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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPFIBP1-SMCO2 (FusionGDB2 ID:67464)

Fusion Gene Summary for PPFIBP1-SMCO2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPFIBP1-SMCO2
Fusion gene ID: 67464
HgeneTgene
Gene symbol

PPFIBP1

SMCO2

Gene ID

8496

341346

Gene namePPFIA binding protein 1single-pass membrane protein with coiled-coil domains 2
SynonymsL2|SGT2|hSGT2|hSgt2pC12orf70
Cytomap

12p11.23-p11.22

12p11.23

Type of geneprotein-codingprotein-coding
Descriptionliprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1single-pass membrane and coiled-coil domain-containing protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000541633, ENST00000228425, 
ENST00000318304, ENST00000537927, 
ENST00000542629, ENST00000535047, 
ENST00000545334, 		ENST00000298876, 
ENST00000416383, ENST00000535986, 
ENST00000538647, 
Fusion gene scores* DoF score20 X 14 X 13=36405 X 4 X 7=140
# samples 269
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPFIBP1 [Title/Abstract] AND SMCO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPFIBP1(27731172)-SMCO2(27648613), # samples:1
PPFIBP1(27677298)-SMCO2(27648613), # samples:1
PPFIBP1(27677298)-SMCO2(27654856), # samples:1
PPFIBP1(27807747)-SMCO2(27627719), # samples:1
PPFIBP1(27677298)-SMCO2(27627719), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPFIBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMCO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FX-01APPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
ChimerDB4BRCATCGA-C8-A12K-01APPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
ChimerDB4OVTCGA-24-1553-01APPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
ChimerDB4OVTCGA-24-1846-01APPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
ChimerDB4UCECTCGA-AP-A05J-01APPFIBP1chr12

27677298

+SMCO2chr12

27627719

+


Top

Fusion Gene ORF analysis for PPFIBP1-SMCO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000541633ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
3UTR-3CDSENST00000541633ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
3UTR-3CDSENST00000541633ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
3UTR-3CDSENST00000541633ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
3UTR-3CDSENST00000541633ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
3UTR-3CDSENST00000541633ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
3UTR-3CDSENST00000541633ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
3UTR-3CDSENST00000541633ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
3UTR-3CDSENST00000541633ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
3UTR-3CDSENST00000541633ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
3UTR-3CDSENST00000541633ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
3UTR-3CDSENST00000541633ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
3UTR-3UTRENST00000541633ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
3UTR-3UTRENST00000541633ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
3UTR-intronENST00000541633ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
3UTR-intronENST00000541633ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5CDS-intronENST00000228425ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
5CDS-intronENST00000318304ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
5CDS-intronENST00000537927ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
5CDS-intronENST00000542629ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000228425ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000228425ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000228425ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000228425ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000228425ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000228425ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000228425ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000228425ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000228425ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000228425ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000228425ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000228425ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000318304ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000318304ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000318304ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000318304ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000318304ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000318304ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000318304ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000318304ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000318304ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000318304ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000318304ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000318304ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000535047ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000535047ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000535047ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000535047ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000535047ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000535047ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000535047ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000535047ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000535047ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000535047ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000535047ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000535047ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000537927ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000537927ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000537927ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000537927ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000537927ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000537927ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000537927ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000537927ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000537927ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000537927ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000537927ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000537927ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000542629ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000542629ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000542629ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000542629ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000542629ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000542629ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000542629ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000542629ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000542629ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000542629ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000542629ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000542629ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000545334ENST00000298876PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000545334ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000545334ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000545334ENST00000298876PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000545334ENST00000416383PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000545334ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000545334ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000545334ENST00000416383PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3CDSENST00000545334ENST00000535986PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000545334ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3CDSENST00000545334ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-3CDSENST00000545334ENST00000535986PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-3UTRENST00000228425ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000228425ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000318304ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000318304ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000535047ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000535047ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000537927ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000537927ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000542629ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000542629ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000545334ENST00000538647PPFIBP1chr12

27731172

+SMCO2chr12

27648613

+
5UTR-3UTRENST00000545334ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27648613

+
5UTR-intronENST00000228425ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-intronENST00000228425ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-intronENST00000318304ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-intronENST00000318304ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-intronENST00000535047ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-intronENST00000535047ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-intronENST00000537927ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-intronENST00000537927ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-intronENST00000542629ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-intronENST00000542629ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
5UTR-intronENST00000545334ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27654856

+
5UTR-intronENST00000545334ENST00000538647PPFIBP1chr12

27677298

+SMCO2chr12

27627719

+
In-frameENST00000228425ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000228425ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000228425ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000318304ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000318304ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000318304ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000537927ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000537927ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000537927ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000542629ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000542629ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
In-frameENST00000542629ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000535047ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000535047ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000535047ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000541633ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000541633ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000541633ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000545334ENST00000298876PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000545334ENST00000416383PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-3CDSENST00000545334ENST00000535986PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-intronENST00000535047ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-intronENST00000541633ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+
intron-intronENST00000545334ENST00000538647PPFIBP1chr12

27807747

+SMCO2chr12

27627719

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537927PPFIBP1chr1227807747+ENST00000416383SMCO2chr1227627719+15606982571495412
ENST00000537927PPFIBP1chr1227807747+ENST00000298876SMCO2chr1227627719+14106982571345362
ENST00000537927PPFIBP1chr1227807747+ENST00000535986SMCO2chr1227627719+15606982571495412
ENST00000318304PPFIBP1chr1227807747+ENST00000416383SMCO2chr1227627719+18419792501776508
ENST00000318304PPFIBP1chr1227807747+ENST00000298876SMCO2chr1227627719+16919792501626458
ENST00000318304PPFIBP1chr1227807747+ENST00000535986SMCO2chr1227627719+18419792501776508
ENST00000542629PPFIBP1chr1227807747+ENST00000416383SMCO2chr1227627719+18239612321758508
ENST00000542629PPFIBP1chr1227807747+ENST00000298876SMCO2chr1227627719+16739612321608458
ENST00000542629PPFIBP1chr1227807747+ENST00000535986SMCO2chr1227627719+18239612321758508
ENST00000228425PPFIBP1chr1227807747+ENST00000416383SMCO2chr1227627719+17919292001726508
ENST00000228425PPFIBP1chr1227807747+ENST00000298876SMCO2chr1227627719+16419292001576458
ENST00000228425PPFIBP1chr1227807747+ENST00000535986SMCO2chr1227627719+17919292001726508

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537927ENST00000416383PPFIBP1chr1227807747+SMCO2chr1227627719+0.0011507660.9988493
ENST00000537927ENST00000298876PPFIBP1chr1227807747+SMCO2chr1227627719+0.001846680.99815327
ENST00000537927ENST00000535986PPFIBP1chr1227807747+SMCO2chr1227627719+0.0011507660.9988493
ENST00000318304ENST00000416383PPFIBP1chr1227807747+SMCO2chr1227627719+0.0019776160.99802244
ENST00000318304ENST00000298876PPFIBP1chr1227807747+SMCO2chr1227627719+0.0024384340.9975616
ENST00000318304ENST00000535986PPFIBP1chr1227807747+SMCO2chr1227627719+0.0019776160.99802244
ENST00000542629ENST00000416383PPFIBP1chr1227807747+SMCO2chr1227627719+0.0019826240.99801743
ENST00000542629ENST00000298876PPFIBP1chr1227807747+SMCO2chr1227627719+0.0025333950.99746656
ENST00000542629ENST00000535986PPFIBP1chr1227807747+SMCO2chr1227627719+0.0019826240.99801743
ENST00000228425ENST00000416383PPFIBP1chr1227807747+SMCO2chr1227627719+0.0019662310.9980338
ENST00000228425ENST00000298876PPFIBP1chr1227807747+SMCO2chr1227627719+0.0024782770.9975217
ENST00000228425ENST00000535986PPFIBP1chr1227807747+SMCO2chr1227627719+0.0019662310.9980338

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Fusion Genomic Features for PPFIBP1-SMCO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPFIBP1chr1227807747+SMCO2chr1227627718+0.404116570.59588337
PPFIBP1chr1227731172+SMCO2chr1227648612+0.0002282880.9997718
PPFIBP1chr1227677298+SMCO2chr1227627718+0.0001817940.99981827
PPFIBP1chr1227677298+SMCO2chr1227654855+7.49E-050.999925
PPFIBP1chr1227677298+SMCO2chr1227648612+3.40E-050.999966
PPFIBP1chr1227807747+SMCO2chr1227627718+0.404116570.59588337
PPFIBP1chr1227731172+SMCO2chr1227648612+0.0002282880.9997718
PPFIBP1chr1227677298+SMCO2chr1227627718+0.0001817940.99981827
PPFIBP1chr1227677298+SMCO2chr1227654855+7.49E-050.999925
PPFIBP1chr1227677298+SMCO2chr1227648612+3.40E-050.999966

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPFIBP1-SMCO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:27731172/chr12:27648613)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMCO2chr12:27807747chr12:27627719ENST0000041638329152_23878344.0Coiled coilOntology_term=ECO:0000255
TgeneSMCO2chr12:27807747chr12:27627719ENST0000053598618152_23878344.0Coiled coilOntology_term=ECO:0000255
TgeneSMCO2chr12:27807747chr12:27627719ENST0000041638329284_30478344.0TransmembraneHelical
TgeneSMCO2chr12:27807747chr12:27627719ENST0000053598618284_30478344.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000228425+830156_4052321006.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000318304+829156_4052321012.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000535047+16156_4050171.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000537927+627156_40579859.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000542629+828156_405232981.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000228425+830647_7112321006.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000228425+830719_7822321006.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000228425+830804_8762321006.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000318304+829647_7112321012.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000318304+829719_7822321012.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000318304+829804_8762321012.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000535047+16647_7110171.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000535047+16719_7820171.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000535047+16804_8760171.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000537927+627647_71179859.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000537927+627719_78279859.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000537927+627804_87679859.0DomainSAM 3
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000542629+828647_711232981.0DomainSAM 1
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000542629+828719_782232981.0DomainSAM 2
HgenePPFIBP1chr12:27807747chr12:27627719ENST00000542629+828804_876232981.0DomainSAM 3


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Fusion Gene Sequence for PPFIBP1-SMCO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67464_67464_1_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000228425_SMCO2_chr12_27627719_ENST00000298876_length(transcript)=1641nt_BP=929nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTC
AGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTGAGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAA
CAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGAAGAACCTCCTTGAACTCTTATTAAAAGACATGCTGACCC
TGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTATG
AATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGAGG
CAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGTGC
AGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTT
ACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGA
GAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTCTCACCAGTA

>67464_67464_1_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000228425_SMCO2_chr12_27627719_ENST00000298876_length(amino acids)=458AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELLLKDMLTLKGQIEKLEDRGLDLDQGTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSH
SSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNL

--------------------------------------------------------------
>67464_67464_2_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000228425_SMCO2_chr12_27627719_ENST00000416383_length(transcript)=1791nt_BP=929nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTC
AGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTGAGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAA
CAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGAAGAACCTCCTTGAACTGTGTCTGAAGGGCATGTTCCTCA
AGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAAAGAACTTGGAGCTGATTACATAGACGGAACGGAGAAAATTGACAATATTA
TTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTTATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACC
GGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGG
AGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGG
AAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGA
AACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCT
TTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAG

>67464_67464_2_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000228425_SMCO2_chr12_27627719_ENST00000416383_length(amino acids)=508AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQ
GTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIF

--------------------------------------------------------------
>67464_67464_3_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000228425_SMCO2_chr12_27627719_ENST00000535986_length(transcript)=1791nt_BP=929nt
GACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCC
GGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTA
AACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGT
TGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCA
TGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCC
AGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATC
AAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGA
AGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGA
CATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATT
ATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTC
AGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTGAGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAA
CAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGAAGAACCTCCTTGAACTGTGTCTGAAGGGCATGTTCCTCA
AGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAAAGAACTTGGAGCTGATTACATAGACGGAACGGAGAAAATTGACAATATTA
TTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTTATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACC
GGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGG
AGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGG
AAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGA
AACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCT
TTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAG

>67464_67464_3_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000228425_SMCO2_chr12_27627719_ENST00000535986_length(amino acids)=508AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQ
GTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIF

--------------------------------------------------------------
>67464_67464_4_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000318304_SMCO2_chr12_27627719_ENST00000298876_length(transcript)=1691nt_BP=979nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGA
GATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGA
GCTAGAGGCTGAGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCA
GTTTTCAAAGAAGAACCTCCTTGAACTCTTATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGA
CCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTG
CAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATAC
GGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACT
GAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGT
GCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACC

>67464_67464_4_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000318304_SMCO2_chr12_27627719_ENST00000298876_length(amino acids)=458AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELLLKDMLTLKGQIEKLEDRGLDLDQGTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSH
SSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNL

--------------------------------------------------------------
>67464_67464_5_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000318304_SMCO2_chr12_27627719_ENST00000416383_length(transcript)=1841nt_BP=979nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGA
GATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGA
GCTAGAGGCTGAGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCA
GTTTTCAAAGAAGAACCTCCTTGAACTGTGTCTGAAGGGCATGTTCCTCAAGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAA
AGAACTTGGAGCTGATTACATAGACGGAACGGAGAAAATTGACAATATTATTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTT
ATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAA
TACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCT
AAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGC
CCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCAC
CGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCAC
ATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCC

>67464_67464_5_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000318304_SMCO2_chr12_27627719_ENST00000416383_length(amino acids)=508AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQ
GTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIF

--------------------------------------------------------------
>67464_67464_6_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000318304_SMCO2_chr12_27627719_ENST00000535986_length(transcript)=1841nt_BP=979nt
GGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTG
GGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATC
ACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCT
GACAAATAATAAAATGATGAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCT
GGAATATTCCAATGGGATTTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCG
TGGATTGTTAGAGATGATGGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCT
TCAGAGTCAAATGACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCT
CGTTCTTCAGGTAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGA
GAAGGTGAATGCCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAAT
ATCTAACTTGAAGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGA
GATCAATGATTTGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGA
GCTAGAGGCTGAGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCA
GTTTTCAAAGAAGAACCTCCTTGAACTGTGTCTGAAGGGCATGTTCCTCAAGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAA
AGAACTTGGAGCTGATTACATAGACGGAACGGAGAAAATTGACAATATTATTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTT
ATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAA
TACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCT
AAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGC
CCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCAC
CGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCAC
ATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCC

>67464_67464_6_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000318304_SMCO2_chr12_27627719_ENST00000535986_length(amino acids)=508AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQ
GTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIF

--------------------------------------------------------------
>67464_67464_7_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000537927_SMCO2_chr12_27627719_ENST00000298876_length(transcript)=1410nt_BP=698nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATT
TGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTG
AGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGA
AGAACCTCCTTGAACTCTTATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAG
GGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGG
AACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGG
AGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCA
TCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAA
TGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGAT

>67464_67464_7_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000537927_SMCO2_chr12_27627719_ENST00000298876_length(amino acids)=362AA_BP=5
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDPQASTSL
QFSKKNLLELLLKDMLTLKGQIEKLEDRGLDLDQGTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEID
TEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNLEVEALL

--------------------------------------------------------------
>67464_67464_8_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000537927_SMCO2_chr12_27627719_ENST00000416383_length(transcript)=1560nt_BP=698nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATT
TGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTG
AGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGA
AGAACCTCCTTGAACTGTGTCTGAAGGGCATGTTCCTCAAGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAAAGAACTTGGAG
CTGATTACATAGACGGAACGGAGAAAATTGACAATATTATTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTTATTAAAAGACA
TGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATG
AAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATC
AAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCT
TTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGAC
TTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTAC
GGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTC

>67464_67464_8_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000537927_SMCO2_chr12_27627719_ENST00000416383_length(amino acids)=412AA_BP=5
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDPQASTSL
QFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQGTSTEV
NTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFDVL

--------------------------------------------------------------
>67464_67464_9_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000537927_SMCO2_chr12_27627719_ENST00000535986_length(transcript)=1560nt_BP=698nt
CAGCTCCCAGCTCGGTGCCTGCCCGGATTCCTGACATGGTGTAGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGA
GCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGAGGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCC
CCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCCAAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAA
ATACAAATGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGG
TAAGTGTGTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATG
CCACAGAAGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGA
AGTTGAAACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATT
TGAGGTTAAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTG
AGCATGACCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGA
AGAACCTCCTTGAACTGTGTCTGAAGGGCATGTTCCTCAAGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAAAGAACTTGGAG
CTGATTACATAGACGGAACGGAGAAAATTGACAATATTATTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTTATTAAAAGACA
TGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATG
AAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATC
AAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCT
TTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGAC
TTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTAC
GGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTC

>67464_67464_9_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000537927_SMCO2_chr12_27627719_ENST00000535986_length(amino acids)=412AA_BP=5
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDPQASTSL
QFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQGTSTEV
NTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFDVL

--------------------------------------------------------------
>67464_67464_10_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000542629_SMCO2_chr12_27627719_ENST00000298876_length(transcript)=1673nt_BP=961nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTT
AAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTGAGCATGA
CCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGAAGAACCT
CCTTGAACTCTTATTAAAAGACATGCTGACCCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAG
CACTGAGGTGAATACTTGTAATGAAGTTTATGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCT
GAGTGCAAAGCTAAGGATGTATCAAATGGAGGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCT
GCTTCCTCAGGCCCCAGCATCCTTTTTAGTGCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTT
TGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGG
GTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAG

>67464_67464_10_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000542629_SMCO2_chr12_27627719_ENST00000298876_length(amino acids)=458AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELLLKDMLTLKGQIEKLEDRGLDLDQGTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSH
SSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNL

--------------------------------------------------------------
>67464_67464_11_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000542629_SMCO2_chr12_27627719_ENST00000416383_length(transcript)=1823nt_BP=961nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTT
AAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTGAGCATGA
CCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGAAGAACCT
CCTTGAACTGTGTCTGAAGGGCATGTTCCTCAAGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAAAGAACTTGGAGCTGATTA
CATAGACGGAACGGAGAAAATTGACAATATTATTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTTATTAAAAGACATGCTGAC
CCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTA
TGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGA
GGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGT
GCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATG
TTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGAT
GAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTCTCACCAG

>67464_67464_11_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000542629_SMCO2_chr12_27627719_ENST00000416383_length(amino acids)=508AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQ
GTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIF

--------------------------------------------------------------
>67464_67464_12_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000542629_SMCO2_chr12_27627719_ENST00000535986_length(transcript)=1823nt_BP=961nt
AGTGCAGGCAGGGTGGGGAAAGGACGGGGAAGGACTCGTGTGCTGCGAGCTGGCGGCCGGGCCGGAGTGCTGGGGCTTTGAACTCCGAGA
GGAGGTGGACCAGAACTTTTGGAACTAGTGCCGGCGGCTCTCCACCCCCCAGTATAAAAGAACGTGTGGATCACTTTGCTGAGTACATCC
AAGATTTGAAGAACTGAAATAAATCAGCTTTAAACCTGCTTTTTAAAAATATCTGGGTTGGAATTTGCCCCTGACAAATAATAAAATGAT
GAGTGATGCAAGTGACATGTTGGCTGCAGCGTTGGAGCAGATGGATGGTATCATAGCAGGTTCTAAGGCTCTGGAATATTCCAATGGGAT
TTTTGATTGCCAATCTCCCACCTCTCCATTCATGGGAAGTTTGCGAGCTCTGCACCTTGTGGAAGACCTGCGTGGATTGTTAGAGATGAT
GGAAACAGATGAGAAAGAAGGCTTGAGATGCCAGATCCCAGATTCAACAGCAGAAACGCTTGTTGAATGGCTTCAGAGTCAAATGACAAA
TGGACACCTACCAGGGAACGGAGATGTGTATCAAGAAAGGCTGGCACGTTTAGAAAATGATAAAGAATCCCTCGTTCTTCAGGTAAGTGT
GTTAACAGACCAGGTGGAGGCTCAGGGAGAGAAGATTCGAGATTTGGAGTTTTGTCTTGAAGAGCACAGAGAGAAGGTGAATGCCACAGA
AGAAATGCTGCAGCAGGAGCTTCTAAGTAGGACATCCTTAGAAACTCAGAAGTTGGATCTGATGGCTGAAATATCTAACTTGAAGTTGAA
ACTGACAGCTGTAGAGAAGGACAGATTGGATTATGAAGATAAGTTCAGAGACACAGAGGGGCTGATTCAGGAGATCAATGATTTGAGGTT
AAAAGTTAGTGAAATGGACAGTGAGAGACTTCAGTATGAAAAAAAGCTTAAATCAACCAAAGGTATGTTGGAGCTAGAGGCTGAGCATGA
CCAGGACCTGAGTAAACAGGATAAGCAAGAAACAGATGTTGATGAGGACCCTCAAGCGTCTACATCTCTGCAGTTTTCAAAGAAGAACCT
CCTTGAACTGTGTCTGAAGGGCATGTTCCTCAAGCTAAACTACTGGAACACAAAGATAGGTCTCCAGGTGAAAGAACTTGGAGCTGATTA
CATAGACGGAACGGAGAAAATTGACAATATTATTAAAAAAATAAATGTAACAGAAAACACAGTGAAGAGCTTATTAAAAGACATGCTGAC
CCTGAAGGGTCAAATTGAAAAGCTGGAGGACCGGGGCCTTGACCTTGATCAAGGGACAAGCACTGAGGTGAATACTTGTAATGAAGTTTA
TGAATTAAAGAAGAAAGTCATAGAAAGGCTGGAGGACCTTTGCAAGAATGTGGAACTGCTGAGTGCAAAGCTAAGGATGTATCAAATGGA
GGCAGAGGACACTGACTCTCACAGTTCTGAGGAAATAGATACGGAAGAGATGGAGGCCCTGCTTCCTCAGGCCCCAGCATCCTTTTTAGT
GCAGAAGTCTCCTCCCCGCAATACAGCATGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATG
TTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGAT
GAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTCTCACCAG

>67464_67464_12_PPFIBP1-SMCO2_PPFIBP1_chr12_27807747_ENST00000542629_SMCO2_chr12_27627719_ENST00000535986_length(amino acids)=508AA_BP=1
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKGMLELEAEHDQDLSKQDKQETDVDEDP
QASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIKKINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQ
GTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPFIBP1-SMCO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPFIBP1-SMCO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPFIBP1-SMCO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource