FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARPC1B-ICA1 (FusionGDB2 ID:6774)

Fusion Gene Summary for ARPC1B-ICA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARPC1B-ICA1
Fusion gene ID: 6774
HgeneTgene
Gene symbol

ARPC1B

ICA1

Gene ID

10095

3382

Gene nameactin related protein 2/3 complex subunit 1Bislet cell autoantigen 1
SynonymsARC41|PLTEID|p40-ARC|p41-ARCICA69|ICAp69
Cytomap

7q22.1

7p21.3

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2/3 complex subunit 1BARP2/3 protein complex subunit p41actin related protein 2/3 complex, subunit 1B, 41kDaarp2/3 complex 41 kDa subunitislet cell autoantigen 169 kDa islet cell autoantigendiabetes mellitus type I autoantigenislet cell autoantigen 1 isoformislet cell autoantigen 1, 69kDaislet cell autoantigen p69p69testicular tissue protein Li 162
Modification date2020031320200327
UniProtAcc

O15143

Q8NDH6

Ensembl transtripts involved in fusion geneENST00000474880, ENST00000252725, 
ENST00000451682, 		ENST00000265577, 
ENST00000396675, ENST00000401396, 
ENST00000402384, ENST00000406470, 
ENST00000422063, ENST00000407906, 
ENST00000476942, 
Fusion gene scores* DoF score16 X 15 X 7=168014 X 8 X 8=896
# samples 1813
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/896*10)=-2.78498710902915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARPC1B [Title/Abstract] AND ICA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARPC1B(98983401)-ICA1(8153674), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARPC1B

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check buttonFusion gene breakpoints across ARPC1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ICA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315384ARPC1Bchr7

98983401

+ICA1chr7

8153674

-


Top

Fusion Gene ORF analysis for ARPC1B-ICA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000474880ENST00000265577ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-3CDSENST00000474880ENST00000396675ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-3CDSENST00000474880ENST00000401396ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-3CDSENST00000474880ENST00000402384ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-3CDSENST00000474880ENST00000406470ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-3CDSENST00000474880ENST00000422063ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-intronENST00000474880ENST00000407906ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
3UTR-intronENST00000474880ENST00000476942ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
5CDS-intronENST00000252725ENST00000407906ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
5CDS-intronENST00000252725ENST00000476942ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
5CDS-intronENST00000451682ENST00000407906ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
5CDS-intronENST00000451682ENST00000476942ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000252725ENST00000265577ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000252725ENST00000402384ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000252725ENST00000406470ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000252725ENST00000422063ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000451682ENST00000265577ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000451682ENST00000402384ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000451682ENST00000406470ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
Frame-shiftENST00000451682ENST00000422063ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
In-frameENST00000252725ENST00000396675ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
In-frameENST00000252725ENST00000401396ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
In-frameENST00000451682ENST00000396675ARPC1Bchr7

98983401

+ICA1chr7

8153674

-
In-frameENST00000451682ENST00000401396ARPC1Bchr7

98983401

+ICA1chr7

8153674

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252725ARPC1Bchr798983401+ENST00000396675ICA1chr78153674-9201843330590
ENST00000252725ARPC1Bchr798983401+ENST00000401396ICA1chr78153674-4501843330590
ENST00000451682ARPC1Bchr798983401+ENST00000396675ICA1chr78153674-1109373109984584
ENST00000451682ARPC1Bchr798983401+ENST00000401396ICA1chr78153674-63937316138273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252725ENST00000396675ARPC1Bchr798983401+ICA1chr78153674-0.49940250.5005975
ENST00000252725ENST00000401396ARPC1Bchr798983401+ICA1chr78153674-0.352578250.6474218
ENST00000451682ENST00000396675ARPC1Bchr798983401+ICA1chr78153674-0.323723880.6762761
ENST00000451682ENST00000401396ARPC1Bchr798983401+ICA1chr78153674-0.293672440.7063276

Top

Fusion Genomic Features for ARPC1B-ICA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARPC1B-ICA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:98983401/chr7:8153674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARPC1B

O15143

ICA1

Q8NDH6

FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000252725+210140_17921373.0RepeatNote=WD 4
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000252725+210242_28021373.0RepeatNote=WD 5
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000252725+210324_36721373.0RepeatNote=WD 6
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000252725+21050_8921373.0RepeatNote=WD 2
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000252725+2106_4521373.0RepeatNote=WD 1
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000252725+21094_13521373.0RepeatNote=WD 3
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000451682+412140_17921373.0RepeatNote=WD 4
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000451682+412242_28021373.0RepeatNote=WD 5
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000451682+412324_36721373.0RepeatNote=WD 6
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000451682+41250_8921373.0RepeatNote=WD 2
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000451682+4126_4521373.0RepeatNote=WD 1
HgeneARPC1Bchr7:98983401chr7:8153674ENST00000451682+41294_13521373.0RepeatNote=WD 3
TgeneICA1chr7:98983401chr7:8153674ENST00000396675121451_254443484.0DomainAH
TgeneICA1chr7:98983401chr7:8153674ENST00000402384121451_254443484.0DomainAH
TgeneICA1chr7:98983401chr7:8153674ENST00000406470121451_254443484.0DomainAH
TgeneICA1chr7:98983401chr7:8153674ENST00000422063121451_254472513.0DomainAH


Top

Fusion Gene Sequence for ARPC1B-ICA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6774_6774_1_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000252725_ICA1_chr7_8153674_ENST00000396675_length(transcript)=920nt_BP=184nt
GGCAGGCCCCGCCCCCCGCCCACGAGGAAGTGGCTGCTGCTCCGGCGCGGAGCCCAGAGCCGGTTCGGCGCGTCGACTGCCCAGAGTCCG
CGGCCGGGGCGCGGGAGGAGCCAAGCCGCCATGGCCTACCACAGCTTCCTGGTGGAGCCCATCAGCTGCCACGCCTGGAACAAGGACCGC
ACCCAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTCAGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGG
AAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGTACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGG
GCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAATTATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATT
GGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTGTATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGAAGCGGTTTC
CAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGCGGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAGAAGCCTACT
TTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGCAGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGCCCCCAGCCT
CTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCCTGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTGGCCAACCAA
AGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTCTCACACTGGTGGAGGAGCTGGGCTTCTGTCCAAGGCACAAACCTTACT

>6774_6774_1_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000252725_ICA1_chr7_8153674_ENST00000396675_length(amino acids)=90AA_BP=51
MLLRRGAQSRFGASTAQSPRPGRGRSQAAMAYHSFLVEPISCHAWNKDRTQPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA

--------------------------------------------------------------
>6774_6774_2_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000252725_ICA1_chr7_8153674_ENST00000401396_length(transcript)=450nt_BP=184nt
GGCAGGCCCCGCCCCCCGCCCACGAGGAAGTGGCTGCTGCTCCGGCGCGGAGCCCAGAGCCGGTTCGGCGCGTCGACTGCCCAGAGTCCG
CGGCCGGGGCGCGGGAGGAGCCAAGCCGCCATGGCCTACCACAGCTTCCTGGTGGAGCCCATCAGCTGCCACGCCTGGAACAAGGACCGC
ACCCAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTCAGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGG
AAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGTACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGG
GCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAATTATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATT

>6774_6774_2_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000252725_ICA1_chr7_8153674_ENST00000401396_length(amino acids)=90AA_BP=51
MLLRRGAQSRFGASTAQSPRPGRGRSQAAMAYHSFLVEPISCHAWNKDRTQPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA

--------------------------------------------------------------
>6774_6774_3_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000451682_ICA1_chr7_8153674_ENST00000396675_length(transcript)=1109nt_BP=373nt
AGAGCCGGTTCGGCGCGTCGACTGCCCAGAGTCCGCGGCCGGGGCGCGGGAGTGTTCCCCCAGGTGAACCTAACTTCCTGGCCTCCAAGA
TTTGGGGTCAGAGTCCCAAGCTGCGTCATTTAGTAGAAGCCGAGTGACTTTGAACAAATCGTTGCTTTTGTCTGAGCCTGGGTTTCCTCC
TGTACAAACTGAAGTGTCTTGTTCTGTTGCCCAGGCTGGAGTGTGGTGACACTACCTTGACTCACTGCAGCATCTGCCTCCCGGGTTCCA
GTGATTCTCCTGCCTCAGCCTCTCAGGAGCCAAGCCGCCATGGCCTACCACAGCTTCCTGGTGGAGCCCATCAGCTGCCACGCCTGGAAC
AAGGACCGCACCCAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTCAGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGAT
GCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGTACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCT
CCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAATTATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCT
GTTTATATTGGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTGTATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGA
AGCGGTTTCCAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGCGGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAG
AAGCCTACTTTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGCAGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGC
CCCCAGCCTCTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCCTGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTG
GCCAACCAAAGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTCTCACACTGGTGGAGGAGCTGGGCTTCTGTCCAAGGCACA

>6774_6774_3_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000451682_ICA1_chr7_8153674_ENST00000396675_length(amino acids)=84AA_BP=

--------------------------------------------------------------
>6774_6774_4_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000451682_ICA1_chr7_8153674_ENST00000401396_length(transcript)=639nt_BP=373nt
AGAGCCGGTTCGGCGCGTCGACTGCCCAGAGTCCGCGGCCGGGGCGCGGGAGTGTTCCCCCAGGTGAACCTAACTTCCTGGCCTCCAAGA
TTTGGGGTCAGAGTCCCAAGCTGCGTCATTTAGTAGAAGCCGAGTGACTTTGAACAAATCGTTGCTTTTGTCTGAGCCTGGGTTTCCTCC
TGTACAAACTGAAGTGTCTTGTTCTGTTGCCCAGGCTGGAGTGTGGTGACACTACCTTGACTCACTGCAGCATCTGCCTCCCGGGTTCCA
GTGATTCTCCTGCCTCAGCCTCTCAGGAGCCAAGCCGCCATGGCCTACCACAGCTTCCTGGTGGAGCCCATCAGCTGCCACGCCTGGAAC
AAGGACCGCACCCAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTCAGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGAT
GCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGTACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCT
CCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAATTATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCT

>6774_6774_4_ARPC1B-ICA1_ARPC1B_chr7_98983401_ENST00000451682_ICA1_chr7_8153674_ENST00000401396_length(amino acids)=73AA_BP=

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARPC1B-ICA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARPC1B-ICA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARPC1B-ICA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource