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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPARA-ATXN10 (FusionGDB2 ID:67313)

Fusion Gene Summary for PPARA-ATXN10

check button Fusion gene summary
Fusion gene informationFusion gene name: PPARA-ATXN10
Fusion gene ID: 67313
HgeneTgene
Gene symbol

PPARA

ATXN10

Gene ID

5465

25814

Gene nameperoxisome proliferator activated receptor alphaataxin 10
SynonymsNR1C1|PPAR|PPARalpha|hPPARE46L|HUMEEP|SCA10
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionperoxisome proliferator-activated receptor alphaPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein
Modification date2020032920200313
UniProtAcc.

Q9UBB4

Ensembl transtripts involved in fusion geneENST00000262735, ENST00000396000, 
ENST00000402126, ENST00000407236, 
ENST00000434345, ENST00000481567, 
ENST00000402380, ENST00000498009, 
ENST00000252934, ENST00000381061, 
Fusion gene scores* DoF score15 X 10 X 10=150024 X 19 X 12=5472
# samples 1828
** MAII scorelog2(18/1500*10)=-3.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5472*10)=-4.28856949794093
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPARA [Title/Abstract] AND ATXN10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPARA(46594488)-ATXN10(46238871), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPARA

GO:0000122

negative regulation of transcription by RNA polymerase II

9748239|12700342

HgenePPARA

GO:0010565

regulation of cellular ketone metabolic process

19955185

HgenePPARA

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

HgenePPARA

GO:0010871

negative regulation of receptor biosynthetic process

12700342

HgenePPARA

GO:0010887

negative regulation of cholesterol storage

19114110

HgenePPARA

GO:0010891

negative regulation of sequestering of triglyceride

12700342

HgenePPARA

GO:0019217

regulation of fatty acid metabolic process

19955185

HgenePPARA

GO:0045820

negative regulation of glycolytic process

19955185

HgenePPARA

GO:0045893

positive regulation of transcription, DNA-templated

12955147

HgenePPARA

GO:0045944

positive regulation of transcription by RNA polymerase II

9748239|19955185|20837115

HgenePPARA

GO:0050728

negative regulation of inflammatory response

21636785

HgenePPARA

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

21636785

HgenePPARA

GO:1903038

negative regulation of leukocyte cell-cell adhesion

21636785

TgeneATXN10

GO:0031175

neuron projection development

16498633


check buttonFusion gene breakpoints across PPARA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATXN10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N7-A4Y8-01APPARAchr22

46594488

-ATXN10chr22

46238871

+
ChimerDB4UCSTCGA-N7-A4Y8PPARAchr22

46594488

+ATXN10chr22

46238871

+


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Fusion Gene ORF analysis for PPARA-ATXN10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262735ENST00000402380PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000262735ENST00000498009PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000396000ENST00000402380PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000396000ENST00000498009PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000402126ENST00000402380PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000402126ENST00000498009PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000407236ENST00000402380PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000407236ENST00000498009PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000434345ENST00000402380PPARAchr22

46594488

+ATXN10chr22

46238871

+
5CDS-intronENST00000434345ENST00000498009PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000262735ENST00000252934PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000262735ENST00000381061PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000396000ENST00000252934PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000396000ENST00000381061PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000402126ENST00000252934PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000402126ENST00000381061PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000407236ENST00000252934PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000407236ENST00000381061PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000434345ENST00000252934PPARAchr22

46594488

+ATXN10chr22

46238871

+
In-frameENST00000434345ENST00000381061PPARAchr22

46594488

+ATXN10chr22

46238871

+
intron-3CDSENST00000481567ENST00000252934PPARAchr22

46594488

+ATXN10chr22

46238871

+
intron-3CDSENST00000481567ENST00000381061PPARAchr22

46594488

+ATXN10chr22

46238871

+
intron-intronENST00000481567ENST00000402380PPARAchr22

46594488

+ATXN10chr22

46238871

+
intron-intronENST00000481567ENST00000498009PPARAchr22

46594488

+ATXN10chr22

46238871

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396000PPARAchr2246594488+ENST00000381061ATXN10chr2246238871+2297473256663135
ENST00000396000PPARAchr2246594488+ENST00000252934ATXN10chr2246238871+2300473256663135
ENST00000262735PPARAchr2246594488+ENST00000381061ATXN10chr2246238871+2214390173580135
ENST00000262735PPARAchr2246594488+ENST00000252934ATXN10chr2246238871+2217390173580135
ENST00000407236PPARAchr2246594488+ENST00000381061ATXN10chr2246238871+2245421204611135
ENST00000407236PPARAchr2246594488+ENST00000252934ATXN10chr2246238871+2248421204611135
ENST00000402126PPARAchr2246594488+ENST00000381061ATXN10chr2246238871+2160336119526135
ENST00000402126PPARAchr2246594488+ENST00000252934ATXN10chr2246238871+2163336119526135
ENST00000434345PPARAchr2246594488+ENST00000381061ATXN10chr2246238871+20322080398132
ENST00000434345PPARAchr2246594488+ENST00000252934ATXN10chr2246238871+20352080398132

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396000ENST00000381061PPARAchr2246594488+ATXN10chr2246238871+0.012189460.9878106
ENST00000396000ENST00000252934PPARAchr2246594488+ATXN10chr2246238871+0.0123882250.98761183
ENST00000262735ENST00000381061PPARAchr2246594488+ATXN10chr2246238871+0.0099959350.990004
ENST00000262735ENST00000252934PPARAchr2246594488+ATXN10chr2246238871+0.009892940.99010706
ENST00000407236ENST00000381061PPARAchr2246594488+ATXN10chr2246238871+0.018084110.98191595
ENST00000407236ENST00000252934PPARAchr2246594488+ATXN10chr2246238871+0.0182454640.9817546
ENST00000402126ENST00000381061PPARAchr2246594488+ATXN10chr2246238871+0.0081644160.9918356
ENST00000402126ENST00000252934PPARAchr2246594488+ATXN10chr2246238871+0.0081665310.99183345
ENST00000434345ENST00000381061PPARAchr2246594488+ATXN10chr2246238871+0.0107490360.989251
ENST00000434345ENST00000252934PPARAchr2246594488+ATXN10chr2246238871+0.010577030.989423

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Fusion Genomic Features for PPARA-ATXN10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPARAchr2246594488+ATXN10chr2246238870+3.85E-060.9999962
PPARAchr2246594488+ATXN10chr2246238870+3.85E-060.9999962

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPARA-ATXN10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46594488/chr22:46238871)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATXN10

Q9UBB4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPARAchr22:46594488chr22:46238871ENST00000262735+3899_17369469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:46238871ENST00000396000+3899_17369469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:46238871ENST00000402126+2799_17369469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:46238871ENST00000407236+3899_17369469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:46238871ENST00000434345+1599_17369188.33333333333334DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:46238871ENST00000262735+38239_46669469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:46238871ENST00000396000+38239_46669469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:46238871ENST00000402126+27239_46669469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:46238871ENST00000407236+38239_46669469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:46238871ENST00000434345+15239_46669188.33333333333334DomainNR LBD
HgenePPARAchr22:46594488chr22:46238871ENST00000262735+38304_43369469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:46238871ENST00000396000+38304_43369469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:46238871ENST00000402126+27304_43369469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:46238871ENST00000407236+38304_43369469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:46238871ENST00000434345+15304_43369188.33333333333334RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:46238871ENST00000262735+38102_12269469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000262735+38139_16169469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000396000+38102_12269469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000396000+38139_16169469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000402126+27102_12269469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000402126+27139_16169469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000407236+38102_12269469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000407236+38139_16169469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000434345+15102_12269188.33333333333334Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:46238871ENST00000434345+15139_16169188.33333333333334Zinc fingerNR C4-type


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Fusion Gene Sequence for PPARA-ATXN10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67313_67313_1_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000262735_ATXN10_chr22_46238871_ENST00000252934_length(transcript)=2217nt_BP=390nt
GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC
TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCG
CGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAG
AAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCT
GTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACC
AAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAA
AGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTT
TTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTT
AACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGA
TAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAA
CTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTC
TGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCAT
TTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGG
GAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTC
AAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATT
AAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAA
AAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGA
CTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAA
AACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATA
AAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGT
AAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTT
CTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACAC
AAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCC
TTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCG

>67313_67313_1_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000262735_ATXN10_chr22_46238871_ENST00000252934_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_2_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000262735_ATXN10_chr22_46238871_ENST00000381061_length(transcript)=2214nt_BP=390nt
GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC
TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCG
CGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAG
AAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCT
GTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACC
AAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAA
AGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTT
TTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTT
AACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGA
TAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAA
CTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTC
TGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCAT
TTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGG
GAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTC
AAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATT
AAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAA
AAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGA
CTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAA
AACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATA
AAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGT
AAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTT
CTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACAC
AAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCC
TTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCG

>67313_67313_2_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000262735_ATXN10_chr22_46238871_ENST00000381061_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_3_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000396000_ATXN10_chr22_46238871_ENST00000252934_length(transcript)=2300nt_BP=473nt
GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC
TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGGTAAATAGAAGGTTTAATTTACTGTTTCCAGATGGAAATA
TTTAAGTGTTTTCAGTGTTTACTTCTGTTGCACTACAGACCAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGT
GGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGG
AAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGG
CTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTT
GATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGAT
CCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCT
TCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGT
ATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACG
TGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGAT
GTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGG
CGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGT
TAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAG
GTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGA
ATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTA
CATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACT
TTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATT
AAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATAT
TATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCT
GTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATA
GCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGAT
TGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAG
TCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCC
TTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAG

>67313_67313_3_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000396000_ATXN10_chr22_46238871_ENST00000252934_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_4_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000396000_ATXN10_chr22_46238871_ENST00000381061_length(transcript)=2297nt_BP=473nt
GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC
TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGGTAAATAGAAGGTTTAATTTACTGTTTCCAGATGGAAATA
TTTAAGTGTTTTCAGTGTTTACTTCTGTTGCACTACAGACCAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGT
GGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGG
AAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGG
CTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTT
GATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGAT
CCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCT
TCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGT
ATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACG
TGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGAT
GTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGG
CGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGT
TAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAG
GTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGA
ATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTA
CATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACT
TTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATT
AAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATAT
TATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCT
GTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATA
GCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGAT
TGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAG
TCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCC
TTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAG

>67313_67313_4_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000396000_ATXN10_chr22_46238871_ENST00000381061_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_5_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000402126_ATXN10_chr22_46238871_ENST00000252934_length(transcript)=2163nt_BP=336nt
CACAGTTCTGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGC
TTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCG
ATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAA
GCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATG
CCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTA
AAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCC
AAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAA
TTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCAT
TAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAAC
CAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATT
CTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTC
ACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTC
TTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCA
TCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAA
TAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGC
CACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGT
TCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACA
AAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTT
TGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCT
TCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCT
AATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCA
TCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATA
GAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGG
ATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGCCTTGTGAGAAT

>67313_67313_5_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000402126_ATXN10_chr22_46238871_ENST00000252934_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_6_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000402126_ATXN10_chr22_46238871_ENST00000381061_length(transcript)=2160nt_BP=336nt
CACAGTTCTGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGC
TTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCG
ATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAA
GCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATG
CCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTA
AAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCC
AAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAA
TTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCAT
TAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAAC
CAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATT
CTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTC
ACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTC
TTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCA
TCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAA
TAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGC
CACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGT
TCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACA
AAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTT
TGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCT
TCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCT
AATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCA
TCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATA
GAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGG
ATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGCCTTGTGAGAAT

>67313_67313_6_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000402126_ATXN10_chr22_46238871_ENST00000381061_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_7_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000407236_ATXN10_chr22_46238871_ENST00000252934_length(transcript)=2248nt_BP=421nt
CCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGACTCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTTC
TGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGTAGCTTGGA
GCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTA
GAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTT
GGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATC
CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA
GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA
CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG
GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG
TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC
TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA
TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC
TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC
ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA
GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT
TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC
AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC
TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC
TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC
AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA
GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT
ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT
AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC
CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG

>67313_67313_7_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000407236_ATXN10_chr22_46238871_ENST00000252934_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_8_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000407236_ATXN10_chr22_46238871_ENST00000381061_length(transcript)=2245nt_BP=421nt
CCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGACTCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTTC
TGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGTAGCTTGGA
GCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTA
GAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTT
GGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATC
CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA
GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA
CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG
GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG
TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC
TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA
TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC
TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC
ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA
GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT
TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC
AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC
TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC
TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC
AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA
GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT
ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT
AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC
CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG

>67313_67313_8_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000407236_ATXN10_chr22_46238871_ENST00000381061_length(amino acids)=135AA_BP=72
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNS

--------------------------------------------------------------
>67313_67313_9_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000434345_ATXN10_chr22_46238871_ENST00000252934_length(transcript)=2035nt_BP=208nt
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA
ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA
GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG
CTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTT
CATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAA
CGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATA
GAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACT
TGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTG
GCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTT
CCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGA
GTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAA
GGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAA
AGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAA
GTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACT
GGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAA
CATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAA
GACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAA
AAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCT
AGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAA
AGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTT
TTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGT

>67313_67313_9_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000434345_ATXN10_chr22_46238871_ENST00000252934_length(amino acids)=132AA_BP=69
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ

--------------------------------------------------------------
>67313_67313_10_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000434345_ATXN10_chr22_46238871_ENST00000381061_length(transcript)=2032nt_BP=208nt
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA
ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA
GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG
CTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTT
CATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAA
CGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATA
GAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACT
TGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTG
GCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTT
CCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGA
GTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAA
GGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAA
AGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAA
GTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACT
GGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAA
CATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAA
GACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAA
AAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCT
AGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAA
AGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTT
TTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGT

>67313_67313_10_PPARA-ATXN10_PPARA_chr22_46594488_ENST00000434345_ATXN10_chr22_46238871_ENST00000381061_length(amino acids)=132AA_BP=69
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPARA-ATXN10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPARA-ATXN10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPARA-ATXN10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource