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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARPC2-ARPC2 (FusionGDB2 ID:6790)

Fusion Gene Summary for ARPC2-ARPC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARPC2-ARPC2
Fusion gene ID: 6790
HgeneTgene
Gene symbol

ARPC2

ARPC2

Gene ID

10109

10109

Gene nameactin related protein 2/3 complex subunit 2actin related protein 2/3 complex subunit 2
SynonymsARC34|PNAS-139|PRO2446|p34-ArcARC34|PNAS-139|PRO2446|p34-Arc
Cytomap

2q35

2q35

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53eactin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53e
Modification date2020031320200313
UniProtAcc

O15144

O15144

Ensembl transtripts involved in fusion geneENST00000295685, ENST00000315717, 
ENST00000477992, 		ENST00000295685, 
ENST00000315717, ENST00000477992, 
Fusion gene scores* DoF score14 X 13 X 5=91011 X 15 X 6=990
# samples 1616
** MAII scorelog2(16/910*10)=-2.5077946401987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/990*10)=-2.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARPC2 [Title/Abstract] AND ARPC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARPC2(219118966)-ARPC2(219093522), # samples:1
ARPC2(219118749)-ARPC2(219118679), # samples:1
ARPC2(219114564)-ARPC2(219118619), # samples:1
Anticipated loss of major functional domain due to fusion event.ARPC2-ARPC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARPC2-ARPC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARPC2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539

TgeneARPC2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check buttonFusion gene breakpoints across ARPC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARPC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE073187ARPC2chr2

219118966

+ARPC2chr2

219093522

+
ChiTaRS5.0N/ACB242231ARPC2chr2

219118749

-ARPC2chr2

219118679

+
ChiTaRS5.0N/ACB321859ARPC2chr2

219114564

-ARPC2chr2

219118619

+


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Fusion Gene ORF analysis for ARPC2-ARPC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000295685ENST00000295685ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000295685ENST00000315717ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000315717ENST00000295685ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000315717ENST00000315717ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-3CDSENST00000477992ENST00000295685ARPC2chr2

219114564

-ARPC2chr2

219118619

+
3UTR-3CDSENST00000477992ENST00000315717ARPC2chr2

219114564

-ARPC2chr2

219118619

+
3UTR-3UTRENST00000295685ENST00000295685ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000295685ENST00000315717ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000295685ENST00000477992ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000315717ENST00000295685ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000315717ENST00000315717ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000315717ENST00000477992ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000295685ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000315717ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000477992ARPC2chr2

219118749

-ARPC2chr2

219118679

+
3UTR-3UTRENST00000477992ENST00000477992ARPC2chr2

219114564

-ARPC2chr2

219118619

+
3UTR-intronENST00000295685ENST00000477992ARPC2chr2

219118966

+ARPC2chr2

219093522

+
3UTR-intronENST00000315717ENST00000477992ARPC2chr2

219118966

+ARPC2chr2

219093522

+
5CDS-3UTRENST00000295685ENST00000477992ARPC2chr2

219114564

-ARPC2chr2

219118619

+
5CDS-3UTRENST00000315717ENST00000477992ARPC2chr2

219114564

-ARPC2chr2

219118619

+
Frame-shiftENST00000295685ENST00000295685ARPC2chr2

219114564

-ARPC2chr2

219118619

+
Frame-shiftENST00000315717ENST00000295685ARPC2chr2

219114564

-ARPC2chr2

219118619

+
In-frameENST00000295685ENST00000315717ARPC2chr2

219114564

-ARPC2chr2

219118619

+
In-frameENST00000315717ENST00000315717ARPC2chr2

219114564

-ARPC2chr2

219118619

+
intron-3CDSENST00000477992ENST00000295685ARPC2chr2

219118966

+ARPC2chr2

219093522

+
intron-3CDSENST00000477992ENST00000315717ARPC2chr2

219118966

+ARPC2chr2

219093522

+
intron-intronENST00000477992ENST00000477992ARPC2chr2

219118966

+ARPC2chr2

219093522

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARPC2-ARPC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARPC2-ARPC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:219118966/chr2:219093522)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARPC2

O15144

ARPC2

O15144

FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARPC2-ARPC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARPC2-ARPC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARPC2-ARPC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARPC2-ARPC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource