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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R12A-DNAH10 (FusionGDB2 ID:67741)

Fusion Gene Summary for PPP1R12A-DNAH10

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R12A-DNAH10
Fusion gene ID: 67741
HgeneTgene
Gene symbol

PPP1R12A

DNAH10

Gene ID

4659

196385

Gene nameprotein phosphatase 1 regulatory subunit 12Adynein axonemal heavy chain 10
SynonymsGUBS|M130|MBS|MYPT1-
Cytomap

12q21.2-q21.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 12Amyosin binding subunitmyosin phosphatase, target subunit 1myosin phosphatase-targeting subunit 1protein phosphatase 1, regulatory (inhibitor) subunit 12Aprotein phosphatase myosin-binding subunitdynein heavy chain 10, axonemalaxonemal beta dynein heavy chain 10ciliary dynein heavy chain 10dynein, axonemal, heavy polypeptide 10
Modification date2020032820200313
UniProtAcc.

P0CZ25

Ensembl transtripts involved in fusion geneENST00000261207, ENST00000437004, 
ENST00000450142, ENST00000550107, 
ENST00000546369, 		ENST00000538983, 
ENST00000409039, 
Fusion gene scores* DoF score25 X 22 X 11=60504 X 4 X 4=64
# samples 284
** MAII scorelog2(28/6050*10)=-4.43343641010435
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R12A [Title/Abstract] AND DNAH10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R12A(80328475)-DNAH10(124303497), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R12A

GO:0030155

regulation of cell adhesion

20354225

HgenePPP1R12A

GO:0035507

regulation of myosin-light-chain-phosphatase activity

20354225

HgenePPP1R12A

GO:0043086

negative regulation of catalytic activity

19245366

HgenePPP1R12A

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366


check buttonFusion gene breakpoints across PPP1R12A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAH10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HO-01APPP1R12Achr12

80328475

-DNAH10chr12

124303497

+


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Fusion Gene ORF analysis for PPP1R12A-DNAH10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261207ENST00000538983PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
5CDS-intronENST00000437004ENST00000538983PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
5CDS-intronENST00000450142ENST00000538983PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
5CDS-intronENST00000550107ENST00000538983PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
Frame-shiftENST00000261207ENST00000409039PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
Frame-shiftENST00000437004ENST00000409039PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
In-frameENST00000450142ENST00000409039PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
In-frameENST00000550107ENST00000409039PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
intron-3CDSENST00000546369ENST00000409039PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+
intron-intronENST00000546369ENST00000538983PPP1R12Achr12

80328475

-DNAH10chr12

124303497

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450142PPP1R12Achr1280328475-ENST00000409039DNAH10chr12124303497+11219504267104933408
ENST00000550107PPP1R12Achr1280328475-ENST00000409039DNAH10chr12124303497+109522370102263408

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450142ENST00000409039PPP1R12Achr1280328475-DNAH10chr12124303497+0.0017692730.99823076
ENST00000550107ENST00000409039PPP1R12Achr1280328475-DNAH10chr12124303497+0.001426490.99857354

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Fusion Genomic Features for PPP1R12A-DNAH10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP1R12Achr1280328474-DNAH10chr12124303496+2.50E-131
PPP1R12Achr1280328474-DNAH10chr12124303496+2.50E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP1R12A-DNAH10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:80328475/chr12:124303497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNAH10

P0CZ25

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-22635_38791031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-22535_3879996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-12535_38791031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-12435_3879975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-22639_68791031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-22539_6879996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-12539_68791031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-12439_6879975.0RepeatNote=ANK 1
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781217_124511424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782747_277011424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783045_313111424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783257_332711424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783567_363811424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919784235_426011424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781832_183911424472.0MotifNote=GPAGTGKT motif
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781882_188811424472.0MotifNote=CFDEFNR motif
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782113_212011424472.0Nucleotide bindingATP
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782455_246211424472.0Nucleotide bindingATP
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782803_281011424472.0Nucleotide bindingATP
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781794_201511424472.0RegionAAA 1
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782075_229411424472.0RegionAAA 2
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782417_266511424472.0RegionAAA 3
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782765_301411424472.0RegionAAA 4
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783029_331311424472.0RegionStalk
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783399_362911424472.0RegionAAA 5
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783845_406211424472.0RegionAAA 6
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781221_125411424472.0RepeatNote=TPR 1
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782736_276911424472.0RepeatNote=TPR 2
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919782771_279711424472.0RepeatNote=TPR 3
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919783802_383711424472.0RepeatNote=TPR 4
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919784074_410811424472.0RepeatNote=TPR 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226519_660791031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226721_753791031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226773_795791031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225519_66079996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225721_75379996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225773_79579996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125519_660791031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125721_753791031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125773_795791031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125519_6600944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125721_7530944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125773_7950944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124519_66079975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124721_75379975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124773_79579975.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-12535_380944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226105_134791031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226138_164791031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226198_227791031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226231_260791031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-22672_101791031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225105_13479996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225138_16479996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225198_22779996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225231_26079996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-22572_10179996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125105_134791031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125138_164791031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125198_227791031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125231_260791031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-12572_101791031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125105_1340944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125138_1640944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125198_2270944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125231_2600944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-12539_680944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-12572_1010944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124105_13479975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124138_16479975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124198_22779975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124231_26079975.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-12472_10179975.0RepeatNote=ANK 2
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781071_110611424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST000004090391978203_22311424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST000004090391978602_62211424472.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH10chr12:80328475chr12:124303497ENST00000409039197818_2511424472.0Compositional biasNote=Poly-Glu
TgeneDNAH10chr12:80328475chr12:124303497ENST000004090391978949_95211424472.0Compositional biasNote=Poly-Glu
TgeneDNAH10chr12:80328475chr12:124303497ENST0000040903919781_179311424472.0RegionStem


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Fusion Gene Sequence for PPP1R12A-DNAH10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67741_67741_1_PPP1R12A-DNAH10_PPP1R12A_chr12_80328475_ENST00000450142_DNAH10_chr12_124303497_ENST00000409039_length(transcript)=11219nt_BP=504nt
GAAGTTACGTTAGATTGGCCGCCGGTGACGGGTGGCCGTGCTGGGGGCGGGAGGGCTTCTGTGGTAGGAAGGGAGGTCCGCTCGGCCGGG
TGCGCCGCCCCAGTGCTCTGTGGGATACTGGAAGTCTCGAGCGTCGGCTCCGGGTTCCCAGCCCTCCTCTGGCCCGCACTCATAGAAACA
TTCACACACCCCCTGCCTCCCCTCTCTTCCCTCTCCGCCTCCCCCTTCCCCCCCTCGCGATAAGAAGACCCGGCGGCAGGAGAGGGGATG
AAGATGGCGGACGCGAAGCAGAAGCGGAACGAGCAGCTGAAACGCTGGATCGGCTCCGAGACGGACCTCGAGCCTCCGGTGGTGAAGCGC
CAGAAGACCAAGGTGAAGTTCGACGATGGCGCCGTCTTCCTGGCTGCTTGCTCCAGCGGCGACACGGACGAGGTCCTCAAGCTGCTGCAC
CGCGGCGCCGACATCAATTACGCCAATGTGGACGGACTCACTGCCCTGCACCAGCCTCCTGATGCAGAGAAAGAACTGGTTGATAAGATT
GAGAGCATATGGTCCAATCTGTTTAATGATTCAGTGAATGTGGAGCATGCTCTTGGGGACATAAAGAGAACTTTCACAGAGCTTACTCGA
GGCGAAATAATGAACTACAGAGTTCAGATAGAGGAGTTTGCAAAGCGTTTTTACAGTGAAGGCCCTGGTTCTGTTGGTGATGATCTTGAT
AAAGGAGTAGAGCTTTTAGGTGTTTATGAAAGAGAGCTGGCAAGACATGAAAAGAGCCGTCAGGAACTGGCTAACGCTGAGAAACTTTTC
GATCTTCCTATTACAATGTACCCAGAGCTGCTGAAAGTGCAGAAGGAAATGAGTGGGCTGAGGATGATTTACGAGCTCTATGAAGGACTA
AAGGTTGCAAAAGAAGAATGGTCTCAGACCCTTTGGATCAACCTGAATGTGCAGATTCTCCAGGAAGGAATTGAAGGTTTTCTCAGGGCT
CTCAGAAAGCTACCTCGGCCAGTCCGTGGCTTATCAGTGACCTACTACTTGGAAGCAAAAATGAAGGCATTCAAAGACTCGATTCCTTTA
CTTCTTGACTTGAAAAACGAGGCACTAAGAGACAGGCATTGGAAAGAACTTATGGAAAAAACGTCTGTCTTTTTTGAAATGACCGAAACG
TTCACCTTGGAAAATATGTTTGCTATGGAACTGCACAAACACACAGATGTTCTCAATGAGATTGTCACAGCAGCAATCAAGGAGGTTGCC
ATTGAGAAGGCTGTGAAGGAAATCCTAGACACGTGGGAAAATATGAAATTCACTGTAGTCAAGTATTGCAAAGGCACACAGGAGCGAGGC
TACATCCTGGGTTCTGTTGACGAAATTATTCAGTCTCTTGATGACAACACTTTCAACCTGCAGAGCATCTCAGGAAGCAGATTTGTGGGG
CCTTTTCTGCAAACTGTTCACAAATGGGAAAAAACGCTTTCTCTAATAGGGGAAGTCATTGAGATTTGGATGTTGGTTCAGAGAAAATGG
ATGTATCTTGAAAGTATTTTTATTGGTGGAGATATAAGATCACAACTTCCGGAAGAGGCAAAAAAGTTTGACAACATCGATAAAGTATTT
AAAAGGATCATGGGTGAGACCTTAAAAGACCCCGTGATCAAGAGGTGCTGTGAAGCCCCAAACCGCCTCAGTGACCTACAGAACGTCAGC
GAGGGCCTGGAGAAATGCCAGAAAAGCCTCAACGACTACTTAGATTCGAAGAGAAATGCTTTCCCAAGGTTCTTCTTCATTTCTGACGAT
GAGTTGCTTAGCATTCTGGGGAGCAGCGACCCACTCTGCGTCCAGGAGCACATGATCAAGATGTACGACAACATAGCATCACTGAGGTTT
AATGACGGCGATAGTGGAGAAAAACTGGTGTCCGCGATGATTTCAGCAGAAGGAGAAGTCATGGAGTTTCGGAAGATCTTGCGGGCTGAA
GGGCGCGTGGAGGACTGGATGACGGCAGTTTTGAATGAGATGAGAAGAACTAATAGACTAATTACCAAAGAGGCTATTTTTAGATACTGT
GAAGACAGAAGCAGAGTCGACTGGATGCTCCTGTACCAGGGCATGGTGGTGCTGGCCGCTAGCCAGGTGTGGTGGACCTGGGAGGTGGAA
GACGTCTTCCACAAAGCGCAAAAAGGGGAGAAGCAGGCCATGAAGAACTATGGCAGGAAAATGCACCGGCAGATCGATGAGTTGGTAACG
CGCATCACCATGCCGCTAAGCAAAAACGACAGGAAAAAATACAACACTGTTCTCATCATTGATGTGCATGCCAGAGACATAGTTGATTCT
TTCATAAGAGGCAGTATCCTGGAGGCCCGAGAGTTTGACTGGGAAAGTCAGTTGCGGTTTTATTGGGACCGGGAGCCGGATGAGCTGAAC
ATCCGCCAGTGCACGGGAACCTTTGGCTACGGCTACGAGTACATGGGCCTGAACGGCAGGCTGGTCATCACGCCCCTCACCGATCGGATT
TACCTGACGCTCACCCAGGCGCTGTCCATGTATCTAGGTGGGGCCCCCGCCGGCCCAGCAGGAACCGGCAAAACCGAGACCACCAAGGAC
CTGGCGAAAGCCTTGGGCTTGCTCTGTGTTGTCACCAACTGTGGCGAAGGCATGGATTACAGGGCCGTGGGGAAGATTTTCTCTGGCCTG
GCACAGTGCGGGGCTTGGGGCTGCTTTGATGAGTTTAATCGAATCGATGCTTCTGTGCTCTCCGTGATCTCCTCCCAGATCCAGACGATC
CGAAATGCTCTGATCCATCAGTTAACCACGTTCCAGTTTGAAGGGCAGGAGATTTCCCTGGACTCCCGCATGGGCATCTTCATCACCATG
AACCCCGGCTACGCAGGCCGCACGGAGCTGCCCGAGTCGGTGAAGGCGCTGTTCAGGCCTGTGGTCGTGATCGTGCCCGACCTGCAGCAG
ATCTGTGAGATCATGCTCTTCTCTGAGGGCTTCCTGGAGGCCAAGACTCTGGCGAAAAAGATGACGGTTCTGTATAAGCTGGCCCGGGAG
CAGCTGTCCAAGCAGTATCACTATGATTTTGGACTCAGAGCCCTGAAATCGGTGCTGGTCATGGCTGGTGAGCTGAAGAGAGGCTCCTCT
GACCTTAGGGAGGACGTGGTGCTGATGAGGGCCTTGCGAGACATGAACTTGCCCAAATTTGTGTTTGAAGATGTTCCTCTTTTCCTTGGT
TTGATTTCGGATCTGTTTCCTGGGCTGGACTGCCCTCGCGTCCGCTACCCTGACTTCAACGATGCGGTAGAGCAGGTCCTGGAGGAGAAC
GGCTACGCGGTCCTACCCATCCAGGTGGATAAAGTGGTTCAAATGTTCGAGACCATGTTAACCCGCCACACGACGATGGTGGTGGGGCCC
ACCAGAGGGGGCAAGTCCGTCGTCATTAACACTCTGTGTCAGGCCCAGACCAAGCTTGGGCTGACGACAAAGTTGTACATCCTGAACCCC
AAAGCCGTGAGTGTCATAGAACTCTACGGCATCCTGGACCCAACCACCCGAGACTGGACAGATGGGGTGTTGTCAAACATCTTCAGGGAA
ATCAACAAGCCAACAGACAAGAAGGAGCGAAAGTATATTTTATTTGATGGTGATGTGGATGCTCTATGGGTGGAAAACATGAATTCTGTG
ATGGATGACAACAGGTTGTTGACATTGGCCAACGGGGAACGCATCCGGCTCCAAGCACACTGTGCCCTGCTCTTTGAGGTTGGAGATTTA
CAGTATGCCTCCCCTGCAACTGTCTCTCGATGTGGAATGGTTTATGTGGATCCTAAAAACTTGAAATATCGACCATACTGGAAAAAATGG
GTTAATCAAATACCAAACAAGGTGGAGCAATACAATTTGAATAGTCTCTTTGAGAAGTATGTGCCCTATCTCATGGATGTGATAGTGGAA
GGAATTGTGGATGGAAGACAAGCAGAAAAGCTGAAGACAATAGTTCCTCAGACAGACCTCAATATGGTAACCCAGTTAGCCAAGATGTTG
GATGCGTTGCTAGAAGGAGAAATAGAAGACCTTGACCTGCTGGAGTGCTACTTCCTGGAGGCTTTGTACTGCTCTCTGGGAGCCTCCCTG
CTTGAGGATGGAAGGATGAAATTTGACGAATATATCAAACGCCTTGCTTCTTTGTCTACTGTTGACACAGAAGGAGTTTGGGCCAACCCT
GGGGAACTGCCAGGTCAACTTCCAACCTTGTATGACTTTCATTTTGATAACAAACGGAATCAATGGGTCCCATGGAGTAAATTAGTTCCA
GAGTATATTCATGCCCCCGAGAGGAAATTCATCAACATCCTGGTTCACACAGTGGATACCACTCGGACTACCTGGATATTGGAACAAATG
GTTAAAATTAAGCAACCTGTTATTTTTGTTGGTGAATCTGGCACTTCTAAGACAGCCACTACCCAGAATTTCCTCAAAAATCTGAGTGAA
GAAACTAACATTGTGTTAATGGTCAACTTCTCCTCCCGCACCACGTCCATGGATATCCAAAGAAATTTAGAAGCAAATGTGGAAAAGCGA
ACCAAAGATACTTACGGCCCACCCATGGGAAAACGCCTGCTGGTGTTCATGGATGACATGAATATGCCAAGGGTGGATGAATATGGCACG
CAGCAGCCCATTGCCTTGCTGAAGCTGCTGTTGGAAAAAGGCTACTTATATGACCGTGGGAAGGAGCTGAACTGTAAAAGCATTCGAGAC
CTTGGCTTTATTGCTGCAATGGGAAAGGCTGGAGGAGGCCGCAATGAAGTTGACCCAAGATTTATTTCGCTATTCAGTGTCTTCAATGTG
CCATTTCCTTCAGAGGAGTCTCTGCATTTAATTTATTCCTCCATCCTGAAAGGCCACACCTCGACGTTTCATGAGAGCATTGTGGCTGTG
AGTGGCAAGCTGACATTCTGCACGCTAGCACTTTACAAAAATATTGTGCAAGACCTACCTCCCACTCCGTCAAAGTTCCATTACATCTTC
AACCTTCGAGATCTCTCACGGGTTTTTAATGGTCTTGTCCTCACTAACCCGGAGCGATTCCAGACGGTGGCCCAGATGGTGAGAGTCTGG
AGGAATGAGTGTCTGAGAGTCTTCCACGACCGGCTGATCAGTGAAACAGACAAGCAGCTGGTACAACAGCACATAGGCAGCTTGGTTGTG
GAACATTTTAAAGATGACGTGGAGGTGGTGATGAGGGATCCCATATTGTTTGGAGACTTCCAGATGGCTCTGCACGAAGGAGAACCACGC
ATTTATGAAGACATCCAGGACTACGAGGCGGCCAAGGCTCTGTTCCAGGAAATTCTTGAAGAGTATAATGAAAGCAACACCAAAATGAAC
TTGGTTCTCTTCGACGATGCTCTGGAGCATTTAACCCGGGTGCACCGTATCATCCGCATGGACCGCGGCCACGCCCTGCTGGTCGGGGTA
GGGGGCTCAGGGAAGCAGTCTCTTTCGAGGCTGGCTGCCTTCACAGCCAGCTGTGAGGTGTTTGAGATCCTGCTGAGCCGAGGCTACTCG
GAGAACAGTTTCCGGGAAGACCTGAAGAGCCTCTATTTGAAACTTGGGATTGAGAACAAAGCGATGATCTTTCTGTTCACGGATGCCCAT
GTGGCTGAGGAGGGCTTCCTGGAGCTCATCAACAACATGCTGACCTCAGGAATTGTACCTGCGCTTTTTTCTGAAGAGGAGAAAGAGTCT
ATCCTGAGTCAGATTGGACAGGAAGCTCTGAAGCAAGGCATGGGGCCGGCCAAGGAGTCTGTGTGGCAGTACTTCGTGAACAAAAGTGCA
AATAACCTGCACATTGTCCTGGGCATGTCGCCAGTGGGGGACACCCTGAGGACCTGGTGCAGAAACTTCCCAGGTATGGTAAATAACACT
GGTATTGACTGGTTCATGCCCTGGCCTCCCCAAGCCCTCCATGCGGTCGCAAAGTCCTTTCTAGGGTATAATCCAATGATCCCGGCAGAA
AATATAGAAAATGTGGTGAAGCATGTTGTCTTGGTTCACCAATCCGTGGACCACTACAGCCAACAGTTTCTACAGAAATTGAGGCGCAGC
AACTATGTCACTCCCAAGAACTACCTTGATTTTATTAACACCTATTCAAAATTGCTGGATGAGAAAACTCAGTGTAATATAGCTCAGTGC
AAGCGTCTGGATGGGGGACTGGACAAGCTGAAGGAGGCCACCATCCAGCTGGACGAGCTGAACCAGAAGCTGGCCGAGCAGAAGATCGTG
CTGGCGGAGAAGTCCGCCGCCTGCGAGGCCTTGCTGGAGGAGATCGCCGTCAACACCGCTGTAGCCGAGGAGAAGAAGAAACTGGCAGAG
GAAAAGGCCATGGAGATAGAGGAGCAGAACAAAGTCATTGCCATGGAGAAGGCCGAGGCCGAGACGACCCTGGCAGAGGTCATGCCCATC
CTGGAGGCCGCCAAGCTGGAACTGCAGAAGCTGGACAAGTCGGACGTGACTGAGATTAGGTCGTTTGCTAAGCCCCCGAAGCAGGTGCAG
ACGGTCTGCGAATGCATCCTCATCATGAAAGGGTACAAAGAGCTGAACTGGAAAACAGCCAAGGGCGTGATGTCCGACCCGAATTTCCTG
CGGTCTCTGATGGAGATTGATTTTGATTCGATTACCCAGAGCCAAGTGAAAAACATCAAAGGCCTCTTGAAGACTCTTAATACCACAACT
GAAGAAATGGAAGCTGTCAGCAAAGCCGGGCTGGGGATGCTGAAATTTGTTGAAGCTGTAATGGGCTACTGTGATGTTTTCAGAGAAATC
AAGCCCAAAAGAGAGAAGGTGGCCAGGCTGGAGCGGAATTTTTACCTCACTAAACGGGAACTGGAAAGGATCCAGAATGAGTTGGCAGCA
ATTCAGAAAGAGCTGGAAACATTGGGTGCCAAATATGAGGCCGCCATACTGGAAAAGCAGAAGCTGCAGGAAGAAGCCGAGATCATGGAG
AGGCGGCTGATTGCCGCAGACAAACTCATCTCGGGTCTGGGGTCAGAAAACATCAGGTGGCTGAACGACCTGGATGAGCTGATGCACCGG
CGCGTGAAGCTGCTGGGGGACTGCCTGCTCTGCGCGGCTTTCCTCAGCTACGAGGGAGCCTTCACCTGGGAGTTCCGTGACGAGATGGTC
AATCGGATTTGGCAAAATGACATCCTGGAGCGGGAGATCCCCCTGAGCCAGCCTTTCCGGCTGGAAAGCCTGCTCACGGATGATGTTGAG
ATCAGCAGATGGGGATCCCAGGGCCTTCCCCCCGATGAGCTCTCCGTTCAGAATGGCATCCTCACCACCCGGGCCAGCCGCTTCCCTCTG
TGTATCGACCCCCAGCAGCAGGCCCTCAACTGGATCAAGAGAAAAGAGGAGAAGAACAATCTGCGGGTCGCTTCCTTTAATGACCCTGAC
TTCCTCAAGCAGCTAGAGATGTCCATAAAGTACGGGACCCCTTTCCTGTTCCGCGATGTTGATGAATACATCGATCCTGTGATTGACAAC
GTCTTAGAAAAAAATATAAAAGTCTCCCAAGGACGGCAGTTTATTATCCTGGGAGACAAGGAAGTGGACTATGATTCAAATTTCAGACTG
TACCTGAACACCAAGCTGGCCAATCCCAGATATTCCCCATCCGTGTTTGGGAAAGCTATGGTGATCAATTACACTGTCACGCTGAAGGGC
CTGGAGGACCAGCTGCTGAGCGTGCTGGTGGCTTACGAGAGGCGGGAGCTGGAGGAGCAGCGGGAGCACCTCATCCAGGAGACCAGCGAG
AACAAGAACCTGCTCAAGGACCTGGAAGATTCCCTCCTTCGGGAGCTGGCCACGTCCACGGGGAACATGCTGGACAATGTGGACCTGGTG
CACACCCTGGAGGAGACCAAATCCAAGGCAACAGAGGTCTCAGAGAAACTCAAGCTGGCGGAGAAGACAGCCTTGGACATCGACAGGCTG
CGGGATGGCTACCGGCCAGCAGCCAGGAGGGGGGCCATCCTGTTCTTCGTCCTGTCTGAGATGGCCCTGGTGAACTCCATGTACCAGTAC
TCCCTGATTGCCTTCTTAGAGGTCTTCAGGCTGTCACTGAAGAAGTCGCTGCCTGATTCCATCCTCATGAAACGCCTGAGGAACATCATG
GACACGCTGACCTTCAGCATCTATAACCACGGCTGCACAGGGCTGTTTGAGAGGCACAAGCTACTCTTTTCTTTTAATATGACCATCAAG
ATAGAACAAGCAGAAGGGAGAGTCCCTCAAGAAGAACTAGATTTCTTTTTAAAAGGAAACATTTCCCTGGAGAAAAGCAAAAGAAAAAAG
CCCTGCGCTTGGTTGTCTGACCAAGGATGGGAAGATATCATTCTTTTATCAGAAATGTTTTCAGACAACTTTGGGCAACTTCCTGATGAT
GTTGAGAATAATCAGACTGTCTGGCAGGAGTGGTATGACCTGGATTCACTGGAGCAGTTTCCCGTCCCCTTGGGTTACGATAACAACATC
ACCCCTTTCCAGAAGTTGCTTATTTTGCGCTGTTTCCGTGTGGATCGGGTCTATCGGGCCGTGACTGACTATGTGACTGTAACAATGGGA
GAGAAGTATGTGCAGCCCCCAATGATCAGCTTTGAAGCTATTTTTGAGCAGAGCACTCCACATTCGCCCATTGTGTTTATCCTGAGTCCT
GGCTCCGACCCTGCCACTGATCTTATGAAATTAGCAGAGCGAAGTGGTTTTGGAGGAAATCGCCTCAAATTCCTTGCAATGGGTCAAGGT
CAAGAAAAGGTGGCCCTGCAGCTGCTGGAGACGGCGGTGGCTCGGGGGCAGTGGCTGATGCTGCAGAACTGCCACCTCCTGGTCAAGTGG
CTGAAAGATCTGGAGAAGTCCCTGGAGAGGATCACCAAGCCCCACCCAGACTTCCGCCTGTGGCTCACCACGGACCCCACCAAGGGCTTC
CCCATTGGGATTCTGCAGAAGTCCCTAAAGGTTGTCACCGAGCCACCCAATGGGCTGAAACTCAACATGAGGGCAACTTACTTCAAGATC
TCTCACGAAATGCTGGACCAGTGCCCGCACCCTGCCTTCAAGCCGCTGGTCTACGTGCTGGCGTTCTTTCATGCTGTGGTGCAGGAGAGA
AGGAAGTTTGGGAAGATTGGCTGGAACGTGTACTATGACTTCAATGAGTCTGACTTCCAGGTCTGCATGGAAATTCTGAACACGTACTTA
ACGAAAGCCTTCCAGCAACGGGACCCAAGGATCCCGTGGGGCAGCCTCAAGTACCTAATTGGAGAGGTCATGTATGGAGGACGGGCCATC
GACAGCTTTGATCGCCGCATCCTGACCATCTACATGGATGAGTACCTGGGGGACTTCATTTTTGATACTTTCCAGCCATTCCACTTCTTC
CGGAACAAGGAAGTGGACTACAAAATCCCTGTTGGTGATGAAAAGGAGAAATTTGTTGAAGCCATCGAGGCCCTCCCGCTTGCCAACACG
CCAGAAGTGTTTGGTCTCCACCCCAACGCTGAGATTGGCTATTACACGCAGGCGGCTCGAGACATGTGGGCTCACCTGCTGGAGCTGCAG
CCTCAGACAGGGGAATCCAGCAGTGGTATCAGCCGCGATGATTATATTGGCCAAGTGGCCAAAGAAATAGAAAACAAGATGCCCAAAGTC
TTTGACTTGGACCAGGTGAGGAAGCGCCTCGGAACAGGACTCTCCCCCACTTCGGTGGTGCTCCTGCAGGAACTGGAACGCTTCAACAAG
CTTGTGGTCCGGATGACGAAGTCTCTGGCTGAACTTCAAAGGGCCTTGGCTGGAGAAGTTGGAATGAGCAATGAGTTAGATGATGTGGCC
AGGTCTCTTTTTATCGGGCATATCCCTAATATCTGGAGAAGGCTTGCTCCTGACACCTTAAAGTCCCTTGGAAACTGGATGGTCTACTTC
CTGCGGCGGTTCAGCCAGTACATGTTGTGGGTGACCGAGAGCGAGCCCAGCGTGATGTGGCTCTCGGGGCTGCACATCCCTGAGTCCTAC
CTCACGGCGCTGGTGCAGGCCACCTGCCGGAAGAACGGCTGGCCACTGGACCGCTCCACCTTGTTCACACAAGTGACCAAGTTCCAGGAT
GCAGATGAAGTGAATGAGCGGGCGGGACAAGGATGCTTTGTCTCAGGACTGTACCTGGAAGGTGCTGACTGGGATATAGAAAAAGGATGT
CTTATCAAGAGCAAACCCAAGGTGCTGGTTGTGGACCTGCCGATCCTGAAGATCATCCCCATTGAAGCCCATCGCCTCAAGCTGCAGAAT
ACTTTCCGGACCCCCGTCTACACCACCTCCATGAGAAGGAACGCCATGGGAGTCGGCTTGGTTTTTGAAGCTGATCTCTTTACCACGAGG
CACATTTCTCACTGGGTGCTGCAAGGAGTATGCCTCACCCTGAATTCTGATTAACCTTTGGGTGAAGAAAACTGCTTAATGAATTCGGAG
CCTGGGGTTGTCAGAGTGATCGGGTCTGCTGTCATTTCTTGGGGCCTCTCAAGAGGCAGGAGGGGGACTGACACTGATTTTTCATTTGAA
ATCAGCCACTTAAATCTCTTTCCATACAAATTAACCTGAATGGTTTTGTTTTTAATACTACTTTTTAAAAGGAATTTATATAATCAAAAA
GTAAATATTGGAGAGTATTTTAAGATGTGTGGAGTTTTCTTTTCCTTCTCAGAGAAAACACTTGATTAGGCAAAAGTGCCTGGCATACAT
AGCATTGGCACAAGTGAGAATCCTAATGTAATTTCCAAAGGTGTGTTTTCGATGATCCAGGTCTGTTTCAGCAGATGCTCCTTTTTGGCA
AGAAGGGCTGATGATGTCGGGCACAGAGCAGAAGTGACCAGTCACCTGGAGCCACTTCTCCCCCTTCCAGAACTCTCTGGCCCTAGCTTC
TTTGGCTCTGACCTGCTACGGCGACTGTGAAGTTGTTGAGCTTAGTGTTTAGTTCCTGCATGAGCTTCTACCCCCAGCCTGCCTGGGTCT
GTGTGGGGTCAGGTAAGGACACAGAACCTCCAGGACCAGTGGTCACTGGGCACCCCTTCCCTCTGTGCACCATGAGGCTGGCCTGGAGCC

>67741_67741_1_PPP1R12A-DNAH10_PPP1R12A_chr12_80328475_ENST00000450142_DNAH10_chr12_124303497_ENST00000409039_length(amino acids)=3408AA_BP=79
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQPPDAEKELVDK
IESIWSNLFNDSVNVEHALGDIKRTFTELTRGEIMNYRVQIEEFAKRFYSEGPGSVGDDLDKGVELLGVYERELARHEKSRQELANAEKL
FDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIP
LLLDLKNEALRDRHWKELMEKTSVFFEMTETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKFTVVKYCKGTQER
GYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFIGGDIRSQLPEEAKKFDNIDKV
FKRIMGETLKDPVIKRCCEAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFISDDELLSILGSSDPLCVQEHMIKMYDNIASLR
FNDGDSGEKLVSAMISAEGEVMEFRKILRAEGRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRVDWMLLYQGMVVLAASQVWWTWEV
EDVFHKAQKGEKQAMKNYGRKMHRQIDELVTRITMPLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQLRFYWDREPDEL
NIRQCTGTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSG
LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFRPVVVIVPDLQ
QICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLMRALRDMNLPKFVFEDVPLFL
GLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVGPTRGGKSVVINTLCQAQTKLGLTTKLYILN
PKAVSVIELYGILDPTTRDWTDGVLSNIFREINKPTDKKERKYILFDGDVDALWVENMNSVMDDNRLLTLANGERIRLQAHCALLFEVGD
LQYASPATVSRCGMVYVDPKNLKYRPYWKKWVNQIPNKVEQYNLNSLFEKYVPYLMDVIVEGIVDGRQAEKLKTIVPQTDLNMVTQLAKM
LDALLEGEIEDLDLLECYFLEALYCSLGASLLEDGRMKFDEYIKRLASLSTVDTEGVWANPGELPGQLPTLYDFHFDNKRNQWVPWSKLV
PEYIHAPERKFINILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKNLSEETNIVLMVNFSSRTTSMDIQRNLEANVEK
RTKDTYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEKGYLYDRGKELNCKSIRDLGFIAAMGKAGGGRNEVDPRFISLFSVFN
VPFPSEESLHLIYSSILKGHTSTFHESIVAVSGKLTFCTLALYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNPERFQTVAQMVRV
WRNECLRVFHDRLISETDKQLVQQHIGSLVVEHFKDDVEVVMRDPILFGDFQMALHEGEPRIYEDIQDYEAAKALFQEILEEYNESNTKM
NLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDA
HVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMGPAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRNFPGMVNN
TGIDWFMPWPPQALHAVAKSFLGYNPMIPAENIENVVKHVVLVHQSVDHYSQQFLQKLRRSNYVTPKNYLDFINTYSKLLDEKTQCNIAQ
CKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLEEIAVNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEVMP
ILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGVMSDPNFLRSLMEIDFDSITQSQVKNIKGLLKTLNTT
TEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKREKVARLERNFYLTKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIM
ERRLIAADKLISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGAFTWEFRDEMVNRIWQNDILEREIPLSQPFRLESLLTDDV
EISRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVDEYIDPVID
NVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERRELEEQREHLIQETS
ENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQ
YSLIAFLEVFRLSLKKSLPDSILMKRLRNIMDTLTFSIYNHGCTGLFERHKLLFSFNMTIKIEQAEGRVPQEELDFFLKGNISLEKSKRK
KPCAWLSDQGWEDIILLSEMFSDNFGQLPDDVENNQTVWQEWYDLDSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTM
GEKYVQPPMISFEAIFEQSTPHSPIVFILSPGSDPATDLMKLAERSGFGGNRLKFLAMGQGQEKVALQLLETAVARGQWLMLQNCHLLVK
WLKDLEKSLERITKPHPDFRLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMRATYFKISHEMLDQCPHPAFKPLVYVLAFFHAVVQE
RRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYLGDFIFDTFQPFHF
FRNKEVDYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNAEIGYYTQAARDMWAHLLELQPQTGESSSGISRDDYIGQVAKEIENKMPK
VFDLDQVRKRLGTGLSPTSVVLLQELERFNKLVVRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVY
FLRRFSQYMLWVTESEPSVMWLSGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKG

--------------------------------------------------------------
>67741_67741_2_PPP1R12A-DNAH10_PPP1R12A_chr12_80328475_ENST00000550107_DNAH10_chr12_124303497_ENST00000409039_length(transcript)=10952nt_BP=237nt
ATGAAGATGGCGGACGCGAAGCAGAAGCGGAACGAGCAGCTGAAACGCTGGATCGGCTCCGAGACGGACCTCGAGCCTCCGGTGGTGAAG
CGCCAGAAGACCAAGGTGAAGTTCGACGATGGCGCCGTCTTCCTGGCTGCTTGCTCCAGCGGCGACACGGACGAGGTCCTCAAGCTGCTG
CACCGCGGCGCCGACATCAATTACGCCAATGTGGACGGACTCACTGCCCTGCACCAGCCTCCTGATGCAGAGAAAGAACTGGTTGATAAG
ATTGAGAGCATATGGTCCAATCTGTTTAATGATTCAGTGAATGTGGAGCATGCTCTTGGGGACATAAAGAGAACTTTCACAGAGCTTACT
CGAGGCGAAATAATGAACTACAGAGTTCAGATAGAGGAGTTTGCAAAGCGTTTTTACAGTGAAGGCCCTGGTTCTGTTGGTGATGATCTT
GATAAAGGAGTAGAGCTTTTAGGTGTTTATGAAAGAGAGCTGGCAAGACATGAAAAGAGCCGTCAGGAACTGGCTAACGCTGAGAAACTT
TTCGATCTTCCTATTACAATGTACCCAGAGCTGCTGAAAGTGCAGAAGGAAATGAGTGGGCTGAGGATGATTTACGAGCTCTATGAAGGA
CTAAAGGTTGCAAAAGAAGAATGGTCTCAGACCCTTTGGATCAACCTGAATGTGCAGATTCTCCAGGAAGGAATTGAAGGTTTTCTCAGG
GCTCTCAGAAAGCTACCTCGGCCAGTCCGTGGCTTATCAGTGACCTACTACTTGGAAGCAAAAATGAAGGCATTCAAAGACTCGATTCCT
TTACTTCTTGACTTGAAAAACGAGGCACTAAGAGACAGGCATTGGAAAGAACTTATGGAAAAAACGTCTGTCTTTTTTGAAATGACCGAA
ACGTTCACCTTGGAAAATATGTTTGCTATGGAACTGCACAAACACACAGATGTTCTCAATGAGATTGTCACAGCAGCAATCAAGGAGGTT
GCCATTGAGAAGGCTGTGAAGGAAATCCTAGACACGTGGGAAAATATGAAATTCACTGTAGTCAAGTATTGCAAAGGCACACAGGAGCGA
GGCTACATCCTGGGTTCTGTTGACGAAATTATTCAGTCTCTTGATGACAACACTTTCAACCTGCAGAGCATCTCAGGAAGCAGATTTGTG
GGGCCTTTTCTGCAAACTGTTCACAAATGGGAAAAAACGCTTTCTCTAATAGGGGAAGTCATTGAGATTTGGATGTTGGTTCAGAGAAAA
TGGATGTATCTTGAAAGTATTTTTATTGGTGGAGATATAAGATCACAACTTCCGGAAGAGGCAAAAAAGTTTGACAACATCGATAAAGTA
TTTAAAAGGATCATGGGTGAGACCTTAAAAGACCCCGTGATCAAGAGGTGCTGTGAAGCCCCAAACCGCCTCAGTGACCTACAGAACGTC
AGCGAGGGCCTGGAGAAATGCCAGAAAAGCCTCAACGACTACTTAGATTCGAAGAGAAATGCTTTCCCAAGGTTCTTCTTCATTTCTGAC
GATGAGTTGCTTAGCATTCTGGGGAGCAGCGACCCACTCTGCGTCCAGGAGCACATGATCAAGATGTACGACAACATAGCATCACTGAGG
TTTAATGACGGCGATAGTGGAGAAAAACTGGTGTCCGCGATGATTTCAGCAGAAGGAGAAGTCATGGAGTTTCGGAAGATCTTGCGGGCT
GAAGGGCGCGTGGAGGACTGGATGACGGCAGTTTTGAATGAGATGAGAAGAACTAATAGACTAATTACCAAAGAGGCTATTTTTAGATAC
TGTGAAGACAGAAGCAGAGTCGACTGGATGCTCCTGTACCAGGGCATGGTGGTGCTGGCCGCTAGCCAGGTGTGGTGGACCTGGGAGGTG
GAAGACGTCTTCCACAAAGCGCAAAAAGGGGAGAAGCAGGCCATGAAGAACTATGGCAGGAAAATGCACCGGCAGATCGATGAGTTGGTA
ACGCGCATCACCATGCCGCTAAGCAAAAACGACAGGAAAAAATACAACACTGTTCTCATCATTGATGTGCATGCCAGAGACATAGTTGAT
TCTTTCATAAGAGGCAGTATCCTGGAGGCCCGAGAGTTTGACTGGGAAAGTCAGTTGCGGTTTTATTGGGACCGGGAGCCGGATGAGCTG
AACATCCGCCAGTGCACGGGAACCTTTGGCTACGGCTACGAGTACATGGGCCTGAACGGCAGGCTGGTCATCACGCCCCTCACCGATCGG
ATTTACCTGACGCTCACCCAGGCGCTGTCCATGTATCTAGGTGGGGCCCCCGCCGGCCCAGCAGGAACCGGCAAAACCGAGACCACCAAG
GACCTGGCGAAAGCCTTGGGCTTGCTCTGTGTTGTCACCAACTGTGGCGAAGGCATGGATTACAGGGCCGTGGGGAAGATTTTCTCTGGC
CTGGCACAGTGCGGGGCTTGGGGCTGCTTTGATGAGTTTAATCGAATCGATGCTTCTGTGCTCTCCGTGATCTCCTCCCAGATCCAGACG
ATCCGAAATGCTCTGATCCATCAGTTAACCACGTTCCAGTTTGAAGGGCAGGAGATTTCCCTGGACTCCCGCATGGGCATCTTCATCACC
ATGAACCCCGGCTACGCAGGCCGCACGGAGCTGCCCGAGTCGGTGAAGGCGCTGTTCAGGCCTGTGGTCGTGATCGTGCCCGACCTGCAG
CAGATCTGTGAGATCATGCTCTTCTCTGAGGGCTTCCTGGAGGCCAAGACTCTGGCGAAAAAGATGACGGTTCTGTATAAGCTGGCCCGG
GAGCAGCTGTCCAAGCAGTATCACTATGATTTTGGACTCAGAGCCCTGAAATCGGTGCTGGTCATGGCTGGTGAGCTGAAGAGAGGCTCC
TCTGACCTTAGGGAGGACGTGGTGCTGATGAGGGCCTTGCGAGACATGAACTTGCCCAAATTTGTGTTTGAAGATGTTCCTCTTTTCCTT
GGTTTGATTTCGGATCTGTTTCCTGGGCTGGACTGCCCTCGCGTCCGCTACCCTGACTTCAACGATGCGGTAGAGCAGGTCCTGGAGGAG
AACGGCTACGCGGTCCTACCCATCCAGGTGGATAAAGTGGTTCAAATGTTCGAGACCATGTTAACCCGCCACACGACGATGGTGGTGGGG
CCCACCAGAGGGGGCAAGTCCGTCGTCATTAACACTCTGTGTCAGGCCCAGACCAAGCTTGGGCTGACGACAAAGTTGTACATCCTGAAC
CCCAAAGCCGTGAGTGTCATAGAACTCTACGGCATCCTGGACCCAACCACCCGAGACTGGACAGATGGGGTGTTGTCAAACATCTTCAGG
GAAATCAACAAGCCAACAGACAAGAAGGAGCGAAAGTATATTTTATTTGATGGTGATGTGGATGCTCTATGGGTGGAAAACATGAATTCT
GTGATGGATGACAACAGGTTGTTGACATTGGCCAACGGGGAACGCATCCGGCTCCAAGCACACTGTGCCCTGCTCTTTGAGGTTGGAGAT
TTACAGTATGCCTCCCCTGCAACTGTCTCTCGATGTGGAATGGTTTATGTGGATCCTAAAAACTTGAAATATCGACCATACTGGAAAAAA
TGGGTTAATCAAATACCAAACAAGGTGGAGCAATACAATTTGAATAGTCTCTTTGAGAAGTATGTGCCCTATCTCATGGATGTGATAGTG
GAAGGAATTGTGGATGGAAGACAAGCAGAAAAGCTGAAGACAATAGTTCCTCAGACAGACCTCAATATGGTAACCCAGTTAGCCAAGATG
TTGGATGCGTTGCTAGAAGGAGAAATAGAAGACCTTGACCTGCTGGAGTGCTACTTCCTGGAGGCTTTGTACTGCTCTCTGGGAGCCTCC
CTGCTTGAGGATGGAAGGATGAAATTTGACGAATATATCAAACGCCTTGCTTCTTTGTCTACTGTTGACACAGAAGGAGTTTGGGCCAAC
CCTGGGGAACTGCCAGGTCAACTTCCAACCTTGTATGACTTTCATTTTGATAACAAACGGAATCAATGGGTCCCATGGAGTAAATTAGTT
CCAGAGTATATTCATGCCCCCGAGAGGAAATTCATCAACATCCTGGTTCACACAGTGGATACCACTCGGACTACCTGGATATTGGAACAA
ATGGTTAAAATTAAGCAACCTGTTATTTTTGTTGGTGAATCTGGCACTTCTAAGACAGCCACTACCCAGAATTTCCTCAAAAATCTGAGT
GAAGAAACTAACATTGTGTTAATGGTCAACTTCTCCTCCCGCACCACGTCCATGGATATCCAAAGAAATTTAGAAGCAAATGTGGAAAAG
CGAACCAAAGATACTTACGGCCCACCCATGGGAAAACGCCTGCTGGTGTTCATGGATGACATGAATATGCCAAGGGTGGATGAATATGGC
ACGCAGCAGCCCATTGCCTTGCTGAAGCTGCTGTTGGAAAAAGGCTACTTATATGACCGTGGGAAGGAGCTGAACTGTAAAAGCATTCGA
GACCTTGGCTTTATTGCTGCAATGGGAAAGGCTGGAGGAGGCCGCAATGAAGTTGACCCAAGATTTATTTCGCTATTCAGTGTCTTCAAT
GTGCCATTTCCTTCAGAGGAGTCTCTGCATTTAATTTATTCCTCCATCCTGAAAGGCCACACCTCGACGTTTCATGAGAGCATTGTGGCT
GTGAGTGGCAAGCTGACATTCTGCACGCTAGCACTTTACAAAAATATTGTGCAAGACCTACCTCCCACTCCGTCAAAGTTCCATTACATC
TTCAACCTTCGAGATCTCTCACGGGTTTTTAATGGTCTTGTCCTCACTAACCCGGAGCGATTCCAGACGGTGGCCCAGATGGTGAGAGTC
TGGAGGAATGAGTGTCTGAGAGTCTTCCACGACCGGCTGATCAGTGAAACAGACAAGCAGCTGGTACAACAGCACATAGGCAGCTTGGTT
GTGGAACATTTTAAAGATGACGTGGAGGTGGTGATGAGGGATCCCATATTGTTTGGAGACTTCCAGATGGCTCTGCACGAAGGAGAACCA
CGCATTTATGAAGACATCCAGGACTACGAGGCGGCCAAGGCTCTGTTCCAGGAAATTCTTGAAGAGTATAATGAAAGCAACACCAAAATG
AACTTGGTTCTCTTCGACGATGCTCTGGAGCATTTAACCCGGGTGCACCGTATCATCCGCATGGACCGCGGCCACGCCCTGCTGGTCGGG
GTAGGGGGCTCAGGGAAGCAGTCTCTTTCGAGGCTGGCTGCCTTCACAGCCAGCTGTGAGGTGTTTGAGATCCTGCTGAGCCGAGGCTAC
TCGGAGAACAGTTTCCGGGAAGACCTGAAGAGCCTCTATTTGAAACTTGGGATTGAGAACAAAGCGATGATCTTTCTGTTCACGGATGCC
CATGTGGCTGAGGAGGGCTTCCTGGAGCTCATCAACAACATGCTGACCTCAGGAATTGTACCTGCGCTTTTTTCTGAAGAGGAGAAAGAG
TCTATCCTGAGTCAGATTGGACAGGAAGCTCTGAAGCAAGGCATGGGGCCGGCCAAGGAGTCTGTGTGGCAGTACTTCGTGAACAAAAGT
GCAAATAACCTGCACATTGTCCTGGGCATGTCGCCAGTGGGGGACACCCTGAGGACCTGGTGCAGAAACTTCCCAGGTATGGTAAATAAC
ACTGGTATTGACTGGTTCATGCCCTGGCCTCCCCAAGCCCTCCATGCGGTCGCAAAGTCCTTTCTAGGGTATAATCCAATGATCCCGGCA
GAAAATATAGAAAATGTGGTGAAGCATGTTGTCTTGGTTCACCAATCCGTGGACCACTACAGCCAACAGTTTCTACAGAAATTGAGGCGC
AGCAACTATGTCACTCCCAAGAACTACCTTGATTTTATTAACACCTATTCAAAATTGCTGGATGAGAAAACTCAGTGTAATATAGCTCAG
TGCAAGCGTCTGGATGGGGGACTGGACAAGCTGAAGGAGGCCACCATCCAGCTGGACGAGCTGAACCAGAAGCTGGCCGAGCAGAAGATC
GTGCTGGCGGAGAAGTCCGCCGCCTGCGAGGCCTTGCTGGAGGAGATCGCCGTCAACACCGCTGTAGCCGAGGAGAAGAAGAAACTGGCA
GAGGAAAAGGCCATGGAGATAGAGGAGCAGAACAAAGTCATTGCCATGGAGAAGGCCGAGGCCGAGACGACCCTGGCAGAGGTCATGCCC
ATCCTGGAGGCCGCCAAGCTGGAACTGCAGAAGCTGGACAAGTCGGACGTGACTGAGATTAGGTCGTTTGCTAAGCCCCCGAAGCAGGTG
CAGACGGTCTGCGAATGCATCCTCATCATGAAAGGGTACAAAGAGCTGAACTGGAAAACAGCCAAGGGCGTGATGTCCGACCCGAATTTC
CTGCGGTCTCTGATGGAGATTGATTTTGATTCGATTACCCAGAGCCAAGTGAAAAACATCAAAGGCCTCTTGAAGACTCTTAATACCACA
ACTGAAGAAATGGAAGCTGTCAGCAAAGCCGGGCTGGGGATGCTGAAATTTGTTGAAGCTGTAATGGGCTACTGTGATGTTTTCAGAGAA
ATCAAGCCCAAAAGAGAGAAGGTGGCCAGGCTGGAGCGGAATTTTTACCTCACTAAACGGGAACTGGAAAGGATCCAGAATGAGTTGGCA
GCAATTCAGAAAGAGCTGGAAACATTGGGTGCCAAATATGAGGCCGCCATACTGGAAAAGCAGAAGCTGCAGGAAGAAGCCGAGATCATG
GAGAGGCGGCTGATTGCCGCAGACAAACTCATCTCGGGTCTGGGGTCAGAAAACATCAGGTGGCTGAACGACCTGGATGAGCTGATGCAC
CGGCGCGTGAAGCTGCTGGGGGACTGCCTGCTCTGCGCGGCTTTCCTCAGCTACGAGGGAGCCTTCACCTGGGAGTTCCGTGACGAGATG
GTCAATCGGATTTGGCAAAATGACATCCTGGAGCGGGAGATCCCCCTGAGCCAGCCTTTCCGGCTGGAAAGCCTGCTCACGGATGATGTT
GAGATCAGCAGATGGGGATCCCAGGGCCTTCCCCCCGATGAGCTCTCCGTTCAGAATGGCATCCTCACCACCCGGGCCAGCCGCTTCCCT
CTGTGTATCGACCCCCAGCAGCAGGCCCTCAACTGGATCAAGAGAAAAGAGGAGAAGAACAATCTGCGGGTCGCTTCCTTTAATGACCCT
GACTTCCTCAAGCAGCTAGAGATGTCCATAAAGTACGGGACCCCTTTCCTGTTCCGCGATGTTGATGAATACATCGATCCTGTGATTGAC
AACGTCTTAGAAAAAAATATAAAAGTCTCCCAAGGACGGCAGTTTATTATCCTGGGAGACAAGGAAGTGGACTATGATTCAAATTTCAGA
CTGTACCTGAACACCAAGCTGGCCAATCCCAGATATTCCCCATCCGTGTTTGGGAAAGCTATGGTGATCAATTACACTGTCACGCTGAAG
GGCCTGGAGGACCAGCTGCTGAGCGTGCTGGTGGCTTACGAGAGGCGGGAGCTGGAGGAGCAGCGGGAGCACCTCATCCAGGAGACCAGC
GAGAACAAGAACCTGCTCAAGGACCTGGAAGATTCCCTCCTTCGGGAGCTGGCCACGTCCACGGGGAACATGCTGGACAATGTGGACCTG
GTGCACACCCTGGAGGAGACCAAATCCAAGGCAACAGAGGTCTCAGAGAAACTCAAGCTGGCGGAGAAGACAGCCTTGGACATCGACAGG
CTGCGGGATGGCTACCGGCCAGCAGCCAGGAGGGGGGCCATCCTGTTCTTCGTCCTGTCTGAGATGGCCCTGGTGAACTCCATGTACCAG
TACTCCCTGATTGCCTTCTTAGAGGTCTTCAGGCTGTCACTGAAGAAGTCGCTGCCTGATTCCATCCTCATGAAACGCCTGAGGAACATC
ATGGACACGCTGACCTTCAGCATCTATAACCACGGCTGCACAGGGCTGTTTGAGAGGCACAAGCTACTCTTTTCTTTTAATATGACCATC
AAGATAGAACAAGCAGAAGGGAGAGTCCCTCAAGAAGAACTAGATTTCTTTTTAAAAGGAAACATTTCCCTGGAGAAAAGCAAAAGAAAA
AAGCCCTGCGCTTGGTTGTCTGACCAAGGATGGGAAGATATCATTCTTTTATCAGAAATGTTTTCAGACAACTTTGGGCAACTTCCTGAT
GATGTTGAGAATAATCAGACTGTCTGGCAGGAGTGGTATGACCTGGATTCACTGGAGCAGTTTCCCGTCCCCTTGGGTTACGATAACAAC
ATCACCCCTTTCCAGAAGTTGCTTATTTTGCGCTGTTTCCGTGTGGATCGGGTCTATCGGGCCGTGACTGACTATGTGACTGTAACAATG
GGAGAGAAGTATGTGCAGCCCCCAATGATCAGCTTTGAAGCTATTTTTGAGCAGAGCACTCCACATTCGCCCATTGTGTTTATCCTGAGT
CCTGGCTCCGACCCTGCCACTGATCTTATGAAATTAGCAGAGCGAAGTGGTTTTGGAGGAAATCGCCTCAAATTCCTTGCAATGGGTCAA
GGTCAAGAAAAGGTGGCCCTGCAGCTGCTGGAGACGGCGGTGGCTCGGGGGCAGTGGCTGATGCTGCAGAACTGCCACCTCCTGGTCAAG
TGGCTGAAAGATCTGGAGAAGTCCCTGGAGAGGATCACCAAGCCCCACCCAGACTTCCGCCTGTGGCTCACCACGGACCCCACCAAGGGC
TTCCCCATTGGGATTCTGCAGAAGTCCCTAAAGGTTGTCACCGAGCCACCCAATGGGCTGAAACTCAACATGAGGGCAACTTACTTCAAG
ATCTCTCACGAAATGCTGGACCAGTGCCCGCACCCTGCCTTCAAGCCGCTGGTCTACGTGCTGGCGTTCTTTCATGCTGTGGTGCAGGAG
AGAAGGAAGTTTGGGAAGATTGGCTGGAACGTGTACTATGACTTCAATGAGTCTGACTTCCAGGTCTGCATGGAAATTCTGAACACGTAC
TTAACGAAAGCCTTCCAGCAACGGGACCCAAGGATCCCGTGGGGCAGCCTCAAGTACCTAATTGGAGAGGTCATGTATGGAGGACGGGCC
ATCGACAGCTTTGATCGCCGCATCCTGACCATCTACATGGATGAGTACCTGGGGGACTTCATTTTTGATACTTTCCAGCCATTCCACTTC
TTCCGGAACAAGGAAGTGGACTACAAAATCCCTGTTGGTGATGAAAAGGAGAAATTTGTTGAAGCCATCGAGGCCCTCCCGCTTGCCAAC
ACGCCAGAAGTGTTTGGTCTCCACCCCAACGCTGAGATTGGCTATTACACGCAGGCGGCTCGAGACATGTGGGCTCACCTGCTGGAGCTG
CAGCCTCAGACAGGGGAATCCAGCAGTGGTATCAGCCGCGATGATTATATTGGCCAAGTGGCCAAAGAAATAGAAAACAAGATGCCCAAA
GTCTTTGACTTGGACCAGGTGAGGAAGCGCCTCGGAACAGGACTCTCCCCCACTTCGGTGGTGCTCCTGCAGGAACTGGAACGCTTCAAC
AAGCTTGTGGTCCGGATGACGAAGTCTCTGGCTGAACTTCAAAGGGCCTTGGCTGGAGAAGTTGGAATGAGCAATGAGTTAGATGATGTG
GCCAGGTCTCTTTTTATCGGGCATATCCCTAATATCTGGAGAAGGCTTGCTCCTGACACCTTAAAGTCCCTTGGAAACTGGATGGTCTAC
TTCCTGCGGCGGTTCAGCCAGTACATGTTGTGGGTGACCGAGAGCGAGCCCAGCGTGATGTGGCTCTCGGGGCTGCACATCCCTGAGTCC
TACCTCACGGCGCTGGTGCAGGCCACCTGCCGGAAGAACGGCTGGCCACTGGACCGCTCCACCTTGTTCACACAAGTGACCAAGTTCCAG
GATGCAGATGAAGTGAATGAGCGGGCGGGACAAGGATGCTTTGTCTCAGGACTGTACCTGGAAGGTGCTGACTGGGATATAGAAAAAGGA
TGTCTTATCAAGAGCAAACCCAAGGTGCTGGTTGTGGACCTGCCGATCCTGAAGATCATCCCCATTGAAGCCCATCGCCTCAAGCTGCAG
AATACTTTCCGGACCCCCGTCTACACCACCTCCATGAGAAGGAACGCCATGGGAGTCGGCTTGGTTTTTGAAGCTGATCTCTTTACCACG
AGGCACATTTCTCACTGGGTGCTGCAAGGAGTATGCCTCACCCTGAATTCTGATTAACCTTTGGGTGAAGAAAACTGCTTAATGAATTCG
GAGCCTGGGGTTGTCAGAGTGATCGGGTCTGCTGTCATTTCTTGGGGCCTCTCAAGAGGCAGGAGGGGGACTGACACTGATTTTTCATTT
GAAATCAGCCACTTAAATCTCTTTCCATACAAATTAACCTGAATGGTTTTGTTTTTAATACTACTTTTTAAAAGGAATTTATATAATCAA
AAAGTAAATATTGGAGAGTATTTTAAGATGTGTGGAGTTTTCTTTTCCTTCTCAGAGAAAACACTTGATTAGGCAAAAGTGCCTGGCATA
CATAGCATTGGCACAAGTGAGAATCCTAATGTAATTTCCAAAGGTGTGTTTTCGATGATCCAGGTCTGTTTCAGCAGATGCTCCTTTTTG
GCAAGAAGGGCTGATGATGTCGGGCACAGAGCAGAAGTGACCAGTCACCTGGAGCCACTTCTCCCCCTTCCAGAACTCTCTGGCCCTAGC
TTCTTTGGCTCTGACCTGCTACGGCGACTGTGAAGTTGTTGAGCTTAGTGTTTAGTTCCTGCATGAGCTTCTACCCCCAGCCTGCCTGGG
TCTGTGTGGGGTCAGGTAAGGACACAGAACCTCCAGGACCAGTGGTCACTGGGCACCCCTTCCCTCTGTGCACCATGAGGCTGGCCTGGA

>67741_67741_2_PPP1R12A-DNAH10_PPP1R12A_chr12_80328475_ENST00000550107_DNAH10_chr12_124303497_ENST00000409039_length(amino acids)=3408AA_BP=79
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQPPDAEKELVDK
IESIWSNLFNDSVNVEHALGDIKRTFTELTRGEIMNYRVQIEEFAKRFYSEGPGSVGDDLDKGVELLGVYERELARHEKSRQELANAEKL
FDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIP
LLLDLKNEALRDRHWKELMEKTSVFFEMTETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKFTVVKYCKGTQER
GYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFIGGDIRSQLPEEAKKFDNIDKV
FKRIMGETLKDPVIKRCCEAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFISDDELLSILGSSDPLCVQEHMIKMYDNIASLR
FNDGDSGEKLVSAMISAEGEVMEFRKILRAEGRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRVDWMLLYQGMVVLAASQVWWTWEV
EDVFHKAQKGEKQAMKNYGRKMHRQIDELVTRITMPLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQLRFYWDREPDEL
NIRQCTGTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSG
LAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFRPVVVIVPDLQ
QICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLMRALRDMNLPKFVFEDVPLFL
GLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVGPTRGGKSVVINTLCQAQTKLGLTTKLYILN
PKAVSVIELYGILDPTTRDWTDGVLSNIFREINKPTDKKERKYILFDGDVDALWVENMNSVMDDNRLLTLANGERIRLQAHCALLFEVGD
LQYASPATVSRCGMVYVDPKNLKYRPYWKKWVNQIPNKVEQYNLNSLFEKYVPYLMDVIVEGIVDGRQAEKLKTIVPQTDLNMVTQLAKM
LDALLEGEIEDLDLLECYFLEALYCSLGASLLEDGRMKFDEYIKRLASLSTVDTEGVWANPGELPGQLPTLYDFHFDNKRNQWVPWSKLV
PEYIHAPERKFINILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKNLSEETNIVLMVNFSSRTTSMDIQRNLEANVEK
RTKDTYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEKGYLYDRGKELNCKSIRDLGFIAAMGKAGGGRNEVDPRFISLFSVFN
VPFPSEESLHLIYSSILKGHTSTFHESIVAVSGKLTFCTLALYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNPERFQTVAQMVRV
WRNECLRVFHDRLISETDKQLVQQHIGSLVVEHFKDDVEVVMRDPILFGDFQMALHEGEPRIYEDIQDYEAAKALFQEILEEYNESNTKM
NLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDA
HVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMGPAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRNFPGMVNN
TGIDWFMPWPPQALHAVAKSFLGYNPMIPAENIENVVKHVVLVHQSVDHYSQQFLQKLRRSNYVTPKNYLDFINTYSKLLDEKTQCNIAQ
CKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLEEIAVNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEVMP
ILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGVMSDPNFLRSLMEIDFDSITQSQVKNIKGLLKTLNTT
TEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKREKVARLERNFYLTKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIM
ERRLIAADKLISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGAFTWEFRDEMVNRIWQNDILEREIPLSQPFRLESLLTDDV
EISRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVDEYIDPVID
NVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERRELEEQREHLIQETS
ENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQ
YSLIAFLEVFRLSLKKSLPDSILMKRLRNIMDTLTFSIYNHGCTGLFERHKLLFSFNMTIKIEQAEGRVPQEELDFFLKGNISLEKSKRK
KPCAWLSDQGWEDIILLSEMFSDNFGQLPDDVENNQTVWQEWYDLDSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTM
GEKYVQPPMISFEAIFEQSTPHSPIVFILSPGSDPATDLMKLAERSGFGGNRLKFLAMGQGQEKVALQLLETAVARGQWLMLQNCHLLVK
WLKDLEKSLERITKPHPDFRLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMRATYFKISHEMLDQCPHPAFKPLVYVLAFFHAVVQE
RRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYLGDFIFDTFQPFHF
FRNKEVDYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNAEIGYYTQAARDMWAHLLELQPQTGESSSGISRDDYIGQVAKEIENKMPK
VFDLDQVRKRLGTGLSPTSVVLLQELERFNKLVVRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVY
FLRRFSQYMLWVTESEPSVMWLSGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP1R12A-DNAH10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000261207-226682_86479.01031.0ROCK2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000437004-225682_86479.0996.0ROCK2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000450142-125682_86479.01031.0ROCK2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000546369-125682_8640944.0ROCK2
HgenePPP1R12Achr12:80328475chr12:124303497ENST00000550107-124682_86479.0975.0ROCK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R12A-DNAH10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R12A-DNAH10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource