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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPAP2A-HCN1 (FusionGDB2 ID:67297)

Fusion Gene Summary for PPAP2A-HCN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPAP2A-HCN1
Fusion gene ID: 67297
HgeneTgene
Gene symbol

PPAP2A

HCN1

Gene ID

8611

348980

Gene namephospholipid phosphatase 1hyperpolarization activated cyclic nucleotide gated potassium channel 1
SynonymsLLP1a|LPP1|PAP-2a|PAP2|PPAP2ABCNG-1|BCNG1|EIEE24|GEFSP10|HAC-2
Cytomap

5q11.2

5p12

Type of geneprotein-codingprotein-coding
Descriptionphospholipid phosphatase 1lipid phosphate phosphohydrolase 1aphosphatidate phosphohydrolase type 2aphosphatidic acid phosphatase 2aphosphatidic acid phosphatase type 2Aphosphatidic acid phosphohydrolase type 2atype-2 phosphatidic acid phosphatase alpotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1brain cyclic nucleotide-gated channel 1
Modification date2020031320200313
UniProtAcc.

O60741

Ensembl transtripts involved in fusion geneENST00000515132, ENST00000264775, 
ENST00000307259, 		ENST00000303230, 
Fusion gene scores* DoF score17 X 8 X 6=8167 X 6 X 6=252
# samples 238
** MAII scorelog2(23/816*10)=-1.82693529102712
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPAP2A [Title/Abstract] AND HCN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPAP2A(54830400)-HCN1(45353348), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPAP2A

GO:0006644

phospholipid metabolic process

9305923|9705349|15461590

HgenePPAP2A

GO:0006670

sphingosine metabolic process

9705349

HgenePPAP2A

GO:0006672

ceramide metabolic process

9305923|9705349

HgenePPAP2A

GO:0046839

phospholipid dephosphorylation

9305923|9705349|15461590|16464866

TgeneHCN1

GO:0051289

protein homotetramerization

28086084

TgeneHCN1

GO:0071320

cellular response to cAMP

22748890


check buttonFusion gene breakpoints across PPAP2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HCN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KC-A4BLPPAP2Achr5

54830400

-HCN1chr5

45353348

-


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Fusion Gene ORF analysis for PPAP2A-HCN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000515132ENST00000303230PPAP2Achr5

54830400

-HCN1chr5

45353348

-
In-frameENST00000264775ENST00000303230PPAP2Achr5

54830400

-HCN1chr5

45353348

-
In-frameENST00000307259ENST00000303230PPAP2Achr5

54830400

-HCN1chr5

45353348

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264775PPAP2Achr554830400-ENST00000303230HCN1chr545353348-45153983441840498
ENST00000307259PPAP2Achr554830400-ENST00000303230HCN1chr545353348-45964794251921498

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264775ENST00000303230PPAP2Achr554830400-HCN1chr545353348-0.0007774120.99922264
ENST00000307259ENST00000303230PPAP2Achr554830400-HCN1chr545353348-0.0008113140.9991887

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Fusion Genomic Features for PPAP2A-HCN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPAP2A-HCN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:54830400/chr5:45353348)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HCN1

O60741

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-165_719286.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-165_719285.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-161_619286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-161_619285.0Topological domainCytoplasmic
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038726_756410891.0Compositional biasNote=Gln-rich
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038857_863410891.0Compositional biasNote=Poly-Pro
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038539_542410891.0Nucleotide bindingcAMP
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038549_550410891.0Nucleotide bindingcAMP
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038590_593410891.0Nucleotide bindingcAMP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16120_12819286.0RegionPhosphatase sequence motif I
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16168_17119286.0RegionPhosphatase sequence motif II
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16216_22719286.0RegionPhosphatase sequence motif III
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16120_12819285.0RegionPhosphatase sequence motif I
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16168_17119285.0RegionPhosphatase sequence motif II
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16216_22719285.0RegionPhosphatase sequence motif III
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16116_16419286.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16186_19919286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16221_22919286.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16251_28419286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-1628_5319286.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-1675_9419286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16116_16419285.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16186_19919285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16221_22919285.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16251_28419285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-1628_5319285.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-1675_9419285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16165_18519286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16200_22019286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-16230_25019286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-1654_7419286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-167_2719286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000264775-1695_11519286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16165_18519285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16200_22019285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-16230_25019285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-1654_7419285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-167_2719285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:45353348ENST00000307259-1695_11519285.0TransmembraneHelical
TgeneHCN1chr5:54830400chr5:45353348ENST00000303230381_80410891.0Compositional biasNote=Gly-rich
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038345_366410891.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038358_362410891.0MotifSelectivity filter
TgeneHCN1chr5:54830400chr5:45353348ENST00000303230381_93410891.0RegionIntrinsically disordered
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038165_173410891.0Topological domainExtracellular
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038195_215410891.0Topological domainCytoplasmic
TgeneHCN1chr5:54830400chr5:45353348ENST00000303230381_142410891.0Topological domainCytoplasmic
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038237_260410891.0Topological domainExtracellular
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038282_295410891.0Topological domainCytoplasmic
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038319_344410891.0Topological domainExtracellular
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038367_371410891.0Topological domainExtracellular
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038393_890410891.0Topological domainCytoplasmic
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038143_164410891.0TransmembraneHelical%3B Name%3DSegment S1
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038174_194410891.0TransmembraneHelical%3B Name%3DSegment S2
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038216_236410891.0TransmembraneHelical%3B Name%3DSegment S3
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038261_281410891.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038296_318410891.0TransmembraneHelical%3B Name%3DSegment S5
TgeneHCN1chr5:54830400chr5:45353348ENST0000030323038372_392410891.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Gene Sequence for PPAP2A-HCN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67297_67297_1_PPAP2A-HCN1_PPAP2A_chr5_54830400_ENST00000264775_HCN1_chr5_45353348_ENST00000303230_length(transcript)=4515nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGTATAAGCAAGTGGAACAATACATGTCATTCCATAAGTTACCAGCTGATATGC
GTCAGAAGATACATGATTACTATGAACACAGATACCAAGGCAAAATCTTTGATGAGGAAAATATTCTCAATGAACTCAATGATCCTCTGA
GAGAGGAGATAGTCAACTTCAACTGTCGGAAACTGGTGGCTACAATGCCTTTATTTGCTAATGCGGATCCTAATTTTGTGACTGCCATGC
TGAGCAAGTTGAGATTTGAGGTGTTTCAACCTGGAGATTATATCATACGAGAAGGAGCCGTGGGTAAAAAAATGTATTTCATTCAACACG
GTGTTGCTGGTGTCATTACAAAATCCAGTAAAGAAATGAAGCTGACAGATGGCTCTTACTTTGGAGAGATTTGCCTGCTGACCAAAGGAC
GTCGTACTGCCAGTGTTCGAGCTGATACATATTGTCGTCTTTACTCACTTTCCGTGGACAATTTCAACGAGGTCCTGGAGGAATATCCAA
TGATGAGGAGAGCCTTTGAGACAGTTGCCATTGACCGACTAGATCGAATAGGAAAGAAAAATTCAATTCTTCTGCAAAAGTTCCAGAAGG
ATCTGAACACTGGTGTTTTCAACAATCAGGAGAACGAAATCCTCAAGCAGATTGTGAAACATGACAGGGAGATGGTGCAGGCAATCGCTC
CCATCAATTATCCTCAAATGACAACCCTGAATTCCACATCGTCTACTACGACCCCGACCTCCCGCATGAGGACACAATCTCCACCGGTGT
ACACAGCGACCAGCCTGTCTCACAGCAACCTGCACTCCCCCAGTCCCAGCACACAGACCCCCCAGCCATCAGCCATCCTGTCACCCTGCT
CCTACACCACCGCGGTCTGCAGCCCTCCTGTACAGAGCCCTCTGGCCGCTCGAACTTTCCACTATGCCTCCCCCACCGCCTCCCAGCTGT
CACTCATGCAACAGCAGCCGCAGCAGCAGGTACAGCAGTCCCAGCCGCCGCAGACTCAGCCACAGCAGCCGTCCCCGCAGCCACAGACAC
CTGGCAGCTCCACGCCGAAAAATGAAGTGCACAAGAGCACGCAGGCGCTTCACAACACCAACCTGACCCGGGAAGTCAGGCCACTCTCCG
CCTCGCAGCCCTCGCTGCCCCATGAGGTGTCCACTCTGATTTCCAGACCTCATCCCACTGTGGGCGAGTCCCTGGCCTCCATCCCTCAAC
CCGTGACGGCGGTCCCCGGAACGGGCCTTCAGGCAGGGGGCAGGAGCACTGTCCCGCAGCGCGTCACCCTCTTCCGACAGATGTCGTCGG
GAGCCATCCCCCCGAACCGAGGAGTCCCTCCAGCACCCCCTCCACCAGCAGCTGCTCTTCCAAGAGAATCTTCCTCAGTCTTAAACACAG
ACCCAGACGCAGAAAAGCCACGATTTGCTTCAAATTTATGATCCCTGCTGATTGTCAAAGCAGAAAGAAATACTCTCATAAACTGAGACT
ATACTCAGATCTTATTTTATTCTATCTCCTGATAGATCCCTCTAGCCTACTATGAAGAGATATTTTAGACAGCTGTGGCCTACACGTGAA
ATGTAAAAATATATATACATATACTATAAAATATATATCTAAATTCCCAAGAGAGGGTCAAAAGACCTGTTTAGCATTCAGTGTTATATG
TCTTCCTTTCTTTAAATCATTAAAGGATTTAAAATGTCGTTGTAAGATTATTTATTTCTAACCTACTTTTACTTAAGTCCTTTGATATGT
ATATTTCTCTATTTTATGAAGAGTTCTTGGATTCAATGGAAACAAAACTGATTTTAAAAAGGCAACTCAAATGAACTAGTAAATAGCACC
AATCAAAACTTTCTTTCATTAGCTGTGTCTCTGCATCTAAATTGTTAATCATTAATGGTGGAGAATTAAATAACAAATCCCATTTTATAG
ATCTAAATTGTATTTCGGTGCTTTCAATTTCAAATTAGGTTAAAGAATGCACTACTTGCTTGGCCACCGTAGGAGACTAGCATTGCCACT
GTTTGTTAAGAATATCACTAACCTCAAACATGTTCATTGATCTTTCAGAAAGCTGAGGGAAAATTAATATTTGTCTTCATGTGTTATCGG
ACTTTTACCAAGACTCGATCAATGTTAGTTGTAAATAACTTTTTCAACCCAAATAAAAATAGCTATTCTGTGTTGTATGAAGGTAAAAGT
CATTGTTTAAGAATTTAGTTTTATTGCTTCACTTCAAAACTTAGAGTTTTAAATTTTACAAAACCTGATTGTGAGAATTATTCAATTGTA
ATGCAATGGCTTGAAACCTACAATATTATTTTAACCTGCAATGTTTTATGCAAAATTGTATGCTCGAATCTACAAATTGCTTGTATTACA
CCAAAAATCGTTACTTTTCTTTCTTCTTGCCATAATCAAGCATCTGAAAATAGTCCCTGCATGCTTCTGGGGAAAAAAAAATAGGTTCAA
ATCAGTCATTGTAGAGAAAGGCTTACAGTATTTCTCGTTTCTAGAAAAGCATAACAATTCATTAATTGCCTATCTTATAATTCCTATAAG
GCTGACTTGGATCTCTGACTTAAGTCTAGAAGTGAGGTTTTCACTTTTATTTAATATTATTGCTATTATTATTTAAATAATTATTTGTAA
ACCACAGCTTGATTTGGAGTTAAGTGTTGTCTGTGTCTTCACTGTAGCTGGTAATTTACTATGGTATTAATTTAAAGAAATAAATTCAAT
ACAGCATCACGTCTGTTTGGGAACACACATTTTGCTCTATGTATATTGTAACTAAATGGTTAGTAAACTTTAAGGCATGTGGTGACTAAC
GTAGCCCTTAGATAGGAGGTTTGTCATTTTTAATGTGTTGAAAATAGTACAGACATGGTGACAGAAAGCAGGGGTAAAGTTGAACGTCTA
TGAGCATTGTCTGTCTGTTTTCTTAACTCTTTACATGATCTGTGAGCACCTGCTTCTTCTCAAAGAACTCCCTTAGTAATCATTTGTGCC
TAATGCATCCCACACATGTGGAGTATGACTGGAACACAATTGAAAGATTCCTAACAACTGGCTGCGGTAAATAACCCAAGTTAAGAGCAT
GACTTAAAGTGGAGGTCTTCAGTATCTCTGGCACTGGCAATACATTTAAGAACATACAGAGATCACACATTATGTGGGACAGGGCCTGCA
GATAGACTTGAGGACAGAAAACAAAAACAAAAGCAGAAACTCTAAAGTGGATCCTTGCTGCCTGTTATGCCTTTTGTGGATATAATACCT
ATAATACCAAAATGAGTTGTTATGTTTAATTTCAAACAAATCCCAACTGGTGTGGAAGTAATTAACTGCTAGTCGATGTAATGTAATCAT
CAATATGCTGGTGACATATGATGGCATGTCAGGAATACTGTTGTAAGAAAGGGATTGTTCAGTCTACCTAGAACCTATGGGAAAGCTGCA
AGACCATTTACATATCAGTACAAAACTCCTTTATTTTATTAAAATATGAGAATTAACTTCAATTTATTAAGATTACGTATTGGTCCTTTA
AATTATTAAAGGTTTACATTTGATAGGATTAATGGATTTGGTAGTGAAATATTTTTATATATATAAATTTTTGGTTTTTTATTTTGAGCA
CTATTGGGAAACATAAGCAAAATTGAAATGCATGGTCTTTCAGTGCAACCATACAATTTTTATTCACTTTGTAATAGAATGGACAAAAAA
ACTAAGGTTTATATATTAAACTAATAAAAAGGTACAGGGTAAATTATATACATATATGTATGAATGTATATATACTTAGATTAAGAAAAA
AAAATGACTCACATTCCTGTAATATAAAGGTCCATTGCTAGTTGAAAAGTGACCTCTTTTCTCTGTACATAGTGAAGCCCGTATGTATGG
AGTTTTAATCTGTACAGAAAGAAATGTATTATTCATTGGTCTTTCTGCTGCTGGAAAGATAATAGAATAGCTGATTCTTACAACAACTGT
ATGATCAGGGATGAGTTAGAGTATTTCTTTTGTCTTTGCTCAAAGCCATACATATATAAATATATATAAAGATTATTAATAAATTCAACA

>67297_67297_1_PPAP2A-HCN1_PPAP2A_chr5_54830400_ENST00000264775_HCN1_chr5_45353348_ENST00000303230_length(amino acids)=498AA_BP=18
MTRRGCRTWPSMCSACCWYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPN
FVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEV
LEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRT
QSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPS
PQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLF

--------------------------------------------------------------
>67297_67297_2_PPAP2A-HCN1_PPAP2A_chr5_54830400_ENST00000307259_HCN1_chr5_45353348_ENST00000303230_length(transcript)=4596nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGTATAAGCAAGTGGAACAATACATGTCATTCCATAAGTTACCAGCTGATATGCGTCAGAAGA
TACATGATTACTATGAACACAGATACCAAGGCAAAATCTTTGATGAGGAAAATATTCTCAATGAACTCAATGATCCTCTGAGAGAGGAGA
TAGTCAACTTCAACTGTCGGAAACTGGTGGCTACAATGCCTTTATTTGCTAATGCGGATCCTAATTTTGTGACTGCCATGCTGAGCAAGT
TGAGATTTGAGGTGTTTCAACCTGGAGATTATATCATACGAGAAGGAGCCGTGGGTAAAAAAATGTATTTCATTCAACACGGTGTTGCTG
GTGTCATTACAAAATCCAGTAAAGAAATGAAGCTGACAGATGGCTCTTACTTTGGAGAGATTTGCCTGCTGACCAAAGGACGTCGTACTG
CCAGTGTTCGAGCTGATACATATTGTCGTCTTTACTCACTTTCCGTGGACAATTTCAACGAGGTCCTGGAGGAATATCCAATGATGAGGA
GAGCCTTTGAGACAGTTGCCATTGACCGACTAGATCGAATAGGAAAGAAAAATTCAATTCTTCTGCAAAAGTTCCAGAAGGATCTGAACA
CTGGTGTTTTCAACAATCAGGAGAACGAAATCCTCAAGCAGATTGTGAAACATGACAGGGAGATGGTGCAGGCAATCGCTCCCATCAATT
ATCCTCAAATGACAACCCTGAATTCCACATCGTCTACTACGACCCCGACCTCCCGCATGAGGACACAATCTCCACCGGTGTACACAGCGA
CCAGCCTGTCTCACAGCAACCTGCACTCCCCCAGTCCCAGCACACAGACCCCCCAGCCATCAGCCATCCTGTCACCCTGCTCCTACACCA
CCGCGGTCTGCAGCCCTCCTGTACAGAGCCCTCTGGCCGCTCGAACTTTCCACTATGCCTCCCCCACCGCCTCCCAGCTGTCACTCATGC
AACAGCAGCCGCAGCAGCAGGTACAGCAGTCCCAGCCGCCGCAGACTCAGCCACAGCAGCCGTCCCCGCAGCCACAGACACCTGGCAGCT
CCACGCCGAAAAATGAAGTGCACAAGAGCACGCAGGCGCTTCACAACACCAACCTGACCCGGGAAGTCAGGCCACTCTCCGCCTCGCAGC
CCTCGCTGCCCCATGAGGTGTCCACTCTGATTTCCAGACCTCATCCCACTGTGGGCGAGTCCCTGGCCTCCATCCCTCAACCCGTGACGG
CGGTCCCCGGAACGGGCCTTCAGGCAGGGGGCAGGAGCACTGTCCCGCAGCGCGTCACCCTCTTCCGACAGATGTCGTCGGGAGCCATCC
CCCCGAACCGAGGAGTCCCTCCAGCACCCCCTCCACCAGCAGCTGCTCTTCCAAGAGAATCTTCCTCAGTCTTAAACACAGACCCAGACG
CAGAAAAGCCACGATTTGCTTCAAATTTATGATCCCTGCTGATTGTCAAAGCAGAAAGAAATACTCTCATAAACTGAGACTATACTCAGA
TCTTATTTTATTCTATCTCCTGATAGATCCCTCTAGCCTACTATGAAGAGATATTTTAGACAGCTGTGGCCTACACGTGAAATGTAAAAA
TATATATACATATACTATAAAATATATATCTAAATTCCCAAGAGAGGGTCAAAAGACCTGTTTAGCATTCAGTGTTATATGTCTTCCTTT
CTTTAAATCATTAAAGGATTTAAAATGTCGTTGTAAGATTATTTATTTCTAACCTACTTTTACTTAAGTCCTTTGATATGTATATTTCTC
TATTTTATGAAGAGTTCTTGGATTCAATGGAAACAAAACTGATTTTAAAAAGGCAACTCAAATGAACTAGTAAATAGCACCAATCAAAAC
TTTCTTTCATTAGCTGTGTCTCTGCATCTAAATTGTTAATCATTAATGGTGGAGAATTAAATAACAAATCCCATTTTATAGATCTAAATT
GTATTTCGGTGCTTTCAATTTCAAATTAGGTTAAAGAATGCACTACTTGCTTGGCCACCGTAGGAGACTAGCATTGCCACTGTTTGTTAA
GAATATCACTAACCTCAAACATGTTCATTGATCTTTCAGAAAGCTGAGGGAAAATTAATATTTGTCTTCATGTGTTATCGGACTTTTACC
AAGACTCGATCAATGTTAGTTGTAAATAACTTTTTCAACCCAAATAAAAATAGCTATTCTGTGTTGTATGAAGGTAAAAGTCATTGTTTA
AGAATTTAGTTTTATTGCTTCACTTCAAAACTTAGAGTTTTAAATTTTACAAAACCTGATTGTGAGAATTATTCAATTGTAATGCAATGG
CTTGAAACCTACAATATTATTTTAACCTGCAATGTTTTATGCAAAATTGTATGCTCGAATCTACAAATTGCTTGTATTACACCAAAAATC
GTTACTTTTCTTTCTTCTTGCCATAATCAAGCATCTGAAAATAGTCCCTGCATGCTTCTGGGGAAAAAAAAATAGGTTCAAATCAGTCAT
TGTAGAGAAAGGCTTACAGTATTTCTCGTTTCTAGAAAAGCATAACAATTCATTAATTGCCTATCTTATAATTCCTATAAGGCTGACTTG
GATCTCTGACTTAAGTCTAGAAGTGAGGTTTTCACTTTTATTTAATATTATTGCTATTATTATTTAAATAATTATTTGTAAACCACAGCT
TGATTTGGAGTTAAGTGTTGTCTGTGTCTTCACTGTAGCTGGTAATTTACTATGGTATTAATTTAAAGAAATAAATTCAATACAGCATCA
CGTCTGTTTGGGAACACACATTTTGCTCTATGTATATTGTAACTAAATGGTTAGTAAACTTTAAGGCATGTGGTGACTAACGTAGCCCTT
AGATAGGAGGTTTGTCATTTTTAATGTGTTGAAAATAGTACAGACATGGTGACAGAAAGCAGGGGTAAAGTTGAACGTCTATGAGCATTG
TCTGTCTGTTTTCTTAACTCTTTACATGATCTGTGAGCACCTGCTTCTTCTCAAAGAACTCCCTTAGTAATCATTTGTGCCTAATGCATC
CCACACATGTGGAGTATGACTGGAACACAATTGAAAGATTCCTAACAACTGGCTGCGGTAAATAACCCAAGTTAAGAGCATGACTTAAAG
TGGAGGTCTTCAGTATCTCTGGCACTGGCAATACATTTAAGAACATACAGAGATCACACATTATGTGGGACAGGGCCTGCAGATAGACTT
GAGGACAGAAAACAAAAACAAAAGCAGAAACTCTAAAGTGGATCCTTGCTGCCTGTTATGCCTTTTGTGGATATAATACCTATAATACCA
AAATGAGTTGTTATGTTTAATTTCAAACAAATCCCAACTGGTGTGGAAGTAATTAACTGCTAGTCGATGTAATGTAATCATCAATATGCT
GGTGACATATGATGGCATGTCAGGAATACTGTTGTAAGAAAGGGATTGTTCAGTCTACCTAGAACCTATGGGAAAGCTGCAAGACCATTT
ACATATCAGTACAAAACTCCTTTATTTTATTAAAATATGAGAATTAACTTCAATTTATTAAGATTACGTATTGGTCCTTTAAATTATTAA
AGGTTTACATTTGATAGGATTAATGGATTTGGTAGTGAAATATTTTTATATATATAAATTTTTGGTTTTTTATTTTGAGCACTATTGGGA
AACATAAGCAAAATTGAAATGCATGGTCTTTCAGTGCAACCATACAATTTTTATTCACTTTGTAATAGAATGGACAAAAAAACTAAGGTT
TATATATTAAACTAATAAAAAGGTACAGGGTAAATTATATACATATATGTATGAATGTATATATACTTAGATTAAGAAAAAAAAATGACT
CACATTCCTGTAATATAAAGGTCCATTGCTAGTTGAAAAGTGACCTCTTTTCTCTGTACATAGTGAAGCCCGTATGTATGGAGTTTTAAT
CTGTACAGAAAGAAATGTATTATTCATTGGTCTTTCTGCTGCTGGAAAGATAATAGAATAGCTGATTCTTACAACAACTGTATGATCAGG
GATGAGTTAGAGTATTTCTTTTGTCTTTGCTCAAAGCCATACATATATAAATATATATAAAGATTATTAATAAATTCAACAAAAAATAAA

>67297_67297_2_PPAP2A-HCN1_PPAP2A_chr5_54830400_ENST00000307259_HCN1_chr5_45353348_ENST00000303230_length(amino acids)=498AA_BP=18
MTRRGCRTWPSMCSACCWYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPN
FVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEV
LEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRT
QSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPS
PQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLF

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Fusion Gene PPI Analysis for PPAP2A-HCN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPAP2A-HCN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPAP2A-HCN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource