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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP1R7-PLK1 (FusionGDB2 ID:67935)

Fusion Gene Summary for PPP1R7-PLK1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R7-PLK1
Fusion gene ID: 67935
HgeneTgene
Gene symbol

PPP1R7

PLK1

Gene ID

5510

5347

Gene nameprotein phosphatase 1 regulatory subunit 7polo like kinase 1
SynonymsSDS22PLK|STPK13
Cytomap

2q37.3

16p12.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 7protein phosphatase 1 regulatory subunit 22protein phosphatase 1, regulatory (inhibitor) subunit 7testis secretory sperm-binding protein Li 210aserine/threonine-protein kinase PLK1PLK-1cell cycle regulated protein kinasepolo (Drosophia)-like kinaseserine/threonine-protein kinase 13
Modification date2020031520200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000234038, ENST00000404405, 
ENST00000406106, ENST00000407025, 
ENST00000272983, ENST00000401987, 
ENST00000402734, ENST00000485630, 
ENST00000564202, ENST00000300093, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 7 X 3=126
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1R7 [Title/Abstract] AND PLK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R7(242093019)-PLK1(23700558), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLK1

GO:0000086

G2/M transition of mitotic cell cycle

19160488

TgenePLK1

GO:0000132

establishment of mitotic spindle orientation

23509069

TgenePLK1

GO:0000278

mitotic cell cycle

18615013

TgenePLK1

GO:0000281

mitotic cytokinesis

19468302

TgenePLK1

GO:0001578

microtubule bundle formation

12939256

TgenePLK1

GO:0006468

protein phosphorylation

19468300|20679239|22701722|23509069

TgenePLK1

GO:0016567

protein ubiquitination

16885022

TgenePLK1

GO:0018105

peptidyl-serine phosphorylation

16885022

TgenePLK1

GO:0030071

regulation of mitotic metaphase/anaphase transition

23509069

TgenePLK1

GO:0031648

protein destabilization

16885022

TgenePLK1

GO:0032465

regulation of cytokinesis

17351640

TgenePLK1

GO:0045862

positive regulation of proteolysis

16885022

TgenePLK1

GO:0071168

protein localization to chromatin

21111234

TgenePLK1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

TgenePLK1

GO:1901673

regulation of mitotic spindle assembly

22621898

TgenePLK1

GO:1904668

positive regulation of ubiquitin protein ligase activity

15148369

TgenePLK1

GO:1904776

regulation of protein localization to cell cortex

23509069


check buttonFusion gene breakpoints across PPP1R7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0897PPP1R7chr2

242093019

+PLK1chr16

23700558

+


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Fusion Gene ORF analysis for PPP1R7-PLK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000234038ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
5CDS-intronENST00000404405ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
5CDS-intronENST00000406106ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
5CDS-intronENST00000407025ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
In-frameENST00000234038ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
In-frameENST00000404405ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
In-frameENST00000406106ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
In-frameENST00000407025ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-3CDSENST00000272983ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-3CDSENST00000401987ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-3CDSENST00000402734ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-3CDSENST00000485630ENST00000300093PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-intronENST00000272983ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-intronENST00000401987ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-intronENST00000402734ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+
intron-intronENST00000485630ENST00000564202PPP1R7chr2

242093019

+PLK1chr16

23700558

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407025PPP1R7chr2242093019+ENST00000300093PLK1chr1623700558+13354892601030256
ENST00000234038PPP1R7chr2242093019+ENST00000300093PLK1chr1623700558+15016554261196256
ENST00000404405PPP1R7chr2242093019+ENST00000300093PLK1chr1623700558+110525930800256
ENST00000406106PPP1R7chr2242093019+ENST00000300093PLK1chr1623700558+104319716738240

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407025ENST00000300093PPP1R7chr2242093019+PLK1chr1623700558+0.0044139950.99558604
ENST00000234038ENST00000300093PPP1R7chr2242093019+PLK1chr1623700558+0.0035184670.99648154
ENST00000404405ENST00000300093PPP1R7chr2242093019+PLK1chr1623700558+0.0036185240.9963814
ENST00000406106ENST00000300093PPP1R7chr2242093019+PLK1chr1623700558+0.0033601890.99663985

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Fusion Genomic Features for PPP1R7-PLK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP1R7chr2242093019+PLK1chr1623700558+3.04E-070.99999964
PPP1R7chr2242093019+PLK1chr1623700558+3.04E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP1R7-PLK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:242093019/chr16:23700558)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLK1chr2:242093019chr16:23700558ENST00000300093610515_584423604.0DomainPOLO box 2
TgenePLK1chr2:242093019chr16:23700558ENST00000300093610493_507423604.0RegionNote=Linker

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210331_36060361.0DomainNote=LRRCT
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19331_3600318.0DomainNote=LRRCT
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18331_3600238.0DomainNote=LRRCT
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29331_36060281.0DomainNote=LRRCT
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311331_36060361.0DomainNote=LRRCT
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210121_14260361.0RepeatNote=LRR 3
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210143_16460361.0RepeatNote=LRR 4
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210165_18660361.0RepeatNote=LRR 5
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210187_20860361.0RepeatNote=LRR 6
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210209_23060361.0RepeatNote=LRR 7
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210231_25260361.0RepeatNote=LRR 8
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210253_27460361.0RepeatNote=LRR 9
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210275_29660361.0RepeatNote=LRR 10
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+210297_31860361.0RepeatNote=LRR 11
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+21077_9860361.0RepeatNote=LRR 1
HgenePPP1R7chr2:242093019chr16:23700558ENST00000234038+21099_12060361.0RepeatNote=LRR 2
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19121_1420318.0RepeatNote=LRR 3
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19143_1640318.0RepeatNote=LRR 4
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19165_1860318.0RepeatNote=LRR 5
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19187_2080318.0RepeatNote=LRR 6
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19209_2300318.0RepeatNote=LRR 7
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19231_2520318.0RepeatNote=LRR 8
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19253_2740318.0RepeatNote=LRR 9
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19275_2960318.0RepeatNote=LRR 10
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+19297_3180318.0RepeatNote=LRR 11
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+1977_980318.0RepeatNote=LRR 1
HgenePPP1R7chr2:242093019chr16:23700558ENST00000272983+1999_1200318.0RepeatNote=LRR 2
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18121_1420238.0RepeatNote=LRR 3
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18143_1640238.0RepeatNote=LRR 4
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18165_1860238.0RepeatNote=LRR 5
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18187_2080238.0RepeatNote=LRR 6
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18209_2300238.0RepeatNote=LRR 7
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18231_2520238.0RepeatNote=LRR 8
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18253_2740238.0RepeatNote=LRR 9
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18275_2960238.0RepeatNote=LRR 10
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+18297_3180238.0RepeatNote=LRR 11
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+1877_980238.0RepeatNote=LRR 1
HgenePPP1R7chr2:242093019chr16:23700558ENST00000401987+1899_1200238.0RepeatNote=LRR 2
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29121_14260281.0RepeatNote=LRR 3
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29143_16460281.0RepeatNote=LRR 4
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29165_18660281.0RepeatNote=LRR 5
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29187_20860281.0RepeatNote=LRR 6
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29209_23060281.0RepeatNote=LRR 7
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29231_25260281.0RepeatNote=LRR 8
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29253_27460281.0RepeatNote=LRR 9
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29275_29660281.0RepeatNote=LRR 10
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+29297_31860281.0RepeatNote=LRR 11
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+2977_9860281.0RepeatNote=LRR 1
HgenePPP1R7chr2:242093019chr16:23700558ENST00000406106+2999_12060281.0RepeatNote=LRR 2
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311121_14260361.0RepeatNote=LRR 3
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311143_16460361.0RepeatNote=LRR 4
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311165_18660361.0RepeatNote=LRR 5
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311187_20860361.0RepeatNote=LRR 6
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311209_23060361.0RepeatNote=LRR 7
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311231_25260361.0RepeatNote=LRR 8
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311253_27460361.0RepeatNote=LRR 9
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311275_29660361.0RepeatNote=LRR 10
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+311297_31860361.0RepeatNote=LRR 11
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+31177_9860361.0RepeatNote=LRR 1
HgenePPP1R7chr2:242093019chr16:23700558ENST00000407025+31199_12060361.0RepeatNote=LRR 2
TgenePLK1chr2:242093019chr16:23700558ENST00000300093610417_480423604.0DomainPOLO box 1
TgenePLK1chr2:242093019chr16:23700558ENST0000030009361053_305423604.0DomainProtein kinase
TgenePLK1chr2:242093019chr16:23700558ENST00000300093610337_340423604.0MotifNote=D-box that targets the protein for proteasomal degradation in anaphase
TgenePLK1chr2:242093019chr16:23700558ENST00000300093610178_181423604.0Nucleotide bindingNote=ATP
TgenePLK1chr2:242093019chr16:23700558ENST0000030009361059_67423604.0Nucleotide bindingNote=ATP
TgenePLK1chr2:242093019chr16:23700558ENST00000300093610194_221423604.0RegionNote=Activation loop


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Fusion Gene Sequence for PPP1R7-PLK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67935_67935_1_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000234038_PLK1_chr16_23700558_ENST00000300093_length(transcript)=1501nt_BP=655nt
AGACGCAGCCAGCGAGGCTCGCAGAGGTCAGGGATGCACGTAGGACTGGCCCGCACCTTGCAGCCACGGAAAGATCCGCCTGGCCCGCGG
CCCCTCCACGCCTCCGAGGTCGAGACAGTGACATAAGTCAACTCTCAAGCCCAGGGCGTCTCTCCACTCTGCCTAGACGTCCACTCCGTC
TGCCTGCAGCTACGGCTCTGTGCGTCCCGCTTCGACTCCCTCTGCTTTCCTTCCCAGCTTCTCGCCTCCAGACTGTTCCGGCTCCGCCGC
CTGAAATTACCTGCTCTGGGGGAGGCGCGGCGCGCGGCCTCATGACGGAACTACAACTCCCATGAGGCGCTGGGCCCACGCAGGCGCGGC
GCGGCTGAAGTCGCCGCGCCGGAATCCCATTGGCAGGGCCGGCTCTGAGGCGGGAGCCCTGATTGGCTGAGGGGTCTGAGGCGACAGATT
CCGGAAAGGGGAAGAGCAGCCAACATGGCGGCGGAACGCGGCGCGGGGCAGCAACAGTCGCAGGAGATGATGGAGGTTGACAGGCGGGTC
GAGTCTGAAGAATCCGGCGATGAAGAAGGGAAGAAACACAGCAGTGGCATCGTGGCCGACCTCAGTGAACAGAGCCTGAAGGATGGGGAG
GAGCGGGGGGAGGAGGACCCAGAAGGGTATCAGCTCTGTGATAACAGCGTGGGGGTGCTCTTCAATGACTCAACACGCCTCATCCTCTAC
AATGATGGTGACAGCCTGCAGTACATAGAGCGTGACGGCACTGAGTCCTACCTCACCGTGAGTTCCCATCCCAACTCCTTGATGAAGAAG
ATCACCCTCCTTAAATATTTCCGCAATTACATGAGCGAGCACTTGCTGAAGGCAGGTGCCAACATCACGCCGCGCGAAGGTGATGAGCTC
GCCCGGCTGCCCTACCTACGGACCTGGTTCCGCACCCGCAGCGCCATCATCCTGCACCTCAGCAACGGCAGCGTGCAGATCAACTTCTTC
CAGGATCACACCAAGCTCATCTTGTGCCCACTGATGGCAGCCGTGACCTACATCGACGAGAAGCGGGACTTCCGCACATACCGCCTGAGT
CTCCTGGAGGAGTACGGCTGCTGCAAGGAGCTGGCCAGCCGGCTCCGCTACGCCCGCACTATGGTGGACAAGCTGCTGAGCTCACGCTCG
GCCAGCAACCGTCTCAAGGCCTCCTAATAGCTGCCCTCCCCTCCGGACTGGTGCCCTCCTCACTCCCACCTGCATCTGGGGCCCATACTG
GTTGGCTCCCGCGGTGCCATGTCTGCAGTGTGCCCCCCAGCCCCGGTGGCTGGGCAGAGCTGCATCATCCTTGCAGGTGGGGGTTGCTGT
ATAAGTTATTTTTGTACATGTTCGGGTGTGGGTTCTACAGCCTTGTCCCCCTCCCCCTCAACCCCACCATATGAATTGTACAGAATATTT

>67935_67935_1_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000234038_PLK1_chr16_23700558_ENST00000300093_length(amino acids)=256AA_BP=76
MRGLRRQIPERGRAANMAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPEGYQLCDNSVGVLFN
DSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSN

--------------------------------------------------------------
>67935_67935_2_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000404405_PLK1_chr16_23700558_ENST00000300093_length(transcript)=1105nt_BP=259nt
GGCCGGCTCTGAGGCGGGAGCCCTGATTGGCTGAGGGGTCTGAGGCGACAGATTCCGGAAAGGGGAAGAGCAGCCAACATGGCGGCGGAA
CGCGGCGCGGGGCAGCAACAGTCGCAGGAGATGATGGAGGTTGACAGGCGGGTCGAGTCTGAAGAATCCGGCGATGAAGAAGGGAAGAAA
CACAGCAGTGGCATCGTGGCCGACCTCAGTGAACAGAGCCTGAAGGATGGGGAGGAGCGGGGGGAGGAGGACCCAGAAGGGTATCAGCTC
TGTGATAACAGCGTGGGGGTGCTCTTCAATGACTCAACACGCCTCATCCTCTACAATGATGGTGACAGCCTGCAGTACATAGAGCGTGAC
GGCACTGAGTCCTACCTCACCGTGAGTTCCCATCCCAACTCCTTGATGAAGAAGATCACCCTCCTTAAATATTTCCGCAATTACATGAGC
GAGCACTTGCTGAAGGCAGGTGCCAACATCACGCCGCGCGAAGGTGATGAGCTCGCCCGGCTGCCCTACCTACGGACCTGGTTCCGCACC
CGCAGCGCCATCATCCTGCACCTCAGCAACGGCAGCGTGCAGATCAACTTCTTCCAGGATCACACCAAGCTCATCTTGTGCCCACTGATG
GCAGCCGTGACCTACATCGACGAGAAGCGGGACTTCCGCACATACCGCCTGAGTCTCCTGGAGGAGTACGGCTGCTGCAAGGAGCTGGCC
AGCCGGCTCCGCTACGCCCGCACTATGGTGGACAAGCTGCTGAGCTCACGCTCGGCCAGCAACCGTCTCAAGGCCTCCTAATAGCTGCCC
TCCCCTCCGGACTGGTGCCCTCCTCACTCCCACCTGCATCTGGGGCCCATACTGGTTGGCTCCCGCGGTGCCATGTCTGCAGTGTGCCCC
CCAGCCCCGGTGGCTGGGCAGAGCTGCATCATCCTTGCAGGTGGGGGTTGCTGTATAAGTTATTTTTGTACATGTTCGGGTGTGGGTTCT
ACAGCCTTGTCCCCCTCCCCCTCAACCCCACCATATGAATTGTACAGAATATTTCTATTGAATTCGGAACTGTCCTTTCCTTGGCTTTAT

>67935_67935_2_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000404405_PLK1_chr16_23700558_ENST00000300093_length(amino acids)=256AA_BP=76
MRGLRRQIPERGRAANMAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPEGYQLCDNSVGVLFN
DSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSN

--------------------------------------------------------------
>67935_67935_3_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000406106_PLK1_chr16_23700558_ENST00000300093_length(transcript)=1043nt_BP=197nt
GGGAAGAGCAGCCAACATGGCGGCGGAACGCGGCGCGGGGCAGCAACAGTCGCAGGAGATGATGGAGGTTGACAGGCGGGTCGAGTCTGA
AGAATCCGGCGATGAAGAAGGGAAGAAACACAGCAGTGGCATCGTGGCCGACCTCAGTGAACAGAGCCTGAAGGATGGGGAGGAGCGGGG
GGAGGAGGACCCAGAAGGGTATCAGCTCTGTGATAACAGCGTGGGGGTGCTCTTCAATGACTCAACACGCCTCATCCTCTACAATGATGG
TGACAGCCTGCAGTACATAGAGCGTGACGGCACTGAGTCCTACCTCACCGTGAGTTCCCATCCCAACTCCTTGATGAAGAAGATCACCCT
CCTTAAATATTTCCGCAATTACATGAGCGAGCACTTGCTGAAGGCAGGTGCCAACATCACGCCGCGCGAAGGTGATGAGCTCGCCCGGCT
GCCCTACCTACGGACCTGGTTCCGCACCCGCAGCGCCATCATCCTGCACCTCAGCAACGGCAGCGTGCAGATCAACTTCTTCCAGGATCA
CACCAAGCTCATCTTGTGCCCACTGATGGCAGCCGTGACCTACATCGACGAGAAGCGGGACTTCCGCACATACCGCCTGAGTCTCCTGGA
GGAGTACGGCTGCTGCAAGGAGCTGGCCAGCCGGCTCCGCTACGCCCGCACTATGGTGGACAAGCTGCTGAGCTCACGCTCGGCCAGCAA
CCGTCTCAAGGCCTCCTAATAGCTGCCCTCCCCTCCGGACTGGTGCCCTCCTCACTCCCACCTGCATCTGGGGCCCATACTGGTTGGCTC
CCGCGGTGCCATGTCTGCAGTGTGCCCCCCAGCCCCGGTGGCTGGGCAGAGCTGCATCATCCTTGCAGGTGGGGGTTGCTGTATAAGTTA
TTTTTGTACATGTTCGGGTGTGGGTTCTACAGCCTTGTCCCCCTCCCCCTCAACCCCACCATATGAATTGTACAGAATATTTCTATTGAA

>67935_67935_3_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000406106_PLK1_chr16_23700558_ENST00000300093_length(amino acids)=240AA_BP=60
MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPEGYQLCDNSVGVLFNDSTRLILYNDGDSLQY
IERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLIL

--------------------------------------------------------------
>67935_67935_4_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000407025_PLK1_chr16_23700558_ENST00000300093_length(transcript)=1335nt_BP=489nt
AAAGGAATAATGGGCGCCTCCGCCCCCGGGCCGGGCAGATGCGGTTTCCTCCCGACTCGCGATCAAAATGGCTTCTCGCCTCCAGACTGT
TCCGGCTCCGCCGCCTGAAATTACCTGCTCTGGGGGAGGCGCGGCGCGCGGCCTCATGACGGAACTACAACTCCCATGAGGCGCTGGGCC
CACGCAGGCGCGGCGCGGCTGAAGTCGCCGCGCCGGAATCCCATTGGCAGGGCCGGCTCTGAGGCGGGAGCCCTGATTGGCTGAGGGGTC
TGAGGCGACAGATTCCGGAAAGGGGAAGAGCAGCCAACATGGCGGCGGAACGCGGCGCGGGGCAGCAACAGTCGCAGGAGATGATGGAGG
TTGACAGGCGGGTCGAGTCTGAAGAATCCGGCGATGAAGAAGGGAAGAAACACAGCAGTGGCATCGTGGCCGACCTCAGTGAACAGAGCC
TGAAGGATGGGGAGGAGCGGGGGGAGGAGGACCCAGAAGGGTATCAGCTCTGTGATAACAGCGTGGGGGTGCTCTTCAATGACTCAACAC
GCCTCATCCTCTACAATGATGGTGACAGCCTGCAGTACATAGAGCGTGACGGCACTGAGTCCTACCTCACCGTGAGTTCCCATCCCAACT
CCTTGATGAAGAAGATCACCCTCCTTAAATATTTCCGCAATTACATGAGCGAGCACTTGCTGAAGGCAGGTGCCAACATCACGCCGCGCG
AAGGTGATGAGCTCGCCCGGCTGCCCTACCTACGGACCTGGTTCCGCACCCGCAGCGCCATCATCCTGCACCTCAGCAACGGCAGCGTGC
AGATCAACTTCTTCCAGGATCACACCAAGCTCATCTTGTGCCCACTGATGGCAGCCGTGACCTACATCGACGAGAAGCGGGACTTCCGCA
CATACCGCCTGAGTCTCCTGGAGGAGTACGGCTGCTGCAAGGAGCTGGCCAGCCGGCTCCGCTACGCCCGCACTATGGTGGACAAGCTGC
TGAGCTCACGCTCGGCCAGCAACCGTCTCAAGGCCTCCTAATAGCTGCCCTCCCCTCCGGACTGGTGCCCTCCTCACTCCCACCTGCATC
TGGGGCCCATACTGGTTGGCTCCCGCGGTGCCATGTCTGCAGTGTGCCCCCCAGCCCCGGTGGCTGGGCAGAGCTGCATCATCCTTGCAG
GTGGGGGTTGCTGTATAAGTTATTTTTGTACATGTTCGGGTGTGGGTTCTACAGCCTTGTCCCCCTCCCCCTCAACCCCACCATATGAAT

>67935_67935_4_PPP1R7-PLK1_PPP1R7_chr2_242093019_ENST00000407025_PLK1_chr16_23700558_ENST00000300093_length(amino acids)=256AA_BP=76
MRGLRRQIPERGRAANMAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPEGYQLCDNSVGVLFN
DSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP1R7-PLK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP1R7-PLK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP1R7-PLK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource