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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPAP2A-SLC38A9 (FusionGDB2 ID:67303)

Fusion Gene Summary for PPAP2A-SLC38A9

check button Fusion gene summary
Fusion gene informationFusion gene name: PPAP2A-SLC38A9
Fusion gene ID: 67303
HgeneTgene
Gene symbol

PPAP2A

SLC38A9

Gene ID

8611

153129

Gene namephospholipid phosphatase 1solute carrier family 38 member 9
SynonymsLLP1a|LPP1|PAP-2a|PAP2|PPAP2AURLC11
Cytomap

5q11.2

5q11.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipid phosphatase 1lipid phosphate phosphohydrolase 1aphosphatidate phosphohydrolase type 2aphosphatidic acid phosphatase 2aphosphatidic acid phosphatase type 2Aphosphatidic acid phosphohydrolase type 2atype-2 phosphatidic acid phosphatase alsodium-coupled neutral amino acid transporter 9putative sodium-coupled neutral amino acid transporter 9up-regulated in lung cancer 11
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264775, ENST00000307259, 
ENST00000515132, 		ENST00000396865, 
ENST00000504880, ENST00000515629, 
ENST00000318672, ENST00000416547, 
ENST00000512595, ENST00000539768, 
Fusion gene scores* DoF score17 X 8 X 6=8168 X 9 X 7=504
# samples 2314
** MAII scorelog2(23/816*10)=-1.82693529102712
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/504*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPAP2A [Title/Abstract] AND SLC38A9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPAP2A(54830400)-SLC38A9(54993820), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPAP2A

GO:0006644

phospholipid metabolic process

9305923|9705349|15461590

HgenePPAP2A

GO:0006670

sphingosine metabolic process

9705349

HgenePPAP2A

GO:0006672

ceramide metabolic process

9305923|9705349

HgenePPAP2A

GO:0046839

phospholipid dephosphorylation

9305923|9705349|15461590|16464866

TgeneSLC38A9

GO:0003333

amino acid transmembrane transport

25567906|29053970

TgeneSLC38A9

GO:0032008

positive regulation of TOR signaling

25561175|25567906

TgeneSLC38A9

GO:0071230

cellular response to amino acid stimulus

25561175|25567906|29053970


check buttonFusion gene breakpoints across PPAP2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC38A9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E7-A85H-01APPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
ChimerDB4BLCATCGA-E7-A85HPPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
ChimerDB4BLCATCGA-FD-A6TG-01APPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
ChimerDB4LUADTCGA-86-8673-01APPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
ChimerDB4PRADTCGA-CH-5754PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
ChimerDB4PRADTCGA-CH-5754PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
ChimerDB4PRADTCGA-V1-A8WLPPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
ChimerDB4TGCTTCGA-2G-AAG6-01APPAP2Achr5

54763697

-SLC38A9chr5

54968523

-


Top

Fusion Gene ORF analysis for PPAP2A-SLC38A9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264775ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000264775ENST00000396865PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000264775ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000264775ENST00000504880PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000264775ENST00000515629PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-5UTRENST00000264775ENST00000515629PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-5UTRENST00000307259ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000307259ENST00000396865PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000307259ENST00000396865PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000307259ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000307259ENST00000504880PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000307259ENST00000504880PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-5UTRENST00000307259ENST00000515629PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-5UTRENST00000307259ENST00000515629PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000318672PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000318672PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000318672PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000396865PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000396865PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000416547PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000416547PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000416547PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000504880PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000504880PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000512595PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000512595PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000512595PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000515629PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000539768PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000264775ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000264775ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000264775ENST00000539768PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000264775ENST00000539768PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000318672PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000396865PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000396865PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000416547PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000504880PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000504880PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000512595PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000515629PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000515629PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
5CDS-intronENST00000307259ENST00000539768PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-5UTRENST00000515132ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-5UTRENST00000515132ENST00000396865PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-5UTRENST00000515132ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-5UTRENST00000515132ENST00000504880PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-5UTRENST00000515132ENST00000515629PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-intronENST00000515132ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000318672PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000318672PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000318672PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-intronENST00000515132ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000396865PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000396865PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-intronENST00000515132ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000416547PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000416547PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000416547PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-intronENST00000515132ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000504880PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000504880PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-intronENST00000515132ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000512595PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000512595PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000512595PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
5UTR-intronENST00000515132ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000515629PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000515629PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000539768PPAP2Achr5

54830399

-SLC38A9chr5

54993820

-
5UTR-intronENST00000515132ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

54931485

-
5UTR-intronENST00000515132ENST00000539768PPAP2Achr5

54830400

-SLC38A9chr5

55000262

-
5UTR-intronENST00000515132ENST00000539768PPAP2Achr5

54763697

-SLC38A9chr5

54968523

-
intron-5UTRENST00000264775ENST00000396865PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-5UTRENST00000264775ENST00000504880PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-5UTRENST00000515132ENST00000396865PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-5UTRENST00000515132ENST00000504880PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-5UTRENST00000515132ENST00000515629PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
intron-intronENST00000264775ENST00000318672PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000264775ENST00000416547PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000264775ENST00000512595PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000264775ENST00000515629PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000264775ENST00000539768PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000515132ENST00000318672PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000515132ENST00000318672PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
intron-intronENST00000515132ENST00000396865PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
intron-intronENST00000515132ENST00000416547PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000515132ENST00000416547PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
intron-intronENST00000515132ENST00000504880PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
intron-intronENST00000515132ENST00000512595PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000515132ENST00000512595PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-
intron-intronENST00000515132ENST00000515629PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000515132ENST00000539768PPAP2Achr5

54771127

-SLC38A9chr5

54993820

-
intron-intronENST00000515132ENST00000539768PPAP2Achr5

54737679

-SLC38A9chr5

54968523

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPAP2A-SLC38A9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPAP2A-SLC38A9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54830400/:54993820)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPAP2A-SLC38A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPAP2A-SLC38A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPAP2A-SLC38A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPAP2A-SLC38A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource