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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPCDC-SCAMP2 (FusionGDB2 ID:67365)

Fusion Gene Summary for PPCDC-SCAMP2

Fusion gene summary

Fusion gene information	Fusion gene name: PPCDC-SCAMP2
	Fusion gene ID: 67365
		Hgene	Tgene
	Gene symbol	PPCDC	SCAMP2
	Gene ID	60490	10066
	Gene name	phosphopantothenoylcysteine decarboxylase	secretory carrier membrane protein 2
	Synonyms	MDS018\|PPC-DC\|coaC	-
	Cytomap	15q24.2	15q24.1
	Type of gene	protein-coding	protein-coding
	Description	phosphopantothenoylcysteine decarboxylase	secretory carrier-associated membrane protein 2testis secretory sperm-binding protein Li 219p
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000342932, ENST00000564923, ENST00000568649, ENST00000567336, ENST00000563298, ENST00000563393,	ENST00000268099,
Fusion gene scores	* DoF score	6 X 4 X 6=144	6 X 6 X 5=180
	# samples	7	6
	** MAII score	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPCDC [Title/Abstract] AND SCAMP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPCDC(75320794)-SCAMP2(75146990), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPCDC	GO:0015937	coenzyme A biosynthetic process	11923312
Tgene	SCAMP2	GO:0015031	protein transport	15840657

Fusion gene breakpoints across PPCDC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCAMP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0AM-01A	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-
ChimerDB4	BRCA	TCGA-AN-A0AM-01A	PPCDC	chr15	75320794	-	SCAMP2	chr15	75146990	-
ChimerDB4	BRCA	TCGA-AN-A0AM-01A	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-

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Fusion Gene ORF analysis for PPCDC-SCAMP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000342932	ENST00000268099	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-
5UTR-3CDS	ENST00000564923	ENST00000268099	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-
5UTR-3CDS	ENST00000568649	ENST00000268099	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-
In-frame	ENST00000342932	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-
In-frame	ENST00000564923	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-
In-frame	ENST00000567336	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-
In-frame	ENST00000568649	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-
intron-3CDS	ENST00000563298	ENST00000268099	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-
intron-3CDS	ENST00000563298	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-
intron-3CDS	ENST00000563393	ENST00000268099	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-
intron-3CDS	ENST00000563393	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-
intron-3CDS	ENST00000567336	ENST00000268099	PPCDC	chr15	75315967	+	SCAMP2	chr15	75146990	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000342932	PPCDC	chr15	75320794	+	ENST00000268099	SCAMP2	chr15	75146990	-	2565	279	63	1211	382
ENST00000564923	PPCDC	chr15	75320794	+	ENST00000268099	SCAMP2	chr15	75146990	-	2533	247	31	1179	382
ENST00000568649	PPCDC	chr15	75320794	+	ENST00000268099	SCAMP2	chr15	75146990	-	2515	229	13	1161	382
ENST00000567336	PPCDC	chr15	75320794	+	ENST00000268099	SCAMP2	chr15	75146990	-	2491	205	70	1137	355

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000342932	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-	0.07566861	0.9243314
ENST00000564923	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-	0.0754202	0.9245798
ENST00000568649	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-	0.07712508	0.9228749
ENST00000567336	ENST00000268099	PPCDC	chr15	75320794	+	SCAMP2	chr15	75146990	-	0.07401617	0.92598385

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Fusion Genomic Features for PPCDC-SCAMP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPCDC-SCAMP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:75320794/chr15:75146990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

175_181

330.0

Topological domain

Lumenal

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

240_262

330.0

Topological domain

Lumenal

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

284_329

330.0

Topological domain

Cytoplasmic

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

154_174

330.0

Transmembrane

Helical

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

182_202

330.0

Transmembrane

Helical

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

219_239

330.0

Transmembrane

Helical

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

263_283

330.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPCDC

chr15:75320794

chr15:75146990

ENST00000342932

104_107

205.0

Nucleotide binding

FMN

Tgene

SCAMP2

chr15:75320794

chr15:75146990

ENST00000268099

1_153

330.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for PPCDC-SCAMP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>67365_67365_1_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000342932_SCAMP2_chr15_75146990_ENST00000268099_length(transcript)=2565nt_BP=279nt
AGTCAGATTCCGCGGGAGAGCGGCAGAGATACCGCGATATTTGGGAGCGGCCCCGAGACGCGCCTGGCGCGGATCCTAAATCCCGACAGC
TTTATAGAGCCCAGGCCTGGCAGGCTCCCAGAACTTGAAGCCACCAGACCCCACATGGAACCAAAGGCCTCCTGTCCAGCTGCTGCACCC
TTGATGGAGAGAAAATTCCATGTTCTTGTGGGTGTCACGGGGAGTGTCGCAGCCCTGAAGTTGCCTCTTCTGGTGTCAAAGCTTTTGGAC
ATTCCTGGGGATCCCTCTGTGACCCAGCTGACCAACGCCCCGCAGGGCGGCCTGGCGGAATTCAACCCCTTCTCAGAGACAAATGCAGCG
ACAACAGTTCCTGTCACCCAACTCCCTGGGTCCTCACAGCCAGCGGTTCTCCAGCCATCAGTGGAACCAACCCAGCCGACCCCCCAGGCC
GTGGTGTCTGCAGCCCAGGCAGGCCTGCTCCGGCAGCAGGAAGAACTGGACAGGAAAGCTGCCGAGCTGGAACGCAAGGAGCGGGAGCTG
CAGAACACTGTAGCCAACTTGCATGTGAGACAGAACAACTGGCCCCCTCTGCCCTCGTGGTGCCCTGTGAAGCCCTGCTTCTATCAGGAT
TTCTCCACAGAGATCCCTGCCGACTACCAGCGGATATGCAAGATGCTCTACTATCTGTGGATGTTGCATTCAGTGACTCTGTTTCTGAAC
CTGCTTGCCTGCCTGGCCTGGTTCTCGGGCAACAGCTCCAAGGGAGTGGACTTTGGCCTCTCCATCCTGTGGTTTCTGATCTTCACTCCC
TGTGCCTTCCTTTGTTGGTACCGACCCATCTATAAGGCCTTTAGGTCCGACAACTCTTTCAGCTTCTTTGTGTTCTTCTTTGTATTTTTT
TGTCAAATAGGGATCTACATCATCCAGTTGGTTGGCATCCCTGGCCTGGGGGACAGCGGTTGGATTGCAGCCCTGTCTACACTGGATAAT
CATTCCCTGGCCATATCAGTCATCATGATGGTGGTGGCTGGCTTCTTCACCCTCTGTGCCGTGCTCTCAGTCTTCCTCCTGCAGCGGGTG
CACTCCCTCTACCGACGGACAGGGGCCAGCTTCCAGCAGGCCCAGGAGGAGTTTTCCCAGGGCATCTTCAGCAGCAGAACCTTCCACAGA
GCTGCTTCATCTGCTGCCCAAGGAGCCTTCCAGGGGAATTAGTCCTCCTCTCTTCTCTCCCCCTCAGCCTTTCTCTCGCCTGCCTTCTGA
GCTGCACTTTCCGTGGGTGCCTTATGTGGTGGTGGTTGTGCCCAGCACAGACCTGGCAGGGTTCTTGCCGTGGCTCTTCCTCCTCCCTCA
GCGACCAGCTCTCCCTGGAACGGGAGGGACAGGGAATTTTTTCCCCCTCTATGTACAAAAAAAAACAAAGCTCTCTTTCCTTCTCTGGTG
ATGGTTTGGTAGGATTCTTTTGTCTCTGGAAGCAGTGGGACTGAAGTTCTCTTCGTCCTGTGCACACACAGACACCCCCACACAGTTGGG
ATCACAGGCTGACCTGGGCCCATCCCAGCTGGAGCTTTCTGCCAGGGTCCTGGGCCTTGACTCCCCCACCCTGCAGGCCTGGCCTGAATC
TGGCTTCTTAGACACAGCCCAGTCCTTCCTGCCTGGGCTGGGAATAAGCCTCTCACAGGTTCTGGTGGACAGATCTGTTCCCCAGGTCAC
TCCAGTGGTCTCCAGGCTTCCAGAGAAGGCTGGTTGCCTCAAGCTCTTCTCTGCCTCATAAACGGATCCAGAGAAGGCTGGTTGCCTTAA
GCTCTTCCCTGCCTCGTGTTCCTGAGAAACGGATTAATAGCCCTTTATCCCCCTGCACCCTCCTGCAGGGGATGGCACTTTGAGCCCTCT
GGAGCCCTCCCCTTGCTGAGCCTTACTCTCTTCAGACTTTCTGAATGTACAATGCCGTTGGTTGGGATTTGGGGACTGGAAGGGACCAAG
GACACTGACCCCAAGCTGTCCTGCCTAGCGTCCAGCGTCTTCTAGGAGGGTGGGGTCTGCCTGTCCTGGTGTGGTTGGTTTGGCCCTGTT
TGCTGTGACTACCCCCCCCCCTCCCCGAACCGAGGGACGGCTGCCTTTGTCTCTGCCTCAGATGCCACCTGCCCCGCCCATGCTCCCCAT
CAGCAGCATCCAGACTTTCAGGAAGGGCAGGGCCAGCCAGTCCAGAACCGCATCCCTCAGCAGGGACTGATAAGCCATCTCTCGGAGGGC
CCCCTAATACCCAGTGGAGTCTGGTTCACACCCTGGGGGGTGTGTCACTGTGATGGGACACGTAGGAGTCCACCCTTAAAACCAGCACCC
TGTCCCTCGAGGCTGCCGAGTGGGTGTGTGGACTGGGGTGCCTTCCCACAAAACTAGCCTCCGGCTCTGGGCCCGAGACAGCCGCAGGCC
CCAGCCACTGAATGATACTGGCAGCGGCTGGGGTTTTATGAACTCCTTTCTGGTATTTTTTCCCCTCTATGTACAAATGTATATGTTACG

>67365_67365_1_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000342932_SCAMP2_chr15_75146990_ENST00000268099_length(amino acids)=382AA_BP=72
MARILNPDSFIEPRPGRLPELEATRPHMEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGDPSVTQLTNAPQGGLAEF
NPFSETNAATTVPVTQLPGSSQPAVLQPSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWC
PVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFS
FFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHSLAISVIMMVVAGFFTLCAVLSVFLLQRVHSLYRRTGASFQQAQEEFSQG

--------------------------------------------------------------
>67365_67365_2_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000564923_SCAMP2_chr15_75146990_ENST00000268099_length(transcript)=2533nt_BP=247nt
CGCGATATTTGGGAGCGGCCCCGAGACGCGCCTGGCGCGGATCCTAAATCCCGACAGCTTTATAGAGCCCAGGCCTGGCAGGCTCCCAGA
ACTTGAAGCCACCAGACCCCACATGGAACCAAAGGCCTCCTGTCCAGCTGCTGCACCCTTGATGGAGAGAAAATTCCATGTTCTTGTGGG
TGTCACGGGGAGTGTCGCAGCCCTGAAGTTGCCTCTTCTGGTGTCAAAGCTTTTGGACATTCCTGGGGATCCCTCTGTGACCCAGCTGAC
CAACGCCCCGCAGGGCGGCCTGGCGGAATTCAACCCCTTCTCAGAGACAAATGCAGCGACAACAGTTCCTGTCACCCAACTCCCTGGGTC
CTCACAGCCAGCGGTTCTCCAGCCATCAGTGGAACCAACCCAGCCGACCCCCCAGGCCGTGGTGTCTGCAGCCCAGGCAGGCCTGCTCCG
GCAGCAGGAAGAACTGGACAGGAAAGCTGCCGAGCTGGAACGCAAGGAGCGGGAGCTGCAGAACACTGTAGCCAACTTGCATGTGAGACA
GAACAACTGGCCCCCTCTGCCCTCGTGGTGCCCTGTGAAGCCCTGCTTCTATCAGGATTTCTCCACAGAGATCCCTGCCGACTACCAGCG
GATATGCAAGATGCTCTACTATCTGTGGATGTTGCATTCAGTGACTCTGTTTCTGAACCTGCTTGCCTGCCTGGCCTGGTTCTCGGGCAA
CAGCTCCAAGGGAGTGGACTTTGGCCTCTCCATCCTGTGGTTTCTGATCTTCACTCCCTGTGCCTTCCTTTGTTGGTACCGACCCATCTA
TAAGGCCTTTAGGTCCGACAACTCTTTCAGCTTCTTTGTGTTCTTCTTTGTATTTTTTTGTCAAATAGGGATCTACATCATCCAGTTGGT
TGGCATCCCTGGCCTGGGGGACAGCGGTTGGATTGCAGCCCTGTCTACACTGGATAATCATTCCCTGGCCATATCAGTCATCATGATGGT
GGTGGCTGGCTTCTTCACCCTCTGTGCCGTGCTCTCAGTCTTCCTCCTGCAGCGGGTGCACTCCCTCTACCGACGGACAGGGGCCAGCTT
CCAGCAGGCCCAGGAGGAGTTTTCCCAGGGCATCTTCAGCAGCAGAACCTTCCACAGAGCTGCTTCATCTGCTGCCCAAGGAGCCTTCCA
GGGGAATTAGTCCTCCTCTCTTCTCTCCCCCTCAGCCTTTCTCTCGCCTGCCTTCTGAGCTGCACTTTCCGTGGGTGCCTTATGTGGTGG
TGGTTGTGCCCAGCACAGACCTGGCAGGGTTCTTGCCGTGGCTCTTCCTCCTCCCTCAGCGACCAGCTCTCCCTGGAACGGGAGGGACAG
GGAATTTTTTCCCCCTCTATGTACAAAAAAAAACAAAGCTCTCTTTCCTTCTCTGGTGATGGTTTGGTAGGATTCTTTTGTCTCTGGAAG
CAGTGGGACTGAAGTTCTCTTCGTCCTGTGCACACACAGACACCCCCACACAGTTGGGATCACAGGCTGACCTGGGCCCATCCCAGCTGG
AGCTTTCTGCCAGGGTCCTGGGCCTTGACTCCCCCACCCTGCAGGCCTGGCCTGAATCTGGCTTCTTAGACACAGCCCAGTCCTTCCTGC
CTGGGCTGGGAATAAGCCTCTCACAGGTTCTGGTGGACAGATCTGTTCCCCAGGTCACTCCAGTGGTCTCCAGGCTTCCAGAGAAGGCTG
GTTGCCTCAAGCTCTTCTCTGCCTCATAAACGGATCCAGAGAAGGCTGGTTGCCTTAAGCTCTTCCCTGCCTCGTGTTCCTGAGAAACGG
ATTAATAGCCCTTTATCCCCCTGCACCCTCCTGCAGGGGATGGCACTTTGAGCCCTCTGGAGCCCTCCCCTTGCTGAGCCTTACTCTCTT
CAGACTTTCTGAATGTACAATGCCGTTGGTTGGGATTTGGGGACTGGAAGGGACCAAGGACACTGACCCCAAGCTGTCCTGCCTAGCGTC
CAGCGTCTTCTAGGAGGGTGGGGTCTGCCTGTCCTGGTGTGGTTGGTTTGGCCCTGTTTGCTGTGACTACCCCCCCCCCTCCCCGAACCG
AGGGACGGCTGCCTTTGTCTCTGCCTCAGATGCCACCTGCCCCGCCCATGCTCCCCATCAGCAGCATCCAGACTTTCAGGAAGGGCAGGG
CCAGCCAGTCCAGAACCGCATCCCTCAGCAGGGACTGATAAGCCATCTCTCGGAGGGCCCCCTAATACCCAGTGGAGTCTGGTTCACACC
CTGGGGGGTGTGTCACTGTGATGGGACACGTAGGAGTCCACCCTTAAAACCAGCACCCTGTCCCTCGAGGCTGCCGAGTGGGTGTGTGGA
CTGGGGTGCCTTCCCACAAAACTAGCCTCCGGCTCTGGGCCCGAGACAGCCGCAGGCCCCAGCCACTGAATGATACTGGCAGCGGCTGGG
GTTTTATGAACTCCTTTCTGGTATTTTTTCCCCTCTATGTACAAATGTATATGTTACGTCTCAATTTTTGTGCTTAAGTAAAAATAAAAA

>67365_67365_2_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000564923_SCAMP2_chr15_75146990_ENST00000268099_length(amino acids)=382AA_BP=72
MARILNPDSFIEPRPGRLPELEATRPHMEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGDPSVTQLTNAPQGGLAEF
NPFSETNAATTVPVTQLPGSSQPAVLQPSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWC
PVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFS
FFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHSLAISVIMMVVAGFFTLCAVLSVFLLQRVHSLYRRTGASFQQAQEEFSQG

--------------------------------------------------------------
>67365_67365_3_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000567336_SCAMP2_chr15_75146990_ENST00000268099_length(transcript)=2491nt_BP=205nt
CCTAAATCCCGACAGCTTTATAGAGCCCAGGCCTGGCAGGCTCCCAGAACTTGAAGCCACCAGACCCCACATGGAACCAAAGGCCTCCTG
TCCAGCTGCTGCACCCTTGATGGAGAGAAAATTCCATGTTCTTGTGGGTGTCACGGGGAGTGTCGCAGCCCTGAAGTTGCCTCTTCTGGT
GTCAAAGCTTTTGGACATTCCTGGGGATCCCTCTGTGACCCAGCTGACCAACGCCCCGCAGGGCGGCCTGGCGGAATTCAACCCCTTCTC
AGAGACAAATGCAGCGACAACAGTTCCTGTCACCCAACTCCCTGGGTCCTCACAGCCAGCGGTTCTCCAGCCATCAGTGGAACCAACCCA
GCCGACCCCCCAGGCCGTGGTGTCTGCAGCCCAGGCAGGCCTGCTCCGGCAGCAGGAAGAACTGGACAGGAAAGCTGCCGAGCTGGAACG
CAAGGAGCGGGAGCTGCAGAACACTGTAGCCAACTTGCATGTGAGACAGAACAACTGGCCCCCTCTGCCCTCGTGGTGCCCTGTGAAGCC
CTGCTTCTATCAGGATTTCTCCACAGAGATCCCTGCCGACTACCAGCGGATATGCAAGATGCTCTACTATCTGTGGATGTTGCATTCAGT
GACTCTGTTTCTGAACCTGCTTGCCTGCCTGGCCTGGTTCTCGGGCAACAGCTCCAAGGGAGTGGACTTTGGCCTCTCCATCCTGTGGTT
TCTGATCTTCACTCCCTGTGCCTTCCTTTGTTGGTACCGACCCATCTATAAGGCCTTTAGGTCCGACAACTCTTTCAGCTTCTTTGTGTT
CTTCTTTGTATTTTTTTGTCAAATAGGGATCTACATCATCCAGTTGGTTGGCATCCCTGGCCTGGGGGACAGCGGTTGGATTGCAGCCCT
GTCTACACTGGATAATCATTCCCTGGCCATATCAGTCATCATGATGGTGGTGGCTGGCTTCTTCACCCTCTGTGCCGTGCTCTCAGTCTT
CCTCCTGCAGCGGGTGCACTCCCTCTACCGACGGACAGGGGCCAGCTTCCAGCAGGCCCAGGAGGAGTTTTCCCAGGGCATCTTCAGCAG
CAGAACCTTCCACAGAGCTGCTTCATCTGCTGCCCAAGGAGCCTTCCAGGGGAATTAGTCCTCCTCTCTTCTCTCCCCCTCAGCCTTTCT
CTCGCCTGCCTTCTGAGCTGCACTTTCCGTGGGTGCCTTATGTGGTGGTGGTTGTGCCCAGCACAGACCTGGCAGGGTTCTTGCCGTGGC
TCTTCCTCCTCCCTCAGCGACCAGCTCTCCCTGGAACGGGAGGGACAGGGAATTTTTTCCCCCTCTATGTACAAAAAAAAACAAAGCTCT
CTTTCCTTCTCTGGTGATGGTTTGGTAGGATTCTTTTGTCTCTGGAAGCAGTGGGACTGAAGTTCTCTTCGTCCTGTGCACACACAGACA
CCCCCACACAGTTGGGATCACAGGCTGACCTGGGCCCATCCCAGCTGGAGCTTTCTGCCAGGGTCCTGGGCCTTGACTCCCCCACCCTGC
AGGCCTGGCCTGAATCTGGCTTCTTAGACACAGCCCAGTCCTTCCTGCCTGGGCTGGGAATAAGCCTCTCACAGGTTCTGGTGGACAGAT
CTGTTCCCCAGGTCACTCCAGTGGTCTCCAGGCTTCCAGAGAAGGCTGGTTGCCTCAAGCTCTTCTCTGCCTCATAAACGGATCCAGAGA
AGGCTGGTTGCCTTAAGCTCTTCCCTGCCTCGTGTTCCTGAGAAACGGATTAATAGCCCTTTATCCCCCTGCACCCTCCTGCAGGGGATG
GCACTTTGAGCCCTCTGGAGCCCTCCCCTTGCTGAGCCTTACTCTCTTCAGACTTTCTGAATGTACAATGCCGTTGGTTGGGATTTGGGG
ACTGGAAGGGACCAAGGACACTGACCCCAAGCTGTCCTGCCTAGCGTCCAGCGTCTTCTAGGAGGGTGGGGTCTGCCTGTCCTGGTGTGG
TTGGTTTGGCCCTGTTTGCTGTGACTACCCCCCCCCCTCCCCGAACCGAGGGACGGCTGCCTTTGTCTCTGCCTCAGATGCCACCTGCCC
CGCCCATGCTCCCCATCAGCAGCATCCAGACTTTCAGGAAGGGCAGGGCCAGCCAGTCCAGAACCGCATCCCTCAGCAGGGACTGATAAG
CCATCTCTCGGAGGGCCCCCTAATACCCAGTGGAGTCTGGTTCACACCCTGGGGGGTGTGTCACTGTGATGGGACACGTAGGAGTCCACC
CTTAAAACCAGCACCCTGTCCCTCGAGGCTGCCGAGTGGGTGTGTGGACTGGGGTGCCTTCCCACAAAACTAGCCTCCGGCTCTGGGCCC
GAGACAGCCGCAGGCCCCAGCCACTGAATGATACTGGCAGCGGCTGGGGTTTTATGAACTCCTTTCTGGTATTTTTTCCCCTCTATGTAC

>67365_67365_3_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000567336_SCAMP2_chr15_75146990_ENST00000268099_length(amino acids)=355AA_BP=45
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGDPSVTQLTNAPQGGLAEFNPFSETNAATTVPVTQLPGSSQPAVLQ
PSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYY
LWMLHSVTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYIIQLVGIPGLGD

--------------------------------------------------------------
>67365_67365_4_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000568649_SCAMP2_chr15_75146990_ENST00000268099_length(transcript)=2515nt_BP=229nt
CCCCGAGACGCGCCTGGCGCGGATCCTAAATCCCGACAGCTTTATAGAGCCCAGGCCTGGCAGGCTCCCAGAACTTGAAGCCACCAGACC
CCACATGGAACCAAAGGCCTCCTGTCCAGCTGCTGCACCCTTGATGGAGAGAAAATTCCATGTTCTTGTGGGTGTCACGGGGAGTGTCGC
AGCCCTGAAGTTGCCTCTTCTGGTGTCAAAGCTTTTGGACATTCCTGGGGATCCCTCTGTGACCCAGCTGACCAACGCCCCGCAGGGCGG
CCTGGCGGAATTCAACCCCTTCTCAGAGACAAATGCAGCGACAACAGTTCCTGTCACCCAACTCCCTGGGTCCTCACAGCCAGCGGTTCT
CCAGCCATCAGTGGAACCAACCCAGCCGACCCCCCAGGCCGTGGTGTCTGCAGCCCAGGCAGGCCTGCTCCGGCAGCAGGAAGAACTGGA
CAGGAAAGCTGCCGAGCTGGAACGCAAGGAGCGGGAGCTGCAGAACACTGTAGCCAACTTGCATGTGAGACAGAACAACTGGCCCCCTCT
GCCCTCGTGGTGCCCTGTGAAGCCCTGCTTCTATCAGGATTTCTCCACAGAGATCCCTGCCGACTACCAGCGGATATGCAAGATGCTCTA
CTATCTGTGGATGTTGCATTCAGTGACTCTGTTTCTGAACCTGCTTGCCTGCCTGGCCTGGTTCTCGGGCAACAGCTCCAAGGGAGTGGA
CTTTGGCCTCTCCATCCTGTGGTTTCTGATCTTCACTCCCTGTGCCTTCCTTTGTTGGTACCGACCCATCTATAAGGCCTTTAGGTCCGA
CAACTCTTTCAGCTTCTTTGTGTTCTTCTTTGTATTTTTTTGTCAAATAGGGATCTACATCATCCAGTTGGTTGGCATCCCTGGCCTGGG
GGACAGCGGTTGGATTGCAGCCCTGTCTACACTGGATAATCATTCCCTGGCCATATCAGTCATCATGATGGTGGTGGCTGGCTTCTTCAC
CCTCTGTGCCGTGCTCTCAGTCTTCCTCCTGCAGCGGGTGCACTCCCTCTACCGACGGACAGGGGCCAGCTTCCAGCAGGCCCAGGAGGA
GTTTTCCCAGGGCATCTTCAGCAGCAGAACCTTCCACAGAGCTGCTTCATCTGCTGCCCAAGGAGCCTTCCAGGGGAATTAGTCCTCCTC
TCTTCTCTCCCCCTCAGCCTTTCTCTCGCCTGCCTTCTGAGCTGCACTTTCCGTGGGTGCCTTATGTGGTGGTGGTTGTGCCCAGCACAG
ACCTGGCAGGGTTCTTGCCGTGGCTCTTCCTCCTCCCTCAGCGACCAGCTCTCCCTGGAACGGGAGGGACAGGGAATTTTTTCCCCCTCT
ATGTACAAAAAAAAACAAAGCTCTCTTTCCTTCTCTGGTGATGGTTTGGTAGGATTCTTTTGTCTCTGGAAGCAGTGGGACTGAAGTTCT
CTTCGTCCTGTGCACACACAGACACCCCCACACAGTTGGGATCACAGGCTGACCTGGGCCCATCCCAGCTGGAGCTTTCTGCCAGGGTCC
TGGGCCTTGACTCCCCCACCCTGCAGGCCTGGCCTGAATCTGGCTTCTTAGACACAGCCCAGTCCTTCCTGCCTGGGCTGGGAATAAGCC
TCTCACAGGTTCTGGTGGACAGATCTGTTCCCCAGGTCACTCCAGTGGTCTCCAGGCTTCCAGAGAAGGCTGGTTGCCTCAAGCTCTTCT
CTGCCTCATAAACGGATCCAGAGAAGGCTGGTTGCCTTAAGCTCTTCCCTGCCTCGTGTTCCTGAGAAACGGATTAATAGCCCTTTATCC
CCCTGCACCCTCCTGCAGGGGATGGCACTTTGAGCCCTCTGGAGCCCTCCCCTTGCTGAGCCTTACTCTCTTCAGACTTTCTGAATGTAC
AATGCCGTTGGTTGGGATTTGGGGACTGGAAGGGACCAAGGACACTGACCCCAAGCTGTCCTGCCTAGCGTCCAGCGTCTTCTAGGAGGG
TGGGGTCTGCCTGTCCTGGTGTGGTTGGTTTGGCCCTGTTTGCTGTGACTACCCCCCCCCCTCCCCGAACCGAGGGACGGCTGCCTTTGT
CTCTGCCTCAGATGCCACCTGCCCCGCCCATGCTCCCCATCAGCAGCATCCAGACTTTCAGGAAGGGCAGGGCCAGCCAGTCCAGAACCG
CATCCCTCAGCAGGGACTGATAAGCCATCTCTCGGAGGGCCCCCTAATACCCAGTGGAGTCTGGTTCACACCCTGGGGGGTGTGTCACTG
TGATGGGACACGTAGGAGTCCACCCTTAAAACCAGCACCCTGTCCCTCGAGGCTGCCGAGTGGGTGTGTGGACTGGGGTGCCTTCCCACA
AAACTAGCCTCCGGCTCTGGGCCCGAGACAGCCGCAGGCCCCAGCCACTGAATGATACTGGCAGCGGCTGGGGTTTTATGAACTCCTTTC

>67365_67365_4_PPCDC-SCAMP2_PPCDC_chr15_75320794_ENST00000568649_SCAMP2_chr15_75146990_ENST00000268099_length(amino acids)=382AA_BP=72
MARILNPDSFIEPRPGRLPELEATRPHMEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGDPSVTQLTNAPQGGLAEF
NPFSETNAATTVPVTQLPGSSQPAVLQPSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWC
PVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFS
FFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHSLAISVIMMVVAGFFTLCAVLSVFLLQRVHSLYRRTGASFQQAQEEFSQG

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Top

Fusion Gene PPI Analysis for PPCDC-SCAMP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SCAMP2	chr15:75320794	chr15:75146990	ENST00000268099		0	9	203_218	19.0	330.0	SLC9A7

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPCDC-SCAMP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPCDC-SCAMP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source