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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PPA2-SPATA5 (FusionGDB2 ID:67283) |
Fusion Gene Summary for PPA2-SPATA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPA2-SPATA5 | Fusion gene ID: 67283 | Hgene | Tgene | Gene symbol | PPA2 | SPATA5 | Gene ID | 27068 | 166378 |
| Gene name | inorganic pyrophosphatase 2 | spermatogenesis associated 5 | |
| Synonyms | HSPC124|SCFAI|SCFI|SID6-306 | AFG2|EHLMRS|SPAF | |
| Cytomap | 4q24 | 4q28.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase (inorganic) 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2 | ATPase family protein 2 homologATPase family gene 2 homologspermatogenesis associated factor SPAFspermatogenesis-associated factor proteinspermatogenesis-associated protein 5 | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000310267, ENST00000341695, ENST00000348706, ENST00000357415, ENST00000380004, ENST00000509426, ENST00000354147, ENST00000432483, | ENST00000422835, ENST00000274008, | |
| Fusion gene scores | * DoF score | 10 X 9 X 7=630 | 5 X 5 X 3=75 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPA2 [Title/Abstract] AND SPATA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PPA2(106367539)-SPATA5(124177170), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PPA2-SPATA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PPA2-SPATA5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across PPA2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SPATA5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-MX-A663 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
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Fusion Gene ORF analysis for PPA2-SPATA5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000310267 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| 5CDS-intron | ENST00000341695 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| 5CDS-intron | ENST00000348706 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| 5CDS-intron | ENST00000357415 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| 5CDS-intron | ENST00000380004 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| 5UTR-3CDS | ENST00000509426 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| 5UTR-intron | ENST00000509426 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| Frame-shift | ENST00000310267 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| In-frame | ENST00000341695 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| In-frame | ENST00000348706 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| In-frame | ENST00000357415 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| In-frame | ENST00000380004 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| intron-3CDS | ENST00000354147 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| intron-3CDS | ENST00000432483 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| intron-intron | ENST00000354147 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| intron-intron | ENST00000432483 | ENST00000422835 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000341695 | PPA2 | chr4 | 106367539 | - | ENST00000274008 | SPATA5 | chr4 | 124177170 | + | 6200 | 472 | 31 | 813 | 260 |
| ENST00000348706 | PPA2 | chr4 | 106367539 | - | ENST00000274008 | SPATA5 | chr4 | 124177170 | + | 6183 | 455 | 14 | 796 | 260 |
| ENST00000380004 | PPA2 | chr4 | 106367539 | - | ENST00000274008 | SPATA5 | chr4 | 124177170 | + | 6129 | 401 | 14 | 742 | 242 |
| ENST00000357415 | PPA2 | chr4 | 106367539 | - | ENST00000274008 | SPATA5 | chr4 | 124177170 | + | 6228 | 500 | 14 | 841 | 275 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000341695 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + | 0.000192537 | 0.99980754 |
| ENST00000348706 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + | 0.00019043 | 0.99980956 |
| ENST00000380004 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + | 0.000251041 | 0.999749 |
| ENST00000357415 | ENST00000274008 | PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + | 0.000234287 | 0.9997657 |
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Fusion Genomic Features for PPA2-SPATA5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + | 5.09E-08 | 1 |
| PPA2 | chr4 | 106367539 | - | SPATA5 | chr4 | 124177170 | + | 5.09E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PPA2-SPATA5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:106367539/chr4:124177170) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SPATA5 | chr4:106367539 | chr4:124177170 | ENST00000274008 | 13 | 16 | 394_401 | 780 | 894.0 | Nucleotide binding | ATP 1 | |
| Tgene | SPATA5 | chr4:106367539 | chr4:124177170 | ENST00000274008 | 13 | 16 | 668_675 | 780 | 894.0 | Nucleotide binding | ATP 2 |
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Fusion Gene Sequence for PPA2-SPATA5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >67283_67283_1_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000341695_SPATA5_chr4_124177170_ENST00000274008_length(transcript)=6200nt_BP=472nt CCGCGCGCACAGCAGGACCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTT GGGGACCAGTGCAGGGACCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCT CTTCTTTAAGAATGTAACTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTAT GAAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGTGGACAAATGCTAAAATGGAGATTGCCAC CAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATG GAATTATGGTACCCTCCCTCAGGCTTTGATGCGGCCTGGAAGAATTGATAGAATCATCTATGTGCCTTTACCGGATGCAGCAACAAGAAG GGAAATATTTAAGCTGCAGTTTCACTCCATGCCTGTCAGTAATGAAGTTGACCTGGATGAACTCATCCTTCAAACCGACGCATACTCAGG AGCAGAGATTGTAGCTGTCTGCAGAGAGGCAGCTCTTCTGGCTCTGGAAGAAGACATTCAAGCCAATCTCATCATGAAAAGACATTTCAC TCAGGCCTTGAGCACTGTGACACCTAGAATTCCTGAGTCATTGAGACGTTTTTATGAAGATTATCAAGAGAAGAGTGGGCTGCATACACT CTGAGAAAATATATATATTCAAGATGCTGAAAATCCTTTCCAGAGAAAATTTGTTTCTTTTTAAAATTTTTTGAGAGTGTTAAAAAAAAT TTTACTAGGCAAAATGTTTGAAGTATGTTCAGTAGAATTTAGGGGCTTTGGTTCTTACAGATTTTCAAGTCATGTAAGTACAGTGAAAAT ATCTCTGAGCATAAGTTTCAATCAGTTTTACCTGGAAATTTGTGGTGTGGTTTAAAAAACAAATGTTTAGCTTTTTCATTTGCGACCTAG TCTGTTCATCCCATGAAGCGATTTCTTTTTCCAGAATCTGTTTGAGTGTCTTTCTAAAATGCCAAACATGTTGGCATCAATTTTATACAG GGATATAAAAAAGTATATGTGGATAAATTTTTTGTAATCTTTAGGGATATAAAAAAGTGTATGTGGATAAATTTTTTGTAATCTTTATTT TTGAAGGCCAGCCAGTAAAATGGCCCAATGTGCCAGCCAGGCTTATGTGGCCTTGTTTTCAAATATACATATATGTGTTATCATTAAAAT TCATATATGCATTTTTGTTTTAGCCTTCTTAATCTCTACCTATGGCCAAAAAAATTTTTTTTGAGAGATATTTTGTATAATACAATGCCC TTTGAAAGTGTAAGCCCACTCTAAGCCTAGATCAGTAGGCTTGGGTTTTTTTTGTTGTTGTTTTGTCTTTTTTTTTTTTTTTTGAGACAG AGTCTCACTCTGTCACCTAAGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCC TCAACCTCCTGAGTAGCTGGGACTACAGGTGTGCACCACCACACGCAGCTAATTTTTATATTTTTAGTAGAGACAAGGTTTCACCATGTT AGCCAGGCCGGTCTCGAACTGCTGGCCTCAGGTGACCCACCCACCTGAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATACC TGGAGAGGTTTTGTGTTTTTGTTTTTTTTTCATAAAATGCTTTTAATAAATCATATGAAGCATTCATGTTTTTACTTATACATATTTTCA GGGTACCAGTAAACTTTTTAGTTCAAAGATAGGCCAAATTGTACTTTTTTTTTTTTATGAGACAGAGTCTCGCTGCTCTGTCGCCCAGGC TAGAGTGCAGTGGCGTGATCTAGGCTCACTGCAAGCTCTGCCTCCTGGGTTTACTTACGCCATTCTCCCGCCTCAGCCTCCTGAGTAGCT GGGACTACAGGTGCCCACCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTATTAGAGACAGGGTTTCACCGTGTTAGCCAGGATG ATCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACTGCGCCCTGCCGCCAAAT TGTAATCTTAAACATATTATGTTGCATTCTAAATATGTATATTTATGCTTCTTGTTATTTATCCTCAGGATTTCTTCACACTTTATTACT TCATAAATACTCTTGAAAAAGCTTTCAGAAAGTGATTCTCTGACTTCAGATCAGAAACTGGCAATGGGAAGAATGTGCACTTAAACTTGA TCACTGTAGATCTTTGAAAATTCCCAGAAAGACAAATCAGACAAGAAATACCTGATTATCAAAATAATGGGCTATACAGTTTTGTGGTGG CATACATTCCTTGTTTGTTTGTTTAGAGATAGGATCTTGTTGTGTCACCCAGGCTGGAATGCAGTGGCACAGTCGTAGCTCACTGCACCT TCAAACTCCTGGAGCTCAAGTGATCCTCCTGACTCAGCCTCCTGAGTAGCTAGGACAACAGGTGCACACTGCCATGTCAGGCTAATTTTT TTTTTTAAACAGAGAGACAGAGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAACTCCTGGCCTCAGGTGACCCTCCTGCCTCAGCTTCCCA AAGGGCTGAGATTACAGGTGTGAGCCACCATGCCCAGCCTGTGGTGACATATATTCTGAAGTCACATCTCAAATATTTAATCCTCAAATA TATTTACATCCTCAAAAATATCAGATTTTCAAGACAACACTGGTTTACCAGTACATAAACCCACCTAGGGGACAAAGAATATTACCACTT AGAACTGTGTTGTCAAATACAATAACCACTAATTGTATCTGACCATTTTAATTAAATTAATTACAATTAAATAATATTTAAGAATTAGTT TATCAGACATATCAGCCACATTTCAAATGCTCAATAGCTACATGTGGCAAGGGTCTGCCACACTGGACAGAGTAGAAAACATTCCCATCA TTCAGAAGGTTCTCTTGGACGCTGCAGATCTGGAAAACAAGACTTCCATATTGAAATAAATACAACCTCAAAACTTTTATGCTCTGTGTT CCCTTTAGTTGTTATCTACATAGAAAATTATGAAACAAGAGAGGAACTTACCTTCTTCCCTATTAAATATATGGCTAAGGGCACAAGAAA ATAAGAGGAAAACTTATCCTTCAGGGCCTAAACAAGGAAATGAAAGAAATCTCATTCCCAATAGAATAAAAACCAGAAGCTTGAAATGAC TCTGGTGCAGGAGGCTGGGTGGTGGGGAGGAGGGTAGCAGTCTCAATCAACAAGTTTAGATATTAATAGCCACTCAAAGCCTTCAGCCCA TATAACATGAAGTGACAACTGAGCTCTGCACATAATGCTCAAGCTCTATAATAACCAACACTCTCAGCACAAGGGTAGACAAGAAAAGAA AAATCTCCTGCTGGCCAGGAAGACCACAAGGAGGCTTTCTGACTTGGCCTGTGCTTTTGATTTTTAAAACATTTTTTAAAAGAGGCCTCT CTGGGCTGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGAAGATCAAGACCATC CTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATTCAAAAAATTAGCCGGGAATGGTGGTGGGCGCCTGTAGTCCCAGTTACTCGGG AGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGACGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAG TGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAACCTCTGAGAATTCTGACTATGAGCTTACCTGCCCATGGCTTTAGAATGATTTGAATT CACACTACCTTCAAATTCATGAAACCTCAAAACCTACAAATTAACCTAAAAACATGGAGCCAAGCTAAAAATGCCCTGGGGGTAACTAGC ACTTGGACTAGTTACAGGAATGTAGCTTCGTCTCAGAGGATTCCAAAAGCTAATGCCTTGCTTACCAAGGGCTTGTAATCTCACAGGATG TGATGGGTGGGGCCTCAGATCTGCTGATGGGAGCATAAATTGGTACAACCACTTTGGAAGGCAACTGGCTATCTAGCAAAGTTGAAGACC CTACAATCTAACAGTTCTCCTAGGTGCATATCCCAGAGCAAGTCTCACATTGATGCAGTGAGATAGTGAATAGGAAAGTTCATAGCACCA TTATTTTTAAGTAGTAAGAACCCGGAAACAATCTAAATATCCATCAGTAATAGATATATGTGATAGTCATACAATGGAATACTGTGGCAA TAAAAAATAATTAGAGCTACATATGAAATAGGGATGAAACATGGATGAACAAAGAATGTTTTAGAGGAATATGATATTTAAAATTTGAAG CATGAAAAATATGTGTTTATGGGGGCATATATAGTGGAAGAATAAATGAATAGAAAAGAAAAGCACCAAATACTGGTGAGGAATTTCCTC AGGGGAGAAAAGTTGAGCTGCTTCAATTGTGTCAGTAATGTTTCATATCTTAGGGTGGGTGATGGGAATATAGGTGCTGATTTAATATAG TCTGTACTTTTTGTGTACCTAAATATTTCGTGATAATTTTTAAAAGATGGGCCTTAAACCAATACAGTCATATCATTTAACTCAATTCCA TGAATTTACAATGCAATCCACAGTGCCCACAACCCCATGTTTCTGGAAAATCAGGAGTATTGGGTACAATGGAATAAAATGCAAGAAGGC AAATAAGAGATCAGGCTTTTAGGACCTAGGAAACAAATAAAGAGGAATTTGTTGCTGAAAGTAATGTGTAGCTGACACTCTCATTACCTG ACACAATGGGAGACATTATGTCTGGGAATAAGACATCTATTTCCATAGCACTGTAGTCCTGCAAAGGAGTTGGAAGTTATGAATTTTTAA AGATTTTAGAACATTATATCTTTAGTCTCTCATAAGCCAATTATTTATATCTCCACATAGCCCATTATTACCATTGAAAAGGCATGCAAT TCTTCTATTTGAAGCTTGTTCCCTTTTTACAAAAGTACTAGTAAAAATCTGAGTCATACAAAAGAGCAGGTCAGGTGTCACTAATAACAG TTTACCTCAGCTTCATCTCCATGAAGGTTTTACTTCTAATCCCAGAGTCTCATGTTTATGTATTACAAGAGTGTATGAAAGCTGGGCATG GTGGCACACACCAGTAGTCCCAGCTACTCGGTCGGGGGTTGAGGTGAGAGGATCGCTTGAACTCAGGAGTTTGAATCCAGCCTGGTCAAT GTAGCGAGATCCTATCTCTTAAAAAAAAAAAAAAAAGGGGGGAACAGTGTATGATCCTATTATTTGGGTTTGTGTGTGATCGAATACATG GTATATAGTTCATGGAAAATTTAAGCTCAGCAAGGAAAGAAAATGGCCAGCTTCCTGTCTTAGGAAGACAATTTACTTTTTGGCATCTGT TTGGTTGAAAGTTTGCCTTTGATCCAGATTCTTTCGGATGTCAGGGATATTCACATTGACATGTCTTTTTAGTGTTCCAGGAGATTTTAG TTTGAATAGTACAATTTTTTCTTCTTACAACAAAACTTAGAACGGCTTCTAACTTATTTCTTCATGGCCAAGAAACTACCCTAACTTATC TCGATAAATATTTAGTTCTGTCTTATTTCTAATGTGTAAAACAGGTTTTAAAAATAATATATAGATTTTGCATTTATAAAAAAAGATTTA ATTTATAGAACCAAACTTGAACATATGTTTAATTTAGCCTAATCAGAAGGTTACAGAAAAAGTTGCTGTAAAGATAGAATAAAGGTATTG TACTGGTCTGTTTTTACTGAAGTTCCAGAATGTGAGGTTATTAGAGTCTTGGCTTATTGTGTCATGTTTTCCTGAATGCTTCCTTTGAAG >67283_67283_1_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000341695_SPATA5_chr4_124177170_ENST00000274008_length(amino acids)=260AA_BP=147 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEN LFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQALMRPGRIDRIIYVPLPDAATRREIFKLQFHSM -------------------------------------------------------------- >67283_67283_2_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000348706_SPATA5_chr4_124177170_ENST00000274008_length(transcript)=6183nt_BP=455nt CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATGAAGAAAGCACGAAATG ATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGTGGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATC CCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATGGAATTATGGTACCCTCC CTCAGGCTTTGATGCGGCCTGGAAGAATTGATAGAATCATCTATGTGCCTTTACCGGATGCAGCAACAAGAAGGGAAATATTTAAGCTGC AGTTTCACTCCATGCCTGTCAGTAATGAAGTTGACCTGGATGAACTCATCCTTCAAACCGACGCATACTCAGGAGCAGAGATTGTAGCTG TCTGCAGAGAGGCAGCTCTTCTGGCTCTGGAAGAAGACATTCAAGCCAATCTCATCATGAAAAGACATTTCACTCAGGCCTTGAGCACTG TGACACCTAGAATTCCTGAGTCATTGAGACGTTTTTATGAAGATTATCAAGAGAAGAGTGGGCTGCATACACTCTGAGAAAATATATATA TTCAAGATGCTGAAAATCCTTTCCAGAGAAAATTTGTTTCTTTTTAAAATTTTTTGAGAGTGTTAAAAAAAATTTTACTAGGCAAAATGT TTGAAGTATGTTCAGTAGAATTTAGGGGCTTTGGTTCTTACAGATTTTCAAGTCATGTAAGTACAGTGAAAATATCTCTGAGCATAAGTT TCAATCAGTTTTACCTGGAAATTTGTGGTGTGGTTTAAAAAACAAATGTTTAGCTTTTTCATTTGCGACCTAGTCTGTTCATCCCATGAA GCGATTTCTTTTTCCAGAATCTGTTTGAGTGTCTTTCTAAAATGCCAAACATGTTGGCATCAATTTTATACAGGGATATAAAAAAGTATA TGTGGATAAATTTTTTGTAATCTTTAGGGATATAAAAAAGTGTATGTGGATAAATTTTTTGTAATCTTTATTTTTGAAGGCCAGCCAGTA AAATGGCCCAATGTGCCAGCCAGGCTTATGTGGCCTTGTTTTCAAATATACATATATGTGTTATCATTAAAATTCATATATGCATTTTTG TTTTAGCCTTCTTAATCTCTACCTATGGCCAAAAAAATTTTTTTTGAGAGATATTTTGTATAATACAATGCCCTTTGAAAGTGTAAGCCC ACTCTAAGCCTAGATCAGTAGGCTTGGGTTTTTTTTGTTGTTGTTTTGTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACC TAAGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAACCTCCTGAGTAGC TGGGACTACAGGTGTGCACCACCACACGCAGCTAATTTTTATATTTTTAGTAGAGACAAGGTTTCACCATGTTAGCCAGGCCGGTCTCGA ACTGCTGGCCTCAGGTGACCCACCCACCTGAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATACCTGGAGAGGTTTTGTGTT TTTGTTTTTTTTTCATAAAATGCTTTTAATAAATCATATGAAGCATTCATGTTTTTACTTATACATATTTTCAGGGTACCAGTAAACTTT TTAGTTCAAAGATAGGCCAAATTGTACTTTTTTTTTTTTATGAGACAGAGTCTCGCTGCTCTGTCGCCCAGGCTAGAGTGCAGTGGCGTG ATCTAGGCTCACTGCAAGCTCTGCCTCCTGGGTTTACTTACGCCATTCTCCCGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCA CCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTATTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGATCTCGATCTCCTGACC TCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACTGCGCCCTGCCGCCAAATTGTAATCTTAAACATAT TATGTTGCATTCTAAATATGTATATTTATGCTTCTTGTTATTTATCCTCAGGATTTCTTCACACTTTATTACTTCATAAATACTCTTGAA AAAGCTTTCAGAAAGTGATTCTCTGACTTCAGATCAGAAACTGGCAATGGGAAGAATGTGCACTTAAACTTGATCACTGTAGATCTTTGA AAATTCCCAGAAAGACAAATCAGACAAGAAATACCTGATTATCAAAATAATGGGCTATACAGTTTTGTGGTGGCATACATTCCTTGTTTG TTTGTTTAGAGATAGGATCTTGTTGTGTCACCCAGGCTGGAATGCAGTGGCACAGTCGTAGCTCACTGCACCTTCAAACTCCTGGAGCTC AAGTGATCCTCCTGACTCAGCCTCCTGAGTAGCTAGGACAACAGGTGCACACTGCCATGTCAGGCTAATTTTTTTTTTTAAACAGAGAGA CAGAGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAACTCCTGGCCTCAGGTGACCCTCCTGCCTCAGCTTCCCAAAGGGCTGAGATTACAG GTGTGAGCCACCATGCCCAGCCTGTGGTGACATATATTCTGAAGTCACATCTCAAATATTTAATCCTCAAATATATTTACATCCTCAAAA ATATCAGATTTTCAAGACAACACTGGTTTACCAGTACATAAACCCACCTAGGGGACAAAGAATATTACCACTTAGAACTGTGTTGTCAAA TACAATAACCACTAATTGTATCTGACCATTTTAATTAAATTAATTACAATTAAATAATATTTAAGAATTAGTTTATCAGACATATCAGCC ACATTTCAAATGCTCAATAGCTACATGTGGCAAGGGTCTGCCACACTGGACAGAGTAGAAAACATTCCCATCATTCAGAAGGTTCTCTTG GACGCTGCAGATCTGGAAAACAAGACTTCCATATTGAAATAAATACAACCTCAAAACTTTTATGCTCTGTGTTCCCTTTAGTTGTTATCT ACATAGAAAATTATGAAACAAGAGAGGAACTTACCTTCTTCCCTATTAAATATATGGCTAAGGGCACAAGAAAATAAGAGGAAAACTTAT CCTTCAGGGCCTAAACAAGGAAATGAAAGAAATCTCATTCCCAATAGAATAAAAACCAGAAGCTTGAAATGACTCTGGTGCAGGAGGCTG GGTGGTGGGGAGGAGGGTAGCAGTCTCAATCAACAAGTTTAGATATTAATAGCCACTCAAAGCCTTCAGCCCATATAACATGAAGTGACA ACTGAGCTCTGCACATAATGCTCAAGCTCTATAATAACCAACACTCTCAGCACAAGGGTAGACAAGAAAAGAAAAATCTCCTGCTGGCCA GGAAGACCACAAGGAGGCTTTCTGACTTGGCCTGTGCTTTTGATTTTTAAAACATTTTTTAAAAGAGGCCTCTCTGGGCTGGGCGCGGTG GCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGAAGATCAAGACCATCCTGGCTAACACAGTGAA ACCCCGTCTCTACTAAAAATTCAAAAAATTAGCCGGGAATGGTGGTGGGCGCCTGTAGTCCCAGTTACTCGGGAGGCTGAGGCAGGAGAA TGGCGTAAACCCGGGAGACGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAA AAAAAAAAAAAAAAAACCTCTGAGAATTCTGACTATGAGCTTACCTGCCCATGGCTTTAGAATGATTTGAATTCACACTACCTTCAAATT CATGAAACCTCAAAACCTACAAATTAACCTAAAAACATGGAGCCAAGCTAAAAATGCCCTGGGGGTAACTAGCACTTGGACTAGTTACAG GAATGTAGCTTCGTCTCAGAGGATTCCAAAAGCTAATGCCTTGCTTACCAAGGGCTTGTAATCTCACAGGATGTGATGGGTGGGGCCTCA GATCTGCTGATGGGAGCATAAATTGGTACAACCACTTTGGAAGGCAACTGGCTATCTAGCAAAGTTGAAGACCCTACAATCTAACAGTTC TCCTAGGTGCATATCCCAGAGCAAGTCTCACATTGATGCAGTGAGATAGTGAATAGGAAAGTTCATAGCACCATTATTTTTAAGTAGTAA GAACCCGGAAACAATCTAAATATCCATCAGTAATAGATATATGTGATAGTCATACAATGGAATACTGTGGCAATAAAAAATAATTAGAGC TACATATGAAATAGGGATGAAACATGGATGAACAAAGAATGTTTTAGAGGAATATGATATTTAAAATTTGAAGCATGAAAAATATGTGTT TATGGGGGCATATATAGTGGAAGAATAAATGAATAGAAAAGAAAAGCACCAAATACTGGTGAGGAATTTCCTCAGGGGAGAAAAGTTGAG CTGCTTCAATTGTGTCAGTAATGTTTCATATCTTAGGGTGGGTGATGGGAATATAGGTGCTGATTTAATATAGTCTGTACTTTTTGTGTA CCTAAATATTTCGTGATAATTTTTAAAAGATGGGCCTTAAACCAATACAGTCATATCATTTAACTCAATTCCATGAATTTACAATGCAAT CCACAGTGCCCACAACCCCATGTTTCTGGAAAATCAGGAGTATTGGGTACAATGGAATAAAATGCAAGAAGGCAAATAAGAGATCAGGCT TTTAGGACCTAGGAAACAAATAAAGAGGAATTTGTTGCTGAAAGTAATGTGTAGCTGACACTCTCATTACCTGACACAATGGGAGACATT ATGTCTGGGAATAAGACATCTATTTCCATAGCACTGTAGTCCTGCAAAGGAGTTGGAAGTTATGAATTTTTAAAGATTTTAGAACATTAT ATCTTTAGTCTCTCATAAGCCAATTATTTATATCTCCACATAGCCCATTATTACCATTGAAAAGGCATGCAATTCTTCTATTTGAAGCTT GTTCCCTTTTTACAAAAGTACTAGTAAAAATCTGAGTCATACAAAAGAGCAGGTCAGGTGTCACTAATAACAGTTTACCTCAGCTTCATC TCCATGAAGGTTTTACTTCTAATCCCAGAGTCTCATGTTTATGTATTACAAGAGTGTATGAAAGCTGGGCATGGTGGCACACACCAGTAG TCCCAGCTACTCGGTCGGGGGTTGAGGTGAGAGGATCGCTTGAACTCAGGAGTTTGAATCCAGCCTGGTCAATGTAGCGAGATCCTATCT CTTAAAAAAAAAAAAAAAAGGGGGGAACAGTGTATGATCCTATTATTTGGGTTTGTGTGTGATCGAATACATGGTATATAGTTCATGGAA AATTTAAGCTCAGCAAGGAAAGAAAATGGCCAGCTTCCTGTCTTAGGAAGACAATTTACTTTTTGGCATCTGTTTGGTTGAAAGTTTGCC TTTGATCCAGATTCTTTCGGATGTCAGGGATATTCACATTGACATGTCTTTTTAGTGTTCCAGGAGATTTTAGTTTGAATAGTACAATTT TTTCTTCTTACAACAAAACTTAGAACGGCTTCTAACTTATTTCTTCATGGCCAAGAAACTACCCTAACTTATCTCGATAAATATTTAGTT CTGTCTTATTTCTAATGTGTAAAACAGGTTTTAAAAATAATATATAGATTTTGCATTTATAAAAAAAGATTTAATTTATAGAACCAAACT TGAACATATGTTTAATTTAGCCTAATCAGAAGGTTACAGAAAAAGTTGCTGTAAAGATAGAATAAAGGTATTGTACTGGTCTGTTTTTAC TGAAGTTCCAGAATGTGAGGTTATTAGAGTCTTGGCTTATTGTGTCATGTTTTCCTGAATGCTTCCTTTGAAGATGAGCACACACCAAAG >67283_67283_2_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000348706_SPATA5_chr4_124177170_ENST00000274008_length(amino acids)=260AA_BP=147 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEN LFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQALMRPGRIDRIIYVPLPDAATRREIFKLQFHSM -------------------------------------------------------------- >67283_67283_3_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000357415_SPATA5_chr4_124177170_ENST00000274008_length(transcript)=6228nt_BP=500nt CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGACACTGAGGCTCAAGGCATTTTTATAGACTTGT CTAAGATCTGGGAAAATGGCATTCCTATGAAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGGT GGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGA ATATCTTCCCTTACAAGGGTTATATATGGAATTATGGTACCCTCCCTCAGGCTTTGATGCGGCCTGGAAGAATTGATAGAATCATCTATG TGCCTTTACCGGATGCAGCAACAAGAAGGGAAATATTTAAGCTGCAGTTTCACTCCATGCCTGTCAGTAATGAAGTTGACCTGGATGAAC TCATCCTTCAAACCGACGCATACTCAGGAGCAGAGATTGTAGCTGTCTGCAGAGAGGCAGCTCTTCTGGCTCTGGAAGAAGACATTCAAG CCAATCTCATCATGAAAAGACATTTCACTCAGGCCTTGAGCACTGTGACACCTAGAATTCCTGAGTCATTGAGACGTTTTTATGAAGATT ATCAAGAGAAGAGTGGGCTGCATACACTCTGAGAAAATATATATATTCAAGATGCTGAAAATCCTTTCCAGAGAAAATTTGTTTCTTTTT AAAATTTTTTGAGAGTGTTAAAAAAAATTTTACTAGGCAAAATGTTTGAAGTATGTTCAGTAGAATTTAGGGGCTTTGGTTCTTACAGAT TTTCAAGTCATGTAAGTACAGTGAAAATATCTCTGAGCATAAGTTTCAATCAGTTTTACCTGGAAATTTGTGGTGTGGTTTAAAAAACAA ATGTTTAGCTTTTTCATTTGCGACCTAGTCTGTTCATCCCATGAAGCGATTTCTTTTTCCAGAATCTGTTTGAGTGTCTTTCTAAAATGC CAAACATGTTGGCATCAATTTTATACAGGGATATAAAAAAGTATATGTGGATAAATTTTTTGTAATCTTTAGGGATATAAAAAAGTGTAT GTGGATAAATTTTTTGTAATCTTTATTTTTGAAGGCCAGCCAGTAAAATGGCCCAATGTGCCAGCCAGGCTTATGTGGCCTTGTTTTCAA ATATACATATATGTGTTATCATTAAAATTCATATATGCATTTTTGTTTTAGCCTTCTTAATCTCTACCTATGGCCAAAAAAATTTTTTTT GAGAGATATTTTGTATAATACAATGCCCTTTGAAAGTGTAAGCCCACTCTAAGCCTAGATCAGTAGGCTTGGGTTTTTTTTGTTGTTGTT TTGTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCTAAGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCCG CCTCCTGAGTTCAAGCAATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGACTACAGGTGTGCACCACCACACGCAGCTAATTTTTATATT TTTAGTAGAGACAAGGTTTCACCATGTTAGCCAGGCCGGTCTCGAACTGCTGGCCTCAGGTGACCCACCCACCTGAGCCTCCCAAAGTGC TGGGATTACAGGCGTGAGCCACCATACCTGGAGAGGTTTTGTGTTTTTGTTTTTTTTTCATAAAATGCTTTTAATAAATCATATGAAGCA TTCATGTTTTTACTTATACATATTTTCAGGGTACCAGTAAACTTTTTAGTTCAAAGATAGGCCAAATTGTACTTTTTTTTTTTTATGAGA CAGAGTCTCGCTGCTCTGTCGCCCAGGCTAGAGTGCAGTGGCGTGATCTAGGCTCACTGCAAGCTCTGCCTCCTGGGTTTACTTACGCCA TTCTCCCGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTATTAGAG ACAGGGTTTCACCGTGTTAGCCAGGATGATCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGG CATGAGCTACTGCGCCCTGCCGCCAAATTGTAATCTTAAACATATTATGTTGCATTCTAAATATGTATATTTATGCTTCTTGTTATTTAT CCTCAGGATTTCTTCACACTTTATTACTTCATAAATACTCTTGAAAAAGCTTTCAGAAAGTGATTCTCTGACTTCAGATCAGAAACTGGC AATGGGAAGAATGTGCACTTAAACTTGATCACTGTAGATCTTTGAAAATTCCCAGAAAGACAAATCAGACAAGAAATACCTGATTATCAA AATAATGGGCTATACAGTTTTGTGGTGGCATACATTCCTTGTTTGTTTGTTTAGAGATAGGATCTTGTTGTGTCACCCAGGCTGGAATGC AGTGGCACAGTCGTAGCTCACTGCACCTTCAAACTCCTGGAGCTCAAGTGATCCTCCTGACTCAGCCTCCTGAGTAGCTAGGACAACAGG TGCACACTGCCATGTCAGGCTAATTTTTTTTTTTAAACAGAGAGACAGAGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAACTCCTGGCCT CAGGTGACCCTCCTGCCTCAGCTTCCCAAAGGGCTGAGATTACAGGTGTGAGCCACCATGCCCAGCCTGTGGTGACATATATTCTGAAGT CACATCTCAAATATTTAATCCTCAAATATATTTACATCCTCAAAAATATCAGATTTTCAAGACAACACTGGTTTACCAGTACATAAACCC ACCTAGGGGACAAAGAATATTACCACTTAGAACTGTGTTGTCAAATACAATAACCACTAATTGTATCTGACCATTTTAATTAAATTAATT ACAATTAAATAATATTTAAGAATTAGTTTATCAGACATATCAGCCACATTTCAAATGCTCAATAGCTACATGTGGCAAGGGTCTGCCACA CTGGACAGAGTAGAAAACATTCCCATCATTCAGAAGGTTCTCTTGGACGCTGCAGATCTGGAAAACAAGACTTCCATATTGAAATAAATA CAACCTCAAAACTTTTATGCTCTGTGTTCCCTTTAGTTGTTATCTACATAGAAAATTATGAAACAAGAGAGGAACTTACCTTCTTCCCTA TTAAATATATGGCTAAGGGCACAAGAAAATAAGAGGAAAACTTATCCTTCAGGGCCTAAACAAGGAAATGAAAGAAATCTCATTCCCAAT AGAATAAAAACCAGAAGCTTGAAATGACTCTGGTGCAGGAGGCTGGGTGGTGGGGAGGAGGGTAGCAGTCTCAATCAACAAGTTTAGATA TTAATAGCCACTCAAAGCCTTCAGCCCATATAACATGAAGTGACAACTGAGCTCTGCACATAATGCTCAAGCTCTATAATAACCAACACT CTCAGCACAAGGGTAGACAAGAAAAGAAAAATCTCCTGCTGGCCAGGAAGACCACAAGGAGGCTTTCTGACTTGGCCTGTGCTTTTGATT TTTAAAACATTTTTTAAAAGAGGCCTCTCTGGGCTGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGG ATCACGAGGTCAGAAGATCAAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATTCAAAAAATTAGCCGGGAATGGTGG TGGGCGCCTGTAGTCCCAGTTACTCGGGAGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGACGGAGCTTGCAGTGAGCTGAGATTGCG CCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAACCTCTGAGAATTCTGACTATGAGCTTACC TGCCCATGGCTTTAGAATGATTTGAATTCACACTACCTTCAAATTCATGAAACCTCAAAACCTACAAATTAACCTAAAAACATGGAGCCA AGCTAAAAATGCCCTGGGGGTAACTAGCACTTGGACTAGTTACAGGAATGTAGCTTCGTCTCAGAGGATTCCAAAAGCTAATGCCTTGCT TACCAAGGGCTTGTAATCTCACAGGATGTGATGGGTGGGGCCTCAGATCTGCTGATGGGAGCATAAATTGGTACAACCACTTTGGAAGGC AACTGGCTATCTAGCAAAGTTGAAGACCCTACAATCTAACAGTTCTCCTAGGTGCATATCCCAGAGCAAGTCTCACATTGATGCAGTGAG ATAGTGAATAGGAAAGTTCATAGCACCATTATTTTTAAGTAGTAAGAACCCGGAAACAATCTAAATATCCATCAGTAATAGATATATGTG ATAGTCATACAATGGAATACTGTGGCAATAAAAAATAATTAGAGCTACATATGAAATAGGGATGAAACATGGATGAACAAAGAATGTTTT AGAGGAATATGATATTTAAAATTTGAAGCATGAAAAATATGTGTTTATGGGGGCATATATAGTGGAAGAATAAATGAATAGAAAAGAAAA GCACCAAATACTGGTGAGGAATTTCCTCAGGGGAGAAAAGTTGAGCTGCTTCAATTGTGTCAGTAATGTTTCATATCTTAGGGTGGGTGA TGGGAATATAGGTGCTGATTTAATATAGTCTGTACTTTTTGTGTACCTAAATATTTCGTGATAATTTTTAAAAGATGGGCCTTAAACCAA TACAGTCATATCATTTAACTCAATTCCATGAATTTACAATGCAATCCACAGTGCCCACAACCCCATGTTTCTGGAAAATCAGGAGTATTG GGTACAATGGAATAAAATGCAAGAAGGCAAATAAGAGATCAGGCTTTTAGGACCTAGGAAACAAATAAAGAGGAATTTGTTGCTGAAAGT AATGTGTAGCTGACACTCTCATTACCTGACACAATGGGAGACATTATGTCTGGGAATAAGACATCTATTTCCATAGCACTGTAGTCCTGC AAAGGAGTTGGAAGTTATGAATTTTTAAAGATTTTAGAACATTATATCTTTAGTCTCTCATAAGCCAATTATTTATATCTCCACATAGCC CATTATTACCATTGAAAAGGCATGCAATTCTTCTATTTGAAGCTTGTTCCCTTTTTACAAAAGTACTAGTAAAAATCTGAGTCATACAAA AGAGCAGGTCAGGTGTCACTAATAACAGTTTACCTCAGCTTCATCTCCATGAAGGTTTTACTTCTAATCCCAGAGTCTCATGTTTATGTA TTACAAGAGTGTATGAAAGCTGGGCATGGTGGCACACACCAGTAGTCCCAGCTACTCGGTCGGGGGTTGAGGTGAGAGGATCGCTTGAAC TCAGGAGTTTGAATCCAGCCTGGTCAATGTAGCGAGATCCTATCTCTTAAAAAAAAAAAAAAAAGGGGGGAACAGTGTATGATCCTATTA TTTGGGTTTGTGTGTGATCGAATACATGGTATATAGTTCATGGAAAATTTAAGCTCAGCAAGGAAAGAAAATGGCCAGCTTCCTGTCTTA GGAAGACAATTTACTTTTTGGCATCTGTTTGGTTGAAAGTTTGCCTTTGATCCAGATTCTTTCGGATGTCAGGGATATTCACATTGACAT GTCTTTTTAGTGTTCCAGGAGATTTTAGTTTGAATAGTACAATTTTTTCTTCTTACAACAAAACTTAGAACGGCTTCTAACTTATTTCTT CATGGCCAAGAAACTACCCTAACTTATCTCGATAAATATTTAGTTCTGTCTTATTTCTAATGTGTAAAACAGGTTTTAAAAATAATATAT AGATTTTGCATTTATAAAAAAAGATTTAATTTATAGAACCAAACTTGAACATATGTTTAATTTAGCCTAATCAGAAGGTTACAGAAAAAG TTGCTGTAAAGATAGAATAAAGGTATTGTACTGGTCTGTTTTTACTGAAGTTCCAGAATGTGAGGTTATTAGAGTCTTGGCTTATTGTGT CATGTTTTCCTGAATGCTTCCTTTGAAGATGAGCACACACCAAAGCATCCTTTGATATTATGTATGGATTAAATTAACACTGCTTTCCAA >67283_67283_3_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000357415_SPATA5_chr4_124177170_ENST00000274008_length(amino acids)=275AA_BP=162 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEDTEAQGIFIDLSKIWE NGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQALMRPGRIDRIIYVPLPD AATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKS -------------------------------------------------------------- >67283_67283_4_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000380004_SPATA5_chr4_124177170_ENST00000274008_length(transcript)=6129nt_BP=401nt CCGTCATTGACGCCATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTGGGGACCAGTGCAGGGA CCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGCGGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAA CTGGTCACTACATTTCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATGAAGAAAGCACGAAATG ATGAATATGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATATGTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCC CTTACAAGGGTTATATATGGAATTATGGTACCCTCCCTCAGGCTTTGATGCGGCCTGGAAGAATTGATAGAATCATCTATGTGCCTTTAC CGGATGCAGCAACAAGAAGGGAAATATTTAAGCTGCAGTTTCACTCCATGCCTGTCAGTAATGAAGTTGACCTGGATGAACTCATCCTTC AAACCGACGCATACTCAGGAGCAGAGATTGTAGCTGTCTGCAGAGAGGCAGCTCTTCTGGCTCTGGAAGAAGACATTCAAGCCAATCTCA TCATGAAAAGACATTTCACTCAGGCCTTGAGCACTGTGACACCTAGAATTCCTGAGTCATTGAGACGTTTTTATGAAGATTATCAAGAGA AGAGTGGGCTGCATACACTCTGAGAAAATATATATATTCAAGATGCTGAAAATCCTTTCCAGAGAAAATTTGTTTCTTTTTAAAATTTTT TGAGAGTGTTAAAAAAAATTTTACTAGGCAAAATGTTTGAAGTATGTTCAGTAGAATTTAGGGGCTTTGGTTCTTACAGATTTTCAAGTC ATGTAAGTACAGTGAAAATATCTCTGAGCATAAGTTTCAATCAGTTTTACCTGGAAATTTGTGGTGTGGTTTAAAAAACAAATGTTTAGC TTTTTCATTTGCGACCTAGTCTGTTCATCCCATGAAGCGATTTCTTTTTCCAGAATCTGTTTGAGTGTCTTTCTAAAATGCCAAACATGT TGGCATCAATTTTATACAGGGATATAAAAAAGTATATGTGGATAAATTTTTTGTAATCTTTAGGGATATAAAAAAGTGTATGTGGATAAA TTTTTTGTAATCTTTATTTTTGAAGGCCAGCCAGTAAAATGGCCCAATGTGCCAGCCAGGCTTATGTGGCCTTGTTTTCAAATATACATA TATGTGTTATCATTAAAATTCATATATGCATTTTTGTTTTAGCCTTCTTAATCTCTACCTATGGCCAAAAAAATTTTTTTTGAGAGATAT TTTGTATAATACAATGCCCTTTGAAAGTGTAAGCCCACTCTAAGCCTAGATCAGTAGGCTTGGGTTTTTTTTGTTGTTGTTTTGTCTTTT TTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCTAAGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCCGCCTCCTGAG TTCAAGCAATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGACTACAGGTGTGCACCACCACACGCAGCTAATTTTTATATTTTTAGTAGA GACAAGGTTTCACCATGTTAGCCAGGCCGGTCTCGAACTGCTGGCCTCAGGTGACCCACCCACCTGAGCCTCCCAAAGTGCTGGGATTAC AGGCGTGAGCCACCATACCTGGAGAGGTTTTGTGTTTTTGTTTTTTTTTCATAAAATGCTTTTAATAAATCATATGAAGCATTCATGTTT TTACTTATACATATTTTCAGGGTACCAGTAAACTTTTTAGTTCAAAGATAGGCCAAATTGTACTTTTTTTTTTTTATGAGACAGAGTCTC GCTGCTCTGTCGCCCAGGCTAGAGTGCAGTGGCGTGATCTAGGCTCACTGCAAGCTCTGCCTCCTGGGTTTACTTACGCCATTCTCCCGC CTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTATTAGAGACAGGGTTT CACCGTGTTAGCCAGGATGATCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTA CTGCGCCCTGCCGCCAAATTGTAATCTTAAACATATTATGTTGCATTCTAAATATGTATATTTATGCTTCTTGTTATTTATCCTCAGGAT TTCTTCACACTTTATTACTTCATAAATACTCTTGAAAAAGCTTTCAGAAAGTGATTCTCTGACTTCAGATCAGAAACTGGCAATGGGAAG AATGTGCACTTAAACTTGATCACTGTAGATCTTTGAAAATTCCCAGAAAGACAAATCAGACAAGAAATACCTGATTATCAAAATAATGGG CTATACAGTTTTGTGGTGGCATACATTCCTTGTTTGTTTGTTTAGAGATAGGATCTTGTTGTGTCACCCAGGCTGGAATGCAGTGGCACA GTCGTAGCTCACTGCACCTTCAAACTCCTGGAGCTCAAGTGATCCTCCTGACTCAGCCTCCTGAGTAGCTAGGACAACAGGTGCACACTG CCATGTCAGGCTAATTTTTTTTTTTAAACAGAGAGACAGAGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAACTCCTGGCCTCAGGTGACC CTCCTGCCTCAGCTTCCCAAAGGGCTGAGATTACAGGTGTGAGCCACCATGCCCAGCCTGTGGTGACATATATTCTGAAGTCACATCTCA AATATTTAATCCTCAAATATATTTACATCCTCAAAAATATCAGATTTTCAAGACAACACTGGTTTACCAGTACATAAACCCACCTAGGGG ACAAAGAATATTACCACTTAGAACTGTGTTGTCAAATACAATAACCACTAATTGTATCTGACCATTTTAATTAAATTAATTACAATTAAA TAATATTTAAGAATTAGTTTATCAGACATATCAGCCACATTTCAAATGCTCAATAGCTACATGTGGCAAGGGTCTGCCACACTGGACAGA GTAGAAAACATTCCCATCATTCAGAAGGTTCTCTTGGACGCTGCAGATCTGGAAAACAAGACTTCCATATTGAAATAAATACAACCTCAA AACTTTTATGCTCTGTGTTCCCTTTAGTTGTTATCTACATAGAAAATTATGAAACAAGAGAGGAACTTACCTTCTTCCCTATTAAATATA TGGCTAAGGGCACAAGAAAATAAGAGGAAAACTTATCCTTCAGGGCCTAAACAAGGAAATGAAAGAAATCTCATTCCCAATAGAATAAAA ACCAGAAGCTTGAAATGACTCTGGTGCAGGAGGCTGGGTGGTGGGGAGGAGGGTAGCAGTCTCAATCAACAAGTTTAGATATTAATAGCC ACTCAAAGCCTTCAGCCCATATAACATGAAGTGACAACTGAGCTCTGCACATAATGCTCAAGCTCTATAATAACCAACACTCTCAGCACA AGGGTAGACAAGAAAAGAAAAATCTCCTGCTGGCCAGGAAGACCACAAGGAGGCTTTCTGACTTGGCCTGTGCTTTTGATTTTTAAAACA TTTTTTAAAAGAGGCCTCTCTGGGCTGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGG TCAGAAGATCAAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATTCAAAAAATTAGCCGGGAATGGTGGTGGGCGCCT GTAGTCCCAGTTACTCGGGAGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGACGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCAC TCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAACCTCTGAGAATTCTGACTATGAGCTTACCTGCCCATGG CTTTAGAATGATTTGAATTCACACTACCTTCAAATTCATGAAACCTCAAAACCTACAAATTAACCTAAAAACATGGAGCCAAGCTAAAAA TGCCCTGGGGGTAACTAGCACTTGGACTAGTTACAGGAATGTAGCTTCGTCTCAGAGGATTCCAAAAGCTAATGCCTTGCTTACCAAGGG CTTGTAATCTCACAGGATGTGATGGGTGGGGCCTCAGATCTGCTGATGGGAGCATAAATTGGTACAACCACTTTGGAAGGCAACTGGCTA TCTAGCAAAGTTGAAGACCCTACAATCTAACAGTTCTCCTAGGTGCATATCCCAGAGCAAGTCTCACATTGATGCAGTGAGATAGTGAAT AGGAAAGTTCATAGCACCATTATTTTTAAGTAGTAAGAACCCGGAAACAATCTAAATATCCATCAGTAATAGATATATGTGATAGTCATA CAATGGAATACTGTGGCAATAAAAAATAATTAGAGCTACATATGAAATAGGGATGAAACATGGATGAACAAAGAATGTTTTAGAGGAATA TGATATTTAAAATTTGAAGCATGAAAAATATGTGTTTATGGGGGCATATATAGTGGAAGAATAAATGAATAGAAAAGAAAAGCACCAAAT ACTGGTGAGGAATTTCCTCAGGGGAGAAAAGTTGAGCTGCTTCAATTGTGTCAGTAATGTTTCATATCTTAGGGTGGGTGATGGGAATAT AGGTGCTGATTTAATATAGTCTGTACTTTTTGTGTACCTAAATATTTCGTGATAATTTTTAAAAGATGGGCCTTAAACCAATACAGTCAT ATCATTTAACTCAATTCCATGAATTTACAATGCAATCCACAGTGCCCACAACCCCATGTTTCTGGAAAATCAGGAGTATTGGGTACAATG GAATAAAATGCAAGAAGGCAAATAAGAGATCAGGCTTTTAGGACCTAGGAAACAAATAAAGAGGAATTTGTTGCTGAAAGTAATGTGTAG CTGACACTCTCATTACCTGACACAATGGGAGACATTATGTCTGGGAATAAGACATCTATTTCCATAGCACTGTAGTCCTGCAAAGGAGTT GGAAGTTATGAATTTTTAAAGATTTTAGAACATTATATCTTTAGTCTCTCATAAGCCAATTATTTATATCTCCACATAGCCCATTATTAC CATTGAAAAGGCATGCAATTCTTCTATTTGAAGCTTGTTCCCTTTTTACAAAAGTACTAGTAAAAATCTGAGTCATACAAAAGAGCAGGT CAGGTGTCACTAATAACAGTTTACCTCAGCTTCATCTCCATGAAGGTTTTACTTCTAATCCCAGAGTCTCATGTTTATGTATTACAAGAG TGTATGAAAGCTGGGCATGGTGGCACACACCAGTAGTCCCAGCTACTCGGTCGGGGGTTGAGGTGAGAGGATCGCTTGAACTCAGGAGTT TGAATCCAGCCTGGTCAATGTAGCGAGATCCTATCTCTTAAAAAAAAAAAAAAAAGGGGGGAACAGTGTATGATCCTATTATTTGGGTTT GTGTGTGATCGAATACATGGTATATAGTTCATGGAAAATTTAAGCTCAGCAAGGAAAGAAAATGGCCAGCTTCCTGTCTTAGGAAGACAA TTTACTTTTTGGCATCTGTTTGGTTGAAAGTTTGCCTTTGATCCAGATTCTTTCGGATGTCAGGGATATTCACATTGACATGTCTTTTTA GTGTTCCAGGAGATTTTAGTTTGAATAGTACAATTTTTTCTTCTTACAACAAAACTTAGAACGGCTTCTAACTTATTTCTTCATGGCCAA GAAACTACCCTAACTTATCTCGATAAATATTTAGTTCTGTCTTATTTCTAATGTGTAAAACAGGTTTTAAAAATAATATATAGATTTTGC ATTTATAAAAAAAGATTTAATTTATAGAACCAAACTTGAACATATGTTTAATTTAGCCTAATCAGAAGGTTACAGAAAAAGTTGCTGTAA AGATAGAATAAAGGTATTGTACTGGTCTGTTTTTACTGAAGTTCCAGAATGTGAGGTTATTAGAGTCTTGGCTTATTGTGTCATGTTTTC CTGAATGCTTCCTTTGAAGATGAGCACACACCAAAGCATCCTTTGATATTATGTATGGATTAAATTAACACTGCTTTCCAAATGTGGTCC >67283_67283_4_PPA2-SPATA5_PPA2_chr4_106367539_ENST00000380004_SPATA5_chr4_124177170_ENST00000274008_length(amino acids)=242AA_BP=129 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYEI ATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PPA2-SPATA5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PPA2-SPATA5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PPA2-SPATA5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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