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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPAPDC1B-TMEM66 (FusionGDB2 ID:67310)

Fusion Gene Summary for PPAPDC1B-TMEM66

check button Fusion gene summary
Fusion gene informationFusion gene name: PPAPDC1B-TMEM66
Fusion gene ID: 67310
HgeneTgene
Gene symbol

PPAPDC1B

TMEM66

Gene ID

84513

51669

Gene namephospholipid phosphatase 5store-operated calcium entry associated regulatory factor
SynonymsDPPL1|HTPAP|PPAPDC1BFOAP-7|HSPC035|TMEM66|XTP3
Cytomap

8p11.23

8p12

Type of geneprotein-codingprotein-coding
Descriptionphospholipid phosphatase 5diacylglycerol pyrophosphate like 1diacylglycerol pyrophosphate phosphatase-like 1phosphatidate phosphatase PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1Bphosphatidic acid phosphatase type 2 domain-containstore-operated calcium entry-associated regulatory factorHBV X-transactivated gene 3 proteinHBV XAg-transactivated protein 3SARAF long isoformSARAF short isoformSOCE-associated regulatory factortesticular secretory protein Li 59transmembrane protei
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000422581, ENST00000424479, 
ENST00000529359, ENST00000531823, 
ENST00000419686, ENST00000530588, 
ENST00000536273, ENST00000545648, 
ENST00000521083, ENST00000256255, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 3 X 3=45
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPAPDC1B [Title/Abstract] AND TMEM66 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPAPDC1B(38124785)-TMEM66(29927575), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPAPDC1B

GO:0046839

phospholipid dephosphorylation

17590538

TgeneTMEM66

GO:2001256

regulation of store-operated calcium entry

22464749


check buttonFusion gene breakpoints across PPAPDC1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM66 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A65M-01APPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
ChimerDB4PRADTCGA-EJ-A65MPPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-


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Fusion Gene ORF analysis for PPAPDC1B-TMEM66

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000422581ENST00000536273PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000422581ENST00000545648PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000424479ENST00000536273PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000424479ENST00000545648PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000529359ENST00000536273PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000529359ENST00000545648PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000531823ENST00000536273PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000531823ENST00000545648PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-intronENST00000422581ENST00000521083PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-intronENST00000424479ENST00000521083PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-intronENST00000529359ENST00000521083PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
5CDS-intronENST00000531823ENST00000521083PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
Frame-shiftENST00000422581ENST00000256255PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
Frame-shiftENST00000424479ENST00000256255PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
Frame-shiftENST00000529359ENST00000256255PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
In-frameENST00000531823ENST00000256255PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-3CDSENST00000419686ENST00000256255PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-3CDSENST00000530588ENST00000256255PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-5UTRENST00000419686ENST00000536273PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-5UTRENST00000419686ENST00000545648PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-5UTRENST00000530588ENST00000536273PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-5UTRENST00000530588ENST00000545648PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-intronENST00000419686ENST00000521083PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-
intron-intronENST00000530588ENST00000521083PPAPDC1Bchr8

38124785

-TMEM66chr8

29927575

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000531823PPAPDC1Bchr838124785-ENST00000256255TMEM66chr829927575-21114974581234258

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531823ENST00000256255PPAPDC1Bchr838124785-TMEM66chr829927575-0.0003642380.9996357

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Fusion Genomic Features for PPAPDC1B-TMEM66


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPAPDC1B-TMEM66


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38124785/chr8:29927575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57108_116154217.0RegionPhosphatase sequence motif I
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57149_152154217.0RegionPhosphatase sequence motif II
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57108_116154265.0RegionPhosphatase sequence motif I
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57149_152154265.0RegionPhosphatase sequence motif II
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46108_116113224.0RegionPhosphatase sequence motif I
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57112_154154217.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-571_5154217.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-5727_54154217.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-5776_90154217.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57112_154154265.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-571_5154265.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-5727_54154265.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-5776_90154265.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-461_5113224.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-4627_54113224.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-4676_90113224.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-5755_75154217.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-576_26154217.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-5791_111154217.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-5755_75154265.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-576_26154265.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-5791_111154265.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-4655_75113224.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-466_26113224.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-4691_111113224.0TransmembraneHelical
TgeneTMEM66chr8:38124785chr8:29927575ENST0000025625516195_33994340.0Topological domainCytoplasmic
TgeneTMEM66chr8:38124785chr8:29927575ENST0000053627305195_3390168.0Topological domainCytoplasmic
TgeneTMEM66chr8:38124785chr8:29927575ENST000005362730531_1730168.0Topological domainLumenal
TgeneTMEM66chr8:38124785chr8:29927575ENST0000054564827195_3390168.0Topological domainCytoplasmic
TgeneTMEM66chr8:38124785chr8:29927575ENST000005456482731_1730168.0Topological domainLumenal
TgeneTMEM66chr8:38124785chr8:29927575ENST0000025625516174_19494340.0TransmembraneHelical
TgeneTMEM66chr8:38124785chr8:29927575ENST0000053627305174_1940168.0TransmembraneHelical
TgeneTMEM66chr8:38124785chr8:29927575ENST0000054564827174_1940168.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57201_211154217.0RegionPhosphatase sequence motif III
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57201_211154265.0RegionPhosphatase sequence motif III
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46149_152113224.0RegionPhosphatase sequence motif II
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46201_211113224.0RegionPhosphatase sequence motif III
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57176_179154217.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57201_208154217.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57229_264154217.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57176_179154265.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57201_208154265.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57229_264154265.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46112_154113224.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46176_179113224.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46201_208113224.0Topological domainExtracellular
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46229_264113224.0Topological domainCytoplasmic
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57155_175154217.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57180_200154217.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000422581-57209_228154217.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57155_175154265.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57180_200154265.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000424479-57209_228154265.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46155_175113224.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46180_200113224.0TransmembraneHelical
HgenePPAPDC1Bchr8:38124785chr8:29927575ENST00000529359-46209_228113224.0TransmembraneHelical
TgeneTMEM66chr8:38124785chr8:29927575ENST000002562551631_17394340.0Topological domainLumenal


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Fusion Gene Sequence for PPAPDC1B-TMEM66


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67310_67310_1_PPAPDC1B-TMEM66_PPAPDC1B_chr8_38124785_ENST00000531823_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=2111nt_BP=497nt
CCTTTGGGGCCGAAGTGGGCGTGCGGCTCGCGCTGTTCGCGGCCTTCCTGGTGACGGAGCTGCTCCCCCCGTTCCAGAGACTCATCCAGC
CGGAGGAGATGTGGCTCTACCGGAACCCCTACGTGGAGGCGGAGTATTTCCCCACCAAGCCGATGTTTGTGCGTGGAGAAAGATCGTCTT
TCCTCCCTCCCCATGACCCGGCTTCCCGCGGGCACCTGTTATTGCATTTCTCTCTCCACTGTCTCTGATCTTCCTGGCCAAATTTCTCAA
GAAGGCAGACACAAGAGACAGCAGACAAGCCTGCCTGGCTGCCAGCCTTGCCCTGGCTCTGAATGGCGTCTTTACCAACACAATAAAACT
GATCGTAGGGAGGCCACGCCCAGATTTCTTCTACCGCTGCTTCCCTGATGGGCTAGCCCATTCTGACTTGATGTGTACAGGGGATAAGGA
CGTGGTGAATGAGGGCCGAAAGAGCTTCCCCAGTGGACATTCTTCCTTGGGAATGTAAGACGGACTTAGATATTGCATACAAATTTGGAA
AAACTGTGGTGAGCTGTGAAGGCTATGAGTCCTCTGAAGACCAGTATGTACTAAGAGGTTCTTGTGGCTTGGAGTATAATTTAGATTATA
CAGAACTTGGCCTGCAGAAACTGAAGGAGTCTGGAAAGCAGCACGGCTTTGCCTCTTTCTCTGATTATTATTATAAGTGGTCCTCGGCGG
ATTCCTGTAACATGAGTGGATTGATTACCATTGTGGTACTCCTTGGGATCGCGTTTGTAGTCTATAAGCTGTTCCTGAGTGACGGGCAGT
ATTCTCCTCCACCGTACTCTGAGTATCCTCCATTTTCCCACCGTTACCAGAGATTCACCAACTCAGCAGGACCTCCTCCCCCAGGCTTTA
AGTCTGAGTTCACAGGACCACAGAATACTGGCCATGGTGCAACTTCTGGTTTTGGCAGTGCTTTTACAGGACAACAAGGATATGAAAATT
CAGGACCAGGGTTCTGGACAGGCTTGGGAACTGGTGGAATACTAGGATATTTGTTTGGCAGCAATAGAGCGGCAACACCCTTCTCAGACT
CGTGGTACTACCCGTCCTATCCTCCCTCCTACCCTGGCACGTGGAATAGGGCTTACTCACCCCTTCATGGAGGCTCGGGCAGCTATTCGG
TATGTTCAAACTCAGACACGAAAACCAGAACTGCATCAGGATATGGTGGTACCAGGAGACGATAAAGTAGAAAGTTGGAGTCAAACACTG
GATGCAGAAATTTTGGATTTTTCATCACTTTCTCTTTAGAAAAAAAGTACTACCTGTTAACAATTGGGAAAAGGGGATATTCAAAAGTTC
TGTGGTGTTATGTCCAGTGTAGCTTTTTGTATTCTATTATTTGAGGCTAAAAGTTGATGTGTGACAAAATACTTATGTGTTGTATGTCAG
TGTAACATGCAGATGTATATTGCAGTTTTTGAAAGTGATCATTACTGTGGAATGCTAAAAATACATTAATTTCTAAAACCTGTGATGCCC
TAAGAAGCATTAAGAATGAAGGTGTTGTACTAATAGAAACTAAGTACAGAAAATTTCAGTTTTAGGTGGTTGTAGCTGATGAGTTATTAC
CTCATAGAGACTATAATATTCTATTTGGTATTATATTATTTGATGTTTGCTGTTCTTCAAACATTTAAATCAAGCTTTGGACTAATTATG
CTAATTTGTGAGTTCTGATCACTTTTGAGCTCTGAAGCTTTGAATCATTCAGTGGTGGAGATGGCCTTCTGGTAACTGAATATTACCTTC
TGTAGGAAAAGGTAGAAAATAAGCATCTAGAAGGTTGTTGTGAATGACTCTGTGCTGGCAAAAATGCTTGAAACCTCTATATTTCTTTCG
TTCATAAGAGGTAAAGGTCAAATTTTTCAACAAAAGTCTTTTAATAACAAAAGCATGCAGTTCTCTGTGAAATCTCAAATATTGTTGTAA
TAGTCTGTTTCAATCTTAAAAAGAATCAATAAAAACAAACAAGGGGTTTAGTCTCATTCTTTCTATTAGCCTAGGCGCAAATAAATGTTA

>67310_67310_1_PPAPDC1B-TMEM66_PPAPDC1B_chr8_38124785_ENST00000531823_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=258AA_BP=13
MRAERASPVDILPWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSC
NMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPAPDC1B-TMEM66


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPAPDC1B-TMEM66


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPAPDC1B-TMEM66


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource