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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPME1-ELP3 (FusionGDB2 ID:67684)

Fusion Gene Summary for PPME1-ELP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PPME1-ELP3
Fusion gene ID: 67684
HgeneTgene
Gene symbol

PPME1

ELP3

Gene ID

51400

55140

Gene nameprotein phosphatase methylesterase 1elongator acetyltransferase complex subunit 3
SynonymsABDH19|PME-1KAT9
Cytomap

11q13.4

8p21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase methylesterase 1testicular secretory protein Li 39elongator complex protein 3elongation protein 3 homologprotein lysine acetyltransferase ELP3tRNA uridine(34) acetyltransferase
Modification date2020031320200322
UniProtAcc.

Q9H9T3

Ensembl transtripts involved in fusion geneENST00000542710, ENST00000328257, 
ENST00000398427, ENST00000543525, 
ENST00000256398, ENST00000521015, 
ENST00000542181, ENST00000380353, 
ENST00000523760, ENST00000524103, 
ENST00000537665, 
Fusion gene scores* DoF score8 X 3 X 5=1205 X 5 X 4=100
# samples 85
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPME1 [Title/Abstract] AND ELP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPME1(73882567)-ELP3(27987019), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPME1

GO:0006482

protein demethylation

10318862

TgeneELP3

GO:0006357

regulation of transcription by RNA polymerase II

11818576


check buttonFusion gene breakpoints across PPME1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ELP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8531-01APPME1chr11

73882567

+ELP3chr8

27987019

+


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Fusion Gene ORF analysis for PPME1-ELP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000542710ENST00000256398PPME1chr11

73882567

+ELP3chr8

27987019

+
3UTR-3CDSENST00000542710ENST00000521015PPME1chr11

73882567

+ELP3chr8

27987019

+
3UTR-3CDSENST00000542710ENST00000542181PPME1chr11

73882567

+ELP3chr8

27987019

+
3UTR-intronENST00000542710ENST00000380353PPME1chr11

73882567

+ELP3chr8

27987019

+
3UTR-intronENST00000542710ENST00000523760PPME1chr11

73882567

+ELP3chr8

27987019

+
3UTR-intronENST00000542710ENST00000524103PPME1chr11

73882567

+ELP3chr8

27987019

+
3UTR-intronENST00000542710ENST00000537665PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000328257ENST00000380353PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000328257ENST00000523760PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000328257ENST00000524103PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000328257ENST00000537665PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000398427ENST00000380353PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000398427ENST00000523760PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000398427ENST00000524103PPME1chr11

73882567

+ELP3chr8

27987019

+
5CDS-intronENST00000398427ENST00000537665PPME1chr11

73882567

+ELP3chr8

27987019

+
In-frameENST00000328257ENST00000256398PPME1chr11

73882567

+ELP3chr8

27987019

+
In-frameENST00000328257ENST00000521015PPME1chr11

73882567

+ELP3chr8

27987019

+
In-frameENST00000328257ENST00000542181PPME1chr11

73882567

+ELP3chr8

27987019

+
In-frameENST00000398427ENST00000256398PPME1chr11

73882567

+ELP3chr8

27987019

+
In-frameENST00000398427ENST00000521015PPME1chr11

73882567

+ELP3chr8

27987019

+
In-frameENST00000398427ENST00000542181PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-3CDSENST00000543525ENST00000256398PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-3CDSENST00000543525ENST00000521015PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-3CDSENST00000543525ENST00000542181PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-intronENST00000543525ENST00000380353PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-intronENST00000543525ENST00000523760PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-intronENST00000543525ENST00000524103PPME1chr11

73882567

+ELP3chr8

27987019

+
intron-intronENST00000543525ENST00000537665PPME1chr11

73882567

+ELP3chr8

27987019

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328257PPME1chr1173882567+ENST00000521015ELP3chr827987019+28824243231450375
ENST00000328257PPME1chr1173882567+ENST00000256398ELP3chr827987019+28824243231450375
ENST00000328257PPME1chr1173882567+ENST00000542181ELP3chr827987019+18204243231450375
ENST00000398427PPME1chr1173882567+ENST00000521015ELP3chr827987019+26592011001227375
ENST00000398427PPME1chr1173882567+ENST00000256398ELP3chr827987019+26592011001227375
ENST00000398427PPME1chr1173882567+ENST00000542181ELP3chr827987019+15972011001227375

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328257ENST00000521015PPME1chr1173882567+ELP3chr827987019+0.0012786040.9987214
ENST00000328257ENST00000256398PPME1chr1173882567+ELP3chr827987019+0.0012786040.9987214
ENST00000328257ENST00000542181PPME1chr1173882567+ELP3chr827987019+0.0026568550.9973431
ENST00000398427ENST00000521015PPME1chr1173882567+ELP3chr827987019+0.0014631760.9985368
ENST00000398427ENST00000256398PPME1chr1173882567+ELP3chr827987019+0.0014631760.9985368
ENST00000398427ENST00000542181PPME1chr1173882567+ELP3chr827987019+0.003549450.99645054

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Fusion Genomic Features for PPME1-ELP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPME1chr1173882567+ELP3chr827987018+0.0001243410.99987566
PPME1chr1173882567+ELP3chr827987018+0.0001243410.99987566

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPME1-ELP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:73882567/chr8:27987019)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ELP3

Q9H9T3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576, PubMed:15902492, PubMed:16713582). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). {ECO:0000250|UniProtKB:D5VRB9, ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:15902492, ECO:0000269|PubMed:16713582, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:29415125}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneELP3chr11:73882567chr8:27987019ENST00000256398615396_547205548.0DomainN-acetyltransferase
TgeneELP3chr11:73882567chr8:27987019ENST00000521015615396_547191534.0DomainN-acetyltransferase
TgeneELP3chr11:73882567chr8:27987019ENST00000256398615474_477205548.0RegionAcetyl-CoA binding
TgeneELP3chr11:73882567chr8:27987019ENST00000256398615497_499205548.0RegionAcetyl-CoA binding
TgeneELP3chr11:73882567chr8:27987019ENST00000521015615474_477191534.0RegionAcetyl-CoA binding
TgeneELP3chr11:73882567chr8:27987019ENST00000521015615497_499191534.0RegionAcetyl-CoA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPME1chr11:73882567chr8:27987019ENST00000328257+114256_26333387.0Compositional biasNote=Poly-Glu
HgenePPME1chr11:73882567chr8:27987019ENST00000543525+18256_2630200.0Compositional biasNote=Poly-Glu
TgeneELP3chr11:73882567chr8:27987019ENST0000025639861582_372205548.0DomainRadical SAM core
TgeneELP3chr11:73882567chr8:27987019ENST0000052101561582_372191534.0DomainRadical SAM core


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Fusion Gene Sequence for PPME1-ELP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67684_67684_1_PPME1-ELP3_PPME1_chr11_73882567_ENST00000328257_ELP3_chr8_27987019_ENST00000256398_length(transcript)=2882nt_BP=424nt
ATTGCGCAGGGTGCATTGCCCTGAAGAGCGCTCCTCCTTCCGGTGAAAGTCGTCGGGTTCCCAGCCGGGAGTCTGCGGAGTTCTCATACT
CTGTTACCCAGCTTCCTTTGTATGAGTGCTGTTGCGCACTTCCGGTGGAAGCGCTGAAGCGAGTGGGTGGAGTTTACGGAGCCGGTGGGC
GGTAGGCGGTGCTACGGGTAGCTGGGTGCTGTCCAAAGGCGACAGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAA
CGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAGCCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCC
TTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAGCGGAGCCAAGATGCGAATGGGGTATTCTGAGAGAAGCCTCACAAAGT
GTATTGGAATTACTATTGAAACCAGACCAGATTACTGCATGAAGCGACATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGA
TTGGGGTGCAGAGTGTTTATGAAGATGTGGCTAGAGACACCAACAGGGGCCACACTGTGAAGGCAGTGTGTGAGTCATTTCACCTGGCCA
AAGATTCCGGTTTTAAAGTGGTGGCCCATATGATGCCTGACCTGCCAAACGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTT
TTGAGAACCCTGCTTTTCGTCCCGATGGGCTGAAACTCTATCCTACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCTTTGGAAATCAG
GAAGATATAAGAGTTACTCTCCTAGTGACCTGGTTGAATTGGTGGCTCGGATCCTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAG
TACAGAGGGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGAGCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCG
GAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCAAGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGA
GAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATACGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCA
AGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGTCTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGA
GCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCATGCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGT
CTGGGAAAATCGCTGTGATATCAGGGGTCGGCACCAGGAATTATTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAGA
TGCTGAAATAATGGCCACACCAGTCCACTCTTCTGCAGTATCCTCCCTGGCAGAACACGGAGAATCAGGATTTCTTAAATACTCAACAGA
GAGGCTGAGCAGAGCAAATGGGGGGCTTCACCCTCATCCCGCAGCTGCAGAGACTGGAAACTGCCTTCAAGGCCACGGCTGGTCATCTGC
TGACCACACCCCAGATCCGCCCTCTCCTGCGTGCACCCCAAAAAATCACTTGCGTTTTTGAGGCTTAAATCATCTATCCAGTTTCTACAT
TTTGCATGAGGCCTGCAGGTGGCCTATTTTGACTCAGACGGTGAAAAAAGCAAATTAACTCATTTGGACACCATAACTCATGCAATAAAA
CTGATTGTCATTCGAGGAGCAAACTTAAGAGTAGTTTATTTATATACCCTGGGGACAGAAAGTCAGGTTGAAACAGGAAAACCACCAGAC
TCTAATCTCAGCCCTTTAACGACATACGCATTGGAGCGCAAGTTAGGAAAATGAGCTTTTGTTTTCATGGAAATCATTCTGATTACAGTG
CTGATGTTTAGAAATAAATAGCAGTGTGACTGGGAAAGAGGAATTGCAGTTGTGGGGGTGTGAGCCTGGCAGCAGCCAGCCAGCAGCCTC
TCCCAGGCGGGAGTCTACCATCCGAGACGGCGATGACAAAGAGCTTCATTCCACATTCTTTGTTATCTCTACTTCCCACCCTCTTGGCAA
CTACAGAGCAGTGTGGGCAGCCCCAAGTGTGGTCCCCAGAGAGCGTTTGGCTTTCCTGTCTGTCTATCCTGAGCGGGTGGAGTCTCAGGT
TGTGTGCCCCTAAATCAAGATTTGCTTCCACAGAAGCCATTACTTGCAATTTTTTTTTTTTTTCTGAGAAAGTCTCGCTGTGTCACCCAG
GCTGGAGTGCAGTGGCGCAATCTCACTGCATCCTCCGCCTCCCGGGTTCAAGCGATTCTCCCGCCTCAGCCTCCTGAGTAGCTGGGATTA
CAGGCACCCGCCGCTGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTCACCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAG
GTGATCAACCCACCTTGGCCTCCCTAAATGCCGGGATTACAGGCATGAGCCACCGCTCCCAGCCTTTGATTTTTTAAGGTGGATTTTGGT
TGTTATAAATGGAGAAAGGTAAGAGTTCAAGTTCAACCCGTGTGTGAAAGCAAAACAATGGAAAACAGGATTGGCTTCTTCAAAGGCTCC
TCTTGTAGAACTGCCTCTTTGAAATTTCGAGGTAATCTACTTTGGAGACTCTGCCTGGAGAGGGTCAGTTCCTAAGTTAAAAGCATCGCT
TAACCTTGGCTCCTGTGGCATTTTACAAAGGTTTAAAGGAATTGATTCCTCTGAAAGGGCCTGAAAATAAAAAGTCTTTAACATACAAAG

>67684_67684_1_PPME1-ELP3_PPME1_chr11_73882567_ENST00000328257_ELP3_chr8_27987019_ENST00000256398_length(amino acids)=375AA_BP=34
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGH
TVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARI
LALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDP
DQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRK

--------------------------------------------------------------
>67684_67684_2_PPME1-ELP3_PPME1_chr11_73882567_ENST00000328257_ELP3_chr8_27987019_ENST00000521015_length(transcript)=2882nt_BP=424nt
ATTGCGCAGGGTGCATTGCCCTGAAGAGCGCTCCTCCTTCCGGTGAAAGTCGTCGGGTTCCCAGCCGGGAGTCTGCGGAGTTCTCATACT
CTGTTACCCAGCTTCCTTTGTATGAGTGCTGTTGCGCACTTCCGGTGGAAGCGCTGAAGCGAGTGGGTGGAGTTTACGGAGCCGGTGGGC
GGTAGGCGGTGCTACGGGTAGCTGGGTGCTGTCCAAAGGCGACAGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAA
CGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAGCCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCC
TTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAGCGGAGCCAAGATGCGAATGGGGTATTCTGAGAGAAGCCTCACAAAGT
GTATTGGAATTACTATTGAAACCAGACCAGATTACTGCATGAAGCGACATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGA
TTGGGGTGCAGAGTGTTTATGAAGATGTGGCTAGAGACACCAACAGGGGCCACACTGTGAAGGCAGTGTGTGAGTCATTTCACCTGGCCA
AAGATTCCGGTTTTAAAGTGGTGGCCCATATGATGCCTGACCTGCCAAACGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTT
TTGAGAACCCTGCTTTTCGTCCCGATGGGCTGAAACTCTATCCTACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCTTTGGAAATCAG
GAAGATATAAGAGTTACTCTCCTAGTGACCTGGTTGAATTGGTGGCTCGGATCCTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAG
TACAGAGGGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGAGCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCG
GAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCAAGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGA
GAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATACGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCA
AGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGTCTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGA
GCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCATGCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGT
CTGGGAAAATCGCTGTGATATCAGGGGTCGGCACCAGGAATTATTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAGA
TGCTGAAATAATGGCCACACCAGTCCACTCTTCTGCAGTATCCTCCCTGGCAGAACACGGAGAATCAGGATTTCTTAAATACTCAACAGA
GAGGCTGAGCAGAGCAAATGGGGGGCTTCACCCTCATCCCGCAGCTGCAGAGACTGGAAACTGCCTTCAAGGCCACGGCTGGTCATCTGC
TGACCACACCCCAGATCCGCCCTCTCCTGCGTGCACCCCAAAAAATCACTTGCGTTTTTGAGGCTTAAATCATCTATCCAGTTTCTACAT
TTTGCATGAGGCCTGCAGGTGGCCTATTTTGACTCAGACGGTGAAAAAAGCAAATTAACTCATTTGGACACCATAACTCATGCAATAAAA
CTGATTGTCATTCGAGGAGCAAACTTAAGAGTAGTTTATTTATATACCCTGGGGACAGAAAGTCAGGTTGAAACAGGAAAACCACCAGAC
TCTAATCTCAGCCCTTTAACGACATACGCATTGGAGCGCAAGTTAGGAAAATGAGCTTTTGTTTTCATGGAAATCATTCTGATTACAGTG
CTGATGTTTAGAAATAAATAGCAGTGTGACTGGGAAAGAGGAATTGCAGTTGTGGGGGTGTGAGCCTGGCAGCAGCCAGCCAGCAGCCTC
TCCCAGGCGGGAGTCTACCATCCGAGACGGCGATGACAAAGAGCTTCATTCCACATTCTTTGTTATCTCTACTTCCCACCCTCTTGGCAA
CTACAGAGCAGTGTGGGCAGCCCCAAGTGTGGTCCCCAGAGAGCGTTTGGCTTTCCTGTCTGTCTATCCTGAGCGGGTGGAGTCTCAGGT
TGTGTGCCCCTAAATCAAGATTTGCTTCCACAGAAGCCATTACTTGCAATTTTTTTTTTTTTTCTGAGAAAGTCTCGCTGTGTCACCCAG
GCTGGAGTGCAGTGGCGCAATCTCACTGCATCCTCCGCCTCCCGGGTTCAAGCGATTCTCCCGCCTCAGCCTCCTGAGTAGCTGGGATTA
CAGGCACCCGCCGCTGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTCACCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAG
GTGATCAACCCACCTTGGCCTCCCTAAATGCCGGGATTACAGGCATGAGCCACCGCTCCCAGCCTTTGATTTTTTAAGGTGGATTTTGGT
TGTTATAAATGGAGAAAGGTAAGAGTTCAAGTTCAACCCGTGTGTGAAAGCAAAACAATGGAAAACAGGATTGGCTTCTTCAAAGGCTCC
TCTTGTAGAACTGCCTCTTTGAAATTTCGAGGTAATCTACTTTGGAGACTCTGCCTGGAGAGGGTCAGTTCCTAAGTTAAAAGCATCGCT
TAACCTTGGCTCCTGTGGCATTTTACAAAGGTTTAAAGGAATTGATTCCTCTGAAAGGGCCTGAAAATAAAAAGTCTTTAACATACAAAG

>67684_67684_2_PPME1-ELP3_PPME1_chr11_73882567_ENST00000328257_ELP3_chr8_27987019_ENST00000521015_length(amino acids)=375AA_BP=34
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGH
TVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARI
LALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDP
DQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRK

--------------------------------------------------------------
>67684_67684_3_PPME1-ELP3_PPME1_chr11_73882567_ENST00000328257_ELP3_chr8_27987019_ENST00000542181_length(transcript)=1820nt_BP=424nt
ATTGCGCAGGGTGCATTGCCCTGAAGAGCGCTCCTCCTTCCGGTGAAAGTCGTCGGGTTCCCAGCCGGGAGTCTGCGGAGTTCTCATACT
CTGTTACCCAGCTTCCTTTGTATGAGTGCTGTTGCGCACTTCCGGTGGAAGCGCTGAAGCGAGTGGGTGGAGTTTACGGAGCCGGTGGGC
GGTAGGCGGTGCTACGGGTAGCTGGGTGCTGTCCAAAGGCGACAGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAA
CGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAGCCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCC
TTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAGCGGAGCCAAGATGCGAATGGGGTATTCTGAGAGAAGCCTCACAAAGT
GTATTGGAATTACTATTGAAACCAGACCAGATTACTGCATGAAGCGACATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGA
TTGGGGTGCAGAGTGTTTATGAAGATGTGGCTAGAGACACCAACAGGGGCCACACTGTGAAGGCAGTGTGTGAGTCATTTCACCTGGCCA
AAGATTCCGGTTTTAAAGTGGTGGCCCATATGATGCCTGACCTGCCAAACGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTT
TTGAGAACCCTGCTTTTCGTCCCGATGGGCTGAAACTCTATCCTACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCTTTGGAAATCAG
GAAGATATAAGAGTTACTCTCCTAGTGACCTGGTTGAATTGGTGGCTCGGATCCTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAG
TACAGAGGGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGAGCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCG
GAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCAAGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGA
GAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATACGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCA
AGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGTCTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGA
GCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCATGCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGT
CTGGGAAAATCGCTGTGATATCAGGGGTCGGCACCAGGAATTATTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAGA
TGCTGAAATAATGGCCACACCAGTCCACTCTTCTGCAGTATCCTCCCTGGCAGAACACGGAGAATCAGGATTTCTTAAATACTCAACAGA
GAGGCTGAGCAGAGCAAATGGGGGGCTTCACCCTCATCCCGCAGCTGCAGAGACTGGAAACTGCCTTCAAGGCCACGGCTGGTCATCTGC
TGACCACACCCCAGATCCGCCCTCTCCTGCGTGCACCCCAAAAAATCACTTGCGTTTTTGAGGCTTAAATCATCTATCCAGTTTCTACAT
TTTGCATGAGGCCTGCAGGTGGCCTATTTTGACTCAGACGGTGAAAAAAGCAAATTAACTCATTTGGACACCATAACTCATGCAATAAAA

>67684_67684_3_PPME1-ELP3_PPME1_chr11_73882567_ENST00000328257_ELP3_chr8_27987019_ENST00000542181_length(amino acids)=375AA_BP=34
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGH
TVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARI
LALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDP
DQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRK

--------------------------------------------------------------
>67684_67684_4_PPME1-ELP3_PPME1_chr11_73882567_ENST00000398427_ELP3_chr8_27987019_ENST00000256398_length(transcript)=2659nt_BP=201nt
AGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAACGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAG
CCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCCTTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAG
CGGAGCCAAGATGCGAATGGGGTATTCTGAGAGAAGCCTCACAAAGTGTATTGGAATTACTATTGAAACCAGACCAGATTACTGCATGAA
GCGACATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGATTGGGGTGCAGAGTGTTTATGAAGATGTGGCTAGAGACACCAA
CAGGGGCCACACTGTGAAGGCAGTGTGTGAGTCATTTCACCTGGCCAAAGATTCCGGTTTTAAAGTGGTGGCCCATATGATGCCTGACCT
GCCAAACGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTTTTGAGAACCCTGCTTTTCGTCCCGATGGGCTGAAACTCTATCC
TACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCTTTGGAAATCAGGAAGATATAAGAGTTACTCTCCTAGTGACCTGGTTGAATTGGT
GGCTCGGATCCTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAGTACAGAGGGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGA
GCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCGGAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCA
AGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGAGAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATA
CGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCAAGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGT
CTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGAGCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCAT
GCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGTCTGGGAAAATCGCTGTGATATCAGGGGTCGGCACCAGGAATTA
TTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAGATGCTGAAATAATGGCCACACCAGTCCACTCTTCTGCAGTATCC
TCCCTGGCAGAACACGGAGAATCAGGATTTCTTAAATACTCAACAGAGAGGCTGAGCAGAGCAAATGGGGGGCTTCACCCTCATCCCGCA
GCTGCAGAGACTGGAAACTGCCTTCAAGGCCACGGCTGGTCATCTGCTGACCACACCCCAGATCCGCCCTCTCCTGCGTGCACCCCAAAA
AATCACTTGCGTTTTTGAGGCTTAAATCATCTATCCAGTTTCTACATTTTGCATGAGGCCTGCAGGTGGCCTATTTTGACTCAGACGGTG
AAAAAAGCAAATTAACTCATTTGGACACCATAACTCATGCAATAAAACTGATTGTCATTCGAGGAGCAAACTTAAGAGTAGTTTATTTAT
ATACCCTGGGGACAGAAAGTCAGGTTGAAACAGGAAAACCACCAGACTCTAATCTCAGCCCTTTAACGACATACGCATTGGAGCGCAAGT
TAGGAAAATGAGCTTTTGTTTTCATGGAAATCATTCTGATTACAGTGCTGATGTTTAGAAATAAATAGCAGTGTGACTGGGAAAGAGGAA
TTGCAGTTGTGGGGGTGTGAGCCTGGCAGCAGCCAGCCAGCAGCCTCTCCCAGGCGGGAGTCTACCATCCGAGACGGCGATGACAAAGAG
CTTCATTCCACATTCTTTGTTATCTCTACTTCCCACCCTCTTGGCAACTACAGAGCAGTGTGGGCAGCCCCAAGTGTGGTCCCCAGAGAG
CGTTTGGCTTTCCTGTCTGTCTATCCTGAGCGGGTGGAGTCTCAGGTTGTGTGCCCCTAAATCAAGATTTGCTTCCACAGAAGCCATTAC
TTGCAATTTTTTTTTTTTTTCTGAGAAAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCACTGCATCCTCCGCCTCCC
GGGTTCAAGCGATTCTCCCGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCGCCGCTGCTAATTTTTGTATTTTTAGTAGAGATG
GGGGTTTCACCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCAACCCACCTTGGCCTCCCTAAATGCCGGGATTACAGG
CATGAGCCACCGCTCCCAGCCTTTGATTTTTTAAGGTGGATTTTGGTTGTTATAAATGGAGAAAGGTAAGAGTTCAAGTTCAACCCGTGT
GTGAAAGCAAAACAATGGAAAACAGGATTGGCTTCTTCAAAGGCTCCTCTTGTAGAACTGCCTCTTTGAAATTTCGAGGTAATCTACTTT
GGAGACTCTGCCTGGAGAGGGTCAGTTCCTAAGTTAAAAGCATCGCTTAACCTTGGCTCCTGTGGCATTTTACAAAGGTTTAAAGGAATT

>67684_67684_4_PPME1-ELP3_PPME1_chr11_73882567_ENST00000398427_ELP3_chr8_27987019_ENST00000256398_length(amino acids)=375AA_BP=34
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGH
TVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARI
LALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDP
DQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRK

--------------------------------------------------------------
>67684_67684_5_PPME1-ELP3_PPME1_chr11_73882567_ENST00000398427_ELP3_chr8_27987019_ENST00000521015_length(transcript)=2659nt_BP=201nt
AGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAACGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAG
CCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCCTTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAG
CGGAGCCAAGATGCGAATGGGGTATTCTGAGAGAAGCCTCACAAAGTGTATTGGAATTACTATTGAAACCAGACCAGATTACTGCATGAA
GCGACATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGATTGGGGTGCAGAGTGTTTATGAAGATGTGGCTAGAGACACCAA
CAGGGGCCACACTGTGAAGGCAGTGTGTGAGTCATTTCACCTGGCCAAAGATTCCGGTTTTAAAGTGGTGGCCCATATGATGCCTGACCT
GCCAAACGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTTTTGAGAACCCTGCTTTTCGTCCCGATGGGCTGAAACTCTATCC
TACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCTTTGGAAATCAGGAAGATATAAGAGTTACTCTCCTAGTGACCTGGTTGAATTGGT
GGCTCGGATCCTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAGTACAGAGGGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGA
GCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCGGAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCA
AGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGAGAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATA
CGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCAAGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGT
CTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGAGCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCAT
GCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGTCTGGGAAAATCGCTGTGATATCAGGGGTCGGCACCAGGAATTA
TTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAGATGCTGAAATAATGGCCACACCAGTCCACTCTTCTGCAGTATCC
TCCCTGGCAGAACACGGAGAATCAGGATTTCTTAAATACTCAACAGAGAGGCTGAGCAGAGCAAATGGGGGGCTTCACCCTCATCCCGCA
GCTGCAGAGACTGGAAACTGCCTTCAAGGCCACGGCTGGTCATCTGCTGACCACACCCCAGATCCGCCCTCTCCTGCGTGCACCCCAAAA
AATCACTTGCGTTTTTGAGGCTTAAATCATCTATCCAGTTTCTACATTTTGCATGAGGCCTGCAGGTGGCCTATTTTGACTCAGACGGTG
AAAAAAGCAAATTAACTCATTTGGACACCATAACTCATGCAATAAAACTGATTGTCATTCGAGGAGCAAACTTAAGAGTAGTTTATTTAT
ATACCCTGGGGACAGAAAGTCAGGTTGAAACAGGAAAACCACCAGACTCTAATCTCAGCCCTTTAACGACATACGCATTGGAGCGCAAGT
TAGGAAAATGAGCTTTTGTTTTCATGGAAATCATTCTGATTACAGTGCTGATGTTTAGAAATAAATAGCAGTGTGACTGGGAAAGAGGAA
TTGCAGTTGTGGGGGTGTGAGCCTGGCAGCAGCCAGCCAGCAGCCTCTCCCAGGCGGGAGTCTACCATCCGAGACGGCGATGACAAAGAG
CTTCATTCCACATTCTTTGTTATCTCTACTTCCCACCCTCTTGGCAACTACAGAGCAGTGTGGGCAGCCCCAAGTGTGGTCCCCAGAGAG
CGTTTGGCTTTCCTGTCTGTCTATCCTGAGCGGGTGGAGTCTCAGGTTGTGTGCCCCTAAATCAAGATTTGCTTCCACAGAAGCCATTAC
TTGCAATTTTTTTTTTTTTTCTGAGAAAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCACTGCATCCTCCGCCTCCC
GGGTTCAAGCGATTCTCCCGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCGCCGCTGCTAATTTTTGTATTTTTAGTAGAGATG
GGGGTTTCACCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCAACCCACCTTGGCCTCCCTAAATGCCGGGATTACAGG
CATGAGCCACCGCTCCCAGCCTTTGATTTTTTAAGGTGGATTTTGGTTGTTATAAATGGAGAAAGGTAAGAGTTCAAGTTCAACCCGTGT
GTGAAAGCAAAACAATGGAAAACAGGATTGGCTTCTTCAAAGGCTCCTCTTGTAGAACTGCCTCTTTGAAATTTCGAGGTAATCTACTTT
GGAGACTCTGCCTGGAGAGGGTCAGTTCCTAAGTTAAAAGCATCGCTTAACCTTGGCTCCTGTGGCATTTTACAAAGGTTTAAAGGAATT

>67684_67684_5_PPME1-ELP3_PPME1_chr11_73882567_ENST00000398427_ELP3_chr8_27987019_ENST00000521015_length(amino acids)=375AA_BP=34
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGH
TVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARI
LALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDP
DQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRK

--------------------------------------------------------------
>67684_67684_6_PPME1-ELP3_PPME1_chr11_73882567_ENST00000398427_ELP3_chr8_27987019_ENST00000542181_length(transcript)=1597nt_BP=201nt
AGGGCGTCGTTAGGGGAGCGAGTCGTGACCGGTTGGGCCACACTCAACGTGGGACGAAGCTTCGCCTACTGTTTGACTACGTGCGTGCAG
CCTCCCCTCGATGTCGGCCCTCGAAAAGAGCATGCACCTCGGCCGCCTTCCCTCTCGCCCACCTCTACCCGGCAGCGGGGGCAGTCAGAG
CGGAGCCAAGATGCGAATGGGGTATTCTGAGAGAAGCCTCACAAAGTGTATTGGAATTACTATTGAAACCAGACCAGATTACTGCATGAA
GCGACATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGATTGGGGTGCAGAGTGTTTATGAAGATGTGGCTAGAGACACCAA
CAGGGGCCACACTGTGAAGGCAGTGTGTGAGTCATTTCACCTGGCCAAAGATTCCGGTTTTAAAGTGGTGGCCCATATGATGCCTGACCT
GCCAAACGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTTTTGAGAACCCTGCTTTTCGTCCCGATGGGCTGAAACTCTATCC
TACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCTTTGGAAATCAGGAAGATATAAGAGTTACTCTCCTAGTGACCTGGTTGAATTGGT
GGCTCGGATCCTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAGTACAGAGGGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGA
GCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCGGAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCA
AGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGAGAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATA
CGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCAAGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGT
CTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGAGCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCAT
GCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGTCTGGGAAAATCGCTGTGATATCAGGGGTCGGCACCAGGAATTA
TTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAGATGCTGAAATAATGGCCACACCAGTCCACTCTTCTGCAGTATCC
TCCCTGGCAGAACACGGAGAATCAGGATTTCTTAAATACTCAACAGAGAGGCTGAGCAGAGCAAATGGGGGGCTTCACCCTCATCCCGCA
GCTGCAGAGACTGGAAACTGCCTTCAAGGCCACGGCTGGTCATCTGCTGACCACACCCCAGATCCGCCCTCTCCTGCGTGCACCCCAAAA
AATCACTTGCGTTTTTGAGGCTTAAATCATCTATCCAGTTTCTACATTTTGCATGAGGCCTGCAGGTGGCCTATTTTGACTCAGACGGTG

>67684_67684_6_PPME1-ELP3_PPME1_chr11_73882567_ENST00000398427_ELP3_chr8_27987019_ENST00000542181_length(amino acids)=375AA_BP=34
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGH
TVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARI
LALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDP
DQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPME1-ELP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPME1-ELP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPME1-ELP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource