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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R10-MUS81 (FusionGDB2 ID:67723)

Fusion Gene Summary for PPP1R10-MUS81

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R10-MUS81
Fusion gene ID: 67723
HgeneTgene
Gene symbol

PPP1R10

MUS81

Gene ID

5514

80198

Gene nameprotein phosphatase 1 regulatory subunit 10MUS81 structure-specific endonuclease subunit
SynonymsCAT53|FB19|PNUTS|PP1R10|R111|p99SLX3
Cytomap

6p21.33

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 1 regulatory subunit 10HLA-C associated transcript 53MHC class I region proline-rich protein CAT53PP1-binding protein of 114 kDaphosphatase 1 nuclear targeting subunitprotein phosphatase 1, regulatory (inhibitor) crossover junction endonuclease MUS81MUS81 endonuclease homologSLX3 structure-specific endonuclease subunit homolog
Modification date2020031320200327
UniProtAcc.

Q96NY9

Ensembl transtripts involved in fusion geneENST00000376511, ENST00000484449, 
ENST00000383586, ENST00000420949, 
ENST00000424446, ENST00000426299, 
ENST00000429597, ENST00000449113, 
ENST00000468706, ENST00000475926, 
ENST00000478528, ENST00000482076, 
ENST00000488513, ENST00000494003, 
ENST00000547333, ENST00000548899, 
ENST00000549281, ENST00000549865, 
ENST00000551493, ENST00000552146, 
ENST00000308110, ENST00000525006, 
ENST00000533035, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 5 X 4=100
# samples 65
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R10 [Title/Abstract] AND MUS81 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R10(30584255)-MUS81(65628146), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R10

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

23426265


check buttonFusion gene breakpoints across PPP1R10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MUS81 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A825-06APPP1R10chr6

30584255

-MUS81chr11

65628146

+


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Fusion Gene ORF analysis for PPP1R10-MUS81

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000376511ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-5UTRENST00000484449ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000376511ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000376511ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000484449ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000484449ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000383586ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000420949ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000424446ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000426299ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000429597ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000449113ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000468706ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000475926ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000478528ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000482076ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000488513ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000494003ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000547333ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000548899ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000549281ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000549865ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000551493ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000552146ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000383586ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000383586ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000420949ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000420949ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000424446ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000424446ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000426299ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000426299ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000429597ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000429597ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000449113ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000449113ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000468706ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000468706ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000475926ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000475926ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000478528ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000478528ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000482076ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000482076ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000488513ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000488513ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000494003ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000494003ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000547333ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000547333ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000548899ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000548899ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549281ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549281ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549865ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549865ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000551493ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000551493ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000552146ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000552146ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP1R10-MUS81


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP1R10-MUS81


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30584255/:65628146)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MUS81

Q96NY9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP1R10-MUS81


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP1R10-MUS81


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R10-MUS81


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R10-MUS81


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource