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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPFIBP1-HP1BP3 (FusionGDB2 ID:67456)

Fusion Gene Summary for PPFIBP1-HP1BP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPFIBP1-HP1BP3
Fusion gene ID: 67456
HgeneTgene
Gene symbol

PPFIBP1

HP1BP3

Gene ID

8496

50809

Gene namePPFIA binding protein 1heterochromatin protein 1 binding protein 3
SynonymsL2|SGT2|hSGT2|hSgt2pHP1-BP74|HP1BP74
Cytomap

12p11.23-p11.22

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionliprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1heterochromatin protein 1-binding protein 3
Modification date2020031320200313
UniProtAcc.

Q5SSJ5

Ensembl transtripts involved in fusion geneENST00000228425, ENST00000318304, 
ENST00000537927, ENST00000542629, 
ENST00000535047, ENST00000541633, 
ENST00000545334, 		ENST00000375003, 
ENST00000375000, ENST00000487117, 
ENST00000312239, 
Fusion gene scores* DoF score20 X 14 X 13=364022 X 14 X 10=3080
# samples 2624
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3080*10)=-3.68182403997374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPFIBP1 [Title/Abstract] AND HP1BP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPFIBP1(27825416)-HP1BP3(21100103), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHP1BP3

GO:0071456

cellular response to hypoxia

25100860


check buttonFusion gene breakpoints across PPFIBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HP1BP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15L-01APPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-


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Fusion Gene ORF analysis for PPFIBP1-HP1BP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000228425ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-5UTRENST00000318304ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-5UTRENST00000537927ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-5UTRENST00000542629ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000228425ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000228425ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000318304ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000318304ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000537927ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000537927ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000542629ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
5CDS-intronENST00000542629ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
In-frameENST00000228425ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
In-frameENST00000318304ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
In-frameENST00000537927ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
In-frameENST00000542629ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-3CDSENST00000535047ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-3CDSENST00000541633ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-3CDSENST00000545334ENST00000312239PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-5UTRENST00000535047ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-5UTRENST00000541633ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-5UTRENST00000545334ENST00000375003PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-intronENST00000535047ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-intronENST00000535047ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-intronENST00000541633ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-intronENST00000541633ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-intronENST00000545334ENST00000375000PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-
intron-intronENST00000545334ENST00000487117PPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537927PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-482013722572683808
ENST00000318304PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-510116532502964904
ENST00000542629PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-499015422322853873
ENST00000228425PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-500015522002863887

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537927ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0004316630.9995683
ENST00000318304ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0004707560.99952924
ENST00000542629ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0006095050.9993905
ENST00000228425ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0006407060.9993593

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Fusion Genomic Features for PPFIBP1-HP1BP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPFIBP1-HP1BP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:27825416/chr1:21100103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HP1BP3

Q5SSJ5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530156_4054391006.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529156_4054561012.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428156_405425981.0Coiled coilOntology_term=ECO:0000255
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313454_553116554.0Compositional biasNote=Lys-rich
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005454_5530134.0Compositional biasNote=Lys-rich
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309454_5530402.0Compositional biasNote=Lys-rich
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313157_232116554.0DomainH15 1
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313255_330116554.0DomainH15 2
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313337_413116554.0DomainH15 3
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005157_2320134.0DomainH15 1
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005255_3300134.0DomainH15 2
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005337_4130134.0DomainH15 3
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309157_2320402.0DomainH15 1
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309255_3300402.0DomainH15 2
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309337_4130402.0DomainH15 3
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313255_259116554.0MotifPxVxL motif
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005255_2590134.0MotifPxVxL motif
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309255_2590402.0MotifPxVxL motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16156_4050171.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327156_405303859.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530647_7114391006.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530719_7824391006.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530804_8764391006.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529647_7114561012.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529719_7824561012.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529804_8764561012.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16647_7110171.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16719_7820171.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16804_8760171.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327647_711303859.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327719_782303859.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327804_876303859.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428647_711425981.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428719_782425981.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428804_876425981.0DomainSAM 3


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Fusion Gene Sequence for PPFIBP1-HP1BP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67456_67456_1_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000228425_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=5000nt_BP=1552nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTC
AGTATGAAAAAAAGCTTAAATCAACCAAAGATGAACTGGCATCTTTAAAAGAACAACTAGAAGAAAAGGAATCTGAAGTAAAAAGGCTAC
AAGAAAAATTGGTTTGCAAGATGAAAGGAGAAGGGGTTGAAATTGTTGATAGAGATGAAAATTTTAAAAAGAAGCTCAAAGAAAAAAACA
TCGAAGTACAAAAAATGAAAAAAGCTGTGGAGTCCTTGATGGCAGCAAATGAAGAAAAGGATCGGAAAATAGAAGATCTTCGACAGTGCC
TGAACAGGTACAAGAAAATGCAAGACACGGTGGTACTGGCCCAAGGTAAAAAAGGCAAAGATGGAGAATATGAAGAGCTGCTCAATTCCA
GTTCCATCTCCTCTTTGCTGGATGCACAGGGTTTCAGTGATCTGGAGAAAAGTCCATCACCCACTCCAGTAATGGGATCTCCCAGTTGTG
ACCCATTTAACACAAGTGTTCCCGAAGAGTTCCATACTACCATCTTGCAAGTTTCCATCCCTTCATTATTGCCAGCAACTGTAAGCATGG
AAACTTCTGAAAAATCAAAGTTGACTCCTAAGCCAGAGACTTCATTTGAAGAAAATGATGGAAACATAATCCTTGGTGCCACTGTTGATA
CCCAACTGTGTGATAAACTTTTTGAGAAAGATCAGTCTAAAGAAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTT
CTGCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCCCAAGATGGATGCAATCTTAACTGAGGCCATTA
AGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGG
GTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTG
TGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGG
AGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATC
CTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCA
AAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCA
TTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATC
AAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCC
AGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATG
AGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCG
CATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTC
CTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCA
GTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAA
GGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTC
CCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCT
TGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGT
TGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAA
CGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTAT
AGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCA
AAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGC
CCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGA
CGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTT
CAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTT
GGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCC
TGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCA
AAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCT
TGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCC
CAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCT
CAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATAT
TTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGA
AAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCA
AGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTA
TTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACA
TTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACT
TTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTG
ATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGA

>67456_67456_1_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000228425_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=887AA_BP=451
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKDELASLKEQLEEKESEVKRLQEKLVCK
MKGEGVEIVDRDENFKKKLKEKNIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKKGKDGEYEELLNSSSISSLL
DAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKL
FEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQA
LKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDI
RPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKK
TLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRG

--------------------------------------------------------------
>67456_67456_2_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000318304_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=5101nt_BP=1653nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGA
GATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAATCTTTAATGGC
CAAACTTTCTAGCATGAAAATCAAGGTGGGTCAGATGCAGTATGAAAAGCAGCGGATGGAACAAAAATGGGAGTCACTGAAGGATGAACT
GGCATCTTTAAAAGAACAACTAGAAGAAAAGGAATCTGAAGTAAAAAGGCTACAAGAAAAATTGGTTTGCAAGATGAAAGGAGAAGGGGT
TGAAATTGTTGATAGAGACATCGAAGTACAAAAAATGAAAAAAGCTGTGGAGTCCTTGATGGCAGCAAATGAAGAAAAGGATCGGAAAAT
AGAAGATCTTCGACAGTGCCTGAACAGGTACAAGAAAATGCAAGACACGGTGGTACTGGCCCAAGGCAAAGATGGAGAATATGAAGAGCT
GCTCAATTCCAGTTCCATCTCCTCTTTGCTGGATGCACAGGGTTTCAGTGATCTGGAGAAAAGTCCATCACCCACTCCAGTAATGGGATC
TCCCAGTTGTGACCCATTTAACACAAGTGTTCCCGAAGAGTTCCATACTACCATCTTGCAAGTTTCCATCCCTTCATTATTGCCAGCAAC
TGTAAGCATGGAAACTTCTGAAAAATCAAAGTTGACTCCTAAGCCAGAGACTTCATTTGAAGAAAATGATGGAAACATAATCCTTGGTGC
CACTGTTGATACCCAACTGTGTGATAAACTTTTTGAGAAAGATCAGTCTAAAGAAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTG
GGCTACCCTTTCTGCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCCCAAGATGGATGCAATCTTAAC
TGAGGCCATTAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCT
GGAGAGAAGGGGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGG
AAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACA
AGTAAAATTGGAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTC
TCAGTATTATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACA
GATAACTGGCAAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAAT
CTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAA
TTCTAACTATCAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAG
TGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGA
AGATGAAGATGAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCC
AGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAA
GAAAGCACCTCCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAA
GCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTT
ATAGGAAAAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACA
TTATTTTCCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCT
GCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCC
CAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAA
AGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAG
ACTTCAGTTATAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTG
GGAATAAGCCAAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTAT
TTTTCACTGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCG
TTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAA
TTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGT
TTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGA
GCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTT
ACCAAAAATCAAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAG
TGGTGTGATCTTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCAC
ACGACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGA
TCCACTCACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATA
TTTTTTAATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAA
TGTTAAGTGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCAC
TTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTT
TCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGT
GGCACTTGACATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTA
TTCATTCCACTTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCAT
AATCATGTGTGATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTAC

>67456_67456_2_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000318304_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=904AA_BP=468
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKW
ESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGK
DGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEEND
GNIILGATVDTQLCDKLFEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIH
KYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYS
LIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVL
ENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQK
KTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSF

--------------------------------------------------------------
>67456_67456_3_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000537927_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=4820nt_BP=1372nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATT
TGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAATCTTTAATGGCCAAACTTTCTA
GCATGAAAATCAAGGTGGGTCAGATGCAGTATGAAAAGCAGCGGATGGAACAAAAATGGGAGTCACTGAAGGATGAACTGGCATCTTTAA
AAGAACAACTAGAAGAAAAGGAATCTGAAGTAAAAAGGCTACAAGAAAAATTGGTTTGCAAGATGAAAGGAGAAGGGGTTGAAATTGTTG
ATAGAGACATCGAAGTACAAAAAATGAAAAAAGCTGTGGAGTCCTTGATGGCAGCAAATGAAGAAAAGGATCGGAAAATAGAAGATCTTC
GACAGTGCCTGAACAGGTACAAGAAAATGCAAGACACGGTGGTACTGGCCCAAGGCAAAGATGGAGAATATGAAGAGCTGCTCAATTCCA
GTTCCATCTCCTCTTTGCTGGATGCACAGGGTTTCAGTGATCTGGAGAAAAGTCCATCACCCACTCCAGTAATGGGATCTCCCAGTTGTG
ACCCATTTAACACAAGTGTTCCCGAAGAGTTCCATACTACCATCTTGCAAGTTTCCATCCCTTCATTATTGCCAGCAACTGTAAGCATGG
AAACTTCTGAAAAATCAAAGTTGACTCCTAAGCCAGAGACTTCATTTGAAGAAAATGATGGAAACATAATCCTTGGTGCCACTGTTGATA
CCCAACTGTGTGATAAACTTTTTGAGAAAGATCAGTCTAAAGAAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTT
CTGCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCCCAAGATGGATGCAATCTTAACTGAGGCCATTA
AGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGG
GTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTG
TGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGG
AGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATC
CTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCA
AAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCA
TTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATC
AAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCC
AGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATG
AGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCG
CATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTC
CTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCA
GTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAA
GGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTC
CCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCT
TGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGT
TGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAA
CGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTAT
AGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCA
AAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGC
CCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGA
CGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTT
CAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTT
GGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCC
TGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCA
AAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCT
TGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCC
CAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCT
CAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATAT
TTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGA
AAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCA
AGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTA
TTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACA
TTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACT
TTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTG
ATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGA

>67456_67456_3_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000537927_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=808AA_BP=372
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDE
LASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEE
LLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILG
ATVDTQLCDKLFEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLE
LERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYV
SQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGT
NSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKS

--------------------------------------------------------------
>67456_67456_4_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000542629_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=4990nt_BP=1542nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTT
AAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGATGAACTGGCATCTTTAAAAGAACAACT
AGAAGAAAAGGAATCTGAAGTAAAAAGGCTACAAGAAAAATTGGTTTGCAAGATGAAAGGAGAAGGGGTTGAAATTGTTGATAGAGACAT
CGAAGTACAAAAAATGAAAAAAGCTGTGGAGTCCTTGATGGCAGCAAATGAAGAAAAGGATCGGAAAATAGAAGATCTTCGACAGTGCCT
GAACAGGTACAAGAAAATGCAAGACACGGTGGTACTGGCCCAAGGCAAAGATGGAGAATATGAAGAGCTGCTCAATTCCAGTTCCATCTC
CTCTTTGCTGGATGCACAGGGTTTCAGTGATCTGGAGAAAAGTCCATCACCCACTCCAGTAATGGGATCTCCCAGTTGTGACCCATTTAA
CACAAGTGTTCCCGAAGAGTTCCATACTACCATCTTGCAAGTTTCCATCCCTTCATTATTGCCAGCAACTGTAAGCATGGAAACTTCTGA
AAAATCAAAGTTGACTCCTAAGCCAGAGACTTCATTTGAAGAAAATGATGGAAACATAATCCTTGGTGCCACTGTTGATACCCAACTGTG
TGATAAACTTTTTGAGAAAGATCAGTCTAAAGAAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTTCTGCCAGCCA
GCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCCCAAGATGGATGCAATCTTAACTGAGGCCATTAAGGCATGCTT
CCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCT
TAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAA
ATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCT
CCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAG
AGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTC
GGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCAT
GAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTT
GCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTT
TCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGA
AGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAA
GCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAA
AACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAA
GGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATG
ATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAAC
ATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTT
AATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATG
GTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCA
GTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATA
ATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGT
GATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATT
GCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTG
CTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCG
AGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTG
GTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCC
CACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCT
TTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTG
CAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTT
TTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCA
AAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATG
AGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACA
GTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGC
TTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAG
TATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGT
CTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCT
GGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCAT
GAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGAAAAATATGAA

>67456_67456_4_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000542629_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=873AA_BP=437
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKDELASLKEQLEEKESEVKRLQEKLVCK
MKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSP
TPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLFEKDQSKEKEKKVK
KTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVK
GKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVE
RGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQI
SGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGK

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Fusion Gene PPI Analysis for PPFIBP1-HP1BP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPFIBP1-HP1BP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPFIBP1-HP1BP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource