FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PPFIBP1-NHP2L1 (FusionGDB2 ID:67459)

Fusion Gene Summary for PPFIBP1-NHP2L1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPFIBP1-NHP2L1
Fusion gene ID: 67459
HgeneTgene
Gene symbol

PPFIBP1

NHP2L1

Gene ID

8496

4809

Gene namePPFIA binding protein 1small nuclear ribonucleoprotein 13
SynonymsL2|SGT2|hSGT2|hSgt2p15.5K|FA-1|FA1|NHP2L1|NHPX|OTK27|SNRNP15-5|SPAG12|SSFA1
Cytomap

12p11.23-p11.22

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionliprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1NHP2-like protein 1NHP2 non-histone chromosome protein 2-like 1SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)U4/U6.U5 tri-snRNP 15.5 kDa protein[U4/U6.U5] tri-snRNP 15.5 kD RNA binding proteinhigh mobility group-like nuclear protein 2 homo
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000228425, ENST00000318304, 
ENST00000537927, ENST00000542629, 
ENST00000535047, ENST00000541633, 
ENST00000545334, 		ENST00000402458, 
ENST00000463675, ENST00000215956, 
ENST00000355257, ENST00000401959, 
Fusion gene scores* DoF score20 X 14 X 13=36405 X 3 X 5=75
# samples 266
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPFIBP1 [Title/Abstract] AND NHP2L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPFIBP1(27803074)-NHP2L1(42076368), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNHP2L1

GO:0000398

mRNA splicing, via spliceosome

28781166


check buttonFusion gene breakpoints across PPFIBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NHP2L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1536-01APPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-


Top

Fusion Gene ORF analysis for PPFIBP1-NHP2L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000228425ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000228425ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000318304ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000318304ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000537927ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000537927ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000542629ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
5CDS-5UTRENST00000542629ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000228425ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000228425ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000228425ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000318304ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000318304ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000318304ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000537927ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000537927ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000537927ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000542629ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000542629ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
In-frameENST00000542629ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000535047ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000535047ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000535047ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000541633ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000541633ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000541633ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000545334ENST00000215956PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000545334ENST00000355257PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-3CDSENST00000545334ENST00000401959PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-5UTRENST00000535047ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-5UTRENST00000535047ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-5UTRENST00000541633ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-5UTRENST00000541633ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-5UTRENST00000545334ENST00000402458PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-
intron-5UTRENST00000545334ENST00000463675PPFIBP1chr12

27803074

+NHP2L1chr22

42076368

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537927PPFIBP1chr1227803074+ENST00000355257NHP2L1chr2242076368-1992605257988243
ENST00000537927PPFIBP1chr1227803074+ENST00000215956NHP2L1chr2242076368-1968605257988243
ENST00000537927PPFIBP1chr1227803074+ENST00000401959NHP2L1chr2242076368-1955605257988243
ENST00000318304PPFIBP1chr1227803074+ENST00000355257NHP2L1chr2242076368-22738862501269339
ENST00000318304PPFIBP1chr1227803074+ENST00000215956NHP2L1chr2242076368-22498862501269339
ENST00000318304PPFIBP1chr1227803074+ENST00000401959NHP2L1chr2242076368-22368862501269339
ENST00000542629PPFIBP1chr1227803074+ENST00000355257NHP2L1chr2242076368-22558682321251339
ENST00000542629PPFIBP1chr1227803074+ENST00000215956NHP2L1chr2242076368-22318682321251339
ENST00000542629PPFIBP1chr1227803074+ENST00000401959NHP2L1chr2242076368-22188682321251339
ENST00000228425PPFIBP1chr1227803074+ENST00000355257NHP2L1chr2242076368-22238362001219339
ENST00000228425PPFIBP1chr1227803074+ENST00000215956NHP2L1chr2242076368-21998362001219339
ENST00000228425PPFIBP1chr1227803074+ENST00000401959NHP2L1chr2242076368-21868362001219339

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537927ENST00000355257PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0033360620.99666387
ENST00000537927ENST00000215956PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0037523310.9962477
ENST00000537927ENST00000401959PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0035375820.9964624
ENST00000318304ENST00000355257PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0028373790.99716264
ENST00000318304ENST00000215956PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0030570520.99694294
ENST00000318304ENST00000401959PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0030828970.9969171
ENST00000542629ENST00000355257PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0031505930.99684936
ENST00000542629ENST00000215956PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0034120260.996588
ENST00000542629ENST00000401959PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0033825210.9966175
ENST00000228425ENST00000355257PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0029848860.9970151
ENST00000228425ENST00000215956PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0032395460.9967604
ENST00000228425ENST00000401959PPFIBP1chr1227803074+NHP2L1chr2242076368-0.0032115730.9967885

Top

Fusion Genomic Features for PPFIBP1-NHP2L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PPFIBP1-NHP2L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:27803074/chr22:42076368)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000228425+730156_4052011006.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000318304+729156_4052011012.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000535047+16156_4050171.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000537927+527156_40548859.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000542629+728156_405201981.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000228425+730647_7112011006.0DomainSAM 1
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000228425+730719_7822011006.0DomainSAM 2
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000228425+730804_8762011006.0DomainSAM 3
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000318304+729647_7112011012.0DomainSAM 1
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000318304+729719_7822011012.0DomainSAM 2
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000318304+729804_8762011012.0DomainSAM 3
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000535047+16647_7110171.0DomainSAM 1
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000535047+16719_7820171.0DomainSAM 2
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000535047+16804_8760171.0DomainSAM 3
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000537927+527647_71148859.0DomainSAM 1
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000537927+527719_78248859.0DomainSAM 2
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000537927+527804_87648859.0DomainSAM 3
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000542629+728647_711201981.0DomainSAM 1
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000542629+728719_782201981.0DomainSAM 2
HgenePPFIBP1chr12:27803074chr22:42076368ENST00000542629+728804_876201981.0DomainSAM 3


Top

Fusion Gene Sequence for PPFIBP1-NHP2L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67459_67459_1_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000228425_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2199nt_BP=836nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTAC
TGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGT
TCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTG
TGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGA
AACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCC
CTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCT
GGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCT
CCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCC
AGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCT
GTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAG
CATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTT
CTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTG
GGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCC
AGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTG
GTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGC

>67459_67459_1_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000228425_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_2_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000228425_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2223nt_BP=836nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTAC
TGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGT
TCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTG
TGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGA
AACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCC
CTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCT
GGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCT
CCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCC
AGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCT
GTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAG
CATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTT
CTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTG
GGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCC
AGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTG
GTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGC

>67459_67459_2_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000228425_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_3_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000228425_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2186nt_BP=836nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTAC
TGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGT
TCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTG
TGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGA
AACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCC
CTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCT
GGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCT
CCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCC
AGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCT
GTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAG
CATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTT
CTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTG
GGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCC
AGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTG
GTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGC

>67459_67459_3_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000228425_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_4_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000318304_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2249nt_BP=886nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGT
GAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCG
GAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCAT
TCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTC
CAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCT
CTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTA
TTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCT
ATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGG
TGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCC
TGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGAT
CAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCG
TTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGC
AGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTC
GGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGA
TGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTG

>67459_67459_4_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000318304_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_5_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000318304_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2273nt_BP=886nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGT
GAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCG
GAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCAT
TCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTC
CAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCT
CTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTA
TTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCT
ATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGG
TGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCC
TGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGAT
CAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCG
TTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGC
AGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTC
GGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGA
TGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTG
TCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAATAAA

>67459_67459_5_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000318304_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_6_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000318304_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2236nt_BP=886nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGT
GAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCG
GAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCAT
TCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTC
CAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCT
CTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTA
TTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCT
ATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGG
TGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCC
TGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGAT
CAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCG
TTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGC
AGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTC
GGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGA
TGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTG

>67459_67459_6_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000318304_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_7_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000537927_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=1968nt_BP=605nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGG
CCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCA
ATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGC
CGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCA
TCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAA
CCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTAC
TCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCC
TTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCG
TTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCG
GGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTC
ATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGT
ACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACC
AAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAA
GCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCC
AAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCA

>67459_67459_7_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000537927_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=243AA_BP=116
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEI

--------------------------------------------------------------
>67459_67459_8_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000537927_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=1992nt_BP=605nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGG
CCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCA
ATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGC
CGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCA
TCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAA
CCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTAC
TCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCC
TTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCG
TTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCG
GGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTC
ATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGT
ACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACC
AAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAA
GCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCC
AAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCA
TGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAATAAATCTGTTCCATT

>67459_67459_8_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000537927_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=243AA_BP=116
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEI

--------------------------------------------------------------
>67459_67459_9_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000537927_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=1955nt_BP=605nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGG
CCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCA
ATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGC
CGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCA
TCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAA
CCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTAC
TCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCC
TTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCG
TTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCG
GGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTC
ATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGT
ACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACC
AAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAA
GCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCC
AAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCA

>67459_67459_9_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000537927_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=243AA_BP=116
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEI

--------------------------------------------------------------
>67459_67459_10_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000542629_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2231nt_BP=868nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGGCCTATCC
CCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGC
CACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCT
GTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTG
TTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGG
CCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTAT
TGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTC
CCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAG
GCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTG
GTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCT
CTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTG
CTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGA
TGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGA
GAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAA
CAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGT

>67459_67459_10_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000542629_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_11_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000542629_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2255nt_BP=868nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGGCCTATCC
CCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGC
CACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCT
GTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTG
TTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGG
CCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTAT
TGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTC
CCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAG
GCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTG
GTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCT
CTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTG
CTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGA
TGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGA
GAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAA
CAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGT
CAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAATAAATCTGTTCCATTTTGATGA

>67459_67459_11_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000542629_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------
>67459_67459_12_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000542629_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2218nt_BP=868nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGACTGAGGCTGATGTGAATCCAAAGGCCTATCC
CCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGC
CACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCT
GTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTG
TTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGG
CCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTAT
TGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTC
CCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAG
GCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTG
GTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCT
CTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTG
CTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGA
TGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGA
GAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAA
CAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGT

>67459_67459_12_PPFIBP1-NHP2L1_PPFIBP1_chr12_27803074_ENST00000542629_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=339AA_BP=212
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTETEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAAD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPFIBP1-NHP2L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNHP2L1chr12:27803074chr22:42076368ENST000002159560336_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:27803074chr22:42076368ENST000003552570336_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:27803074chr22:42076368ENST000004019591436_481.0129.0U4 snRNA and U4atac snRNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PPFIBP1-NHP2L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PPFIBP1-NHP2L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource