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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:PPP1R15A-ATP1A1 (FusionGDB2 ID:67831)

Fusion Gene Summary for PPP1R15A-ATP1A1

Fusion gene summary

Fusion gene information	Fusion gene name: PPP1R15A-ATP1A1
	Fusion gene ID: 67831
		Hgene	Tgene
	Gene symbol	PPP1R15A	ATP1A1
	Gene ID	23645	480
	Gene name	protein phosphatase 1 regulatory subunit 15A	ATPase Na+/K+ transporting subunit alpha 4
	Synonyms	GADD34	ATP1A1\|ATP1AL2
	Cytomap	19q13.33	1q23.2
	Type of gene	protein-coding	protein-coding
	Description	protein phosphatase 1 regulatory subunit 15Agrowth arrest and DNA damage-inducible protein GADD34growth arrest and DNA-damage-inducible 34myeloid differentiation primary response protein MyD116 homologprotein phosphatase 1, regulatory (inhibitor) subu	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su
	Modification date	20200313	20200313
	UniProtAcc	.	Q5TC04
	Ensembl transtripts involved in fusion gene	ENST00000200453,	ENST00000491156, ENST00000295598, ENST00000369496, ENST00000537345,
Fusion gene scores	* DoF score	5 X 6 X 2=60	19 X 23 X 5=2185
	# samples	6	24
	** MAII score	log2(6/60*10)=0	log2(24/2185*10)=-3.18652696877944 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPP1R15A [Title/Abstract] AND ATP1A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP1R15A(49377085)-ATP1A1(116933006), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP1R15A	GO:0032515	negative regulation of phosphoprotein phosphatase activity	11564868
Hgene	PPP1R15A	GO:0032516	positive regulation of phosphoprotein phosphatase activity	11564868
Hgene	PPP1R15A	GO:0034976	response to endoplasmic reticulum stress	12556489
Hgene	PPP1R15A	GO:0035308	negative regulation of protein dephosphorylation	11564868
Hgene	PPP1R15A	GO:0036496	regulation of translational initiation by eIF2 alpha dephosphorylation	12556489
Hgene	PPP1R15A	GO:1902310	positive regulation of peptidyl-serine dephosphorylation	11564868\|12556489\|21518769
Hgene	PPP1R15A	GO:1903917	positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation	21518769
Tgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Tgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599

Fusion gene breakpoints across PPP1R15A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CN305317	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+

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Fusion Gene ORF analysis for PPP1R15A-ATP1A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000200453	ENST00000491156	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+
In-frame	ENST00000200453	ENST00000295598	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+
In-frame	ENST00000200453	ENST00000369496	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+
In-frame	ENST00000200453	ENST00000537345	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000200453

PPP1R15A

chr19

49377085

ENST00000295598

ATP1A1

chr1

116933006

3537

1330

1395

3206

603

ENST00000200453

PPP1R15A

chr19

49377085

ENST00000537345

ATP1A1

chr1

116933006

3535

1330

1395

3206

603

ENST00000200453

PPP1R15A

chr19

49377085

ENST00000369496

ATP1A1

chr1

116933006

3535

1330

1395

3206

603

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000200453	ENST00000295598	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+	0.002870596	0.9971294
ENST00000200453	ENST00000537345	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+	0.002875968	0.997124
ENST00000200453	ENST00000369496	PPP1R15A	chr19	49377085	+	ATP1A1	chr1	116933006	+	0.002875968	0.997124

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Fusion Genomic Features for PPP1R15A-ATP1A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP1R15A-ATP1A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49377085/chr1:116933006)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ATP1A1 Q5TC04
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

82_84

1024.0

Region

Phosphoinositide-3 kinase binding

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

82_84

993.0

Region

Phosphoinositide-3 kinase binding

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

82_84

1024.0

Region

Phosphoinositide-3 kinase binding

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

1007_1023

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

109_131

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

153_288

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

309_320

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

339_772

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

6_87

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

793_802

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

824_843

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

867_918

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

939_951

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

971_985

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

1007_1023

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

109_131

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

153_288

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

309_320

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

339_772

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

6_87

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

793_802

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

824_843

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

867_918

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

939_951

993.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

971_985

993.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

1007_1023

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

109_131

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

153_288

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

309_320

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

339_772

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

6_87

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

793_802

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

824_843

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

867_918

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

939_951

1024.0

Topological domain

Cytoplasmic

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

971_985

1024.0

Topological domain

Extracellular

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

132_152

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

289_308

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

321_338

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

773_792

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

803_823

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

844_866

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

88_108

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

919_938

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

952_970

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000295598

986_1006

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

132_152

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

289_308

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

321_338

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

773_792

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

803_823

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

844_866

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

88_108

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

919_938

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

952_970

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000369496

986_1006

993.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

132_152

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

289_308

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

321_338

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

773_792

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

803_823

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

844_866

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

88_108

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

919_938

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

952_970

1024.0

Transmembrane

Helical

Tgene

ATP1A1

chr19:49377085

chr1:116933006

ENST00000537345

986_1006

1024.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

112_115

675.0

Compositional bias

Note=Poly-Asp

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

160_503

675.0

Compositional bias

Note=Glu-rich

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

518_521

675.0

Compositional bias

Note=Poly-Pro

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

661_666

675.0

Compositional bias

Note=Poly-Ala

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

22_39

675.0

Intramembrane

Helical

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

1_60

675.0

Region

Note=Required for localization in the endoplasmic reticulum

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

337_369

675.0

Repeat

Note=1

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

384_417

675.0

Repeat

Note=2

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

427_460

675.0

Repeat

Note=3

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

477_510

675.0

Repeat

Note=4

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

1_21

675.0

Topological domain

Cytoplasmic

Hgene

PPP1R15A

chr19:49377085

chr1:116933006

ENST00000200453

40_674

675.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for PPP1R15A-ATP1A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>67831_67831_1_PPP1R15A-ATP1A1_PPP1R15A_chr19_49377085_ENST00000200453_ATP1A1_chr1_116933006_ENST00000295598_length(transcript)=3537nt_BP=1330nt
ATAAAAGCCTAGTGGCCATTGTGTTCGTTGCTCTTATCGGTTCCCATCCCAGTTGTTGATCTTATGCAAGACGCTGCACGACCCCGCGCC
CGCTTGTCGCCACGGCACTTGAGGCAGCCGGAGATACTCTGAGTTACTCGGAGCCCGACGCCTGAGGGTGAGATGAACGCGCTGGCCTCC
CTAACCGTCCGGACCTGTGATCGCTTCTGGCAGACCGAACCGGCGCTCCTGCCCCCGGGGTGACGCGCAGCTCCCAGCCGTAAAGAAAGA
AGCTCACAGAACCTCTACTTCTGCCTTGTCTCCAGGATCCAAGCCCAGCACTTGGGTGTCTTGCCCAGGGGAGGAAGAGAATCAAGCCAC
GGAGGATAAAAGAACAGAAAGAAGTAAAGGAGCCAGGAAGACCTCCGTGTCCCCCCGATCTTCAGGCTCCGACCCCAGGTCCTGGGAGTA
TCGTTCAGGAGAGGCGTCCGAGGAGAAGGAGGAAAAGGCACACAAAGAAACTGGGAAAGGAGAAGCTGCCCCAGGGCCGCAATCCTCAGC
CCCAGCCCAGAGGCCCCAGCTCAAGTCCTGGTGGTGCCAACCCAGTGATGAAGAGGAGGGTGAGGTCAAGGCTTTGGGGGCAGCTGAGAA
GGATGGAGAAGCTGAGTGTCCTCCCTGCATCCCCCCACCAAGTGCCTTCCTGAAGGCCTGGGTGTATTGGCCAGGAGAGGACACAGAGGA
AGAGGAAGATGAGGAAGAAGATGAGGACAGTGACTCTGGATCAGATGAGGAAGAGGGAGAAGCTGAGGCTTCCTCTTCCACTCCTGCTAC
AGGTGTCTTCTTGAAGTCCTGGGTCTATCAGCCAGGAGAGGACACAGAGGAGGAGGAAGATGAGGACAGTGATACAGGATCAGCCGAGGA
TGAAAGAGAAGCTGAGACTTCTGCTTCCACACCCCCTGCAAGTGCTTTCTTGAAGGCCTGGGTGTATCGGCCAGGAGAGGACACGGAGGA
GGAGGAAGATGAGGATGTGGATAGTGAGGATAAGGAAGATGATTCAGAAGCAGCCTTGGGAGAAGCTGAGTCAGACCCACATCCCTCCCA
CCCGGACCAGAGGGCCCACTTCAGGGGCTGGGGATATCGACCTGGAAAAGAGACAGAGGAAGAGGAAGCTGCTGAGGACTGGGGAGAAGC
TGAGCCCTGCCCCTTCCGAGTGGCCATCTATGTACCTGGAGAGAAGCCACCGCCTCCCTGGGCTCCTCCTAGGCTGCCCCTCCGACTGCA
AAGGCGGCTCAAGCGCCCAGAAACCCCTACTCATGATCCGGACCCTGAGACTCCCCTAAAGGCCAGAAAGAAGCTGATACGACAGAGAAT
CAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCT
AACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGT
TCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAAC
CCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGC
AAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTC
TGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTT
GTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATG
GTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCT
GCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCC
GAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGC
CAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGG
ATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGT
CGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATT
GCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAG
CAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGG
CAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGC
CTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAG
TTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTC
CAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGT
GTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGA
AAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCC
ACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATG
TGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGAC
AGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTA

>67831_67831_1_PPP1R15A-ATP1A1_PPP1R15A_chr19_49377085_ENST00000200453_ATP1A1_chr1_116933006_ENST00000295598_length(amino acids)=603AA_BP=
MSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGA
PERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVF
ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYF
VILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE

--------------------------------------------------------------
>67831_67831_2_PPP1R15A-ATP1A1_PPP1R15A_chr19_49377085_ENST00000200453_ATP1A1_chr1_116933006_ENST00000369496_length(transcript)=3535nt_BP=1330nt
ATAAAAGCCTAGTGGCCATTGTGTTCGTTGCTCTTATCGGTTCCCATCCCAGTTGTTGATCTTATGCAAGACGCTGCACGACCCCGCGCC
CGCTTGTCGCCACGGCACTTGAGGCAGCCGGAGATACTCTGAGTTACTCGGAGCCCGACGCCTGAGGGTGAGATGAACGCGCTGGCCTCC
CTAACCGTCCGGACCTGTGATCGCTTCTGGCAGACCGAACCGGCGCTCCTGCCCCCGGGGTGACGCGCAGCTCCCAGCCGTAAAGAAAGA
AGCTCACAGAACCTCTACTTCTGCCTTGTCTCCAGGATCCAAGCCCAGCACTTGGGTGTCTTGCCCAGGGGAGGAAGAGAATCAAGCCAC
GGAGGATAAAAGAACAGAAAGAAGTAAAGGAGCCAGGAAGACCTCCGTGTCCCCCCGATCTTCAGGCTCCGACCCCAGGTCCTGGGAGTA
TCGTTCAGGAGAGGCGTCCGAGGAGAAGGAGGAAAAGGCACACAAAGAAACTGGGAAAGGAGAAGCTGCCCCAGGGCCGCAATCCTCAGC
CCCAGCCCAGAGGCCCCAGCTCAAGTCCTGGTGGTGCCAACCCAGTGATGAAGAGGAGGGTGAGGTCAAGGCTTTGGGGGCAGCTGAGAA
GGATGGAGAAGCTGAGTGTCCTCCCTGCATCCCCCCACCAAGTGCCTTCCTGAAGGCCTGGGTGTATTGGCCAGGAGAGGACACAGAGGA
AGAGGAAGATGAGGAAGAAGATGAGGACAGTGACTCTGGATCAGATGAGGAAGAGGGAGAAGCTGAGGCTTCCTCTTCCACTCCTGCTAC
AGGTGTCTTCTTGAAGTCCTGGGTCTATCAGCCAGGAGAGGACACAGAGGAGGAGGAAGATGAGGACAGTGATACAGGATCAGCCGAGGA
TGAAAGAGAAGCTGAGACTTCTGCTTCCACACCCCCTGCAAGTGCTTTCTTGAAGGCCTGGGTGTATCGGCCAGGAGAGGACACGGAGGA
GGAGGAAGATGAGGATGTGGATAGTGAGGATAAGGAAGATGATTCAGAAGCAGCCTTGGGAGAAGCTGAGTCAGACCCACATCCCTCCCA
CCCGGACCAGAGGGCCCACTTCAGGGGCTGGGGATATCGACCTGGAAAAGAGACAGAGGAAGAGGAAGCTGCTGAGGACTGGGGAGAAGC
TGAGCCCTGCCCCTTCCGAGTGGCCATCTATGTACCTGGAGAGAAGCCACCGCCTCCCTGGGCTCCTCCTAGGCTGCCCCTCCGACTGCA
AAGGCGGCTCAAGCGCCCAGAAACCCCTACTCATGATCCGGACCCTGAGACTCCCCTAAAGGCCAGAAAGAAGCTGATACGACAGAGAAT
CAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCT
AACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGT
TCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAAC
CCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGC
AAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTC
TGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTT
GTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATG
GTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCT
GCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCC
GAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGC
CAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGG
ATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGT
CGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATT
GCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAG
CAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGG
CAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGC
CTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAG
TTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTC
CAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGT
GTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGA
AAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCC
ACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATG
TGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGAC
AGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTA

>67831_67831_2_PPP1R15A-ATP1A1_PPP1R15A_chr19_49377085_ENST00000200453_ATP1A1_chr1_116933006_ENST00000369496_length(amino acids)=603AA_BP=
MSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGA
PERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVF
ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYF
VILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE

--------------------------------------------------------------
>67831_67831_3_PPP1R15A-ATP1A1_PPP1R15A_chr19_49377085_ENST00000200453_ATP1A1_chr1_116933006_ENST00000537345_length(transcript)=3535nt_BP=1330nt
ATAAAAGCCTAGTGGCCATTGTGTTCGTTGCTCTTATCGGTTCCCATCCCAGTTGTTGATCTTATGCAAGACGCTGCACGACCCCGCGCC
CGCTTGTCGCCACGGCACTTGAGGCAGCCGGAGATACTCTGAGTTACTCGGAGCCCGACGCCTGAGGGTGAGATGAACGCGCTGGCCTCC
CTAACCGTCCGGACCTGTGATCGCTTCTGGCAGACCGAACCGGCGCTCCTGCCCCCGGGGTGACGCGCAGCTCCCAGCCGTAAAGAAAGA
AGCTCACAGAACCTCTACTTCTGCCTTGTCTCCAGGATCCAAGCCCAGCACTTGGGTGTCTTGCCCAGGGGAGGAAGAGAATCAAGCCAC
GGAGGATAAAAGAACAGAAAGAAGTAAAGGAGCCAGGAAGACCTCCGTGTCCCCCCGATCTTCAGGCTCCGACCCCAGGTCCTGGGAGTA
TCGTTCAGGAGAGGCGTCCGAGGAGAAGGAGGAAAAGGCACACAAAGAAACTGGGAAAGGAGAAGCTGCCCCAGGGCCGCAATCCTCAGC
CCCAGCCCAGAGGCCCCAGCTCAAGTCCTGGTGGTGCCAACCCAGTGATGAAGAGGAGGGTGAGGTCAAGGCTTTGGGGGCAGCTGAGAA
GGATGGAGAAGCTGAGTGTCCTCCCTGCATCCCCCCACCAAGTGCCTTCCTGAAGGCCTGGGTGTATTGGCCAGGAGAGGACACAGAGGA
AGAGGAAGATGAGGAAGAAGATGAGGACAGTGACTCTGGATCAGATGAGGAAGAGGGAGAAGCTGAGGCTTCCTCTTCCACTCCTGCTAC
AGGTGTCTTCTTGAAGTCCTGGGTCTATCAGCCAGGAGAGGACACAGAGGAGGAGGAAGATGAGGACAGTGATACAGGATCAGCCGAGGA
TGAAAGAGAAGCTGAGACTTCTGCTTCCACACCCCCTGCAAGTGCTTTCTTGAAGGCCTGGGTGTATCGGCCAGGAGAGGACACGGAGGA
GGAGGAAGATGAGGATGTGGATAGTGAGGATAAGGAAGATGATTCAGAAGCAGCCTTGGGAGAAGCTGAGTCAGACCCACATCCCTCCCA
CCCGGACCAGAGGGCCCACTTCAGGGGCTGGGGATATCGACCTGGAAAAGAGACAGAGGAAGAGGAAGCTGCTGAGGACTGGGGAGAAGC
TGAGCCCTGCCCCTTCCGAGTGGCCATCTATGTACCTGGAGAGAAGCCACCGCCTCCCTGGGCTCCTCCTAGGCTGCCCCTCCGACTGCA
AAGGCGGCTCAAGCGCCCAGAAACCCCTACTCATGATCCGGACCCTGAGACTCCCCTAAAGGCCAGAAAGAAGCTGATACGACAGAGAAT
CAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCT
AACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGT
TCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAAC
CCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGC
AAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTC
TGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTT
GTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATG
GTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCT
GCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCC
GAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGC
CAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGG
ATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGT
CGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATT
GCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAG
CAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGG
CAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGC
CTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAG
TTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTC
CAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGT
GTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGA
AAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCC
ACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATG
TGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGAC
AGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTA

>67831_67831_3_PPP1R15A-ATP1A1_PPP1R15A_chr19_49377085_ENST00000200453_ATP1A1_chr1_116933006_ENST00000537345_length(amino acids)=603AA_BP=
MSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGA
PERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVF
ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYF
VILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PPP1R15A-ATP1A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PPP1R15A	chr19:49377085	chr1:116933006	ENST00000200453	+	1	3	483_555	0	675.0	KMT2A/MLL1
Hgene	PPP1R15A	chr19:49377085	chr1:116933006	ENST00000200453	+	1	3	337_510	0	675.0	SMAD7
Hgene	PPP1R15A	chr19:49377085	chr1:116933006	ENST00000200453	+	1	3	536_583	0	675.0	SMARCB1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for PPP1R15A-ATP1A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PPP1R15A-ATP1A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source