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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R37-HNRNPUL1 (FusionGDB2 ID:67910)

Fusion Gene Summary for PPP1R37-HNRNPUL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R37-HNRNPUL1
Fusion gene ID: 67910
HgeneTgene
Gene symbol

PPP1R37

HNRNPUL1

Gene ID

284352

11100

Gene nameprotein phosphatase 1 regulatory subunit 37heterogeneous nuclear ribonucleoprotein U like 1
SynonymsLRRC68E1B-AP5|E1BAP5|HNRPUL1
Cytomap

19q13.32

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68heterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5
Modification date2020031320200327
UniProtAcc

O75864

Q9BUJ2

Ensembl transtripts involved in fusion geneENST00000496125, ENST00000221462, 
ENST00000421905, 		ENST00000594207, 
ENST00000263367, ENST00000352456, 
ENST00000378215, ENST00000392006, 
ENST00000593587, ENST00000595018, 
ENST00000602130, 
Fusion gene scores* DoF score20 X 7 X 13=182030 X 17 X 8=4080
# samples 2732
** MAII scorelog2(27/1820*10)=-2.75290713803523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/4080*10)=-3.6724253419715
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R37 [Title/Abstract] AND HNRNPUL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R37(45596785)-HNRNPUL1(41774128), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R37

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across PPP1R37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HNRNPUL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-A4SO-01APPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+


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Fusion Gene ORF analysis for PPP1R37-HNRNPUL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000496125ENST00000594207PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000263367PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000352456PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000378215PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000392006PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000593587PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000595018PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
3UTR-5UTRENST00000496125ENST00000602130PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000221462ENST00000594207PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-3UTRENST00000421905ENST00000594207PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000263367PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000352456PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000378215PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000392006PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000593587PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000595018PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000221462ENST00000602130PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000263367PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000352456PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000378215PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000392006PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000593587PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000595018PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+
5CDS-5UTRENST00000421905ENST00000602130PPP1R37chr19

45596785

+HNRNPUL1chr19

41774128

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP1R37-HNRNPUL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP1R37chr1945596785+HNRNPUL1chr1941774127+4.98E-121
PPP1R37chr1945596785+HNRNPUL1chr1941774127+4.98E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP1R37-HNRNPUL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45596785/:41774128)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R37

O75864

HNRNPUL1

Q9BUJ2

FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP1R37-HNRNPUL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP1R37-HNRNPUL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R37-HNRNPUL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R37-HNRNPUL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource