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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R12A-ZZEF1 (FusionGDB2 ID:67762)

Fusion Gene Summary for PPP1R12A-ZZEF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R12A-ZZEF1
Fusion gene ID: 67762
HgeneTgene
Gene symbol

PPP1R12A

ZZEF1

Gene ID

4659

23140

Gene nameprotein phosphatase 1 regulatory subunit 12Azinc finger ZZ-type and EF-hand domain containing 1
SynonymsGUBS|M130|MBS|MYPT1ZZZ4
Cytomap

12q21.2-q21.31

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 12Amyosin binding subunitmyosin phosphatase, target subunit 1myosin phosphatase-targeting subunit 1protein phosphatase 1, regulatory (inhibitor) subunit 12Aprotein phosphatase myosin-binding subunitzinc finger ZZ-type and EF-hand domain-containing protein 1zinc finger, ZZ-type with EF hand domain 1
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261207, ENST00000437004, 
ENST00000450142, ENST00000546369, 
ENST00000550107, 		ENST00000574474, 
ENST00000381638, 
Fusion gene scores* DoF score25 X 22 X 11=605012 X 15 X 6=1080
# samples 2815
** MAII scorelog2(28/6050*10)=-4.43343641010435
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1080*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R12A [Title/Abstract] AND ZZEF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R12A(80214554)-ZZEF1(4020460), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP1R12A-ZZEF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R12A

GO:0030155

regulation of cell adhesion

20354225

HgenePPP1R12A

GO:0035507

regulation of myosin-light-chain-phosphatase activity

20354225

HgenePPP1R12A

GO:0043086

negative regulation of catalytic activity

19245366

HgenePPP1R12A

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366


check buttonFusion gene breakpoints across PPP1R12A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZZEF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48P-01APPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-


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Fusion Gene ORF analysis for PPP1R12A-ZZEF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261207ENST00000574474PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
5CDS-5UTRENST00000437004ENST00000574474PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
5CDS-5UTRENST00000450142ENST00000574474PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
5CDS-5UTRENST00000546369ENST00000574474PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
5CDS-5UTRENST00000550107ENST00000574474PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
Frame-shiftENST00000261207ENST00000381638PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
Frame-shiftENST00000437004ENST00000381638PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
Frame-shiftENST00000546369ENST00000381638PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
In-frameENST00000450142ENST00000381638PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-
In-frameENST00000550107ENST00000381638PPP1R12Achr12

80214554

-ZZEF1chr17

4020460

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450142PPP1R12Achr1280214554-ENST00000381638ZZEF1chr174020460-12213138126797673166
ENST00000550107PPP1R12Achr1280214554-ENST00000381638ZZEF1chr174020460-119461114095003166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450142ENST00000381638PPP1R12Achr1280214554-ZZEF1chr174020460-0.0019282620.99807173
ENST00000550107ENST00000381638PPP1R12Achr1280214554-ZZEF1chr174020460-0.0015852350.99841475

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Fusion Genomic Features for PPP1R12A-ZZEF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP1R12A-ZZEF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:80214554/chr17:4020460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-92635_383711031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-92535_38371996.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-82535_383711031.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-82535_38284944.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-82435_38371975.0MotifNote=KVKF motif
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926105_1343711031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926138_1643711031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926198_2273711031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926231_2603711031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-92639_683711031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-92672_1013711031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925105_134371996.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925138_164371996.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925198_227371996.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925231_260371996.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-92539_68371996.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-92572_101371996.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825105_1343711031.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825138_1643711031.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825198_2273711031.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825231_2603711031.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-82539_683711031.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-82572_1013711031.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825105_134284944.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825138_164284944.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825198_227284944.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825231_260284944.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-82539_68284944.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-82572_101284944.0RepeatNote=ANK 2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824105_134371975.0RepeatNote=ANK 3
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824138_164371975.0RepeatNote=ANK 4
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824198_227371975.0RepeatNote=ANK 5
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824231_260371975.0RepeatNote=ANK 6
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-82439_68371975.0RepeatNote=ANK 1
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-82472_101371975.0RepeatNote=ANK 2
TgeneZZEF1chr12:80214554chr17:4020460ENST00000381638155226_4051662962.0DomainDOC
TgeneZZEF1chr12:80214554chr17:4020460ENST000003816381551777_18251662962.0Zinc fingerZZ-type 1
TgeneZZEF1chr12:80214554chr17:4020460ENST000003816381551826_18721662962.0Zinc fingerZZ-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926519_6603711031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926721_7533711031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926773_7953711031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925519_660371996.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925721_753371996.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925773_795371996.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825519_6603711031.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825721_7533711031.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825773_7953711031.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825519_660284944.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825721_753284944.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825773_795284944.0Compositional biasNote=Ser-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824519_660371975.0Compositional biasNote=Ser/Thr-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824721_753371975.0Compositional biasNote=Glu/Lys-rich
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824773_795371975.0Compositional biasNote=Ser-rich
TgeneZZEF1chr12:80214554chr17:4020460ENST00000381638155111_1461662962.0DomainEF-hand


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Fusion Gene Sequence for PPP1R12A-ZZEF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67762_67762_1_PPP1R12A-ZZEF1_PPP1R12A_chr12_80214554_ENST00000450142_ZZEF1_chr17_4020460_ENST00000381638_length(transcript)=12213nt_BP=1381nt
GAAGTTACGTTAGATTGGCCGCCGGTGACGGGTGGCCGTGCTGGGGGCGGGAGGGCTTCTGTGGTAGGAAGGGAGGTCCGCTCGGCCGGG
TGCGCCGCCCCAGTGCTCTGTGGGATACTGGAAGTCTCGAGCGTCGGCTCCGGGTTCCCAGCCCTCCTCTGGCCCGCACTCATAGAAACA
TTCACACACCCCCTGCCTCCCCTCTCTTCCCTCTCCGCCTCCCCCTTCCCCCCCTCGCGATAAGAAGACCCGGCGGCAGGAGAGGGGATG
AAGATGGCGGACGCGAAGCAGAAGCGGAACGAGCAGCTGAAACGCTGGATCGGCTCCGAGACGGACCTCGAGCCTCCGGTGGTGAAGCGC
CAGAAGACCAAGGTGAAGTTCGACGATGGCGCCGTCTTCCTGGCTGCTTGCTCCAGCGGCGACACGGACGAGGTCCTCAAGCTGCTGCAC
CGCGGCGCCGACATCAATTACGCCAATGTGGACGGACTCACTGCCCTGCACCAGGCTTGCATTGATGACAATGTTGATATGGTGAAGTTT
CTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGCAGCTTCCTGTGGATATCTTGATATT
GCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTTAGATATTGCGGAGGAGGAGGCAATG
GAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGAAGAACGGATCATGCTTAGAGATGCC
AGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACTTCACGTTGCAGCTGCTAAAGGCTAT
ACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTGGACACCTCTTCATGCTGCAGCTCAT
TGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAAAGTGGGCCAAACAGCCTTTGATGTA
GCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGAAAAACGGGACAAGAAATCTCCACTA
ATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTTGATTATTGAACCAGAGAAAAATGCA
TCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTCTAGCTGCTCTAGTGAAGAAGATGAG
GAAGATGACTCGGAATCAGAAGCTGAAACAGGTTTCACAGACATATTTTCAGAGTCGAAGGAGGGCCTTGATATTCACTCGTCAATGATA
CTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGGTGATGCCCTACCCGATGCTGGAGCACTGCAATAACATGTGCACCATGCGGTCT
TCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAAAGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGTCCAGAGATGGATAAACTC
AAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACATCCTCCAACTCGGCAGACATTGACAAGATGACAAATGGAGAAACCTCATCCTAC
TGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTCGTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCACCTGTCCATTGCAGTGGCT
GCCACTGACCAGAGCTACATGCCACAGCAGGTGACAGTAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAAGTCCGAGATGTGCACATC
CCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAAATGCCAACGTCAGTCAGCTCTATGTCCAGATTAACATAAAGCGTTGTCTTAGC
GATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTGTTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCAGTCTCAGATGCTTCTGCA
ATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGGCTTCTATGGAGACAAATCCCGCCTTTGTCCAGACAGTGCTGCACAATACTCAG
AAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCACCAGGATCTACAGATTTCTCAACTTTCCTCTCCCCTAATGTGCTGGAAGAAGTG
GACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTACCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCTCTCGCAAGAGGAAGTGTT
GCCAAAGTCATGAGCTCTCTATGCACCATCACTGACCATCTGGACACGCAGTATGATGCCTCATCCCTCATCTTGTCCATGGCGTCAGTC
AGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCCAGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAAGAAGATAAGTCTGGACCC
GAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTTTTCTTACGGAAACTGGAAAAACCAGAGCCAGCACTATTTTTTCTACCGGAACT
GAATCTGCCTTCCAAGTTACACAGATAAGAATTATGGTTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTGGTGTTTGCCTATAACTCA
TCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAAGGTTTGAAAAATATGACAAATGGAAGCTTCAGGAGCTCAGGCAATTTGTAAAA
AGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGGATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAATGGGATGAAGCAGATGTG
AAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGGTGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAGCGCTTGGGAGTGCAAGGC
TTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAGAAGCAGAACAGAGCGTCACCTGTGCACACTGCAGAAAGGACACAGAGGAGAGT
GTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGTTTATCCAGCAGCTCGCCCATGACCTGGTGCAGCAGAAGGAAAGTGGCTTAAAA
TATAAATCTTTTCTGGACTTCGCGGGTCTTGATTTGCAGATCTTCTGGAATTTTTACAGTAAATTAAAGCAAAACCCGAGGGAAGAATGC
GTCTCTGCCCAAACCCTGCTTCTGCAGCTACTCCAGAGCTGCTTCTCTGTGCTGCAGGGAGATGTACTGGCTGCTTCTGAGGAGGAAAAG
GCTCCAATCCAAAGCCCTAAAGGAGTAGAGGCTGCCAAGGAGCTGTACACACACTTGTGTGATGTGGTGGACAAGGTGGATGGAGACTCT
GTGCCCATGGAGATACTAAAACAAGAAGTCAGGAATACCCTTCTCAATGGGGCTGCCATCTTCTTTCCTAATCGACAGACCCGACGGAAC
CATCTCTTCACCATGATGAATGTCACCGAGCAGGAGCACAAGCAGTCCCTGCAGCTCACTTTCCGTTCACTGTGCACGTATTTTAGTGAC
AAGGATCCAGGCGGCCTTCTTCTTTTACCTGAGAAGAACGACCTGGCCAAGATGAACATCAGTGAAGTCCTGGCGGTCATGGACACTCTC
GTCTCTGTTGCTGCTCGAGAGTGCGAGCTGTTAATGCTCAGTGGGGCCCCAGGGGAGGTGGGCTCTGTGCTCTTCTCCCTGTTCTGGTCC
GTCCAAGGCAGCCTGCTATCCTGGTGCTACCTGCAGCTGAAGAGCACGGACTCTGGAGCCAAAGATCTTGCCGTGGACCTTATTGAAAAA
TATGTGGGCCAGTTTCTGGCAAGCATGAGAGCGATTTTGGAATCCCTTTTCTCACAGTACAGTGGAAAAACCATAGTAGAAAGATTATGT
AACTCAGTGTTTTCAATGGCAGCTCGTCAACTGGTTATCTTCCTGCTGGACTTCTGCACTTTAGACATCCCACACTGCGTGCTCTTGAGA
GAGTTCAGCGTCCTCACAGAACTCCTGAAGAAGCTCTGTAGTGGCCCCGAAGGAGGACTGAGGAAGCTGGATGTTGAGACCTGGCAACAG
GAACAGCCTGTGGTGTTACATACGTGGACGAAGGAATCTGCCCACAACTATGAAAATAATTGCCATGAGGTATCCGTCTTTGTTAGCCCA
GGGGCAACCTATTTTGAAGTGGAATTCGATGACAGGTGTGAAACTGAAAAAAGGTATGATTATCTGGAATTTACCGACGCTAGAGGTCGG
AAAACACGCTATGACACAAAAGTTGGCACTGATAAATGGCCCAAGAAAGTGACCTTCAAGGCCGGTCCTCGGTTGCAGTTCCTCTTTCAC
TCTGACAGCAGTCACAACGAATGGGGCTACAAATTCACTGTCACTGCCTGTGGGCTGCCCGATGTTGCCGTGTCTTGGGGGCTGGATTTA
CAGCTCCTCGTCTCCCGGCTGATGGGACGCCTGGCTTCCCAGTGCATGGCGCTCAAGTCTGTGCGCCAGTTAGGAAGTAACATGGTAGTA
CCTCAGGCAAAAATGGCATTAGTCCTAAGCTCCCCACTGTGGAAACCTGTCTTCAGGCATCAGGTTTGTCCAGAGTTGGAATTAGAAGCA
AGCTGGCCCACTCACCCACACCGGAATAGTAAGGAGGTTAAGAACATTCCTGACGACCCCTGCCGCCATTTTCTTCTTGATTTTGCCCAG
TCAGAGCCTGCTCAGAACTTCTGTGGGCCATATTCAGAACTTTTCAAAGGATTCATACAGGCATGTAGAAAACAGGCCCCAAAGACAGAT
ATAGTTGCTGGTTCCACTATTGATCAAGCTGTGAACGCCACCTTTGCTGCTCTGGTGTATCGCACTCCAGATTTATATGAGAAGCTGCAA
AAATATGTCAACAGTGGGGGCAAAATAGCCCTGAGTGAAGAGTTTGCCCAGGTTTATTCCTTGGCAGATGGGATTCGAATATGGATGTTA
GAGATGAAGCAGAAGTCCCTGATGAGCCTGGGGAATGAAGCAGAAGAAAAACATAGTTCAGAAGCTACTGAGGTGAACCCTGAGAGCCTG
GCAAAAGAGTGCATTGAGAAGAGTCTTCTATTACTAAAATTTCTGCCCACGGGCATAAGTTCAAAAGAAAGCTGCGAAAAGTTGGAGACT
GCTGATGAAACCAGTCATCTCCAGCCACTCAACAAGCGTCAGAGGACAAGCTCTGTGGTGGAAGAGCATTTCCAAGCCTCAGTATCTCCC
ACTGAAGCCGCACCCCCTGCCACAGGAGACCAGAGTCCTGGCCTGGGCACCCAGCCAAAGCTGCCATCCAGCAGTGGCCTTCCTGCTGCA
GACGTGTCCCCTGCCACAGCTGAAGAGCCCTTGTCACCTTCCACACCCACCCGCCGGCCTCCCTTCACCCGAGGGCGACTCCGGCTGCTC
TCCTTTCGATCCATGGAGGAGGCCAGACTGGTGCCCACAGTGAAAGAGAAATACCCTGTGCTGAAGGACGTCATGGACTTCATTAAGGAT
CAGTCGCTCTCGCACAGGAGTGTTGTGAAGGTTCTTTCCCTGAGGAAAGCCCAGGCCCAGAGCATCCTGGAAGTCCTGAAGATAACTCAG
CACTGTGCAGAATCCCTTGGGCAGCCCCACTGCTTCCATCCACCTTTCATACTTTTCCTGTTGGAACTTCTGACCTGTCAGAAAGATTTT
ACCAATTATTTTGGACACCTGGAAGGCTGTGGTGCTGATCTACACAAAGAAATTCGAGACACTTACTATCAACTTGTTCTGTTTTTGGTC
AAAGCAGTTAAAGGATTTAGTAGCCTAAATGACAGGTCCTTGCTCCCTGCCTTATCCTGTGTTCAGACAGCCCTGCTTCATCTTTTGGAT
ATGGGCTGGGAACCCAATGATCTCGCCTTCTTTGTTGATATTCAGTTACCAGATCTCCTCATGAAAATGTCACAGGAGAATATAAGTGTC
CATGACAGTGTGATCAGCCAATGGAGTGAAGAAGATGAGCTTGCTGATGCCAAGCAGAATTCAGAATGGATGGATGAGTGTCAGGATGGC
ATGTTTGAGGCCTGGTATGAAAAAATAGCCCAGGAAGATCCAGAGAAGCAGAGGAAAATGCACATGTTCATTGCTCGCTACTGTGACCTG
TTAAATGTGGACATCTCTTGTGATGGGTGTGATGAGATTGCCCCCTGGCATCGATACCGCTGTCTGCAGTGCAGCGACATGGATCTCTGC
AAAACTTGCTTCCTAGGTGGGGTGAAGCCTGAGGGCCACGGAGACGACCATGAAATGGTCAACATGGAGTTTACCTGTGACCACTGCCAG
GGTTTGATCATAGGCCGGAGGATGAACTGCAATGTTTGCGATGACTTTGATCTTTGCTACGGATGCTATGCAGCGAAGAAATACTCCTAC
GGCCATTTGCCTACCCACAGCATCACGGCCCACCCAATGGTAACCATTCGGATCAGTGACCGGCAGAGGCTCATCCAGCCATATATCCAT
AACTACTCCTGGCTGCTCTTTGCTGCCCTGGCTCTCTATAGCGCCCACCTGGCCAGTGCAGAGGATGTGGATGGGGAGAAGCTGGACCCC
CAGACGCGCAGCAGTGCCACCACCCTGCGGAGCCAGTGCATGCAGCTCGTCGGGGACTGTCTGATGAAGGCTCATCAGGGAAAAGGCCTT
AAAGCTCTAGCTTTGCTGGGTGTATTGCCAGATGGGGACTCGAGCCTAGAAGATCAGGCCCTACCAGTCACTGTGCCCACCGGAGCGTCA
GAGGAGCAGCTAGAGAAGAAAGCTGTCCAGGGTGCTGAGCTGTCAGAAGCAGGCAATGGAAAGAGAGCTGTTCATGAGGAAATCAGACCT
GTAGATTTCAAGCAGAGAAATAAGGCAGATAAAGGTGTATCATTATCGAAGGATCCTTCATGCCAGACCCAAATTTCAGATTCACCTGCA
GATGCTAGCCCACCTACAGGACTTCCAGATGCTGAAGATTCAGAAGTGTCATCTCAGAAGCCCATAGAGGAAAAAGCAGTTACTCCAAGC
CCTGAGCAAGTGTTTGCTGAGTGTTCCCAGAAGAGGATTTTGGGATTACTAGCAGCCATGTTACCTCCCTTAAAGTCGGGCCCCACGGTT
CCCCTGATAGACCTGGAGCACGTCCTTCCACTCATGTTTCAGGTTGTCATCTCAAACGCAGGCCACCTGAATGAAACCTACCATCTCACC
CTGGGTCTTCTCGGCCAGTTAATTATCCGTCTTTTGCCAGCAGAGGTAGACGCCGCAGTGATCAAAGTCCTCTCAGCCAAACACAACCTG
TTTGCTGCAGGGGACAGTTCCATTGTGCCAGATGGCTGGAAAACCACCCACCTGCTCTTTAGCCTGGGAGCTGTGTGTCTGGACAGCCGG
GTGGGCTTGGACTGGGCGTGCTCCATGGCAGAGATCCTGCGGTCACTCAACAGTGCCCCACTGTGGCGTGATGTCATTGCCACCTTCACA
GACCACTGCATCAAGCAGCTGCCATTCCAGCTGAAGCACACCAACATCTTCACCCTGCTCGTGCTGGTTGGCTTCCCCCAGGTCCTCTGT
GTGGGAACCCGCTGCGTTTATATGGATAATGCCAATGAACCCCATAATGTGATCATCTTGAAGCACTTTACTGAGAAGAACAGGGCTGTG
ATTGTTGATGTCAAAACTCGGAAGAGGAAAACAGTGAAGGACTACCAGCTGGTCCAGAAGGGAGGAGGACAAGAGTGTGGTGACTCTCGG
GCCCAGCTGAGCCAGTACTCCCAGCACTTTGCCTTTATCGCCAGTCACCTTCTGCAAAGCAGCATGGACAGCCATTGTCCCGAGGCAGTA
GAAGCAACTTGGGTCCTGTCCCTGGCCCTGAAAGGATTGTATAAAACACTAAAGGCTCACGGTTTTGAGGAGATCCGTGCTACTTTCCTT
CAGACCGATTTGCTGAAGTTGCTGGTGAAAAAGTGCAGCAAAGGGACTGGCTTTAGTAAAACGTGGCTCCTCCGGGACCTGGAAATTTTG
TCCATCATGCTGTACTCCTCAAAAAAGGAGATCAACGCTTTGGCTGAGCACGGAGACCTAGAGCTGGATGAGCGAGGGGACCGAGAGGAA
GAGGTGGAACGGCCAGTCAGCAGCCCTGGCGACCCAGAGCAGAAAAAGCTGGACCCCCTTGAGGGCCTGGATGAGCCCACCAGAATATGT
TTCTTGATGGCTCATGATGCCCTCAATGCCCCTCTGCACATTCTCCGGGCCATATACGAACTGCAGATGAAAAAGACCGATTATTTCTTC
CTGGAGGTTCAGAAGAGGTTTGATGGTGATGAGCTCACCACAGATGAAAGGATACGGTCCCTGGCTCAGCGGTGGCAGCCCAGTAAGAGT
CTGAGGCTGGAAGAACAGAGCGCCAAAGCTGTGGATACAGACATGATTATCCTGCCATGCTTGTCCCGGCCTGCACGCTGTGACCAAGCC
ACTGCTGAATCGAACCCTGTGACCCAGAAGCTGATCTCCAGCACAGAGAGCGAACTGCAGCAGAGCTATGCCAAGCAGCGCCGTAGCAAG
AGCGCCGCCCTCCTGCACAAGGAGCTGAACTGCAAGAGTAAGAGGGCTGTCCGGGACTACCTCTTCCGAGTGAACGAGGCCACAGCTGTC
CTGTACGCCCGCCACGTGCTTGCATCCCTGCTCGCCGAGTGGCCTAGCCACGTGCCAGTGAGCGAGGACATCCTGGAGCTCAGTGGCCCT
GCCCATATGACCTACATTTTGGATATGTTCATGCAGCTGGAAGAAAAGCATGAGTGGGAGAAGATCCTGCAGAAAGTGCTCCAGGGCTGC
CGAGAGGACATGCTGGGGACCATGGCCCTGGCTGCATGCCAGTTCATGGAGGAGCCAGGAATGGAGGTGCAAGTGAGGGAGTCGAAACAC
CCGTATAACAACAACACCAACTTCGAGGATAAAGTTCACATTCCTGGTGCCATCTACCTCTCAATCAAATTCGACTCTCAGTGCAACACA
GAGGAGGGCTGTGACGAGTTAGCCATGTCCAGCAGCAGTGACTTCCAGCAAGACCGACACAGCTTCAGCGGGTCTCAGCAGAAGTGGAAA
GATTTTGAACTTCCAGGAGACACTCTGTATTACCGCTTCACCTCCGACATGAGCAACACCGAGTGGGGCTACAGATTCACCGTGACGGCC
GGACACCTGGGGCGGTTCCAGACAGGATTCGAGATTTTGAAGCAGATGTTGTCAGAAGAAAGGGTCGTGCCTCATCTCCCATTGGCAAAA
ATTTGGGAATGGCTGGTGGGCGTGGCCTGTCGCCAGACTGGCCATCAACGATTAAAAGCCATCCACTTACTTCTGAGGATTGTGCGATGC
TGCGGCCACAGTGACCTGTGTGACCTTGCGCTGTTGAAGCCCCTGTGGCAGCTCTTTACCCACATGGAGTACGGCCTGTTTGAGGACGTG
ACGCAGCCCGGCATCCTCCTTCCCCTGCATCGTGCCCTCACTGAGCTCTTCTTCGTCACCGAGAACCGTGCCCAGGAGCTTGGCGTGCTG
CAGGATTACCTGCTGGCCCTAACCACGGACGACCACCTTCTCCGCTGTGCGGCACAGGCTCTGCAGAACATTGCTGCCATCAGCCTGGCC
ATCAACTACCCAAACAAGGCCACCCGCCTCTGGAATGTGGAGTGTTAGCCCTTGGTGGGGCGTGCATGGGACTAGTTCATCTGCCACAGG
GATTTTAGAGCAGACATCTAACCTCATTCAGGAAAACTCCTGTAGCGCCAGTGCCCAGCTCTCCTTGAGCTGACCACTCCAGTTAGGATG
CCAAGCAGCCACGTCTCCAAGAGCTCCCGTGCGTAGGCTGGACACAAGCACAGGCTGTAGCATGGTGAAAATAAGCCAAGCAGTGCAGAA
TGCCTCAGAAAGGGTGGGCAGGGGGCCCTTAAGAAGGTTCAGAGACCAGCCTTCTCCAGAGGCTGTCACTGCAGGAGCCGTGGGCCTGGG
AAGACTTGGAAGCGGCCTCTCTCAACTGGTTTCTGTCTCCGTGGAGCTGGAACTGCCTGCACTTGCCTTCAGAGGGAGGCACAGTCCACC
CAGATCCACCTTTCCAGCAAGACCCCCAGTGGCTGCCCAGCCTGGGAGCACCTCTTTGCTTTTCACACCAAACCAAAACTGGCGAGAGCC
CCTCCTAGCCACCAGTGATCCCCAAGCATCCAGTACAGAACCAGGCATCGAGCTAGCTCCCTGCACGGCCGCACCCTCCCAGAGAACTCC
TTGAGGAGAACAAGTGCCCTTGGGGACAGCCGGCAGGCGCCCCTGTACGTCTGCTCATGCACCAGGCAGCACAGCCGCAGTTCCTCAGTT
GTTGTTTTGACATATTTCAGTTTCCACCTCACGTTTTTAGAGCAGAACCACACTGTCTCCCTGGAGGGGCTCGAGGGCATGACCGGGGAC
TGACCATTCTGTGAAAGGAGCAGAATGTGAGGAGCACGCGTGAGCTTATGTACCGTGAAGATGATCAGAGGATATCTTATTTTAAGAGTA
AAAACCCACATAATTTTATTTCTGCTTGATAGTCATGGTAGTCTGTCATACCCACCTCTGGGACTCTGCGTGGCTGTTTGGCTGTCACTT
GTAGCAATAACGACATTAGTTCTAGTCAGTGCTGTTTTACATTTTTCTTTTGATGGGTTTAGTCTTGCCCTGGAGTGCCGATGATGATTC
TCCCTCCAGAGCCACGCTTGGGAACATGAAGCAAGTCTGGCGTGTGGGCTGCGTGCCGGCCTTAGTGGGACCCGTGGGGTTGGAGCATGC
CTTTAGGGGCAGTGTCTGGGCCGAAGCACGTCCCACCACACAGTGCCAGAGCCAGAGAAGGGGCCCCACCACCAAGGCCAAGCTTGACCA
GGTCAGCATTGCCATGGCCCAGTGTGCCCCGTGGCCTCTGAAGATCCCTCTGTGCAGGGTCTGCAGGGATCTGGATTGCAAGGGCCCAAG
TCTGCAGGTCTGGAAGCATCTTCCTATAAGAGCACTTTCGCCTTCTGGGTCAGGACTCCAAGGTGCAGCGGGCTTCACAGCCCTACAATT
GGGTTCTCAGCTAAGCCCCAGAGTTCTGGTAGAACCATCCCGGGGCGGGTGGAGGGTGGGATTTAAGGGAGACGGGAACACATGGGGCAG
GTCCTGGAACTTGGTGGCCTGAGGACTGAGGCCATTGCCCTGGTGGAAAGGCCTGGCCTGGTTCCTGTGGCTTGGGACCTGAATAGGCAG
GTGCTGCTGGCTCCGTAGAAACCCTTTTCCCATCTTTTGCTCTTTGCCAAACCTACCTTGCTTTGGGAGCTGCCTGCACCACCCCAGAGA
AGGCCCCACCTTCTTCATCCCTCAGACCCGAGGAGGCCTCCCAGTAAGGAGTTTCCCAAGAGGGGACTCACAGGAAACAAGTCTTAGTGC
TTGGGAGGGAGGCCCCGCTGCGTGCTCAGACTCACAGCCAACCTGGAAGGTAGACGAGATAGCGCCACCCACGCCCCTCCACACCCCAGA
CTCCGAGTAAAGCGGGCGGTAGGGCCGGAGTCACCTCCCCTATGGCAGTGGCCGCCGCTGTACTCCATCCTCCCGTCAGGAAGATCAGCT
GTAAATAAACGCTGGGCTCCCCAGAGCACCTGTCCGCCCACTGCCCTTGCTGTTCTGGGATCTTCGCTGCAGTTCACGGGAAACAAGCCT
GAGTCCGCTCGCACCCGCGGCTGCTCTCCCGGCTCGGCCCGGCCGCCTCTGTCTCCGGCCACCGGGTGGCGCTGCCGAGCCAGAGCCGCC
GCGTCCCGGCGCTTTCCAGGAGCCCCAGGCCCGGAGGAGGCGAAGCCCGCAGAGCAAAGGTGGAAACACGTGCCTACGCTGTAAAGAAAT
CCTGTTCCAGAGCATACCTGTTGTACAAACAGACACTGTTCCTAACGAGAGGAGTGACGTATTTTCATCACCGTTTTTAATTTGTTTTCT
TACGGGTTTACGATTTTGAATTTTTCTTATTTGGTTGAAAGAATTTTGATTCTATCAGCCTGAGTGAGTTCAGCCTGTAAAAAGGATGTT

>67762_67762_1_PPP1R12A-ZZEF1_PPP1R12A_chr12_80214554_ENST00000450142_ZZEF1_chr17_4020460_ENST00000381638_length(amino acids)=3166AA_BP=371
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETGFTDIFSESKEGLDIHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDK
LKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVH
IPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNT
QKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMAS
VRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYN
SSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQ
GLTISGYLRPARAEAEQSVTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQNPREE
CVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRR
NHLFTMMNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVLFSLFW
SVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLL
REFSVLTELLKKLCSGPEGGLRKLDVETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARG
RKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMV
VPQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKT
DIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPES
LAKECIEKSLLLLKFLPTGISSKESCEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSSSGLPA
ADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDVMDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKIT
QHCAESLGQPHCFHPPFILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTALLHLL
DMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCD
LLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYAAKKYS
YGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKG
LKALALLGVLPDGDSSLEDQALPVTVPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQISDSP
ADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHL
TLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRDVIATF
TDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDS
RAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEI
LSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLDEPTRICFLMAHDALNAPLHILRAIYELQMKKTDYF
FLEVQKRFDGDELTTDERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYAKQRRS
KSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQG
CREDMLGTMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKW
KDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVR
CCGHSDLCDLALLKPLWQLFTHMEYGLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNIAAISL

--------------------------------------------------------------
>67762_67762_2_PPP1R12A-ZZEF1_PPP1R12A_chr12_80214554_ENST00000550107_ZZEF1_chr17_4020460_ENST00000381638_length(transcript)=11946nt_BP=1114nt
ATGAAGATGGCGGACGCGAAGCAGAAGCGGAACGAGCAGCTGAAACGCTGGATCGGCTCCGAGACGGACCTCGAGCCTCCGGTGGTGAAG
CGCCAGAAGACCAAGGTGAAGTTCGACGATGGCGCCGTCTTCCTGGCTGCTTGCTCCAGCGGCGACACGGACGAGGTCCTCAAGCTGCTG
CACCGCGGCGCCGACATCAATTACGCCAATGTGGACGGACTCACTGCCCTGCACCAGGCTTGCATTGATGACAATGTTGATATGGTGAAG
TTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGCAGCTTCCTGTGGATATCTTGAT
ATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTTAGATATTGCGGAGGAGGAGGCA
ATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGAAGAACGGATCATGCTTAGAGAT
GCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACTTCACGTTGCAGCTGCTAAAGGC
TATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTGGACACCTCTTCATGCTGCAGCT
CATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAAAGTGGGCCAAACAGCCTTTGAT
GTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGAAAAACGGGACAAGAAATCTCCA
CTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTTGATTATTGAACCAGAGAAAAAT
GCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTCTAGCTGCTCTAGTGAAGAAGAT
GAGGAAGATGACTCGGAATCAGAAGCTGAAACAGGTTTCACAGACATATTTTCAGAGTCGAAGGAGGGCCTTGATATTCACTCGTCAATG
ATACTGCGCTTCCTGCACCGCAATCGGCTCTCCAGCGCGGTGATGCCCTACCCGATGCTGGAGCACTGCAATAACATGTGCACCATGCGG
TCTTCCGTCCTGAAGGAGTCTCTGGATCAGCTGGTACAAAAGGAAAAGGAAAGCCCTGGAGATCTAACTAGAAGTCCAGAGATGGATAAA
CTCAAGTCAGTAGCAAAGTGCTATGCTTATATAGAAACATCCTCCAACTCGGCAGACATTGACAAGATGACAAATGGAGAAACCTCATCC
TACTGGCAGTCAGATGGCAGTGCCTGTTCACACTGGATTCGTTTAAAAATGAAGCCAGATGTTGTGCTTAGGCACCTGTCCATTGCAGTG
GCTGCCACTGACCAGAGCTACATGCCACAGCAGGTGACAGTAGCTGTAGGGAGGAATGCCAGCGATCTTCAGGAAGTCCGAGATGTGCAC
ATCCCCAGCAATGTCACTGGCTATGTGACGCTGCTGGAAAATGCCAACGTCAGTCAGCTCTATGTCCAGATTAACATAAAGCGTTGTCTT
AGCGATGGCTGCGACACTAGAATTCATGGTCTCAGGGCTGTTGGCTTTCAGAGAGTTAAGAAGTCTGGGGTCTCAGTCTCAGATGCTTCT
GCAATATGGTATTGGTCTCTGCTGACATCTCTGGTGACGGCTTCTATGGAGACAAATCCCGCCTTTGTCCAGACAGTGCTGCACAATACT
CAGAAGGCGCTGCGGCACATGCCTCCACTCTCTCTCTCACCAGGATCTACAGATTTCTCAACTTTCCTCTCCCCTAATGTGCTGGAAGAA
GTGGACAGTTTCCTCATAAGGATAACTAGCTGCTGTTCTACCCCAGAGGTAGAACTGACTCTTCTGGCTTTTGCTCTCGCAAGAGGAAGT
GTTGCCAAAGTCATGAGCTCTCTATGCACCATCACTGACCATCTGGACACGCAGTATGATGCCTCATCCCTCATCTTGTCCATGGCGTCA
GTCAGACAGAACCTGCTCCTCAAATATGGTAAACCTCTCCAGTTGACTCTTCAGGCATGTGATGTCAAAGGAAAAGAAGATAAGTCTGGA
CCCGAAAACCTCCTTGTTGAACCGTGGACAAGGGATGGTTTTCTTACGGAAACTGGAAAAACCAGAGCCAGCACTATTTTTTCTACCGGA
ACTGAATCTGCCTTCCAAGTTACACAGATAAGAATTATGGTTCGACGTGGTGGCATTGGTGCCCAGTGTGGGTTGGTGTTTGCCTATAAC
TCATCTTCAGATAAATTTTGTGCGGAAGAACACTTCAAAAGGTTTGAAAAATATGACAAATGGAAGCTTCAGGAGCTCAGGCAATTTGTA
AAAAGCAGGATTGGTTGCTCATCTGATGACCTTGGAGAGGATGATCCTATTGGCTGGTTTGAACTGGAAGAAGAATGGGATGAAGCAGAT
GTGAAGCTGCAACAGTGCAGAGTTGCCAAATATTTGATGGTGAAGTTCCTCTGCACCCGTCAGGAGTCAGCAGAGCGCTTGGGAGTGCAA
GGCTTGACCATCAGTGGGTACCTCCGGCCTGCAAGAGCAGAAGCAGAACAGAGCGTCACCTGTGCACACTGCAGAAAGGACACAGAGGAG
AGTGTCTGTGGGGCCACGTTGCTCCTCAGGACCCTTCAGTTTATCCAGCAGCTCGCCCATGACCTGGTGCAGCAGAAGGAAAGTGGCTTA
AAATATAAATCTTTTCTGGACTTCGCGGGTCTTGATTTGCAGATCTTCTGGAATTTTTACAGTAAATTAAAGCAAAACCCGAGGGAAGAA
TGCGTCTCTGCCCAAACCCTGCTTCTGCAGCTACTCCAGAGCTGCTTCTCTGTGCTGCAGGGAGATGTACTGGCTGCTTCTGAGGAGGAA
AAGGCTCCAATCCAAAGCCCTAAAGGAGTAGAGGCTGCCAAGGAGCTGTACACACACTTGTGTGATGTGGTGGACAAGGTGGATGGAGAC
TCTGTGCCCATGGAGATACTAAAACAAGAAGTCAGGAATACCCTTCTCAATGGGGCTGCCATCTTCTTTCCTAATCGACAGACCCGACGG
AACCATCTCTTCACCATGATGAATGTCACCGAGCAGGAGCACAAGCAGTCCCTGCAGCTCACTTTCCGTTCACTGTGCACGTATTTTAGT
GACAAGGATCCAGGCGGCCTTCTTCTTTTACCTGAGAAGAACGACCTGGCCAAGATGAACATCAGTGAAGTCCTGGCGGTCATGGACACT
CTCGTCTCTGTTGCTGCTCGAGAGTGCGAGCTGTTAATGCTCAGTGGGGCCCCAGGGGAGGTGGGCTCTGTGCTCTTCTCCCTGTTCTGG
TCCGTCCAAGGCAGCCTGCTATCCTGGTGCTACCTGCAGCTGAAGAGCACGGACTCTGGAGCCAAAGATCTTGCCGTGGACCTTATTGAA
AAATATGTGGGCCAGTTTCTGGCAAGCATGAGAGCGATTTTGGAATCCCTTTTCTCACAGTACAGTGGAAAAACCATAGTAGAAAGATTA
TGTAACTCAGTGTTTTCAATGGCAGCTCGTCAACTGGTTATCTTCCTGCTGGACTTCTGCACTTTAGACATCCCACACTGCGTGCTCTTG
AGAGAGTTCAGCGTCCTCACAGAACTCCTGAAGAAGCTCTGTAGTGGCCCCGAAGGAGGACTGAGGAAGCTGGATGTTGAGACCTGGCAA
CAGGAACAGCCTGTGGTGTTACATACGTGGACGAAGGAATCTGCCCACAACTATGAAAATAATTGCCATGAGGTATCCGTCTTTGTTAGC
CCAGGGGCAACCTATTTTGAAGTGGAATTCGATGACAGGTGTGAAACTGAAAAAAGGTATGATTATCTGGAATTTACCGACGCTAGAGGT
CGGAAAACACGCTATGACACAAAAGTTGGCACTGATAAATGGCCCAAGAAAGTGACCTTCAAGGCCGGTCCTCGGTTGCAGTTCCTCTTT
CACTCTGACAGCAGTCACAACGAATGGGGCTACAAATTCACTGTCACTGCCTGTGGGCTGCCCGATGTTGCCGTGTCTTGGGGGCTGGAT
TTACAGCTCCTCGTCTCCCGGCTGATGGGACGCCTGGCTTCCCAGTGCATGGCGCTCAAGTCTGTGCGCCAGTTAGGAAGTAACATGGTA
GTACCTCAGGCAAAAATGGCATTAGTCCTAAGCTCCCCACTGTGGAAACCTGTCTTCAGGCATCAGGTTTGTCCAGAGTTGGAATTAGAA
GCAAGCTGGCCCACTCACCCACACCGGAATAGTAAGGAGGTTAAGAACATTCCTGACGACCCCTGCCGCCATTTTCTTCTTGATTTTGCC
CAGTCAGAGCCTGCTCAGAACTTCTGTGGGCCATATTCAGAACTTTTCAAAGGATTCATACAGGCATGTAGAAAACAGGCCCCAAAGACA
GATATAGTTGCTGGTTCCACTATTGATCAAGCTGTGAACGCCACCTTTGCTGCTCTGGTGTATCGCACTCCAGATTTATATGAGAAGCTG
CAAAAATATGTCAACAGTGGGGGCAAAATAGCCCTGAGTGAAGAGTTTGCCCAGGTTTATTCCTTGGCAGATGGGATTCGAATATGGATG
TTAGAGATGAAGCAGAAGTCCCTGATGAGCCTGGGGAATGAAGCAGAAGAAAAACATAGTTCAGAAGCTACTGAGGTGAACCCTGAGAGC
CTGGCAAAAGAGTGCATTGAGAAGAGTCTTCTATTACTAAAATTTCTGCCCACGGGCATAAGTTCAAAAGAAAGCTGCGAAAAGTTGGAG
ACTGCTGATGAAACCAGTCATCTCCAGCCACTCAACAAGCGTCAGAGGACAAGCTCTGTGGTGGAAGAGCATTTCCAAGCCTCAGTATCT
CCCACTGAAGCCGCACCCCCTGCCACAGGAGACCAGAGTCCTGGCCTGGGCACCCAGCCAAAGCTGCCATCCAGCAGTGGCCTTCCTGCT
GCAGACGTGTCCCCTGCCACAGCTGAAGAGCCCTTGTCACCTTCCACACCCACCCGCCGGCCTCCCTTCACCCGAGGGCGACTCCGGCTG
CTCTCCTTTCGATCCATGGAGGAGGCCAGACTGGTGCCCACAGTGAAAGAGAAATACCCTGTGCTGAAGGACGTCATGGACTTCATTAAG
GATCAGTCGCTCTCGCACAGGAGTGTTGTGAAGGTTCTTTCCCTGAGGAAAGCCCAGGCCCAGAGCATCCTGGAAGTCCTGAAGATAACT
CAGCACTGTGCAGAATCCCTTGGGCAGCCCCACTGCTTCCATCCACCTTTCATACTTTTCCTGTTGGAACTTCTGACCTGTCAGAAAGAT
TTTACCAATTATTTTGGACACCTGGAAGGCTGTGGTGCTGATCTACACAAAGAAATTCGAGACACTTACTATCAACTTGTTCTGTTTTTG
GTCAAAGCAGTTAAAGGATTTAGTAGCCTAAATGACAGGTCCTTGCTCCCTGCCTTATCCTGTGTTCAGACAGCCCTGCTTCATCTTTTG
GATATGGGCTGGGAACCCAATGATCTCGCCTTCTTTGTTGATATTCAGTTACCAGATCTCCTCATGAAAATGTCACAGGAGAATATAAGT
GTCCATGACAGTGTGATCAGCCAATGGAGTGAAGAAGATGAGCTTGCTGATGCCAAGCAGAATTCAGAATGGATGGATGAGTGTCAGGAT
GGCATGTTTGAGGCCTGGTATGAAAAAATAGCCCAGGAAGATCCAGAGAAGCAGAGGAAAATGCACATGTTCATTGCTCGCTACTGTGAC
CTGTTAAATGTGGACATCTCTTGTGATGGGTGTGATGAGATTGCCCCCTGGCATCGATACCGCTGTCTGCAGTGCAGCGACATGGATCTC
TGCAAAACTTGCTTCCTAGGTGGGGTGAAGCCTGAGGGCCACGGAGACGACCATGAAATGGTCAACATGGAGTTTACCTGTGACCACTGC
CAGGGTTTGATCATAGGCCGGAGGATGAACTGCAATGTTTGCGATGACTTTGATCTTTGCTACGGATGCTATGCAGCGAAGAAATACTCC
TACGGCCATTTGCCTACCCACAGCATCACGGCCCACCCAATGGTAACCATTCGGATCAGTGACCGGCAGAGGCTCATCCAGCCATATATC
CATAACTACTCCTGGCTGCTCTTTGCTGCCCTGGCTCTCTATAGCGCCCACCTGGCCAGTGCAGAGGATGTGGATGGGGAGAAGCTGGAC
CCCCAGACGCGCAGCAGTGCCACCACCCTGCGGAGCCAGTGCATGCAGCTCGTCGGGGACTGTCTGATGAAGGCTCATCAGGGAAAAGGC
CTTAAAGCTCTAGCTTTGCTGGGTGTATTGCCAGATGGGGACTCGAGCCTAGAAGATCAGGCCCTACCAGTCACTGTGCCCACCGGAGCG
TCAGAGGAGCAGCTAGAGAAGAAAGCTGTCCAGGGTGCTGAGCTGTCAGAAGCAGGCAATGGAAAGAGAGCTGTTCATGAGGAAATCAGA
CCTGTAGATTTCAAGCAGAGAAATAAGGCAGATAAAGGTGTATCATTATCGAAGGATCCTTCATGCCAGACCCAAATTTCAGATTCACCT
GCAGATGCTAGCCCACCTACAGGACTTCCAGATGCTGAAGATTCAGAAGTGTCATCTCAGAAGCCCATAGAGGAAAAAGCAGTTACTCCA
AGCCCTGAGCAAGTGTTTGCTGAGTGTTCCCAGAAGAGGATTTTGGGATTACTAGCAGCCATGTTACCTCCCTTAAAGTCGGGCCCCACG
GTTCCCCTGATAGACCTGGAGCACGTCCTTCCACTCATGTTTCAGGTTGTCATCTCAAACGCAGGCCACCTGAATGAAACCTACCATCTC
ACCCTGGGTCTTCTCGGCCAGTTAATTATCCGTCTTTTGCCAGCAGAGGTAGACGCCGCAGTGATCAAAGTCCTCTCAGCCAAACACAAC
CTGTTTGCTGCAGGGGACAGTTCCATTGTGCCAGATGGCTGGAAAACCACCCACCTGCTCTTTAGCCTGGGAGCTGTGTGTCTGGACAGC
CGGGTGGGCTTGGACTGGGCGTGCTCCATGGCAGAGATCCTGCGGTCACTCAACAGTGCCCCACTGTGGCGTGATGTCATTGCCACCTTC
ACAGACCACTGCATCAAGCAGCTGCCATTCCAGCTGAAGCACACCAACATCTTCACCCTGCTCGTGCTGGTTGGCTTCCCCCAGGTCCTC
TGTGTGGGAACCCGCTGCGTTTATATGGATAATGCCAATGAACCCCATAATGTGATCATCTTGAAGCACTTTACTGAGAAGAACAGGGCT
GTGATTGTTGATGTCAAAACTCGGAAGAGGAAAACAGTGAAGGACTACCAGCTGGTCCAGAAGGGAGGAGGACAAGAGTGTGGTGACTCT
CGGGCCCAGCTGAGCCAGTACTCCCAGCACTTTGCCTTTATCGCCAGTCACCTTCTGCAAAGCAGCATGGACAGCCATTGTCCCGAGGCA
GTAGAAGCAACTTGGGTCCTGTCCCTGGCCCTGAAAGGATTGTATAAAACACTAAAGGCTCACGGTTTTGAGGAGATCCGTGCTACTTTC
CTTCAGACCGATTTGCTGAAGTTGCTGGTGAAAAAGTGCAGCAAAGGGACTGGCTTTAGTAAAACGTGGCTCCTCCGGGACCTGGAAATT
TTGTCCATCATGCTGTACTCCTCAAAAAAGGAGATCAACGCTTTGGCTGAGCACGGAGACCTAGAGCTGGATGAGCGAGGGGACCGAGAG
GAAGAGGTGGAACGGCCAGTCAGCAGCCCTGGCGACCCAGAGCAGAAAAAGCTGGACCCCCTTGAGGGCCTGGATGAGCCCACCAGAATA
TGTTTCTTGATGGCTCATGATGCCCTCAATGCCCCTCTGCACATTCTCCGGGCCATATACGAACTGCAGATGAAAAAGACCGATTATTTC
TTCCTGGAGGTTCAGAAGAGGTTTGATGGTGATGAGCTCACCACAGATGAAAGGATACGGTCCCTGGCTCAGCGGTGGCAGCCCAGTAAG
AGTCTGAGGCTGGAAGAACAGAGCGCCAAAGCTGTGGATACAGACATGATTATCCTGCCATGCTTGTCCCGGCCTGCACGCTGTGACCAA
GCCACTGCTGAATCGAACCCTGTGACCCAGAAGCTGATCTCCAGCACAGAGAGCGAACTGCAGCAGAGCTATGCCAAGCAGCGCCGTAGC
AAGAGCGCCGCCCTCCTGCACAAGGAGCTGAACTGCAAGAGTAAGAGGGCTGTCCGGGACTACCTCTTCCGAGTGAACGAGGCCACAGCT
GTCCTGTACGCCCGCCACGTGCTTGCATCCCTGCTCGCCGAGTGGCCTAGCCACGTGCCAGTGAGCGAGGACATCCTGGAGCTCAGTGGC
CCTGCCCATATGACCTACATTTTGGATATGTTCATGCAGCTGGAAGAAAAGCATGAGTGGGAGAAGATCCTGCAGAAAGTGCTCCAGGGC
TGCCGAGAGGACATGCTGGGGACCATGGCCCTGGCTGCATGCCAGTTCATGGAGGAGCCAGGAATGGAGGTGCAAGTGAGGGAGTCGAAA
CACCCGTATAACAACAACACCAACTTCGAGGATAAAGTTCACATTCCTGGTGCCATCTACCTCTCAATCAAATTCGACTCTCAGTGCAAC
ACAGAGGAGGGCTGTGACGAGTTAGCCATGTCCAGCAGCAGTGACTTCCAGCAAGACCGACACAGCTTCAGCGGGTCTCAGCAGAAGTGG
AAAGATTTTGAACTTCCAGGAGACACTCTGTATTACCGCTTCACCTCCGACATGAGCAACACCGAGTGGGGCTACAGATTCACCGTGACG
GCCGGACACCTGGGGCGGTTCCAGACAGGATTCGAGATTTTGAAGCAGATGTTGTCAGAAGAAAGGGTCGTGCCTCATCTCCCATTGGCA
AAAATTTGGGAATGGCTGGTGGGCGTGGCCTGTCGCCAGACTGGCCATCAACGATTAAAAGCCATCCACTTACTTCTGAGGATTGTGCGA
TGCTGCGGCCACAGTGACCTGTGTGACCTTGCGCTGTTGAAGCCCCTGTGGCAGCTCTTTACCCACATGGAGTACGGCCTGTTTGAGGAC
GTGACGCAGCCCGGCATCCTCCTTCCCCTGCATCGTGCCCTCACTGAGCTCTTCTTCGTCACCGAGAACCGTGCCCAGGAGCTTGGCGTG
CTGCAGGATTACCTGCTGGCCCTAACCACGGACGACCACCTTCTCCGCTGTGCGGCACAGGCTCTGCAGAACATTGCTGCCATCAGCCTG
GCCATCAACTACCCAAACAAGGCCACCCGCCTCTGGAATGTGGAGTGTTAGCCCTTGGTGGGGCGTGCATGGGACTAGTTCATCTGCCAC
AGGGATTTTAGAGCAGACATCTAACCTCATTCAGGAAAACTCCTGTAGCGCCAGTGCCCAGCTCTCCTTGAGCTGACCACTCCAGTTAGG
ATGCCAAGCAGCCACGTCTCCAAGAGCTCCCGTGCGTAGGCTGGACACAAGCACAGGCTGTAGCATGGTGAAAATAAGCCAAGCAGTGCA
GAATGCCTCAGAAAGGGTGGGCAGGGGGCCCTTAAGAAGGTTCAGAGACCAGCCTTCTCCAGAGGCTGTCACTGCAGGAGCCGTGGGCCT
GGGAAGACTTGGAAGCGGCCTCTCTCAACTGGTTTCTGTCTCCGTGGAGCTGGAACTGCCTGCACTTGCCTTCAGAGGGAGGCACAGTCC
ACCCAGATCCACCTTTCCAGCAAGACCCCCAGTGGCTGCCCAGCCTGGGAGCACCTCTTTGCTTTTCACACCAAACCAAAACTGGCGAGA
GCCCCTCCTAGCCACCAGTGATCCCCAAGCATCCAGTACAGAACCAGGCATCGAGCTAGCTCCCTGCACGGCCGCACCCTCCCAGAGAAC
TCCTTGAGGAGAACAAGTGCCCTTGGGGACAGCCGGCAGGCGCCCCTGTACGTCTGCTCATGCACCAGGCAGCACAGCCGCAGTTCCTCA
GTTGTTGTTTTGACATATTTCAGTTTCCACCTCACGTTTTTAGAGCAGAACCACACTGTCTCCCTGGAGGGGCTCGAGGGCATGACCGGG
GACTGACCATTCTGTGAAAGGAGCAGAATGTGAGGAGCACGCGTGAGCTTATGTACCGTGAAGATGATCAGAGGATATCTTATTTTAAGA
GTAAAAACCCACATAATTTTATTTCTGCTTGATAGTCATGGTAGTCTGTCATACCCACCTCTGGGACTCTGCGTGGCTGTTTGGCTGTCA
CTTGTAGCAATAACGACATTAGTTCTAGTCAGTGCTGTTTTACATTTTTCTTTTGATGGGTTTAGTCTTGCCCTGGAGTGCCGATGATGA
TTCTCCCTCCAGAGCCACGCTTGGGAACATGAAGCAAGTCTGGCGTGTGGGCTGCGTGCCGGCCTTAGTGGGACCCGTGGGGTTGGAGCA
TGCCTTTAGGGGCAGTGTCTGGGCCGAAGCACGTCCCACCACACAGTGCCAGAGCCAGAGAAGGGGCCCCACCACCAAGGCCAAGCTTGA
CCAGGTCAGCATTGCCATGGCCCAGTGTGCCCCGTGGCCTCTGAAGATCCCTCTGTGCAGGGTCTGCAGGGATCTGGATTGCAAGGGCCC
AAGTCTGCAGGTCTGGAAGCATCTTCCTATAAGAGCACTTTCGCCTTCTGGGTCAGGACTCCAAGGTGCAGCGGGCTTCACAGCCCTACA
ATTGGGTTCTCAGCTAAGCCCCAGAGTTCTGGTAGAACCATCCCGGGGCGGGTGGAGGGTGGGATTTAAGGGAGACGGGAACACATGGGG
CAGGTCCTGGAACTTGGTGGCCTGAGGACTGAGGCCATTGCCCTGGTGGAAAGGCCTGGCCTGGTTCCTGTGGCTTGGGACCTGAATAGG
CAGGTGCTGCTGGCTCCGTAGAAACCCTTTTCCCATCTTTTGCTCTTTGCCAAACCTACCTTGCTTTGGGAGCTGCCTGCACCACCCCAG
AGAAGGCCCCACCTTCTTCATCCCTCAGACCCGAGGAGGCCTCCCAGTAAGGAGTTTCCCAAGAGGGGACTCACAGGAAACAAGTCTTAG
TGCTTGGGAGGGAGGCCCCGCTGCGTGCTCAGACTCACAGCCAACCTGGAAGGTAGACGAGATAGCGCCACCCACGCCCCTCCACACCCC
AGACTCCGAGTAAAGCGGGCGGTAGGGCCGGAGTCACCTCCCCTATGGCAGTGGCCGCCGCTGTACTCCATCCTCCCGTCAGGAAGATCA
GCTGTAAATAAACGCTGGGCTCCCCAGAGCACCTGTCCGCCCACTGCCCTTGCTGTTCTGGGATCTTCGCTGCAGTTCACGGGAAACAAG
CCTGAGTCCGCTCGCACCCGCGGCTGCTCTCCCGGCTCGGCCCGGCCGCCTCTGTCTCCGGCCACCGGGTGGCGCTGCCGAGCCAGAGCC
GCCGCGTCCCGGCGCTTTCCAGGAGCCCCAGGCCCGGAGGAGGCGAAGCCCGCAGAGCAAAGGTGGAAACACGTGCCTACGCTGTAAAGA
AATCCTGTTCCAGAGCATACCTGTTGTACAAACAGACACTGTTCCTAACGAGAGGAGTGACGTATTTTCATCACCGTTTTTAATTTGTTT
TCTTACGGGTTTACGATTTTGAATTTTTCTTATTTGGTTGAAAGAATTTTGATTCTATCAGCCTGAGTGAGTTCAGCCTGTAAAAAGGAT

>67762_67762_2_PPP1R12A-ZZEF1_PPP1R12A_chr12_80214554_ENST00000550107_ZZEF1_chr17_4020460_ENST00000381638_length(amino acids)=3166AA_BP=371
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVK
FLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFD
VADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSSEED
EEDDSESEAETGFTDIFSESKEGLDIHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDK
LKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVH
IPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNT
QKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMAS
VRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYN
SSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQ
GLTISGYLRPARAEAEQSVTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQNPREE
CVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRR
NHLFTMMNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVLFSLFW
SVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLL
REFSVLTELLKKLCSGPEGGLRKLDVETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARG
RKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMV
VPQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKT
DIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPES
LAKECIEKSLLLLKFLPTGISSKESCEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSSSGLPA
ADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDVMDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKIT
QHCAESLGQPHCFHPPFILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTALLHLL
DMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCD
LLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYAAKKYS
YGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKG
LKALALLGVLPDGDSSLEDQALPVTVPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQISDSP
ADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHL
TLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRDVIATF
TDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDS
RAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEI
LSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLDEPTRICFLMAHDALNAPLHILRAIYELQMKKTDYF
FLEVQKRFDGDELTTDERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYAKQRRS
KSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQG
CREDMLGTMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKW
KDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVR
CCGHSDLCDLALLKPLWQLFTHMEYGLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNIAAISL

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Fusion Gene PPI Analysis for PPP1R12A-ZZEF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000261207-926682_864371.33333333333331031.0ROCK2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000437004-925682_864371.3333333333333996.0ROCK2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000450142-825682_864371.33333333333331031.0ROCK2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000546369-825682_864284.3333333333333944.0ROCK2
HgenePPP1R12Achr12:80214554chr17:4020460ENST00000550107-824682_864371.3333333333333975.0ROCK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R12A-ZZEF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R12A-ZZEF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource