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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R37-APOC4 (FusionGDB2 ID:67899)

Fusion Gene Summary for PPP1R37-APOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R37-APOC4
Fusion gene ID: 67899
HgeneTgene
Gene symbol

PPP1R37

APOC4

Gene ID

284352

100533990

Gene nameprotein phosphatase 1 regulatory subunit 37APOC4-APOC2 readthrough (NMD candidate)
SynonymsLRRC68APOC4|Apo-CIV|ApoC-IV
Cytomap

19q13.32

19q13.32

Type of geneprotein-codingncRNA
Descriptionprotein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68Apolipoprotein C-IVApolipoprotein C4
Modification date2020031320200313
UniProtAcc

O75864

.
Ensembl transtripts involved in fusion geneENST00000496125, ENST00000221462, 
ENST00000421905, 		ENST00000419266, 
ENST00000591600, ENST00000592954, 
Fusion gene scores* DoF score20 X 7 X 13=18201 X 2 X 2=4
# samples 272
** MAII scorelog2(27/1820*10)=-2.75290713803523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: PPP1R37 [Title/Abstract] AND APOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R37(45596785)-APOC4(45451723), # samples:1
PPP1R37(45596785)-APOC4(45448006), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R37

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across PPP1R37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1Z4-06APPP1R37chr19

45596785

+APOC4chr19

45451723

+
ChimerDB4UCSTCGA-NA-A4R1PPP1R37chr19

45596785

+APOC4chr19

45448006

+


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Fusion Gene ORF analysis for PPP1R37-APOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000496125ENST00000419266PPP1R37chr19

45596785

+APOC4chr19

45448006

+
3UTR-3CDSENST00000496125ENST00000591600PPP1R37chr19

45596785

+APOC4chr19

45448006

+
3UTR-3CDSENST00000496125ENST00000592954PPP1R37chr19

45596785

+APOC4chr19

45448006

+
3UTR-3UTRENST00000496125ENST00000419266PPP1R37chr19

45596785

+APOC4chr19

45451723

+
3UTR-intronENST00000496125ENST00000591600PPP1R37chr19

45596785

+APOC4chr19

45451723

+
3UTR-intronENST00000496125ENST00000592954PPP1R37chr19

45596785

+APOC4chr19

45451723

+
5CDS-3UTRENST00000221462ENST00000419266PPP1R37chr19

45596785

+APOC4chr19

45451723

+
5CDS-3UTRENST00000421905ENST00000419266PPP1R37chr19

45596785

+APOC4chr19

45451723

+
5CDS-intronENST00000221462ENST00000591600PPP1R37chr19

45596785

+APOC4chr19

45451723

+
5CDS-intronENST00000221462ENST00000592954PPP1R37chr19

45596785

+APOC4chr19

45451723

+
5CDS-intronENST00000421905ENST00000591600PPP1R37chr19

45596785

+APOC4chr19

45451723

+
5CDS-intronENST00000421905ENST00000592954PPP1R37chr19

45596785

+APOC4chr19

45451723

+
In-frameENST00000221462ENST00000419266PPP1R37chr19

45596785

+APOC4chr19

45448006

+
In-frameENST00000221462ENST00000591600PPP1R37chr19

45596785

+APOC4chr19

45448006

+
In-frameENST00000221462ENST00000592954PPP1R37chr19

45596785

+APOC4chr19

45448006

+
In-frameENST00000421905ENST00000419266PPP1R37chr19

45596785

+APOC4chr19

45448006

+
In-frameENST00000421905ENST00000591600PPP1R37chr19

45596785

+APOC4chr19

45448006

+
In-frameENST00000421905ENST00000592954PPP1R37chr19

45596785

+APOC4chr19

45448006

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000421905PPP1R37chr1945596785+ENST00000592954APOC4chr1945448006+1067568258875205
ENST00000421905PPP1R37chr1945596785+ENST00000419266APOC4chr1945448006+2213568258875205
ENST00000421905PPP1R37chr1945596785+ENST00000591600APOC4chr1945448006+836568793233186
ENST00000221462PPP1R37chr1945596785+ENST00000592954APOC4chr1945448006+1065566256873205
ENST00000221462PPP1R37chr1945596785+ENST00000419266APOC4chr1945448006+2211566256873205
ENST00000221462PPP1R37chr1945596785+ENST00000591600APOC4chr1945448006+834566791231186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000421905ENST00000592954PPP1R37chr1945596785+APOC4chr1945448006+0.220624850.77937514
ENST00000421905ENST00000419266PPP1R37chr1945596785+APOC4chr1945448006+0.193147120.8068529
ENST00000421905ENST00000591600PPP1R37chr1945596785+APOC4chr1945448006+0.24681250.75318754
ENST00000221462ENST00000592954PPP1R37chr1945596785+APOC4chr1945448006+0.231191920.76880807
ENST00000221462ENST00000419266PPP1R37chr1945596785+APOC4chr1945448006+0.224670650.77532935
ENST00000221462ENST00000591600PPP1R37chr1945596785+APOC4chr1945448006+0.258832130.74116784

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Fusion Genomic Features for PPP1R37-APOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP1R37chr1945596785+APOC4chr1945451722+5.61E-081
PPP1R37chr1945596785+APOC4chr1945448005+7.81E-091
PPP1R37chr1945596785+APOC4chr1945451722+5.61E-081
PPP1R37chr1945596785+APOC4chr1945448005+7.81E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP1R37-APOC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45596785/chr19:45451723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R37

O75864

.
FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113514_52267741.6666666666666Compositional biasNote=Poly-Glu
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113527_65367741.6666666666666Compositional biasNote=Pro-rich
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113220_24067741.6666666666666RepeatNote=LRR 1
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113248_26967741.6666666666666RepeatNote=LRR 2
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113277_29767741.6666666666666RepeatNote=LRR 3
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113306_32667741.6666666666666RepeatNote=LRR 4
HgenePPP1R37chr19:45596785chr19:45448006ENST00000221462+113334_35467741.6666666666666RepeatNote=LRR 5


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Fusion Gene Sequence for PPP1R37-APOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67899_67899_1_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000221462_APOC4_chr19_45448006_ENST00000419266_length(transcript)=2211nt_BP=566nt
GCAGATTCGCTGCTCACGTTTCTTTTTTCCGTGGCCCTTCCTGCCCTTTGTTTCTCTCTTCATGTCACCCGCGGGACAACTCTACGTGCA
AGTCGCTGAAATCGATTTTCTGCTTCTTATAGTAAGCGGCGGGCTCGCCAGCCTCGAGCGAAAGTGTGACTGCGAACGGGCAGGCGCGCG
CGGGGCTCGGCGGAGGCGCGCTTGGGCTCCCGGCGGCGACGACTACGACCACTAGGAGAGCGGACGGAGGCGGCGCCTGAAGCGGCGGCG
GAGCCCATGCCCCGGGACGGCGGGCGGACCCGGAGAGACAAATCCGGGGCCCGGGGCATGTCCCCGGGGCCCCCGTGAGGAGGCGGCGGC
GGCTATGGAGATCGCGCCGCAGGAGGCGCCGCCCGTGCCGGGCGCGGACGGCGACATTGAAGAGGCCCCAGCTGAGGCCGGGTCTCCCAG
CCCCGCGTCGCCCCCCGCCGATGGGCGCCTCAAGGCTGCAGCCAAGCGCGTCACATTCCCGTCCGACGAGGATATCGTGTCTGGAGCAGT
GGAGCCCAAAGACCCCTGGAGACATGCATGCCAGCCAGAGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGCTG
GAGCCTGGTGAGGGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTCTGGAGCCCGAGCAC
CTTCCGGGGCTTCATGCAGACCTACTATGACGACCACCTGAGGGACCTGGGTCCGCTCACCAAGGCCTGGTTCCTCGAATCCAAAGACAG
CCTCTTGAAGAAGACCCACAGCCTGTGCCCCAGGCTTGTCTGTGGGGACAAGGACCAGGGTTAAAATGTTCATAAAAGCCAGGTGTGGTT
GTGGCGGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTAAAACAAAAAGAAAAAAAAAAGTTCATACTTCTCCAATAAATAAAGTC
TCACCTGTGTCCCTGTCTGGATCCTTCCCCAGTGTGGCCAGAAAAAAACCCACCCCACTGCCTCCCAGGAATCAATGAGTAGAAGAGGTG
ACACCTGATGGGGAAGGAAGAGTAGGGAGGTCGGGAAGGGTATCAAGGAATAACACCCTATTGTGGGCTTGCGGAGAATGGGGGACTTCA
AGGCGTGTCAGTTTCAGGAGGGTGAGGGCAGGAGCGTGGGTGGAGTCAGCAGGTCCCCATGATGGCCCTCACTGAGAGCTTCGCCCTTGT
CTCCTACAAGCTCTGACTCCATTCCCAGTGGGCACCCAGCACCTCCAACCCCTCCACAGCCCCCAACCCAGCCTCTGTCGGAGGCGAATT
CTCAGAGTGAGGGTTCCCTGTCACTTGAGAGAAGGTTCCCTGTGACGTGACCTTGGGGGACGTCATTGCCCTTTCTGTCCCCACCCACCC
CCTCCGCAGTTCTGTTGGCCAGGACTTTGGCCTAGACAAAGGATGGGGGTTGTGGCTGTGGAGCGGAAGTGGGTCTCAACCACTATAAAT
CCTCTCTGTGCCCGTCCGGAGCTGGTGAGGACAGCCTGCCAGAGTCTGGTCTCTGGACACTATGGGCACACGACTCCTCCCAGCTCTGTT
TCTTGTCCTCCTGGTATTGGGATTTGAGGTCCAGGGGACCCAACAGCCCCAGCAAGATGAGATGCCTAGCCCGACCTTCCTCACCCAGGT
GAAGGAATCTCTCTCCAGTTACTGGGAGTCAGCAAAGACAGCCGCCCAGAACCTGTACGAGAAGACATACCTGCCCGCTGTAGATGAGAA
ACTCAGGGACTTGTACAGCAAAAGCACAGCAGCCATGAGCACTTACACAGGCATTTTTACTGACCAAGTTCTTTCTGTGCTGAAGGGAGA
GGAGTAACAGCCAGACCCCCCATCAGTGGACAAGGGGAGAGTCCCCTACTCCCCTGATCCCCCAGGTTCAGACTGAGCTCCCCCTTCCCA
GTAGCTCTTGCATCCTCCTCCCAACTCTAGCCTGAATTCTTTTCAATAAAAAATACAATTCAAGTTGCTTCTCATGGATGGCACTGCTTT
TCTGAGGACTCAAGGGCCAAGATGGAGGGGCTGACTCAGTCCAGCCAACATTTAATGAGCACCTACTTTATGTATGGAGCTCTAACCCAT

>67899_67899_1_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000221462_APOC4_chr19_45448006_ENST00000419266_length(amino acids)=205AA_BP=103
MKRRRSPCPGTAGGPGETNPGPGACPRGPREEAAAAMEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDI
VSGAVEPKDPWRHACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFL

--------------------------------------------------------------
>67899_67899_2_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000221462_APOC4_chr19_45448006_ENST00000591600_length(transcript)=834nt_BP=566nt
GCAGATTCGCTGCTCACGTTTCTTTTTTCCGTGGCCCTTCCTGCCCTTTGTTTCTCTCTTCATGTCACCCGCGGGACAACTCTACGTGCA
AGTCGCTGAAATCGATTTTCTGCTTCTTATAGTAAGCGGCGGGCTCGCCAGCCTCGAGCGAAAGTGTGACTGCGAACGGGCAGGCGCGCG
CGGGGCTCGGCGGAGGCGCGCTTGGGCTCCCGGCGGCGACGACTACGACCACTAGGAGAGCGGACGGAGGCGGCGCCTGAAGCGGCGGCG
GAGCCCATGCCCCGGGACGGCGGGCGGACCCGGAGAGACAAATCCGGGGCCCGGGGCATGTCCCCGGGGCCCCCGTGAGGAGGCGGCGGC
GGCTATGGAGATCGCGCCGCAGGAGGCGCCGCCCGTGCCGGGCGCGGACGGCGACATTGAAGAGGCCCCAGCTGAGGCCGGGTCTCCCAG
CCCCGCGTCGCCCCCCGCCGATGGGCGCCTCAAGGCTGCAGCCAAGCGCGTCACATTCCCGTCCGACGAGGATATCGTGTCTGGAGCAGT
GGAGCCCAAAGACCCCTGGAGACATGCATGCCAGCCAGAGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGCTG
GAGCCTGGTGAGGGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTCTGGTGAGGGTGTGC
TGGGCTGGGTGGTGGGAGGGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGCCTGGACCCCTGAGTCTCAGGGAGGAGGAAAGGGTGGG

>67899_67899_2_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000221462_APOC4_chr19_45448006_ENST00000591600_length(amino acids)=186AA_BP=1
MRLRGPGPSPSSLRPRSPLPPPSPAHPHQNHCHPSLVLFTTVSSSSFILPLTRLQRLIFSFGGGLRVPSWASGWHACLQGSLGSTAPDTI
SSSDGNVTRLAAALRRPSAGGDAGLGDPASAGASSMSPSAPGTGGASCGAISIAAAASSRGPRGHAPGPGFVSPGPPAVPGHGLRRRFRR

--------------------------------------------------------------
>67899_67899_3_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000221462_APOC4_chr19_45448006_ENST00000592954_length(transcript)=1065nt_BP=566nt
GCAGATTCGCTGCTCACGTTTCTTTTTTCCGTGGCCCTTCCTGCCCTTTGTTTCTCTCTTCATGTCACCCGCGGGACAACTCTACGTGCA
AGTCGCTGAAATCGATTTTCTGCTTCTTATAGTAAGCGGCGGGCTCGCCAGCCTCGAGCGAAAGTGTGACTGCGAACGGGCAGGCGCGCG
CGGGGCTCGGCGGAGGCGCGCTTGGGCTCCCGGCGGCGACGACTACGACCACTAGGAGAGCGGACGGAGGCGGCGCCTGAAGCGGCGGCG
GAGCCCATGCCCCGGGACGGCGGGCGGACCCGGAGAGACAAATCCGGGGCCCGGGGCATGTCCCCGGGGCCCCCGTGAGGAGGCGGCGGC
GGCTATGGAGATCGCGCCGCAGGAGGCGCCGCCCGTGCCGGGCGCGGACGGCGACATTGAAGAGGCCCCAGCTGAGGCCGGGTCTCCCAG
CCCCGCGTCGCCCCCCGCCGATGGGCGCCTCAAGGCTGCAGCCAAGCGCGTCACATTCCCGTCCGACGAGGATATCGTGTCTGGAGCAGT
GGAGCCCAAAGACCCCTGGAGACATGCATGCCAGCCAGAGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGCTG
GAGCCTGGTGAGGGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTCTGGAGCCCGAGCAC
CTTCCGGGGCTTCATGCAGACCTACTATGACGACCACCTGAGGGACCTGGGTCCGCTCACCAAGGCCTGGTTCCTCGAATCCAAAGACAG
CCTCTTGAAGAAGACCCACAGCCTGTGCCCCAGGCTTGTCTGTGGGGACAAGGACCAGGGTTAAAATGTTCATAAAAGCCAGGTGTGGTT
GTGGCGGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTAGGATGATGGCTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACACA

>67899_67899_3_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000221462_APOC4_chr19_45448006_ENST00000592954_length(amino acids)=205AA_BP=103
MKRRRSPCPGTAGGPGETNPGPGACPRGPREEAAAAMEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDI
VSGAVEPKDPWRHACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFL

--------------------------------------------------------------
>67899_67899_4_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000421905_APOC4_chr19_45448006_ENST00000419266_length(transcript)=2213nt_BP=568nt
CTGCAGATTCGCTGCTCACGTTTCTTTTTTCCGTGGCCCTTCCTGCCCTTTGTTTCTCTCTTCATGTCACCCGCGGGACAACTCTACGTG
CAAGTCGCTGAAATCGATTTTCTGCTTCTTATAGTAAGCGGCGGGCTCGCCAGCCTCGAGCGAAAGTGTGACTGCGAACGGGCAGGCGCG
CGCGGGGCTCGGCGGAGGCGCGCTTGGGCTCCCGGCGGCGACGACTACGACCACTAGGAGAGCGGACGGAGGCGGCGCCTGAAGCGGCGG
CGGAGCCCATGCCCCGGGACGGCGGGCGGACCCGGAGAGACAAATCCGGGGCCCGGGGCATGTCCCCGGGGCCCCCGTGAGGAGGCGGCG
GCGGCTATGGAGATCGCGCCGCAGGAGGCGCCGCCCGTGCCGGGCGCGGACGGCGACATTGAAGAGGCCCCAGCTGAGGCCGGGTCTCCC
AGCCCCGCGTCGCCCCCCGCCGATGGGCGCCTCAAGGCTGCAGCCAAGCGCGTCACATTCCCGTCCGACGAGGATATCGTGTCTGGAGCA
GTGGAGCCCAAAGACCCCTGGAGACATGCATGCCAGCCAGAGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGC
TGGAGCCTGGTGAGGGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTCTGGAGCCCGAGC
ACCTTCCGGGGCTTCATGCAGACCTACTATGACGACCACCTGAGGGACCTGGGTCCGCTCACCAAGGCCTGGTTCCTCGAATCCAAAGAC
AGCCTCTTGAAGAAGACCCACAGCCTGTGCCCCAGGCTTGTCTGTGGGGACAAGGACCAGGGTTAAAATGTTCATAAAAGCCAGGTGTGG
TTGTGGCGGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTAAAACAAAAAGAAAAAAAAAAGTTCATACTTCTCCAATAAATAAAG
TCTCACCTGTGTCCCTGTCTGGATCCTTCCCCAGTGTGGCCAGAAAAAAACCCACCCCACTGCCTCCCAGGAATCAATGAGTAGAAGAGG
TGACACCTGATGGGGAAGGAAGAGTAGGGAGGTCGGGAAGGGTATCAAGGAATAACACCCTATTGTGGGCTTGCGGAGAATGGGGGACTT
CAAGGCGTGTCAGTTTCAGGAGGGTGAGGGCAGGAGCGTGGGTGGAGTCAGCAGGTCCCCATGATGGCCCTCACTGAGAGCTTCGCCCTT
GTCTCCTACAAGCTCTGACTCCATTCCCAGTGGGCACCCAGCACCTCCAACCCCTCCACAGCCCCCAACCCAGCCTCTGTCGGAGGCGAA
TTCTCAGAGTGAGGGTTCCCTGTCACTTGAGAGAAGGTTCCCTGTGACGTGACCTTGGGGGACGTCATTGCCCTTTCTGTCCCCACCCAC
CCCCTCCGCAGTTCTGTTGGCCAGGACTTTGGCCTAGACAAAGGATGGGGGTTGTGGCTGTGGAGCGGAAGTGGGTCTCAACCACTATAA
ATCCTCTCTGTGCCCGTCCGGAGCTGGTGAGGACAGCCTGCCAGAGTCTGGTCTCTGGACACTATGGGCACACGACTCCTCCCAGCTCTG
TTTCTTGTCCTCCTGGTATTGGGATTTGAGGTCCAGGGGACCCAACAGCCCCAGCAAGATGAGATGCCTAGCCCGACCTTCCTCACCCAG
GTGAAGGAATCTCTCTCCAGTTACTGGGAGTCAGCAAAGACAGCCGCCCAGAACCTGTACGAGAAGACATACCTGCCCGCTGTAGATGAG
AAACTCAGGGACTTGTACAGCAAAAGCACAGCAGCCATGAGCACTTACACAGGCATTTTTACTGACCAAGTTCTTTCTGTGCTGAAGGGA
GAGGAGTAACAGCCAGACCCCCCATCAGTGGACAAGGGGAGAGTCCCCTACTCCCCTGATCCCCCAGGTTCAGACTGAGCTCCCCCTTCC
CAGTAGCTCTTGCATCCTCCTCCCAACTCTAGCCTGAATTCTTTTCAATAAAAAATACAATTCAAGTTGCTTCTCATGGATGGCACTGCT
TTTCTGAGGACTCAAGGGCCAAGATGGAGGGGCTGACTCAGTCCAGCCAACATTTAATGAGCACCTACTTTATGTATGGAGCTCTAACCC

>67899_67899_4_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000421905_APOC4_chr19_45448006_ENST00000419266_length(amino acids)=205AA_BP=103
MKRRRSPCPGTAGGPGETNPGPGACPRGPREEAAAAMEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDI
VSGAVEPKDPWRHACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFL

--------------------------------------------------------------
>67899_67899_5_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000421905_APOC4_chr19_45448006_ENST00000591600_length(transcript)=836nt_BP=568nt
CTGCAGATTCGCTGCTCACGTTTCTTTTTTCCGTGGCCCTTCCTGCCCTTTGTTTCTCTCTTCATGTCACCCGCGGGACAACTCTACGTG
CAAGTCGCTGAAATCGATTTTCTGCTTCTTATAGTAAGCGGCGGGCTCGCCAGCCTCGAGCGAAAGTGTGACTGCGAACGGGCAGGCGCG
CGCGGGGCTCGGCGGAGGCGCGCTTGGGCTCCCGGCGGCGACGACTACGACCACTAGGAGAGCGGACGGAGGCGGCGCCTGAAGCGGCGG
CGGAGCCCATGCCCCGGGACGGCGGGCGGACCCGGAGAGACAAATCCGGGGCCCGGGGCATGTCCCCGGGGCCCCCGTGAGGAGGCGGCG
GCGGCTATGGAGATCGCGCCGCAGGAGGCGCCGCCCGTGCCGGGCGCGGACGGCGACATTGAAGAGGCCCCAGCTGAGGCCGGGTCTCCC
AGCCCCGCGTCGCCCCCCGCCGATGGGCGCCTCAAGGCTGCAGCCAAGCGCGTCACATTCCCGTCCGACGAGGATATCGTGTCTGGAGCA
GTGGAGCCCAAAGACCCCTGGAGACATGCATGCCAGCCAGAGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGC
TGGAGCCTGGTGAGGGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTCTGGTGAGGGTGT
GCTGGGCTGGGTGGTGGGAGGGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGCCTGGACCCCTGAGTCTCAGGGAGGAGGAAAGGGTG

>67899_67899_5_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000421905_APOC4_chr19_45448006_ENST00000591600_length(amino acids)=186AA_BP=1
MRLRGPGPSPSSLRPRSPLPPPSPAHPHQNHCHPSLVLFTTVSSSSFILPLTRLQRLIFSFGGGLRVPSWASGWHACLQGSLGSTAPDTI
SSSDGNVTRLAAALRRPSAGGDAGLGDPASAGASSMSPSAPGTGGASCGAISIAAAASSRGPRGHAPGPGFVSPGPPAVPGHGLRRRFRR

--------------------------------------------------------------
>67899_67899_6_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000421905_APOC4_chr19_45448006_ENST00000592954_length(transcript)=1067nt_BP=568nt
CTGCAGATTCGCTGCTCACGTTTCTTTTTTCCGTGGCCCTTCCTGCCCTTTGTTTCTCTCTTCATGTCACCCGCGGGACAACTCTACGTG
CAAGTCGCTGAAATCGATTTTCTGCTTCTTATAGTAAGCGGCGGGCTCGCCAGCCTCGAGCGAAAGTGTGACTGCGAACGGGCAGGCGCG
CGCGGGGCTCGGCGGAGGCGCGCTTGGGCTCCCGGCGGCGACGACTACGACCACTAGGAGAGCGGACGGAGGCGGCGCCTGAAGCGGCGG
CGGAGCCCATGCCCCGGGACGGCGGGCGGACCCGGAGAGACAAATCCGGGGCCCGGGGCATGTCCCCGGGGCCCCCGTGAGGAGGCGGCG
GCGGCTATGGAGATCGCGCCGCAGGAGGCGCCGCCCGTGCCGGGCGCGGACGGCGACATTGAAGAGGCCCCAGCTGAGGCCGGGTCTCCC
AGCCCCGCGTCGCCCCCCGCCGATGGGCGCCTCAAGGCTGCAGCCAAGCGCGTCACATTCCCGTCCGACGAGGATATCGTGTCTGGAGCA
GTGGAGCCCAAAGACCCCTGGAGACATGCATGCCAGCCAGAGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGC
TGGAGCCTGGTGAGGGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTCTGGAGCCCGAGC
ACCTTCCGGGGCTTCATGCAGACCTACTATGACGACCACCTGAGGGACCTGGGTCCGCTCACCAAGGCCTGGTTCCTCGAATCCAAAGAC
AGCCTCTTGAAGAAGACCCACAGCCTGTGCCCCAGGCTTGTCTGTGGGGACAAGGACCAGGGTTAAAATGTTCATAAAAGCCAGGTGTGG
TTGTGGCGGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTAGGATGATGGCTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACA

>67899_67899_6_PPP1R37-APOC4_PPP1R37_chr19_45596785_ENST00000421905_APOC4_chr19_45448006_ENST00000592954_length(amino acids)=205AA_BP=103
MKRRRSPCPGTAGGPGETNPGPGACPRGPREEAAAAMEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDI
VSGAVEPKDPWRHACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNRTRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFL

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Fusion Gene PPI Analysis for PPP1R37-APOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R37-APOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R37-APOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource