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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPIL6-REPS1 (FusionGDB2 ID:67574)

Fusion Gene Summary for PPIL6-REPS1

Fusion gene summary

Fusion gene information	Fusion gene name: PPIL6-REPS1
	Fusion gene ID: 67574
		Hgene	Tgene
	Gene symbol	PPIL6	REPS1
	Gene ID	285755	85021
	Gene name	peptidylprolyl isomerase like 6	RALBP1 associated Eps domain containing 1
	Synonyms	PPIase\|RSPH12\|bA425D10.6\|dJ919F19.1	NBIA7\|RALBP1
	Cytomap	6q21	6q24.1
	Type of gene	protein-coding	protein-coding
	Description	probable inactive peptidyl-prolyl cis-trans isomerase-like 6cyclophilin-like protein PPIL6peptidyl-prolyl cis-trans isomerase-like 6peptidyl-prolyl cis-trans isomerase-like variant apeptidylprolyl isomerase (cyclophilin)-like 6problable inactive pept	ralBP1-associated Eps domain-containing protein 1ralBP1-interacting protein 1
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000424445, ENST00000440797, ENST00000521072, ENST00000524031,	ENST00000531675, ENST00000258062, ENST00000367663, ENST00000409812, ENST00000415951, ENST00000450536,
Fusion gene scores	* DoF score	3 X 3 X 2=18	13 X 11 X 7=1001
	# samples	3	13
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPIL6 [Title/Abstract] AND REPS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPIL6(109752359)-REPS1(139226269), # samples:1
Anticipated loss of major functional domain due to fusion event.	PPIL6-REPS1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PPIL6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across REPS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	135N	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-

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Fusion Gene ORF analysis for PPIL6-REPS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000424445	ENST00000531675	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5CDS-intron	ENST00000440797	ENST00000531675	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5CDS-intron	ENST00000521072	ENST00000531675	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5UTR-3CDS	ENST00000524031	ENST00000258062	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5UTR-3CDS	ENST00000524031	ENST00000367663	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5UTR-3CDS	ENST00000524031	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5UTR-3CDS	ENST00000524031	ENST00000415951	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5UTR-3CDS	ENST00000524031	ENST00000450536	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
5UTR-intron	ENST00000524031	ENST00000531675	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000424445	ENST00000258062	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000424445	ENST00000367663	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000424445	ENST00000415951	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000424445	ENST00000450536	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000440797	ENST00000258062	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000440797	ENST00000367663	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000440797	ENST00000415951	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000440797	ENST00000450536	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000521072	ENST00000258062	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000521072	ENST00000367663	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000521072	ENST00000415951	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
Frame-shift	ENST00000521072	ENST00000450536	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
In-frame	ENST00000424445	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
In-frame	ENST00000440797	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-
In-frame	ENST00000521072	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000521072	PPIL6	chr6	109752359	-	ENST00000409812	REPS1	chr6	139226269	-	1264	1001	485	1069	194
ENST00000424445	PPIL6	chr6	109752359	-	ENST00000409812	REPS1	chr6	139226269	-	1168	905	485	973	162
ENST00000440797	PPIL6	chr6	109752359	-	ENST00000409812	REPS1	chr6	139226269	-	1264	1001	485	1069	194

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000521072	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-	0.006168632	0.9938314
ENST00000424445	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-	0.024516737	0.9754833
ENST00000440797	ENST00000409812	PPIL6	chr6	109752359	-	REPS1	chr6	139226269	-	0.006168632	0.9938314

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Fusion Genomic Features for PPIL6-REPS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPIL6-REPS1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:109752359/chr6:139226269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000409812

751_791

683

706.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPIL6

chr6:109752359

chr6:139226269

ENST00000440797

145_308

140

338.0

Domain

PPIase cyclophilin-type

Hgene

PPIL6

chr6:109752359

chr6:139226269

ENST00000521072

145_308

140

312.0

Domain

PPIase cyclophilin-type

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000258062

331_342

773

796.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000409812

331_342

683

706.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000450536

331_342

774

797.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000258062

751_791

773

796.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000450536

751_791

774

797.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000258062

541_604

773

796.0

Compositional bias

Note=Pro-rich

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000409812

541_604

683

706.0

Compositional bias

Note=Pro-rich

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000450536

541_604

774

797.0

Compositional bias

Note=Pro-rich

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000258062

10_113

773

796.0

Domain

EH 1

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000258062

285_374

773

796.0

Domain

EH 2

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000258062

318_353

773

796.0

Domain

EF-hand

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000409812

10_113

683

706.0

Domain

EH 1

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000409812

285_374

683

706.0

Domain

EH 2

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000409812

318_353

683

706.0

Domain

EF-hand

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000450536

10_113

774

797.0

Domain

EH 1

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000450536

285_374

774

797.0

Domain

EH 2

Tgene

REPS1

chr6:109752359

chr6:139226269

ENST00000450536

318_353

774

797.0

Domain

EF-hand

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Fusion Gene Sequence for PPIL6-REPS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>67574_67574_1_PPIL6-REPS1_PPIL6_chr6_109752359_ENST00000424445_REPS1_chr6_139226269_ENST00000409812_length(transcript)=1168nt_BP=905nt
CAGCAGTTGAGGTTGAAGATCCGCAGTCGCAGGGAGAAGTTGGGCTTCATGGTTGGGGAGCTCCAGGGGCGCTAGGCGGCTCGAACTCTC
CAGCGACGGCCGCGGTGGGGACGGGGGCGGCCGGCGGCGCCTTCTCCCCAGACCGTTCCTTCTTCGCAGGCGGCGCGCACAGGTGGGCAC
CAAGCCCGCGTGGCTCAGGTCGGGCCCGACTCCCGCGTTCCCCCGGCAACCGGCCGGCTGTTCCCAATCAGGCGGGCCGCCAACCCGGAA
AGGCGATCCGCTGCCGAAATCCGGGCGCCCAGGCTCGGTAAGGGCCGCGCGCTAGGACCCTGGGGGTCCGGAGAGCGCCCCCGGGTGGGC
GGCTCCCGGTTCCTTTTCCTCCAAGCTCGTCCCCGGCGGTCGCGGCCGCCCGCGCGCCGGCGGCCCAGCAACAGGCGCAAAGTTGAGGAA
AGGCCCAGCCGCCACGGGCCGCCCTCGACCCGCCCCTGGGCCCCGCCTCCTGCGAGCGGCGGAGGCGGGGCCGCGCGGTTGCCGGAGCGA
CGCGCAGTGTTTGGGGTCACCGGGCGTCCCCGGGCGCGGCCATGGCAAGGCCGCAGCCGTGCGGGCCCCCGCACGCTAGGTGCGGCTCGC
CGTCGCTGCCGGAGCGGCCGCTGCAGGTGAAGGTGGTGGGGCTCTTCAGCTGCCCCAACTTTCAGATTGCGAAGAGCGCCGCTGAGGAAC
TCAAAAATGAAACCTGGGAATATTCTTCCTCTGTGATTTCTTTTGTTAATGGTCAGTTTCTGGGTGATGCATTGGATCTGCAGAAATGGG
CCCACGAGGTGTGGGATATAGTTGACATTAAACCCTCTGCACTTTATGACGCACTCACTGAGGATTTTTCCGCTAAGTTCTTAAGAGACA
CCAAGGATGTTCTTGAGGAGAGAATTTCCCTGGAAGTTCAACTGGAACAACTTCGACCATTCTCTCACCTATAAGCCAATTGCCGTTAAC
TGTGAACATACTTGTTTTTAAGTGGTTTTGGGTTCAAAGCCAATTTGGAGACCTAGACATTCAGCTCACTGCTTAACTCAACATTAAATT

>67574_67574_1_PPIL6-REPS1_PPIL6_chr6_109752359_ENST00000424445_REPS1_chr6_139226269_ENST00000409812_length(amino acids)=162AA_BP=140
MGPASCERRRRGRAVAGATRSVWGHRASPGAAMARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAEELKNETWEYSSSV

--------------------------------------------------------------
>67574_67574_2_PPIL6-REPS1_PPIL6_chr6_109752359_ENST00000440797_REPS1_chr6_139226269_ENST00000409812_length(transcript)=1264nt_BP=1001nt
CAGCAGTTGAGGTTGAAGATCCGCAGTCGCAGGGAGAAGTTGGGCTTCATGGTTGGGGAGCTCCAGGGGCGCTAGGCGGCTCGAACTCTC
CAGCGACGGCCGCGGTGGGGACGGGGGCGGCCGGCGGCGCCTTCTCCCCAGACCGTTCCTTCTTCGCAGGCGGCGCGCACAGGTGGGCAC
CAAGCCCGCGTGGCTCAGGTCGGGCCCGACTCCCGCGTTCCCCCGGCAACCGGCCGGCTGTTCCCAATCAGGCGGGCCGCCAACCCGGAA
AGGCGATCCGCTGCCGAAATCCGGGCGCCCAGGCTCGGTAAGGGCCGCGCGCTAGGACCCTGGGGGTCCGGAGAGCGCCCCCGGGTGGGC
GGCTCCCGGTTCCTTTTCCTCCAAGCTCGTCCCCGGCGGTCGCGGCCGCCCGCGCGCCGGCGGCCCAGCAACAGGCGCAAAGTTGAGGAA
AGGCCCAGCCGCCACGGGCCGCCCTCGACCCGCCCCTGGGCCCCGCCTCCTGCGAGCGGCGGAGGCGGGGCCGCGCGGTTGCCGGAGCGA
CGCGCAGTGTTTGGGGTCACCGGGCGTCCCCGGGCGCGGCCATGGCAAGGCCGCAGCCGTGCGGGCCCCCGCACGCTAGGTGCGGCTCGC
CGTCGCTGCCGGAGCGGCCGCTGCAGGTGAAGGTGGTGGGGCTCTTCAGCTGCCCCAACTTTCAGATTGCGAAGAGCGCCGCTGAGAATC
TGAAGAATAATCATCCATCCAAATTTGAAGATCCTATATTAGTTCCTCTTCAAGAATTTGCATGGCATCAATATCTACAGGAGAAAAAAA
GGGAACTCAAAAATGAAACCTGGGAATATTCTTCCTCTGTGATTTCTTTTGTTAATGGTCAGTTTCTGGGTGATGCATTGGATCTGCAGA
AATGGGCCCACGAGGTGTGGGATATAGTTGACATTAAACCCTCTGCACTTTATGACGCACTCACTGAGGATTTTTCCGCTAAGTTCTTAA
GAGACACCAAGGATGTTCTTGAGGAGAGAATTTCCCTGGAAGTTCAACTGGAACAACTTCGACCATTCTCTCACCTATAAGCCAATTGCC
GTTAACTGTGAACATACTTGTTTTTAAGTGGTTTTGGGTTCAAAGCCAATTTGGAGACCTAGACATTCAGCTCACTGCTTAACTCAACAT
TAAATTTTATGATTCTGTTTTGCCCTATATGTTCACCGTTGTATTTAAGTATCTTTTATTTTTTAATTTCGACAATAAAAAGGTCAGGAT

>67574_67574_2_PPIL6-REPS1_PPIL6_chr6_109752359_ENST00000440797_REPS1_chr6_139226269_ENST00000409812_length(amino acids)=194AA_BP=172
MGPASCERRRRGRAVAGATRSVWGHRASPGAAMARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAENLKNNHPSKFEDP
ILVPLQEFAWHQYLQEKKRELKNETWEYSSSVISFVNGQFLGDALDLQKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTKDVLEERIS

--------------------------------------------------------------
>67574_67574_3_PPIL6-REPS1_PPIL6_chr6_109752359_ENST00000521072_REPS1_chr6_139226269_ENST00000409812_length(transcript)=1264nt_BP=1001nt
CAGCAGTTGAGGTTGAAGATCCGCAGTCGCAGGGAGAAGTTGGGCTTCATGGTTGGGGAGCTCCAGGGGCGCTAGGCGGCTCGAACTCTC
CAGCGACGGCCGCGGTGGGGACGGGGGCGGCCGGCGGCGCCTTCTCCCCAGACCGTTCCTTCTTCGCAGGCGGCGCGCACAGGTGGGCAC
CAAGCCCGCGTGGCTCAGGTCGGGCCCGACTCCCGCGTTCCCCCGGCAACCGGCCGGCTGTTCCCAATCAGGCGGGCCGCCAACCCGGAA
AGGCGATCCGCTGCCGAAATCCGGGCGCCCAGGCTCGGTAAGGGCCGCGCGCTAGGACCCTGGGGGTCCGGAGAGCGCCCCCGGGTGGGC
GGCTCCCGGTTCCTTTTCCTCCAAGCTCGTCCCCGGCGGTCGCGGCCGCCCGCGCGCCGGCGGCCCAGCAACAGGCGCAAAGTTGAGGAA
AGGCCCAGCCGCCACGGGCCGCCCTCGACCCGCCCCTGGGCCCCGCCTCCTGCGAGCGGCGGAGGCGGGGCCGCGCGGTTGCCGGAGCGA
CGCGCAGTGTTTGGGGTCACCGGGCGTCCCCGGGCGCGGCCATGGCAAGGCCGCAGCCGTGCGGGCCCCCGCACGCTAGGTGCGGCTCGC
CGTCGCTGCCGGAGCGGCCGCTGCAGGTGAAGGTGGTGGGGCTCTTCAGCTGCCCCAACTTTCAGATTGCGAAGAGCGCCGCTGAGAATC
TGAAGAATAATCATCCATCCAAATTTGAAGATCCTATATTAGTTCCTCTTCAAGAATTTGCATGGCATCAATATCTACAGGAGAAAAAAA
GGGAACTCAAAAATGAAACCTGGGAATATTCTTCCTCTGTGATTTCTTTTGTTAATGGTCAGTTTCTGGGTGATGCATTGGATCTGCAGA
AATGGGCCCACGAGGTGTGGGATATAGTTGACATTAAACCCTCTGCACTTTATGACGCACTCACTGAGGATTTTTCCGCTAAGTTCTTAA
GAGACACCAAGGATGTTCTTGAGGAGAGAATTTCCCTGGAAGTTCAACTGGAACAACTTCGACCATTCTCTCACCTATAAGCCAATTGCC
GTTAACTGTGAACATACTTGTTTTTAAGTGGTTTTGGGTTCAAAGCCAATTTGGAGACCTAGACATTCAGCTCACTGCTTAACTCAACAT
TAAATTTTATGATTCTGTTTTGCCCTATATGTTCACCGTTGTATTTAAGTATCTTTTATTTTTTAATTTCGACAATAAAAAGGTCAGGAT

>67574_67574_3_PPIL6-REPS1_PPIL6_chr6_109752359_ENST00000521072_REPS1_chr6_139226269_ENST00000409812_length(amino acids)=194AA_BP=172
MGPASCERRRRGRAVAGATRSVWGHRASPGAAMARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAAENLKNNHPSKFEDP
ILVPLQEFAWHQYLQEKKRELKNETWEYSSSVISFVNGQFLGDALDLQKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTKDVLEERIS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPIL6-REPS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	REPS1	chr6:109752359	chr6:139226269	ENST00000258062		18	20	652_796	773.0	796.0	RALBP1
Tgene	REPS1	chr6:109752359	chr6:139226269	ENST00000409812		15	17	652_796	683.0	706.0	RALBP1
Tgene	REPS1	chr6:109752359	chr6:139226269	ENST00000450536		18	20	652_796	774.0	797.0	RALBP1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PPIL6-REPS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PPIL6-REPS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source