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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R18-PPP1R18 (FusionGDB2 ID:67859)

Fusion Gene Summary for PPP1R18-PPP1R18

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R18-PPP1R18
Fusion gene ID: 67859
HgeneTgene
Gene symbol

PPP1R18

PPP1R18

Gene ID

170954

170954

Gene nameprotein phosphatase 1 regulatory subunit 18protein phosphatase 1 regulatory subunit 18
SynonymsHKMT1098|KIAA1949HKMT1098|KIAA1949
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionphostensinprotein phosphatase 1 F-actin cytoskeleton targeting subunitphostensinprotein phosphatase 1 F-actin cytoskeleton targeting subunit
Modification date2020031320200313
UniProtAcc

Q6NYC8

Q6NYC8

Ensembl transtripts involved in fusion geneENST00000274853, ENST00000383573, 
ENST00000399199, ENST00000400554, 
ENST00000412189, ENST00000435006, 
ENST00000435929, ENST00000437121, 
ENST00000438815, ENST00000438945, 
ENST00000443517, ENST00000444206, 
ENST00000449705, ENST00000451544, 
ENST00000455935, ENST00000465704, 
ENST00000472334, ENST00000487859, 
ENST00000488324, ENST00000491628, 
ENST00000492746, ENST00000493833, 
ENST00000498031, ENST00000548255, 
ENST00000550073, ENST00000551034, 
ENST00000551049, ENST00000551784, 
ENST00000552716, 
ENST00000274853, 
ENST00000399199, ENST00000488324, 
ENST00000383573, ENST00000400554, 
ENST00000412189, ENST00000435006, 
ENST00000435929, ENST00000437121, 
ENST00000438815, ENST00000438945, 
ENST00000443517, ENST00000444206, 
ENST00000449705, ENST00000451544, 
ENST00000455935, ENST00000465704, 
ENST00000472334, ENST00000487859, 
ENST00000491628, ENST00000492746, 
ENST00000493833, ENST00000498031, 
ENST00000548255, ENST00000550073, 
ENST00000551034, ENST00000551049, 
ENST00000551784, ENST00000552716, 
Fusion gene scores* DoF score6 X 8 X 3=1447 X 8 X 5=280
# samples 99
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R18 [Title/Abstract] AND PPP1R18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R18(30644277)-PPP1R18(30644651), # samples:1
PPP1R18(30644278)-PPP1R18(30644652), # samples:1
PPP1R18(30652928)-PPP1R18(30654067), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP1R18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP1R18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM983871PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
ChiTaRS5.0N/ACA430558PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
ChiTaRS5.0N/ACF125787PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-


Top

Fusion Gene ORF analysis for PPP1R18-PPP1R18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000274853ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000274853ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000274853ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000274853ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000383573ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000383573ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000383573ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000383573ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000399199ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000399199ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000399199ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000399199ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000400554ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000400554ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000400554ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000400554ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000412189ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000412189ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000412189ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000412189ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000435006ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000435006ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000435006ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000435006ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000435929ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000435929ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000435929ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000435929ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000437121ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000437121ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000437121ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000437121ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000438815ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000438815ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000438815ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000438815ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000438945ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000438945ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000438945ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000438945ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000443517ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000443517ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000443517ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000443517ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000444206ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000444206ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000444206ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000444206ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000449705ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000449705ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000449705ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000449705ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000451544ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000451544ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000451544ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000451544ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000455935ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000455935ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000455935ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000455935ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000465704ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000465704ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000465704ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000465704ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000472334ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000472334ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000472334ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000472334ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000487859ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000487859ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000487859ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000487859ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000488324ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000488324ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000488324ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000488324ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000491628ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000491628ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000491628ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000491628ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000492746ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000492746ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000492746ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000492746ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000493833ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000493833ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000493833ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000493833ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000498031ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000498031ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000498031ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000498031ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000548255ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000548255ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000548255ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000548255ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000550073ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000550073ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000550073ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000550073ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000551034ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000551034ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000551034ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000551034ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000551049ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000551049ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000551049ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000551049ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000551784ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000551784ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000551784ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000551784ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000552716ENST00000274853PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000552716ENST00000274853PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-3UTRENST00000552716ENST00000399199PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-3UTRENST00000552716ENST00000399199PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000274853ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000274853ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000274853ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000383573ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000383573ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000383573ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000399199ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000399199ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000399199ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000400554ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000400554ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000400554ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000412189ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000412189ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000412189ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000435006ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000435006ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000435006ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000435929ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-5UTRENST00000435929ENST00000488324PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-5UTRENST00000435929ENST00000488324PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-5UTRENST00000437121ENST00000274853PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
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30644652

-
intron-intronENST00000552716ENST00000444206PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000449705PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000449705PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000449705PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000451544PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000451544PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000451544PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000455935PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000455935PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000455935PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000465704PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000465704PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000465704PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000472334PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000472334PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000472334PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000487859PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000487859PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000487859PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000488324PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000491628PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000491628PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000491628PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000492746PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000492746PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000492746PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000493833PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000493833PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000493833PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000498031PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000498031PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000498031PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000548255PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000548255PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000548255PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000550073PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000550073PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000550073PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000551034PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000551034PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000551034PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000551049PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000551049PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000551049PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000551784PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000551784PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000551784PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-
intron-intronENST00000552716ENST00000552716PPP1R18chr6

30644277

+PPP1R18chr6

30644651

-
intron-intronENST00000552716ENST00000552716PPP1R18chr6

30644278

+PPP1R18chr6

30644652

-
intron-intronENST00000552716ENST00000552716PPP1R18chr6

30652928

-PPP1R18chr6

30654067

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP1R18-PPP1R18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP1R18-PPP1R18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30644277/:30644651)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R18

Q6NYC8

PPP1R18

Q6NYC8

FUNCTION: [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.FUNCTION: [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP1R18-PPP1R18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP1R18-PPP1R18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R18-PPP1R18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R18-PPP1R18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource