FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PPAP2A-SMN1 (FusionGDB2 ID:67304)

Fusion Gene Summary for PPAP2A-SMN1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPAP2A-SMN1
Fusion gene ID: 67304
HgeneTgene
Gene symbol

PPAP2A

SMN1

Gene ID

8611

6606

Gene namephospholipid phosphatase 1survival of motor neuron 1, telomeric
SynonymsLLP1a|LPP1|PAP-2a|PAP2|PPAP2ABCD541|GEMIN1|SMA|SMA1|SMA2|SMA3|SMA4|SMA@|SMN|SMNT|T-BCD541|TDRD16A
Cytomap

5q11.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipid phosphatase 1lipid phosphate phosphohydrolase 1aphosphatidate phosphohydrolase type 2aphosphatidic acid phosphatase 2aphosphatidic acid phosphatase type 2Aphosphatidic acid phosphohydrolase type 2atype-2 phosphatidic acid phosphatase alsurvival motor neuron proteincomponent of gems 1gemin-1survival motor neuron 1 proteinsurvival of motor neuron 1 isoform D2A2B345survival of motor neuron 1 isoform D2A2B3457survival of motor neuron 1 isoform D2A3457survival of motor neuron 1 isofor
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264775, ENST00000307259, 
ENST00000515132, 		ENST00000351205, 
ENST00000380707, ENST00000506163, 
ENST00000510679, ENST00000514951, 
ENST00000503079, 
Fusion gene scores* DoF score17 X 8 X 6=8165 X 7 X 4=140
# samples 235
** MAII scorelog2(23/816*10)=-1.82693529102712
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/140*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPAP2A [Title/Abstract] AND SMN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPAP2A(54830399)-SMN1(70248265), # samples:2
PPAP2A(54830399)-SMN1(70247767), # samples:2
Anticipated loss of major functional domain due to fusion event.PPAP2A-SMN1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PPAP2A-SMN1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPAP2A

GO:0006644

phospholipid metabolic process

9305923|9705349|15461590

HgenePPAP2A

GO:0006670

sphingosine metabolic process

9705349

HgenePPAP2A

GO:0006672

ceramide metabolic process

9305923|9705349

HgenePPAP2A

GO:0046839

phospholipid dephosphorylation

9305923|9705349|15461590|16464866

TgeneSMN1

GO:0000387

spliceosomal snRNP assembly

18984161


check buttonFusion gene breakpoints across PPAP2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A8MJPPAP2Achr5

54830399

-SMN1chr5

70247767

+
ChimerDB4PRADTCGA-V1-A8MJPPAP2Achr5

54830399

-SMN1chr5

70248265

+
ChimerDB4PRADTCGA-V1-A8MJPPAP2Achr5

54830400

-SMN1chr5

70247768

+
ChimerDB4PRADTCGA-V1-A8MJPPAP2Achr5

54830400

-SMN1chr5

70248266

+


Top

Fusion Gene ORF analysis for PPAP2A-SMN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264775ENST00000351205PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000264775ENST00000351205PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000264775ENST00000380707PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000264775ENST00000380707PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000264775ENST00000506163PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000264775ENST00000506163PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000264775ENST00000510679PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5CDS-3UTRENST00000264775ENST00000510679PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000264775ENST00000510679PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5CDS-3UTRENST00000264775ENST00000510679PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000264775ENST00000514951PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000264775ENST00000514951PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000307259ENST00000351205PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000307259ENST00000351205PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000307259ENST00000380707PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000307259ENST00000380707PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000307259ENST00000506163PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000307259ENST00000506163PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000307259ENST00000510679PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5CDS-3UTRENST00000307259ENST00000510679PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000307259ENST00000510679PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5CDS-3UTRENST00000307259ENST00000510679PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-3UTRENST00000307259ENST00000514951PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-3UTRENST00000307259ENST00000514951PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-intronENST00000264775ENST00000503079PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-intronENST00000264775ENST00000503079PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-intronENST00000264775ENST00000506163PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5CDS-intronENST00000264775ENST00000506163PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5CDS-intronENST00000307259ENST00000503079PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5CDS-intronENST00000307259ENST00000503079PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5CDS-intronENST00000307259ENST00000506163PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5CDS-intronENST00000307259ENST00000506163PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5UTR-3CDSENST00000515132ENST00000351205PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5UTR-3CDSENST00000515132ENST00000351205PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5UTR-3CDSENST00000515132ENST00000380707PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5UTR-3CDSENST00000515132ENST00000380707PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5UTR-3CDSENST00000515132ENST00000503079PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5UTR-3CDSENST00000515132ENST00000503079PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5UTR-3CDSENST00000515132ENST00000514951PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5UTR-3CDSENST00000515132ENST00000514951PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5UTR-3UTRENST00000515132ENST00000351205PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5UTR-3UTRENST00000515132ENST00000351205PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5UTR-3UTRENST00000515132ENST00000380707PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5UTR-3UTRENST00000515132ENST00000380707PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5UTR-3UTRENST00000515132ENST00000506163PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5UTR-3UTRENST00000515132ENST00000506163PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5UTR-3UTRENST00000515132ENST00000510679PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5UTR-3UTRENST00000515132ENST00000510679PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5UTR-3UTRENST00000515132ENST00000510679PPAP2Achr5

54830400

-SMN1chr5

70247768

+
5UTR-3UTRENST00000515132ENST00000510679PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5UTR-3UTRENST00000515132ENST00000514951PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5UTR-3UTRENST00000515132ENST00000514951PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5UTR-intronENST00000515132ENST00000503079PPAP2Achr5

54830399

-SMN1chr5

70248265

+
5UTR-intronENST00000515132ENST00000503079PPAP2Achr5

54830400

-SMN1chr5

70248266

+
5UTR-intronENST00000515132ENST00000506163PPAP2Achr5

54830399

-SMN1chr5

70247767

+
5UTR-intronENST00000515132ENST00000506163PPAP2Achr5

54830400

-SMN1chr5

70247768

+
Frame-shiftENST00000264775ENST00000503079PPAP2Achr5

54830399

-SMN1chr5

70247767

+
Frame-shiftENST00000264775ENST00000503079PPAP2Achr5

54830400

-SMN1chr5

70247768

+
Frame-shiftENST00000307259ENST00000503079PPAP2Achr5

54830399

-SMN1chr5

70247767

+
Frame-shiftENST00000307259ENST00000503079PPAP2Achr5

54830400

-SMN1chr5

70247768

+
In-frameENST00000264775ENST00000351205PPAP2Achr5

54830399

-SMN1chr5

70247767

+
In-frameENST00000264775ENST00000351205PPAP2Achr5

54830400

-SMN1chr5

70247768

+
In-frameENST00000264775ENST00000380707PPAP2Achr5

54830399

-SMN1chr5

70247767

+
In-frameENST00000264775ENST00000380707PPAP2Achr5

54830400

-SMN1chr5

70247768

+
In-frameENST00000264775ENST00000514951PPAP2Achr5

54830399

-SMN1chr5

70247767

+
In-frameENST00000264775ENST00000514951PPAP2Achr5

54830400

-SMN1chr5

70247768

+
In-frameENST00000307259ENST00000351205PPAP2Achr5

54830399

-SMN1chr5

70247767

+
In-frameENST00000307259ENST00000351205PPAP2Achr5

54830400

-SMN1chr5

70247768

+
In-frameENST00000307259ENST00000380707PPAP2Achr5

54830399

-SMN1chr5

70247767

+
In-frameENST00000307259ENST00000380707PPAP2Achr5

54830400

-SMN1chr5

70247768

+
In-frameENST00000307259ENST00000514951PPAP2Achr5

54830399

-SMN1chr5

70247767

+
In-frameENST00000307259ENST00000514951PPAP2Achr5

54830400

-SMN1chr5

70247768

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264775PPAP2Achr554830399-ENST00000351205SMN1chr570247767+102839882477131
ENST00000264775PPAP2Achr554830399-ENST00000380707SMN1chr570247767+102639882477131
ENST00000264775PPAP2Achr554830399-ENST00000514951SMN1chr570247767+102539882567161
ENST00000307259PPAP2Achr554830399-ENST00000351205SMN1chr570247767+1109479163558131
ENST00000307259PPAP2Achr554830399-ENST00000380707SMN1chr570247767+1107479163558131
ENST00000307259PPAP2Achr554830399-ENST00000514951SMN1chr570247767+1106479163648161
ENST00000264775PPAP2Achr554830400-ENST00000351205SMN1chr570247768+102839882477131
ENST00000264775PPAP2Achr554830400-ENST00000380707SMN1chr570247768+102639882477131
ENST00000264775PPAP2Achr554830400-ENST00000514951SMN1chr570247768+102539882567161
ENST00000307259PPAP2Achr554830400-ENST00000351205SMN1chr570247768+1109479163558131
ENST00000307259PPAP2Achr554830400-ENST00000380707SMN1chr570247768+1107479163558131
ENST00000307259PPAP2Achr554830400-ENST00000514951SMN1chr570247768+1106479163648161

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264775ENST00000351205PPAP2Achr554830399-SMN1chr570247767+0.83047780.16952223
ENST00000264775ENST00000380707PPAP2Achr554830399-SMN1chr570247767+0.83180210.16819783
ENST00000264775ENST00000514951PPAP2Achr554830399-SMN1chr570247767+0.120200350.87979966
ENST00000307259ENST00000351205PPAP2Achr554830399-SMN1chr570247767+0.951794560.048205398
ENST00000307259ENST00000380707PPAP2Achr554830399-SMN1chr570247767+0.949894550.050105404
ENST00000307259ENST00000514951PPAP2Achr554830399-SMN1chr570247767+0.231088240.76891184
ENST00000264775ENST00000351205PPAP2Achr554830400-SMN1chr570247768+0.83047780.16952223
ENST00000264775ENST00000380707PPAP2Achr554830400-SMN1chr570247768+0.83180210.16819783
ENST00000264775ENST00000514951PPAP2Achr554830400-SMN1chr570247768+0.120200350.87979966
ENST00000307259ENST00000351205PPAP2Achr554830400-SMN1chr570247768+0.951794560.048205398
ENST00000307259ENST00000380707PPAP2Achr554830400-SMN1chr570247768+0.949894550.050105404
ENST00000307259ENST00000514951PPAP2Achr554830400-SMN1chr570247768+0.231088240.76891184

Top

Fusion Genomic Features for PPAP2A-SMN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPAP2Achr554830399-SMN1chr570248265+2.33E-101
PPAP2Achr554830399-SMN1chr570247767+2.26E-101
PPAP2Achr554830399-SMN1chr570248265+2.33E-101
PPAP2Achr554830399-SMN1chr570247767+2.26E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for PPAP2A-SMN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:54830399/chr5:70248265)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-165_719286.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-165_719285.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-165_719286.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-165_719285.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-161_619286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-161_619285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-161_619286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-161_619285.0Topological domainCytoplasmic
TgeneSMN1chr5:54830399chr5:70247767ENST0000035120558244_248246373.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000050307957244_248246263.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000050616308195_2030283.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000050616308217_2260283.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000050616308244_2480283.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000035120558244_248246373.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000050307957244_248246263.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000050616308195_2030283.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000050616308217_2260283.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000050616308244_2480283.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST000005061630891_1510283.0DomainTudor
TgeneSMN1chr5:54830400chr5:70247768ENST000005061630891_1510283.0DomainTudor
TgeneSMN1chr5:54830399chr5:70247767ENST000005061630813_440283.0RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830399chr5:70247767ENST0000050616308240_2670283.0RegionNote=P2 (binding site for SNRPB)
TgeneSMN1chr5:54830400chr5:70247768ENST000005061630813_440283.0RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830400chr5:70247768ENST0000050616308240_2670283.0RegionNote=P2 (binding site for SNRPB)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16120_12819286.0RegionPhosphatase sequence motif I
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16168_17119286.0RegionPhosphatase sequence motif II
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16216_22719286.0RegionPhosphatase sequence motif III
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16120_12819285.0RegionPhosphatase sequence motif I
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16168_17119285.0RegionPhosphatase sequence motif II
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16216_22719285.0RegionPhosphatase sequence motif III
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16120_12819286.0RegionPhosphatase sequence motif I
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16168_17119286.0RegionPhosphatase sequence motif II
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16216_22719286.0RegionPhosphatase sequence motif III
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16120_12819285.0RegionPhosphatase sequence motif I
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16168_17119285.0RegionPhosphatase sequence motif II
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16216_22719285.0RegionPhosphatase sequence motif III
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16116_16419286.0Topological domainExtracellular
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16186_19919286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16221_22919286.0Topological domainExtracellular
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16251_28419286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-1628_5319286.0Topological domainExtracellular
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-1675_9419286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16116_16419285.0Topological domainExtracellular
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16186_19919285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16221_22919285.0Topological domainExtracellular
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16251_28419285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-1628_5319285.0Topological domainExtracellular
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-1675_9419285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16116_16419286.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16186_19919286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16221_22919286.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16251_28419286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-1628_5319286.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-1675_9419286.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16116_16419285.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16186_19919285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16221_22919285.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16251_28419285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-1628_5319285.0Topological domainExtracellular
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-1675_9419285.0Topological domainCytoplasmic
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16165_18519286.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16200_22019286.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-16230_25019286.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-1654_7419286.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-167_2719286.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000264775-1695_11519286.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16165_18519285.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16200_22019285.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-16230_25019285.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-1654_7419285.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-167_2719285.0TransmembraneHelical
HgenePPAP2Achr5:54830399chr5:70247767ENST00000307259-1695_11519285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16165_18519286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16200_22019286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-16230_25019286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-1654_7419286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-167_2719286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000264775-1695_11519286.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16165_18519285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16200_22019285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-16230_25019285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-1654_7419285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-167_2719285.0TransmembraneHelical
HgenePPAP2Achr5:54830400chr5:70247768ENST00000307259-1695_11519285.0TransmembraneHelical
TgeneSMN1chr5:54830399chr5:70247767ENST0000035120558195_203246373.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000035120558217_226246373.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000038070769195_203278434.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000038070769217_226278434.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000038070769244_248278434.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000050307957195_203246263.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST0000050307957217_226246263.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000035120558195_203246373.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000035120558217_226246373.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000038070769195_203278434.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000038070769217_226278434.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000038070769244_248278434.6666666666667Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000050307957195_203246263.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830400chr5:70247768ENST0000050307957217_226246263.0Compositional biasNote=Poly-Pro
TgeneSMN1chr5:54830399chr5:70247767ENST000003512055891_151246373.6666666666667DomainTudor
TgeneSMN1chr5:54830399chr5:70247767ENST000003807076991_151278434.6666666666667DomainTudor
TgeneSMN1chr5:54830399chr5:70247767ENST000005030795791_151246263.0DomainTudor
TgeneSMN1chr5:54830400chr5:70247768ENST000003512055891_151246373.6666666666667DomainTudor
TgeneSMN1chr5:54830400chr5:70247768ENST000003807076991_151278434.6666666666667DomainTudor
TgeneSMN1chr5:54830400chr5:70247768ENST000005030795791_151246263.0DomainTudor
TgeneSMN1chr5:54830399chr5:70247767ENST000003512055813_44246373.6666666666667RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830399chr5:70247767ENST0000035120558240_267246373.6666666666667RegionNote=P2 (binding site for SNRPB)
TgeneSMN1chr5:54830399chr5:70247767ENST000003807076913_44278434.6666666666667RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830399chr5:70247767ENST0000038070769240_267278434.6666666666667RegionNote=P2 (binding site for SNRPB)
TgeneSMN1chr5:54830399chr5:70247767ENST000005030795713_44246263.0RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830399chr5:70247767ENST0000050307957240_267246263.0RegionNote=P2 (binding site for SNRPB)
TgeneSMN1chr5:54830400chr5:70247768ENST000003512055813_44246373.6666666666667RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830400chr5:70247768ENST0000035120558240_267246373.6666666666667RegionNote=P2 (binding site for SNRPB)
TgeneSMN1chr5:54830400chr5:70247768ENST000003807076913_44278434.6666666666667RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830400chr5:70247768ENST0000038070769240_267278434.6666666666667RegionNote=P2 (binding site for SNRPB)
TgeneSMN1chr5:54830400chr5:70247768ENST000005030795713_44246263.0RegionNote=P1 (binding site for GEMIN2)
TgeneSMN1chr5:54830400chr5:70247768ENST0000050307957240_267246263.0RegionNote=P2 (binding site for SNRPB)


Top

Fusion Gene Sequence for PPAP2A-SMN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67304_67304_1_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000264775_SMN1_chr5_70247767_ENST00000351205_length(transcript)=1028nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAG
GAGAAATGCTGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTG
GCCTCATTTCTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAA
ATGCAATGTGAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGG
CAGTTGAGAAAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTT
TATAAAAGACTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGT
ATGTGAGGCGTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTA

>67304_67304_1_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000264775_SMN1_chr5_70247767_ENST00000351205_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_2_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000264775_SMN1_chr5_70247767_ENST00000380707_length(transcript)=1026nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAG
GAGAAATGCTGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTG
GCCTCATTTCTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAA
ATGCAATGTGAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGG
CAGTTGAGAAAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTT
TATAAAAGACTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGT
ATGTGAGGCGTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTA

>67304_67304_2_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000264775_SMN1_chr5_70247767_ENST00000380707_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_3_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000264775_SMN1_chr5_70247767_ENST00000514951_length(transcript)=1025nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAG
GAGTAAGTCTGCCAGCATTATGAAAGTGAATCTTACTTTTGTAAAACTTTATGGTTTGTGGAAAACAAATGTTTTTGAACATTTAAAAAG
TTCAGATGTTAAAAAGTTGAAAGGTTAATGTAAAACAATCAATATTAAAGAATTTTGATGCCAAAACTATTAGATAAAAGGTTAATCTAC
ATCCCTACTAGAATTCTCATACTTAACTGGTTGGTTATGTGGAAGAAACATACTTTCACAATAAAGAGCTTTAGGATATGATGCCATTTT
ATATCACTAGTAGGCAGACCAGCAGACTTTTTTTTATTGTGATATGGGATAACCTAGGCATACTGCACTGTACACTCTGACATATGAAGT
GCTCTAGTCAAGTTTAACTGGTGTCCACAGAGGACATGGTTTAACTGGAATTCGTCAAGCCTCTGGTTCTAATTTCTCATTTGCAGGAAA
TGCTGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCA

>67304_67304_3_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000264775_SMN1_chr5_70247767_ENST00000514951_length(amino acids)=161AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_4_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000307259_SMN1_chr5_70247767_ENST00000351205_length(transcript)=1109nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAGGAGAAATGC
TGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCATTT
CTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAAATGCAATGT
GAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGGCAGTTGAGA
AAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTTTATAAAAGA
CTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGTATGTGAGGC
GTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTAAAAGTATAT

>67304_67304_4_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000307259_SMN1_chr5_70247767_ENST00000351205_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_5_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000307259_SMN1_chr5_70247767_ENST00000380707_length(transcript)=1107nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAGGAGAAATGC
TGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCATTT
CTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAAATGCAATGT
GAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGGCAGTTGAGA
AAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTTTATAAAAGA
CTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGTATGTGAGGC
GTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTAAAAGTATAT

>67304_67304_5_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000307259_SMN1_chr5_70247767_ENST00000380707_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_6_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000307259_SMN1_chr5_70247767_ENST00000514951_length(transcript)=1106nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAGGAGTAAGTC
TGCCAGCATTATGAAAGTGAATCTTACTTTTGTAAAACTTTATGGTTTGTGGAAAACAAATGTTTTTGAACATTTAAAAAGTTCAGATGT
TAAAAAGTTGAAAGGTTAATGTAAAACAATCAATATTAAAGAATTTTGATGCCAAAACTATTAGATAAAAGGTTAATCTACATCCCTACT
AGAATTCTCATACTTAACTGGTTGGTTATGTGGAAGAAACATACTTTCACAATAAAGAGCTTTAGGATATGATGCCATTTTATATCACTA
GTAGGCAGACCAGCAGACTTTTTTTTATTGTGATATGGGATAACCTAGGCATACTGCACTGTACACTCTGACATATGAAGTGCTCTAGTC
AAGTTTAACTGGTGTCCACAGAGGACATGGTTTAACTGGAATTCGTCAAGCCTCTGGTTCTAATTTCTCATTTGCAGGAAATGCTGGCAT
AGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCATTTCTTCAA

>67304_67304_6_PPAP2A-SMN1_PPAP2A_chr5_54830399_ENST00000307259_SMN1_chr5_70247767_ENST00000514951_length(amino acids)=161AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_7_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000264775_SMN1_chr5_70247768_ENST00000351205_length(transcript)=1028nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAG
GAGAAATGCTGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTG
GCCTCATTTCTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAA
ATGCAATGTGAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGG
CAGTTGAGAAAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTT
TATAAAAGACTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGT
ATGTGAGGCGTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTA

>67304_67304_7_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000264775_SMN1_chr5_70247768_ENST00000351205_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_8_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000264775_SMN1_chr5_70247768_ENST00000380707_length(transcript)=1026nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAG
GAGAAATGCTGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTG
GCCTCATTTCTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAA
ATGCAATGTGAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGG
CAGTTGAGAAAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTT
TATAAAAGACTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGT
ATGTGAGGCGTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTA

>67304_67304_8_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000264775_SMN1_chr5_70247768_ENST00000380707_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_9_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000264775_SMN1_chr5_70247768_ENST00000514951_length(transcript)=1025nt_BP=398nt
CCTGTGGGAGAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCG
GCTGGCACACGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCC
GCCCGGTCTCAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGA
GAATCAAGGGCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCT
GCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAG
GAGTAAGTCTGCCAGCATTATGAAAGTGAATCTTACTTTTGTAAAACTTTATGGTTTGTGGAAAACAAATGTTTTTGAACATTTAAAAAG
TTCAGATGTTAAAAAGTTGAAAGGTTAATGTAAAACAATCAATATTAAAGAATTTTGATGCCAAAACTATTAGATAAAAGGTTAATCTAC
ATCCCTACTAGAATTCTCATACTTAACTGGTTGGTTATGTGGAAGAAACATACTTTCACAATAAAGAGCTTTAGGATATGATGCCATTTT
ATATCACTAGTAGGCAGACCAGCAGACTTTTTTTTATTGTGATATGGGATAACCTAGGCATACTGCACTGTACACTCTGACATATGAAGT
GCTCTAGTCAAGTTTAACTGGTGTCCACAGAGGACATGGTTTAACTGGAATTCGTCAAGCCTCTGGTTCTAATTTCTCATTTGCAGGAAA
TGCTGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCA

>67304_67304_9_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000264775_SMN1_chr5_70247768_ENST00000514951_length(amino acids)=161AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_10_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000307259_SMN1_chr5_70247768_ENST00000351205_length(transcript)=1109nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAGGAGAAATGC
TGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCATTT
CTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAAATGCAATGT
GAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGGCAGTTGAGA
AAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTTTATAAAAGA
CTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGTATGTGAGGC
GTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTAAAAGTATAT

>67304_67304_10_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000307259_SMN1_chr5_70247768_ENST00000351205_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_11_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000307259_SMN1_chr5_70247768_ENST00000380707_length(transcript)=1107nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAGGAGAAATGC
TGGCATAGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCATTT
CTTCAAAATATCAAGTGTTGGGAAAGAAAAAAGGAAGTGGAATGGGTAACTCTTCTTGATTAAAAGTTATGTAATAACCAAATGCAATGT
GAAATATTTTACTGGACTCTATTTTGAAAAACCATCTGTAAAAGACTGGGGTGGGGGTGGGAGGCCAGCACGGTGGTGAGGCAGTTGAGA
AAATTTGAATGTGGATTAGATTTTGAATGATATTGGATAATTATTGGTAATTTTATGAGCTGTGAGAAGGGTGTTGTAGTTTATAAAAGA
CTGTCTTAATTTGCATACTTAAGCATTTAGGAATGAAGTGTTAGAGTGTCTTAAAATGTTTCAAATGGTTTAACAAAATGTATGTGAGGC
GTATGTGGCAAAATGTTACAGAATCTAACTGGTGGACATGGCTGTTCATTGTACTGTTTTTTTCTATCTTCTATATGTTTAAAAGTATAT

>67304_67304_11_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000307259_SMN1_chr5_70247768_ENST00000380707_length(amino acids)=131AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------
>67304_67304_12_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000307259_SMN1_chr5_70247768_ENST00000514951_length(transcript)=1106nt_BP=479nt
GCTGCTCAGCGGGAGGGGCTGGACCCCGCGTTCCTCCTCCCTGCCGGTCCCCATCCTTAAAGCGAGAGTCTGGACGCCCCGCCTGTGGGA
GAGAGCGCCGGGATCCGGACGGGGAGCAACCGGGGCAGGCCGTGCCGGCTGAGGAGGTCCTGAGGCTACAGAGCTGCCGCGGCTGGCACA
CGAGCGCCTCGGCACTAACCGAGTGTTCGCGGGGGCTGTGAGGGGAGGGCCCCGGGCGCCATTGCTGGCGGTGGGAGCGCCGCCCGGTCT
CAGCCCGCCCTCGGCTGCTCTCCTCCTCCGGCTGGGAGGGGCCGTAGCTCGGGGCCGTCGCCAGCCCCGGCCCGGGCTCGAGAATCAAGG
GCCTCGGCCGCCGTCCCGCAGCTCAGTCCATCGCCCTTGCCGGGCAGCCCGGGCAGAGACCATGTTTGACAAGACGCGGCTGCCGTACGT
GGCCCTCGATGTGCTCTGCGTGTTGCTGGGGTTTCAGACAAAATCAAAAAGAAGGAAGGTGCTCACATTCCTTAAATTAAGGAGTAAGTC
TGCCAGCATTATGAAAGTGAATCTTACTTTTGTAAAACTTTATGGTTTGTGGAAAACAAATGTTTTTGAACATTTAAAAAGTTCAGATGT
TAAAAAGTTGAAAGGTTAATGTAAAACAATCAATATTAAAGAATTTTGATGCCAAAACTATTAGATAAAAGGTTAATCTACATCCCTACT
AGAATTCTCATACTTAACTGGTTGGTTATGTGGAAGAAACATACTTTCACAATAAAGAGCTTTAGGATATGATGCCATTTTATATCACTA
GTAGGCAGACCAGCAGACTTTTTTTTATTGTGATATGGGATAACCTAGGCATACTGCACTGTACACTCTGACATATGAAGTGCTCTAGTC
AAGTTTAACTGGTGTCCACAGAGGACATGGTTTAACTGGAATTCGTCAAGCCTCTGGTTCTAATTTCTCATTTGCAGGAAATGCTGGCAT
AGAGCAGCACTAAATGACACCACTAAAGAAACGATCAGACAGATCTGGAATGTGAAGCGTTATAGAAGATAACTGGCCTCATTTCTTCAA

>67304_67304_12_PPAP2A-SMN1_PPAP2A_chr5_54830400_ENST00000307259_SMN1_chr5_70247768_ENST00000514951_length(amino acids)=161AA_BP=103
MPRLAHERLGTNRVFAGAVRGGPRAPLLAVGAPPGLSPPSAALLLRLGGAVARGRRQPRPGLENQGPRPPSRSSVHRPCRAARAETMFDK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPAP2A-SMN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PPAP2A-SMN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PPAP2A-SMN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource