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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:PPARG-CRYBA4 (FusionGDB2 ID:67349) |
Fusion Gene Summary for PPARG-CRYBA4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PPARG-CRYBA4 | Fusion gene ID: 67349 | Hgene | Tgene | Gene symbol | PPARG | CRYBA4 | Gene ID | 5468 | 1413 |
Gene name | peroxisome proliferator activated receptor gamma | crystallin beta A4 | |
Synonyms | CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma | CTRCT23|CYRBA4|MCOPCT4 | |
Cytomap | 3p25.2 | 22q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1 | beta-crystallin A4beta crystallin A4 chain transcript PSbeta crystallin alpha 4 chainbeta-A4 crystallincrystallin, beta polypeptide A4eye lens structural protein | |
Modification date | 20200329 | 20200328 | |
UniProtAcc | . | P53673 | |
Ensembl transtripts involved in fusion gene | ENST00000287820, ENST00000309576, ENST00000397000, ENST00000397010, ENST00000397012, ENST00000397015, ENST00000397026, ENST00000539812, | ENST00000466315, ENST00000354760, | |
Fusion gene scores | * DoF score | 7 X 9 X 5=315 | 3 X 3 X 3=27 |
# samples | 13 | 3 | |
** MAII score | log2(13/315*10)=-1.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PPARG [Title/Abstract] AND CRYBA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | PPARG(12422990)-CRYBA4(27019198), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPARG | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12700342 |
Hgene | PPARG | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18293083 |
Hgene | PPARG | GO:0007165 | signal transduction | 9568716 |
Hgene | PPARG | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
Hgene | PPARG | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 19114110 |
Hgene | PPARG | GO:0010871 | negative regulation of receptor biosynthetic process | 12700342 |
Hgene | PPARG | GO:0010887 | negative regulation of cholesterol storage | 19114110 |
Hgene | PPARG | GO:0010891 | negative regulation of sequestering of triglyceride | 12700342 |
Hgene | PPARG | GO:0016525 | negative regulation of angiogenesis | 28566713 |
Hgene | PPARG | GO:0030224 | monocyte differentiation | 9568716 |
Hgene | PPARG | GO:0032526 | response to retinoic acid | 16239304 |
Hgene | PPARG | GO:0042953 | lipoprotein transport | 9568716 |
Hgene | PPARG | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 28566713 |
Hgene | PPARG | GO:0045713 | low-density lipoprotein particle receptor biosynthetic process | 9568716 |
Hgene | PPARG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9568715|12700342|16239304|17611579 |
Hgene | PPARG | GO:0048469 | cell maturation | 9568716 |
Hgene | PPARG | GO:0048662 | negative regulation of smooth muscle cell proliferation | 20622039 |
Hgene | PPARG | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 18293083 |
Hgene | PPARG | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 28566713 |
Hgene | PPARG | GO:0071404 | cellular response to low-density lipoprotein particle stimulus | 9568716 |
Hgene | PPARG | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 28522568 |
Fusion gene breakpoints across PPARG (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CRYBA4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-HQ-A2OE-01A | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
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Fusion Gene ORF analysis for PPARG-CRYBA4 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000287820 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000309576 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000397000 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000397010 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000397012 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000397015 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000397026 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
5CDS-intron | ENST00000539812 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000287820 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000309576 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000397000 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000397010 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000397012 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000397015 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000397026 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
In-frame | ENST00000539812 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000397010 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1517 | 780 | 1358 | 369 | 329 |
ENST00000309576 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1370 | 633 | 1211 | 222 | 329 |
ENST00000397015 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1255 | 518 | 122 | 1069 | 315 |
ENST00000397012 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1506 | 769 | 1347 | 358 | 329 |
ENST00000397026 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1534 | 797 | 1375 | 395 | 326 |
ENST00000397000 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1201 | 464 | 68 | 1015 | 315 |
ENST00000539812 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1201 | 464 | 68 | 1015 | 315 |
ENST00000287820 | PPARG | chr3 | 12422990 | + | ENST00000354760 | CRYBA4 | chr22 | 27019198 | + | 1338 | 601 | 121 | 1152 | 343 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000397010 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.010919459 | 0.98908055 |
ENST00000309576 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.009764364 | 0.9902356 |
ENST00000397015 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.009794493 | 0.99020547 |
ENST00000397012 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.005357375 | 0.9946426 |
ENST00000397026 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.003373044 | 0.996627 |
ENST00000397000 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.009976292 | 0.9900238 |
ENST00000539812 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.009976292 | 0.9900238 |
ENST00000287820 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + | 0.003349697 | 0.9966503 |
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Fusion Genomic Features for PPARG-CRYBA4 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019197 | + | 0.000456111 | 0.99954385 |
PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019197 | + | 0.000456111 | 0.99954385 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PPARG-CRYBA4 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:12422990/chr22:27019198) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | CRYBA4 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 139_159 | 160 | 506.0 | Zinc finger | NR C4-type |
Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | 1 | 6 | 105_146 | 13 | 197.0 | Domain | Beta/gamma crystallin 'Greek key' 3 | |
Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | 1 | 6 | 12_51 | 13 | 197.0 | Domain | Beta/gamma crystallin 'Greek key' 1 | |
Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | 1 | 6 | 147_195 | 13 | 197.0 | Domain | Beta/gamma crystallin 'Greek key' 4 | |
Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | 1 | 6 | 52_98 | 13 | 197.0 | Domain | Beta/gamma crystallin 'Greek key' 2 | |
Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | 1 | 6 | 99_104 | 13 | 197.0 | Region | Note=Connecting peptide |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 136_210 | 160 | 506.0 | DNA binding | Nuclear receptor |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 136_210 | 132 | 478.0 | DNA binding | Nuclear receptor |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 136_210 | 132 | 478.0 | DNA binding | Nuclear receptor |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 136_210 | 132 | 478.0 | DNA binding | Nuclear receptor |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 136_210 | 132 | 478.0 | DNA binding | Nuclear receptor |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 238_503 | 160 | 506.0 | Domain | NR LBD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 238_503 | 132 | 478.0 | Domain | NR LBD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 238_503 | 132 | 478.0 | Domain | NR LBD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 238_503 | 132 | 478.0 | Domain | NR LBD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 238_503 | 132 | 478.0 | Domain | NR LBD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 495_503 | 160 | 506.0 | Motif | 9aaTAD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 495_503 | 132 | 478.0 | Motif | 9aaTAD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 495_503 | 132 | 478.0 | Motif | 9aaTAD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 495_503 | 132 | 478.0 | Motif | 9aaTAD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 495_503 | 132 | 478.0 | Motif | 9aaTAD |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 176_198 | 160 | 506.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 139_159 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 176_198 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 139_159 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 176_198 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 139_159 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 176_198 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 139_159 | 132 | 478.0 | Zinc finger | NR C4-type |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 176_198 | 132 | 478.0 | Zinc finger | NR C4-type |
Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | 1 | 6 | 2_11 | 13 | 197.0 | Region | Note=N-terminal arm |
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Fusion Gene Sequence for PPARG-CRYBA4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>67349_67349_1_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000287820_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1338nt_BP=601nt ACTCATGGGTGTATTCACAAATTCTGTTACTTCAAGTCTTTTTCTTTTAACGGATTGATCTTTTGCTAGATAGAGACAAAATATCAGTGT GAATTACAGCAAACCCCTATTCCATGCTGTTATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATAC ACTGTCTGCAAACATATCACAAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCT CTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGA CATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCC TGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCG TGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCA GGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGC GTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAA CACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGA GAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCA CGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTA CAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGG AGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAAC >67349_67349_1_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000287820_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=343AA_BP=160 MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAEC PSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELS -------------------------------------------------------------- >67349_67349_2_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000309576_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1370nt_BP=633nt CCCGCCCCCGCGCCGGGCCCGGCTCGGCCCGACCCGGCTCCGCCGCGGGCAGGCGGGGCCCAGCGCACTCGGAGCCCGAGCCCGAGCCGC AGCCGCCGCCTGGGGCGCTTGGGTCGGCCTCGAGGACACCGGAGAGGGGCGCCACGCCGCCGTGGCCGCAGATTTGAAAGAAGCCAACAC TAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGATGCCATTCTGG CCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGAC TTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTT CAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAG CCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGC AAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAG ACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGC GAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCAC CGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATG GGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTAT GTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGC AGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTC TCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTCAAACGAATAAA >67349_67349_2_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000309576_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=329AA_BP=0 MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC -------------------------------------------------------------- >67349_67349_3_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397000_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1201nt_BP=464nt GAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGA TGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCA CTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATG ACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGC CTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTT GTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGC TTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTC TGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCT GTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCC TCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAG GATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGC AGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGT GGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTC >67349_67349_3_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397000_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=315AA_BP=132 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC -------------------------------------------------------------- >67349_67349_4_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397010_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1517nt_BP=780nt AACTTACAAACGCAAGGAACTCTGAAAGTGTGCAGCACCACCGATCAGAAGAGAAAACCAAGGGACCCGAAATATGCTTTAATTAAATTT TCTTTTAAAATGTCACTGGAAAGAACATCTTGGGAAGACGGCCTGGCCGATCGCCGTGTGAAGGGCAAGCCACTCTGGCCGAGAGGGAGC CCCACACCTCGGTCTCCCCAGACCGGCCCTGGCCGGGGGCATCCCCCTAAACTTCGGATCCCTCCTCGGAAATGGGACCCTCTCTGGGCC GCCTCCCAGCGGTGGTGGCGAGGAGCAAACGACACCAGATTTGAAAGAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTC AAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTC TCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGAC ATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCT GCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGT GTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAG GGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCG TGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAAC ACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAG AACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCAC GTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTAC AAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGA GGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACC >67349_67349_4_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397010_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=329AA_BP=0 MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC -------------------------------------------------------------- >67349_67349_5_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397012_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1506nt_BP=769nt CTTTGTGGGCTCCTGCAAGTGCCAGGCGCTGACCACTCCTCCTGGGAGCCTAACTGAGGGGGGTAGAGGCAGCAGAGGTTAACAGAAATC TCAGGTCCCTTGGTGGAAGGTGGGTGTGTAGTCGTGGTACTTTACGCCTCGGTGTTTAGGGAGGAGCCTAAGGTAAGGAGTCAGAAACGG GGAGTAACCGAGCTGCGGCTTTTATATAAGGTCAGTGGTAGGTAAGGAAGGGGCCTTAACCTCTGCTGGTGACCAGAAGCCTGCATTTCT GCATTCTGCTTAATTCCCTTTCCTTAGATTTGAAAGAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTC AGCCTTTAACGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGA AGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCAC AAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACC TTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGA TAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCA CGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTT TGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCC CGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGG CAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGG GGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCG GGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGC GTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATG >67349_67349_5_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397012_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=329AA_BP=0 MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC -------------------------------------------------------------- >67349_67349_6_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397015_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1255nt_BP=518nt GCCGCGGGCAGGCGGGGCCCAGCGCACTCGGAGCCCGAGCCCGAGCCGCAGCCGCCGCCTGGGGCGCTTGGGTCGGCCTCGAGGACACCG GAGAGGGGCGCCACGCCGCCGTGGCCGCAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCG TGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATT ACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAG TGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTG AATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACG GCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGA GTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGG GCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCG AGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGT CCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCG GTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGC GGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTG >67349_67349_6_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397015_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=315AA_BP=132 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC -------------------------------------------------------------- >67349_67349_7_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397026_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1534nt_BP=797nt CCTTAACCTCTGCTGGTGACCAGAAGCCTGCATTTCTGCATTCTGCTTAATTCCCTTTCCTTAGATTTGAAAGAAGCCAACACTAAACCA CAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGTGTTTCAGGATGATTCTTGTCTCTGGATGTCGCTGTCATGAT GGGAGAGGAATTAGTAAATTCCCAGGTCAGTTTACACTGCAGAGTGATCTTGATCTGCATGAATCAGTAAGGATGGGCTGGATAAACAAG TTGGAACCACAGTTATGAGTACCATGACATTAACTGAAACAAATGAGAAGGGATTGAAAAATCGGCGGTTAAGTGTCTTTTAAGGTCATT TCCAACAAAACTACAAAGGACCTATGAAAGGCTTTTCAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGA TCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTA CTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTG CAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCA TGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGG ATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGA AAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGG ATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGA CAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATG AAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATC ACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAA CAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCC TGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTCAAACGAATAAAAAAGAGAAAGTCTGGT >67349_67349_7_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397026_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=326AA_BP=0 MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC -------------------------------------------------------------- >67349_67349_8_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000539812_CRYBA4_chr22_27019198_ENST00000354760_length(transcript)=1201nt_BP=464nt GAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGA TGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCA CTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATG ACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGC CTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTT GTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGC TTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTC TGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCT GTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCC TCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAG GATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGC AGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGT GGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTC >67349_67349_8_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000539812_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=315AA_BP=132 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PPARG-CRYBA4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 205_280 | 160.0 | 506.0 | FAM120B |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 205_280 | 132.0 | 478.0 | FAM120B |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 205_280 | 132.0 | 478.0 | FAM120B |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 205_280 | 132.0 | 478.0 | FAM120B |
Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 205_280 | 132.0 | 478.0 | FAM120B |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PPARG-CRYBA4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PPARG-CRYBA4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |