993020/chr10:74268027)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MICU1 Q9BPX6
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269\|PubMed:16002733, ECO:0000269\|PubMed:20693986, ECO:0000269\|PubMed:22904319, ECO:0000269\|PubMed:23101630, ECO:0000269\|PubMed:23747253, ECO:0000269\|PubMed:24313810, ECO:0000269\|PubMed:24332854, ECO:0000269\|PubMed:24503055, ECO:0000269\|PubMed:24560927, ECO:0000269\|PubMed:26341627, ECO:0000269\|PubMed:26903221, ECO:0000269\|PubMed:27099988}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

231_242

179

477.0

Calcium binding

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

421_432

179

477.0

Calcium binding

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

231_242

279.0

Calcium binding

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

421_432

279.0

Calcium binding

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

231_242

279.0

Calcium binding

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

421_432

279.0

Calcium binding

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

218_253

179

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

408_443

179

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

218_253

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

408_443

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

218_253

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

408_443

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

455_465

179

477.0

Region

C-helix region

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

455_465

279.0

Region

C-helix region

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

99_110

279.0

Region

Polybasic region

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

455_465

279.0

Region

C-helix region

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

99_110

279.0

Region

Polybasic region

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

53_476

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

53_476

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000398763

34_52

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000418483

34_52

279.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

99_110

179

477.0

Region

Polybasic region

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

53_476

179

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:71993020

chr10:74268027

ENST00000361114

34_52

179

477.0

Transmembrane

Helical

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Fusion Gene Sequence for PPA1-MICU1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>67270_67270_1_PPA1-MICU1_PPA1_chr10_71993020_ENST00000373232_MICU1_chr10_74268027_ENST00000361114_length(transcript)=1913nt_BP=164nt
AGTGCTCGCAGTGCGCAGGCGTGGGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGA
CTCCGGCACTATGAGCGGCTTCAGCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATTTCCCAGGAAC
GAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTG
TTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAAC
AGGTTCAGAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGT
GTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGC
ATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACA
GTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGG
AGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGA
CCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCA
ATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTC
GCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACC
CCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCG
GGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCC
CATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAA
GAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACA
TTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGA
TGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGC
TCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCT
CGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCT
CCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCAT

>67270_67270_1_PPA1-MICU1_PPA1_chr10_71993020_ENST00000373232_MICU1_chr10_74268027_ENST00000361114_length(amino acids)=248AA_BP=
MFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPV
DGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVEL

--------------------------------------------------------------
>67270_67270_2_PPA1-MICU1_PPA1_chr10_71993020_ENST00000373232_MICU1_chr10_74268027_ENST00000398761_length(transcript)=1913nt_BP=164nt
AGTGCTCGCAGTGCGCAGGCGTGGGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGA
CTCCGGCACTATGAGCGGCTTCAGCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATTTCCCAGGAAC
GAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTG
TTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAAC
AGGCAATTAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGT
GTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGC
ATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACA
GTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGG
AGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGA
CCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCA
ATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTC
GCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACC
CCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCG
GGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCC
CATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAA
GAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACA
TTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGA
TGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGC
TCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCT
CGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCT
CCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCAT

>67270_67270_2_PPA1-MICU1_PPA1_chr10_71993020_ENST00000373232_MICU1_chr10_74268027_ENST00000398761_length(amino acids)=248AA_BP=
MFDLNGDGEVDMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPV
DGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVEL

--------------------------------------------------------------
>67270_67270_3_PPA1-MICU1_PPA1_chr10_71993020_ENST00000373232_MICU1_chr10_74268027_ENST00000401998_length(transcript)=1913nt_BP=164nt
AGTGCTCGCAGTGCGCAGGCGTGGGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGA
CTCCGGCACTATGAGCGGCTTCAGCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATTTCCCAGGAAC
GAGAAAAATTTGCTGATGAAGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTG
TTCTTTCCACTCCTCAGAGAAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAAC
AGGCAATTAGCATCATTCGCTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGT
GTTCAGCCCTCACAACCTACTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGC
ATGATGTTCTGAAGCTTGAGTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACA
GTGGGGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGG
AGAACTTCTTTACTTTCCTAAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGA
CCATGCAGCAGGTGGCCAGGACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCA
ATGGCGAACTGAGCAATAAGGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTC
GCCTCATGCAGGCCATGTGGAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACC
CCTCCACCCCCAGTACCCTGGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCG
GGATGACCTCAGGACTCTGTCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCC
CATAGGTTCTCAAAAACATGAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAA
GAATTCAGGGAACCATCCACACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACA
TTCCTTGACTTCCCTCCTGCTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGA
TGAGGATGACCTAGGCACCCTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGC
TCTAGGAAGGCAGCATGCTCAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCT
CGCAGCCTCCCTAAGATGACTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCT
CCAGGATGGGCCTCTAAAGCTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCAT

>67270_67270_3_PPA1-MICU1_PPA1_chr10_71993020_ENST00000373232_MICU1_chr10_74268027_ENST00000401998_length(amino acids)=248AA_BP=
MFDLNGDGEVDMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPV
DGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVEL

--------------------------------------------------------------
>67270_67270_4_PPA1-MICU1_PPA1_chr10_71993020_ENST00000608321_MICU1_chr10_74268027_ENST00000361114_length(transcript)=1890nt_BP=141nt
GGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGACTCCGGCACTATGAGCGGCTTCA
GCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGC
AGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAAT
TTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCGCTCC
CAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTT
TTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTT
GAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTG
ACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAG
AACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACA
GTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAA
TTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAA
TGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGAC
CCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGG
TTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAAC
AAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACA
CCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGG
TGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTAC
GCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGT
GGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCC
AGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGA
GGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAAAGTT

>67270_67270_4_PPA1-MICU1_PPA1_chr10_71993020_ENST00000608321_MICU1_chr10_74268027_ENST00000361114_length(amino acids)=248AA_BP=
MFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPV
DGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVEL

--------------------------------------------------------------
>67270_67270_5_PPA1-MICU1_PPA1_chr10_71993020_ENST00000608321_MICU1_chr10_74268027_ENST00000398761_length(transcript)=1890nt_BP=141nt
GGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGACTCCGGCACTATGAGCGGCTTCA
GCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGC
AGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAAT
TTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCC
CAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTT
TTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTT
GAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTG
ACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAG
AACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACA
GTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAA
TTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAA
TGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGAC
CCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGG
TTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAAC
AAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACA
CCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGG
TGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTAC
GCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGT
GGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCC
AGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGA
GGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAAAGTT

>67270_67270_5_PPA1-MICU1_PPA1_chr10_71993020_ENST00000608321_MICU1_chr10_74268027_ENST00000398761_length(amino acids)=248AA_BP=
MFDLNGDGEVDMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPV
DGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVEL

--------------------------------------------------------------
>67270_67270_6_PPA1-MICU1_PPA1_chr10_71993020_ENST00000608321_MICU1_chr10_74268027_ENST00000401998_length(transcript)=1890nt_BP=141nt
GGGCTCTCTCCTTGTCAGTCGGCGCCGCGTGCGGGCTGGTGGCTCTGTGGCAGCGGCGGCGGCAGGACTCCGGCACTATGAGCGGCTTCA
GCACCGAGGAGCGCGCCGCGCCCTTCTCCCTGGAGTACCGAGTCTTCCTCAAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGC
AGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAAT
TTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCC
CAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTT
TTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTT
GAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTG
ACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAG
AACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACA
GTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAA
TTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAA
TGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGAC
CCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGG
TTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAAC
AAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACA
CCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGG
TGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTAC
GCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGT
GGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCC
AGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGA
GGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAAAGTT

>67270_67270_6_PPA1-MICU1_PPA1_chr10_71993020_ENST00000608321_MICU1_chr10_74268027_ENST00000401998_length(amino acids)=248AA_BP=
MFDLNGDGEVDMEEFEQAISIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPV
DGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVEL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPA1-MICU1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPA1-MICU1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPA1-MICU1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source