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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R21-TTC7B (FusionGDB2 ID:67885)

Fusion Gene Summary for PPP1R21-TTC7B

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R21-TTC7B
Fusion gene ID: 67885
HgeneTgene
Gene symbol

PPP1R21

TTC7B

Gene ID

129285

145567

Gene nameprotein phosphatase 1 regulatory subunit 21tetratricopeptide repeat domain 7B
SynonymsCCDC128|KLRAQ1TTC7L1|c14_5685
Cytomap

2p16.3

14q32.11

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 21KLRAQ motif containing 1KLRAQ motif-containing protein 1coiled-coil domain containing 128coiled-coil domain-containing protein 128tetratricopeptide repeat protein 7BTPR repeat protein 7-like-1TPR repeat protein 7Btetratricopeptide repeat domain 7 like 1tetratricopeptide repeat protein 7-like-1
Modification date2020031320200313
UniProtAcc

Q6ZMI0

.
Ensembl transtripts involved in fusion geneENST00000476199, ENST00000281394, 
ENST00000294952, ENST00000449090, 
ENST00000328459, ENST00000357056, 
ENST00000554654, 
Fusion gene scores* DoF score12 X 11 X 5=66011 X 11 X 5=605
# samples 1312
** MAII scorelog2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/605*10)=-2.33390073655344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R21 [Title/Abstract] AND TTC7B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R21(48737252)-TTC7B(91124731), # samples:2
TTC7B(91142867)-PPP1R21(48734408), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTTC7B

GO:0046854

phosphatidylinositol phosphorylation

23229899|26571211

TgeneTTC7B

GO:0072659

protein localization to plasma membrane

23229899|26571211


check buttonFusion gene breakpoints across PPP1R21 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTC7B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0905-01BPPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
ChimerDB4OVTCGA-13-0905PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-


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Fusion Gene ORF analysis for PPP1R21-TTC7B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476199ENST00000328459PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
3UTR-3CDSENST00000476199ENST00000357056PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
3UTR-intronENST00000476199ENST00000554654PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
5CDS-intronENST00000281394ENST00000554654PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
5CDS-intronENST00000294952ENST00000554654PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
5CDS-intronENST00000449090ENST00000554654PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
In-frameENST00000281394ENST00000328459PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
In-frameENST00000281394ENST00000357056PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
In-frameENST00000294952ENST00000328459PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
In-frameENST00000294952ENST00000357056PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
In-frameENST00000449090ENST00000328459PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-
In-frameENST00000449090ENST00000357056PPP1R21chr2

48737252

+TTC7Bchr14

91124731

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281394PPP1R21chr248737252+ENST00000357056TTC7Bchr1491124731-4546233616437661200
ENST00000281394PPP1R21chr248737252+ENST00000328459TTC7Bchr1491124731-4495233616437151183
ENST00000294952PPP1R21chr248737252+ENST00000357056TTC7Bchr1491124731-4551234113637711211
ENST00000294952PPP1R21chr248737252+ENST00000328459TTC7Bchr1491124731-4500234113637201194
ENST00000449090PPP1R21chr248737252+ENST00000357056TTC7Bchr1491124731-436521557635851169
ENST00000449090PPP1R21chr248737252+ENST00000328459TTC7Bchr1491124731-431421557635341152

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281394ENST00000357056PPP1R21chr248737252+TTC7Bchr1491124731-0.0046095590.9953904
ENST00000281394ENST00000328459PPP1R21chr248737252+TTC7Bchr1491124731-0.0040750620.99592495
ENST00000294952ENST00000357056PPP1R21chr248737252+TTC7Bchr1491124731-0.0050734090.9949266
ENST00000294952ENST00000328459PPP1R21chr248737252+TTC7Bchr1491124731-0.0026585680.99734145
ENST00000449090ENST00000357056PPP1R21chr248737252+TTC7Bchr1491124731-0.0025761390.9974239
ENST00000449090ENST00000328459PPP1R21chr248737252+TTC7Bchr1491124731-0.0023013250.9976987

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Fusion Genomic Features for PPP1R21-TTC7B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP1R21-TTC7B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:48737252/chr14:91124731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R21

Q6ZMI0

.
FUNCTION: Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571). {ECO:0000269|PubMed:30520571, ECO:0000305|PubMed:19389623}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R21chr2:48737252chr14:91124731ENST00000281394+19211_207717770.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000281394+1921556_607717770.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000294952+20221_207728781.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000294952+2022556_607728781.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000449090+18201_207686739.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000449090+1820556_607686739.0Coiled coilOntology_term=ECO:0000255
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820397_430384844.0RepeatNote=TPR 4
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820479_514384844.0RepeatNote=TPR 5
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820516_548384844.0RepeatNote=TPR 6
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820549_582384844.0RepeatNote=TPR 7
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820696_729384844.0RepeatNote=TPR 8
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820730_763384844.0RepeatNote=TPR 9
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820765_797384844.0RepeatNote=TPR 10
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820798_831384844.0RepeatNote=TPR 11
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821397_430384861.0RepeatNote=TPR 4
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821479_514384861.0RepeatNote=TPR 5
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821516_548384861.0RepeatNote=TPR 6
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821549_582384861.0RepeatNote=TPR 7
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821696_729384861.0RepeatNote=TPR 8
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821730_763384861.0RepeatNote=TPR 9
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821765_797384861.0RepeatNote=TPR 10
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821798_831384861.0RepeatNote=TPR 11

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R21chr2:48737252chr14:91124731ENST00000281394+1921693_742717770.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000294952+2022693_742728781.0Coiled coilOntology_term=ECO:0000255
HgenePPP1R21chr2:48737252chr14:91124731ENST00000449090+1820693_742686739.0Coiled coilOntology_term=ECO:0000255
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820329_333384844.0Compositional biasNote=Poly-Leu
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821329_333384861.0Compositional biasNote=Poly-Leu
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820219_252384844.0RepeatNote=TPR 2
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000328459820363_396384844.0RepeatNote=TPR 3
TgeneTTC7Bchr2:48737252chr14:91124731ENST0000032845982097_131384844.0RepeatNote=TPR 1
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821219_252384861.0RepeatNote=TPR 2
TgeneTTC7Bchr2:48737252chr14:91124731ENST00000357056821363_396384861.0RepeatNote=TPR 3
TgeneTTC7Bchr2:48737252chr14:91124731ENST0000035705682197_131384861.0RepeatNote=TPR 1


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Fusion Gene Sequence for PPP1R21-TTC7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67885_67885_1_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000281394_TTC7B_chr14_91124731_ENST00000328459_length(transcript)=4495nt_BP=2336nt
CCACCTTCCTCCCACCCCGGGAACCCGGAAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATA
CTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGG
AGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAA
AAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAA
TGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGA
AAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGA
ATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGA
CAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAAC
TAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATG
AAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTC
TGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGG
CTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGA
AGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATA
CTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCT
ATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGA
AAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAA
ACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAG
CTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATG
GAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCA
TTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTG
TGCCTTATGAAGAAGCACTGGCAAACCGCCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTT
TGGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGC
GAATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGG
ATGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATC
ACTACATGGCAAGGATAGTGGAACTTACGTCTCAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGT
CTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGTGCC
TAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTG
CCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGC
ACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTC
TGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGA
GGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGG
GGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACC
ATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCT
GCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTG
GACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAG
GCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGC
AGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCA
CAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCA
TGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACC
AGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCG
AGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCT
TCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTG
TGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAA
TCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCAT
GTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAA
ATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCC
CAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATA
ATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAG
AGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAAT

>67885_67885_1_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000281394_TTC7B_chr14_91124731_ENST00000328459_length(amino acids)=1183AA_BP=723
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNI
SRLQCLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKA
KGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLS
AQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDF
SDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIA
ELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEAS

--------------------------------------------------------------
>67885_67885_2_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000281394_TTC7B_chr14_91124731_ENST00000357056_length(transcript)=4546nt_BP=2336nt
CCACCTTCCTCCCACCCCGGGAACCCGGAAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATA
CTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGG
AGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAA
AAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAA
TGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGA
AAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGA
ATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGA
CAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAAC
TAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATG
AAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTC
TGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGG
CTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGA
AGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATA
CTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCT
ATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGA
AAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAA
ACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAG
CTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATG
GAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCA
TTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTG
TGCCTTATGAAGAAGCACTGGCAAACCGCCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTT
TGGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGC
GAATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGG
ATGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATC
ACTACATGGCAAGGATAGTGGAACTTACGTCTCAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGT
CTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGTGCC
TAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTG
CCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGC
ACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTC
TGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGA
GGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGG
GGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACC
ATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCT
GCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTG
GACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAG
GCAACTCTCCAGAAGCATACTTTCATGGTTTTCCTTCCCTTTTTTCAGTTAGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGG
AGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCT
GGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGT
CCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCA
TCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGG
ACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGG
AGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCC
AGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGC
CAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTG
CCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAA
AATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAA
AGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCA
CTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACA
AAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATG
TGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTT

>67885_67885_2_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000281394_TTC7B_chr14_91124731_ENST00000357056_length(amino acids)=1200AA_BP=723
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNI
SRLQCLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKA
KGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLS
AQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDF
SDPETGNSPEAYFHGFPSLFSVSSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAA
NLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGN

--------------------------------------------------------------
>67885_67885_3_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000294952_TTC7B_chr14_91124731_ENST00000328459_length(transcript)=4500nt_BP=2341nt
AAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATACTGCCTGACCCGTTCCCGGGAGCGTGTC
TGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGGAGGCCATGGCCTCGGCTGAGTTGCAGGG
GAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAAAAGGTGTTGTGGATGAACAAGCAAATTC
TGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAATGGACAGTTTGACATTTCGAAATCTGCA
GCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGAAAAACAAGAAAAGTGGAGAATCTTCTTC
TCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGAATGAACGGTTGCATATACAATTTTTTGA
AGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGACAGAAGCAGCCCAGCACCAAGCTGTGGT
TGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAACTAGAAGTGAAATCTCAGACTCTAGAAAA
GGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATGAAGATTTGTCAGGTAGATTAGAGGAATC
CTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTCTGAACGTTCCACTCCACAATAGGAGACA
CCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGGCTCTTCTAAACTTTCATACCTACACAGA
ACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGAAGTTCTCACAATACCTTCATGAAAATGC
GTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATACTGTGACTGTCTTGGAGACAACTGTGAA
ATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCTATCAGTTAAAAAGTTTAGAAGAAGAATG
TGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGAAAAAAATGACAGCTGTGTTTGAGAAGCT
GCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAAACTACAGTTCTGTGTTAACAAATGTTGG
TGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAGCTGCAATAGAGCATGAACTTCCAACAGC
AACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATGGAGCAGGAAAGATTGCATCCTTCTTCAG
CAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCATTAGTCCTCTTTCAGCTGAATGCATGCT
ACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTGTGCCTTATGAAGAAGCACTGGCAAACCG
CCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTTTGGAAAAGATTTCTAAACTGGAGCAGGA
AAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCGAATTGCAGATAAGCTGAAGAATACAGG
TAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGATGAAGCCACAGCTAAGGCTGTGTTGGA
GCCCATTCAGAGCACCAGTCTAATTGGGACTTTAACCAGGACATCTGACAGTGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAA
AAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGC
ACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCA
GTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGC
CCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTC
CCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTT
AGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATT
TCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGC
TCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCA
TTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTC
ACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGA
TTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGA
GACAGGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCC
TAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGA
AGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGG
AAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCT
TCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCT
GGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGT
GCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGG
GCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACC
CCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGG
ATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAG
TTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTT
TGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGT
CAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTT
ACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTT
CAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTTGGCTACATGGGAAGATGATGTTAATAATAAAATGATTTTTAAATGG

>67885_67885_3_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000294952_TTC7B_chr14_91124731_ENST00000328459_length(amino acids)=1194AA_BP=734
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEAL
TEEMKLASQNISRLQCLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVV
DVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDA
NSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADR
RQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMS
HNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATE

--------------------------------------------------------------
>67885_67885_4_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000294952_TTC7B_chr14_91124731_ENST00000357056_length(transcript)=4551nt_BP=2341nt
AAGTGGAGGAGGAGGCGCGGCGGCGGCGGCGGCGGCGGCTGCGGTGGCCAAGCAGGCAGATACTGCCTGACCCGTTCCCGGGAGCGTGTC
TGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGGGGAGGCCATGGCCTCGGCTGAGTTGCAGGG
GAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAAAAAAGGTGTTGTGGATGAACAAGCAAATTC
TGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAATGGACAGTTTGACATTTCGAAATCTGCA
GCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAAGAAAAACAAGAAAAGTGGAGAATCTTCTTC
TCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGAATGAACGGTTGCATATACAATTTTTTGA
AGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGAGACAGAAGCAGCCCAGCACCAAGCTGTGGT
TGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAACTAGAAGTGAAATCTCAGACTCTAGAAAA
GGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCATGAAGATTTGTCAGGTAGATTAGAGGAATC
CTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGCTCTGAACGTTCCACTCCACAATAGGAGACA
CCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGACGGCTCTTCTAAACTTTCATACCTACACAGA
ACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGAAGTTCTCACAATACCTTCATGAAAATGC
GTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGATACTGTGACTGTCTTGGAGACAACTGTGAA
ATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCTATCAGTTAAAAAGTTTAGAAGAAGAATG
TGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACATGAAAAAAATGACAGCTGTGTTTGAGAAGCT
GCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGACAAACTACAGTTCTGTGTTAACAAATGTTGG
TGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAAAGCTGCAATAGAGCATGAACTTCCAACAGC
AACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATGGAGCAGGAAAGATTGCATCCTTCTTCAG
CAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATTCATTAGTCCTCTTTCAGCTGAATGCATGCT
ACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGCCCCTCTTGGAGTCTGTGCCTTATGAAGAAGCACTGGCAAACCG
CCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGCCTTGCACAGCAAGTTCAACAGAGTTTGGAAAAGATTTCTAAACTGGAGCAGGA
AAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCGAATTGCAGATAAGCTGAAGAATACAGG
TAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGATGAAGCCACAGCTAAGGCTGTGTTGGA
GCCCATTCAGAGCACCAGTCTAATTGGGACTTTAACCAGGACATCTGACAGTGAGGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAA
AAATCACTACATGGCAAGGATAGTGGAACTTACGTCTCAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGC
ACTGTCTAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCA
GTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGC
CCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTC
CCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTT
AGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATT
TCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGC
TCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCA
TTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTC
ACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGA
TTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGA
GACAGGCAACTCTCCAGAAGCATACTTTCATGGTTTTCCTTCCCTTTTTTCAGTTAGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAG
AGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACA
GATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCC
AATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTT
AGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCT
CCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGC
TACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGC
CTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACT
GAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTT
TTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTC
AGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGC
TGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCT
CAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTA
GAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTT
TTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGA

>67885_67885_4_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000294952_TTC7B_chr14_91124731_ENST00000357056_length(amino acids)=1211AA_BP=734
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVS
NTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEAL
TEEMKLASQNISRLQCLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVV
DVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDA
NSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADR
RQLNTITLPDFSDPETGNSPEAYFHGFPSLFSVSSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKP
AEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWN

--------------------------------------------------------------
>67885_67885_5_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000449090_TTC7B_chr14_91124731_ENST00000328459_length(transcript)=4314nt_BP=2155nt
TACTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGG
GGAGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAA
AAAAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGA
AATGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAA
GAAAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGA
GAATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGA
GACAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAA
ACTAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCA
TGAAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGC
TCTGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGAC
GGCTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCA
GAAGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGA
TACTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCC
CTATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACAT
GAAAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGAC
AAACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAA
AGCTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAA
TGGAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATT
CATTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGGTTCAACAGAGTTT
GGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCG
AATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGA
TGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCA
CTACATGGCAAGGATAGTGGAACTTACGTCTCAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTC
TAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGTGCCT
AGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGC
CGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCA
CTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCT
GGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAG
GGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGG
GTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCA
TGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTG
CCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTGG
ACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGG
CTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCA
GGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCAC
AGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCAT
GGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCA
GCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGA
GGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTT
CACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGT
GCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAAT
CATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATG
TGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAA
TTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCC
AGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAA
TTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGA
GAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATG

>67885_67885_5_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000449090_TTC7B_chr14_91124731_ENST00000328459_length(amino acids)=1152AA_BP=692
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
VQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLVPDVESRED
LIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQCLERAMKFAFEEFHLWYQFALSLMAAG
KSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKAL
LAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVK
LQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQS
SAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLA

--------------------------------------------------------------
>67885_67885_6_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000449090_TTC7B_chr14_91124731_ENST00000357056_length(transcript)=4365nt_BP=2155nt
TACTGCCTGACCCGTTCCCGGGAGCGTGTCTGGGTTTGGGGGCGGGAGACAGGCTGAGCCGCCTGGGCGGCCTGGCCTGTACGGGGCGGG
GGAGGCCATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAGCTTCGGGCTCAGAATCAGGTTCTGAA
AAAAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCTTTAAAGGAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGA
AATGGACAGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTAGCTCTAAGTGAACCACGAGGCAA
GAAAAACAAGAAAAGTGGAGAATCTTCTTCTCAGTTGAGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGA
GAATGAACGGTTGCATATACAATTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTGAGGAGTCGACTGGCCACTCTGGA
GACAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGTCTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAA
ACTAGAAGTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATGTCAATTACAGTTAAAGACTCTTCA
TGAAGATTTGTCAGGTAGATTAGAGGAATCCTTATCAATCATCAATGAAAAAGTACCTTTTAATGATACAAAATATAGTCAGTACAACGC
TCTGAACGTTCCACTCCACAATAGGAGACACCAGCTGAAGATGCGAGATATTGCTGGGCAGGCCCTGGCTTTTGTTCAGGATCTTGTGAC
GGCTCTTCTAAACTTTCATACCTACACAGAACAGAGGATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCA
GAAGTTCTCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCATTTATTTGAAAGTATCACTGAGGA
TACTGTGACTGTCTTGGAGACAACTGTGAAATTGAAAACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCC
CTATCAGTTAAAAAGTTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGGAATCTAGAGCTGTCCCAGGACAT
GAAAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACTTACATAGCTCTTCTTGCCTTGCCAAGTACAGAGCCAGATGGACTCCTTCGGAC
AAACTACAGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAGATATTTCCAAACATTATAGTCAAAA
AGCTGCAATAGAGCATGAACTTCCAACAGCAACACAGAAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAA
TGGAGCAGGAAAGATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTATGGACCTAAGGCAGCGAGTGGATT
CATTAGTCCTCTTTCAGCTGAATGCATGCTACAGTATAAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAGGTTCAACAGAGTTT
GGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAACATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCG
AATTGCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCTGCTGTGTCAAATACTGCTGGCCAGGA
TGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATTCAGAGCACCAGTCTAGTTCCAGATGTGGAATCTCGTGAAGACTTAATTAAAAATCA
CTACATGGCAAGGATAGTGGAACTTACGTCTCAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAGTGCCGAGCACTGTC
TAAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCCAGTCAGAACATCAGCAGACTTCAGTGCCT
AGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGC
CGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCA
CTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCT
GGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAG
GGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGG
GTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCA
TGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTG
CCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTGG
ACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGG
CAACTCTCCAGAAGCATACTTTCATGGTTTTCCTTCCCTTTTTTCAGTTAGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGA
GCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTG
GCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTC
CCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCAT
CAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGA
CGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGA
GTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCA
GCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCC
AGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGC
CAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAA
ATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAA
GAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCAC
TAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAA
AGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGT
GAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTTG

>67885_67885_6_PPP1R21-TTC7B_PPP1R21_chr2_48737252_ENST00000449090_TTC7B_chr14_91124731_ENST00000357056_length(amino acids)=1169AA_BP=692
MYGAGEAMASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALS
EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ
NDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV
QDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL
RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK
HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK
VQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLVPDVESRED
LIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQCLERAMKFAFEEFHLWYQFALSLMAAG
KSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKAL
LAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVK
LQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGNSPEAYFHGFPSLFSVSSVHATSVA
ASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP1R21-TTC7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R21-TTC7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R21-TTC7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource