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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R1A-CENPP (FusionGDB2 ID:67973)

Fusion Gene Summary for PPP2R1A-CENPP

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R1A-CENPP
Fusion gene ID: 67973
HgeneTgene
Gene symbol

PPP2R1A

CENPP

Gene ID

5518

401541

Gene nameprotein phosphatase 2 scaffold subunit Aalphacentromere protein P
SynonymsMRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65ACENP-P
Cytomap

19q13.41

9q22.31

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (Pcentromere protein P
Modification date2020031320200313
UniProtAcc.

Q6IPU0

Ensembl transtripts involved in fusion geneENST00000322088, ENST00000444322, 
ENST00000477989, ENST00000462990, 
ENST00000473455, 		ENST00000375576, 
ENST00000375579, ENST00000375587, 
Fusion gene scores* DoF score10 X 8 X 7=56012 X 10 X 6=720
# samples 1115
** MAII scorelog2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/720*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R1A [Title/Abstract] AND CENPP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R1A(52693427)-CENPP(95373596), # samples:3
Anticipated loss of major functional domain due to fusion event.PPP2R1A-CENPP seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PPP2R1A-CENPP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PPP2R1A-CENPP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP2R1A-CENPP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R1A

GO:0007059

chromosome segregation

16580887


check buttonFusion gene breakpoints across PPP2R1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CENPP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3328-01APPP2R1Achr19

52693427

-CENPPchr9

95373596

+
ChimerDB4KIRCTCGA-A3-3328-01APPP2R1Achr19

52693427

+CENPPchr9

95373596

+


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Fusion Gene ORF analysis for PPP2R1A-CENPP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000322088ENST00000375576PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
Frame-shiftENST00000444322ENST00000375576PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
Frame-shiftENST00000444322ENST00000375579PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
Frame-shiftENST00000444322ENST00000375587PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
Frame-shiftENST00000477989ENST00000375576PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
In-frameENST00000322088ENST00000375579PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
In-frameENST00000322088ENST00000375587PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
In-frameENST00000477989ENST00000375579PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
In-frameENST00000477989ENST00000375587PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
intron-3CDSENST00000462990ENST00000375576PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
intron-3CDSENST00000462990ENST00000375579PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
intron-3CDSENST00000462990ENST00000375587PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
intron-3CDSENST00000473455ENST00000375576PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
intron-3CDSENST00000473455ENST00000375579PPP2R1Achr19

52693427

+CENPPchr9

95373596

+
intron-3CDSENST00000473455ENST00000375587PPP2R1Achr19

52693427

+CENPPchr9

95373596

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000322088PPP2R1Achr1952693427+ENST00000375587CENPPchr995373596+782313671247771215
ENST00000322088PPP2R1Achr1952693427+ENST00000375579CENPPchr995373596+245413658438126
ENST00000477989PPP2R1Achr1952693427+ENST00000375587CENPPchr995373596+77718470727719215
ENST00000477989PPP2R1Achr1952693427+ENST00000375579CENPPchr995373596+2402846386126

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000322088ENST00000375587PPP2R1Achr1952693427+CENPPchr995373596+0.45557840.5444216
ENST00000322088ENST00000375579PPP2R1Achr1952693427+CENPPchr995373596+0.0153846870.98461527
ENST00000477989ENST00000375587PPP2R1Achr1952693427+CENPPchr995373596+0.447523650.5524763
ENST00000477989ENST00000375579PPP2R1Achr1952693427+CENPPchr995373596+0.0133279570.98667204

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Fusion Genomic Features for PPP2R1A-CENPP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP2R1Achr1952693427+CENPPchr995373595+2.82E-070.99999976
PPP2R1Achr1952693427+CENPPchr995373595+2.82E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP2R1A-CENPP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52693427/chr9:95373596)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CENPP

Q6IPU0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16622420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115400_58926590.0RegionNote=PP2A subunit C binding
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+11547_32126590.0RegionNote=Polyoma small and medium T antigens Binding
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+11585_23926590.0RegionNote=SV40 small T antigen binding
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+1158_39926590.0RegionNote=PP2A subunit B binding
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115124_16126590.0RepeatNote=HEAT 4
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115162_20026590.0RepeatNote=HEAT 5
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115201_23926590.0RepeatNote=HEAT 6
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115240_27826590.0RepeatNote=HEAT 7
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115279_32126590.0RepeatNote=HEAT 8
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115322_36026590.0RepeatNote=HEAT 9
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115361_39926590.0RepeatNote=HEAT 10
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115400_43826590.0RepeatNote=HEAT 11
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115439_47726590.0RepeatNote=HEAT 12
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115478_51626590.0RepeatNote=HEAT 13
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+11547_8426590.0RepeatNote=HEAT 2
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115517_55526590.0RepeatNote=HEAT 14
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+115556_58926590.0RepeatNote=HEAT 15
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+11585_12326590.0RepeatNote=HEAT 3
HgenePPP2R1Achr19:52693427chr9:95373596ENST00000322088+1158_4626590.0RepeatNote=HEAT 1
TgeneCENPPchr19:52693427chr9:95373596ENST00000375587481_71188289.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for PPP2R1A-CENPP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67973_67973_1_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000322088_CENPP_chr9_95373596_ENST00000375579_length(transcript)=2454nt_BP=136nt
CCCCCCACGTTTCAGCACAGCGCTGGCCGCAGTCTGACAGGAAAGGGACGGAGCCAAGATGGCGGCGGCCGACGGCGACGACTCGCTGTA
CCCCATCGCGGTGCTCATAGACGAACTCCGCAATGAGGACGTTCAGGAAAAGTACCCAGATGCCGTGTACCTCTCGGAGGGGCCCTCCTC
CTGCTCCATGGGGATCCGCAGCGCCAGCCGGCCAGGGTTTGAATTAGTCATTGTTTGGAGGATACAAATAGATGAAGATGGGAAGGTTTT
TCCAAAGCTGGATCTTCTCACCAAAGTCCCACAGCGAGCCCTGGAGCTGGACAAGAACAGAGCCATAGAAACTGCTCCTCTCAGCTTCCG
AACCCTGGTAGGACTGCTTGGAATCGAAGCTGCTCTGGAAAGCCTGATAAAATCGCTTTGTGCAGAGGAGAACAACTAGTTCCAAAACAG
TGAACGTGGAGGATGAAGATGCTGCGTGGAGGAACATGCAATTTTATTCAATATAAACATTTGCTATTTTCTGCTTAGAAACCACACCCT
GAAGACGTGCTGTCTATGCAGTTATGGCACATTATATGGAAACTCTCATGACATGAAAAATAAATACAACTAGTTAAGTATAAAATGCCA
AATAAAAGTGACACGTACAATGTGGTTTATAAAAATAAGCTTAACATCTGAGAAAATGTACCAAGTGGTTGTGTGTCCTCAGATGTGTGG
GGAGGATCCATCCCCCACCCACTGCAGCCTCACACCGAGTCCACCTTGGACATGGTGGCCACATTACTCAGCTGGGAGAAGCCACCCTTA
TCCTGGTTCCTGCCTCCTGGGGGCTCTGGAGACGGATGCCTATGGCGCCTCATCTTTAAACTGTCCTTAGTAGCCCAGGGGAGCCACACC
CTCACTCCCTGCCTCCCCCCGGTCCGCATGGTGGCACCGTGAGGCAGTCTCAGCAAGTCCTCATGCTGTTCTTGGTCTTCCACAAGAAAG
TGAAGCTGTCAGCTTAATAACAAGAATGGCCTAAGACAGCAAAGACAGCACTGTTCCTGGGCTGGGACGCAAGGAATGAGGTCCTTTATG
AAAGAAAGACCCCCCTGCATAGCCTAAGTGCTATATCGATCGTCCCGGATGTGCCTTAAGAACCGTGACCTCATCAGTCGCCCATTTAGC
ATTGTTAAGATCTGTGAACGCGTGTTGTCTCAAACCAGTCAGGGCCGTCATGACTACGCAGCAGCAGCAGTTTCCAAGACGGGCCAGAAA
CGCATCCACAGCAGTGGCACCCGCGGCTCAGGGGCTCCTCACAGCCCGGGCTGGTGGGAGCCAAGACCAGACAGAGTGGGGGTCTCCATC
TGTTTTCTCTTCTCCCTCAAATACAGGCTGTTTTCATCGTGTCTAGTCCAGCCCTGTCTGGGCCCTGTGCTAGGCAATAACTCTTGCAGC
CCTGAAGGACCTAGGGAGCCCAGCCCACCTTCCCACGGACTGGGGTTCCCTCACATGTGCACTTGAACCCAGGACCCAGCATCCTCCACA
CACCGTGACAATGGGCAAAATCATCCCAAACCAGGCTGCCCCAGCCCCAGCCCAGCAACAGTGAACTCCCTTGGGTCAAGACAGTACTCA
ACGGCCACTACCTCCACGCTTCCCAGAGCCTGCGGCTTGTCCGTGAGCTCCGTGCACTTCACCAAAGCCCCCATCCCAGCACACAGGACC
CGTGTGTATGAGACGGTGTCATTGGAAGTGAGAAGAAAACAGTAAAAGTGTCCAGTTAGATAAGTATCTTTTTGCACCTCTGAGAGTAGA
ATTAGAAGTAAATATGACAGAATTGAACAATAAATTCTAGAAGAGTTGCCTTGATTCAAACAAGTATAATTCTCAAGTTATCACAAAATT
TCCCACAAAAATTTACAATCAGCAAAATAGTTTCCTTATTTCTCATGTATCATTTTCATATAATTCCATGGTTTCACTAATATTATATGT
TACAATAAGCCTCCATTAGTCCCTCAAAACGATGATATAAATAAGTCTGTACAACCTAGCATAGAATAAAAAACTGAAACCAAGATTCCC
AACGTTTTTCATAGCAGCCGGGCACACTTTGGTGACCCCAACGAGAACCCTCTCGGCAGCAGCCAGGAGCTGTTCACCTTCCAGAAGCAG
GGCCTGTGGCAGCCTAACAGGGAGAGGCCACGGGGCCCAAAAACGCAACACGTCTCAAGGCAAACCCGAGGGAGGAACTTGGTCTGGGAG
GAAGAGAGAACTCGCTCCTCAACCACCCCAGACACTGGAGTGTCAGGAAAGCACTGAGCTGTTGGGGCACACTGCCCAGCCCGGCCACAG
CAGCTCAGCCAGTCACAGCTCCACCTCCAACTTCTACAGCAGCAATTTTTAGTGGGAAAGAACAGCTCATCTCCCCCTCATGTGAAAGAT

>67973_67973_1_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000322088_CENPP_chr9_95373596_ENST00000375579_length(amino acids)=126AA_BP=16
MAAADGDDSLYPIAVLIDELRNEDVQEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLTKVPQRALELDKN

--------------------------------------------------------------
>67973_67973_2_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000322088_CENPP_chr9_95373596_ENST00000375587_length(transcript)=7823nt_BP=136nt
CCCCCCACGTTTCAGCACAGCGCTGGCCGCAGTCTGACAGGAAAGGGACGGAGCCAAGATGGCGGCGGCCGACGGCGACGACTCGCTGTA
CCCCATCGCGGTGCTCATAGACGAACTCCGCAATGAGGACGTTCAGGAAAAGTACCCAGATGCCGTGTACCTCTCGGAGGGGCCCTCCTC
CTGCTCCATGGGGATCCGCAGCGCCAGCCGGCCAGGGTTTGAATTAGTCATTGTTTGGAGGATACAAATAGATGAAGATGGGAAGGTTTT
TCCAAAGCTGGATCTTCTCACCAAAGTCCCACAGCGAGCCCTGGAGCTGGACAAGAACAGAGCCATAGAAACTGCTCCTCTCAGCTTCCG
AACCCTGGTAGGACTGCTTGGAATCGAAGCTGCTCTGGAAAGCCTGATAAAATCGCTTTGTGCAGAGGAGAACAACTAGTTCCAAAACAG
TGAACGTGGAGGATGAAGATGCTGCGTGGAGGAACATGCAATTTTATTCAATATAAACATTTGCTATTTTCTGCTTAGAAACCACACCCT
GAAGACGTGCTGTCTATGCAGTTATGGCACATTATATGGAAACTCTCATGACATGAAAAATAAATACAACTAGTTAAGTATAAAATGCCA
AATAAAAGTGACACGTACAATGTGGTTTATAAAAATAAGCTTAACATCTGAGAAAATGTACCAAGTGGTTGTGTGTCCTCAGATGTGTGG
GGAGGATCCATCCCCCACCCACTGCAGCCTCACACCGAGTCCACCTTGGACATGGTGGCCACATTACTCAGCTGGGAGAAGCCACCCTTA
TCCTGGTTCCTGCCTCCTGGGGGCTCTGGAGACGGATGCCTATGGCGCCTCATCTTTAAACTGTCCTTAGTAGCCCAGGGGAGCCACACC
CTCACTCCCTGCCTCCCCCCGGTCCGCATGGTGGCACCGTGAGGCAGTCTCAGCAAGTCCTCATGCTGTTCTTGGTCTTCCACAAGAAAG
TGAAGCTGTCAGCTTAATAACAAGAATGGCCTAAGACAGCAAAGACAGCACTGTTCCTGGGCTGGGACGCAAGGAATGAGGTCCTTTATG
AAAGAAAGACCCCCCTGCATAGCCTAAGTGCTATATCGATCGTCCCGGATGTGCCTTAAGAACCGTGACCTCATCAGTCGCCCATTTAGC
ATTGTTAAGATCTGTGAACGCGTGTTGTCTCAAACCAGTCAGGGCCGTCATGACTACGCAGCAGCAGCAGTTTCCAAGACGGGCCAGAAA
CGCATCCACAGCAGTGGCACCCGCGGCTCAGGGGCTCCTCACAGCCCGGGCTGGTGGGAGCCAAGACCAGACAGAGTGGGGGTCTCCATC
TGTTTTCTCTTCTCCCTCAAATACAGGCTGTTTTCATCGTGTCTAGTCCAGCCCTGTCTGGGCCCTGTGCTAGGCAATAACTCTTGCAGC
CCTGAAGGACCTAGGGAGCCCAGCCCACCTTCCCACGGACTGGGGTTCCCTCACATGTGCACTTGAACCCAGGACCCAGCATCCTCCACA
CACCGTGACAATGGGCAAAATCATCCCAAACCAGGCTGCCCCAGCCCCAGCCCAGCAACAGTGAACTCCCTTGGGTCAAGACAGTACTCA
ACGGCCACTACCTCCACGCTTCCCAGAGCCTGCGGCTTGTCCGTGAGCTCCGTGCACTTCACCAAAGCCCCCATCCCAGCACACAGGACC
CGTGTGTATGAGACGGTGTCATTGGAAGTGAGAAGAAAACAGTAAAAGTGTCCAGTTAGATAAGTATCTTTTTGCACCTCTGAGAGTAGA
ATTAGAAGTAAATATGACAGAATTGAACAATAAATTCTAGAAGAGTTGCCTTGATTCAAACAAGTATAATTCTCAAGTTATCACAAAATT
TCCCACAAAAATTTACAATCAGCAAAATAGTTTCCTTATTTCTCATGTATCATTTTCATATAATTCCATGGTTTCACTAATATTATATGT
TACAATAAGCCTCCATTAGTCCCTCAAAACGATGATATAAATAAGTCTGTACAACCTAGCATAGAATAAAAAACTGAAACCAAGATTCCC
AACGTTTTTCATAGCAGCCGGGCACACTTTGGTGACCCCAACGAGAACCCTCTCGGCAGCAGCCAGGAGCTGTTCACCTTCCAGAAGCAG
GGCCTGTGGCAGCCTAACAGGGAGAGGCCACGGGGCCCAAAAACGCAACACGTCTCAAGGCAAACCCGAGGGAGGAACTTGGTCTGGGAG
GAAGAGAGAACTCGCTCCTCAACCACCCCAGACACTGGAGTGTCAGGAAAGCACTGAGCTGTTGGGGCACACTGCCCAGCCCGGCCACAG
CAGCTCAGCCAGTCACAGCTCCACCTCCAACTTCTACAGCAGCAATTTTTAGTGGGAAAGAACAGCTCATCTCCCCCTCATGTGAAAGAT
TAAATTGTAAAGCAAAAAAAAAAAGGTCAATGCTCGCATGAGTGGTGTCCATCCTGACCTGAGCCTTGCGCTCCCTGCTGCCCTGTGTGG
AACTGTGGGCTTCAGCACCTCCACAGGGACCCTGAGTCTACACTGCTCAGAATCGGCATCTGCGCGACCACGAGGTCACGCTGTGCAGCA
GGGAACCACCTAAAAACCTGTGTTGATATGTGGCTTGCACTGAAAAAGTGACCATGTAACTCAGCTGGGGGAAGTTCCAGTAGTATCCAT
GTTTTCTTAAAAGTCCAAACTGTAAAATGTATGTGACAATTCAAGTTTTCTATGTTAGGAGTCTGGTGGTAGCAGATCCAAACCTTGGGT
CTTAGAATAAGGCTTTTCGCATTAGAGAATCAGACATGAGCCCTGGTTGGGAAAGAAGAACTATCCAGAACGTCTTCCCAGGGCTTAACG
GACACTTCCATTTTAAGAGTGTGAGCAGCTTCCTGGGACACAGCACTCACTTCCTACATTCCTTGTCCAGGAAGTTGTTTCTAGTGCTCT
TCAATTCCATGTCTCCAAGAGGCAATCCCACCTCAAAAGGGGTTAAAAGCAAAAACATTCACAACCAAAGGTCACCCAACACAACAGAAA
ATATCTCTATCATTCAGCCTTCACATTATGTTCAAGTTTCAAAGACACTGCAGGGAAAGAGTTAGACCTTGTGGAGAACTAATGTGCAAT
CTTCGCTTTCCTTGAACCGAGTCGACATCACGGCGTTGTCTTTGGCACGTACAGTCTTTGAATAATAGTTGACGATCTTGCCGTCCAGTT
TATACTGATGGGGAATGCTCTCGTAGGGCTTGAGGTCAAGGTCCAGCACAGACACGGAAAAGGCAAACCTGGACCTCGATGAAGGGACGA
CAGGCCTTTGATCAGAGCTGCAAGTAAAAAGTACCATTTCAGGATACACAAGCCCCCCATTCATTTCCCTCCCTCCCGTTCTCTCTCCCT
TTCTTCTTTCAACTAGTATGTTTTTATGTTTTTTCTTTGACTTCTGCAAAGTTAGATAAATCAATCTCTTTTAAAAGAGAAGTGAATGGC
CTCACACCCCAGCTCACAAAGAGCACTCGTTCTGTGCACCTGTGATCTGTGCGTGTGACAGCTGTCTGTGCCGGCTGTGTGCACCAGCGT
GCAAAGCTTCCTCAGGCCAGTGCACCCCACCATACCAGGCGAGAGAGGGTTAAAGGACTGAAAGATGGAAAAGTAATTATGTGGAACATG
TGAGCGATGTTCCCCCAGCCCAGTGGTATAAACGAACGCTGAAAAATCACTTTATCATGAGCCAAGTATTACAAAACCCAACAAAAAGTA
AAAAGTAGATCTGGCCATTCCAGCGCCAAATGGATGGAATGTCGACAAGCCTTCTTCTTTGCCTCTCCTGTCTGCTGAGAAACGCAAGCT
CCTTTGGTTCACATTTGAAGAGATCTGGTTTCTCATTTTATTCTCAAATTTTATCTTCAGTCCTTTGTATTTTGCTTCTCAGGGCTTAGT
TTTGTGGTTTTAACCTCAGAAGTCGTGTGCTTATAACAAGATGTGATTAATTATTTGCCCTGAAAAACACATTTAGGATTACTCCGAGTC
CTGAGCTCTGACTGCTGTGTGTCCCGCTTTTCGTCTCCGGGCACTCAGCGCACAGCACTCAAGACACTGGCTAAACAAGTGACCTAAGCT
CAGTTCAGTCCAAGAGAAGTATCCTGGGTTCTGGTGTCCCAATGTTTACTACGCTTTGAGATTTAGAAATCAACAAGCCAAACCCCAACT
TCAAAAGCTCCTGCCGAGGAGAGGAAATACTGATCAGCACGTCCCTGCTCTGACGCTGCTCACCATGGCCTTGGCGCTCACTGCTGCCCT
GCCCCAGAATCCTGTTTGTAGAAAAAACAAATCCCTGACTAAGCTGCTGGGGTAAGTAACTATTCTCATCTGAAGAGTAAACAGCAAATA
ACTCATTTACAAATTAAGGTCATGAGTCTCGCTCCAGAAGCTGGAGTGTGCCTGCAGCTCATCCCAAGGGGCCACATTTTATTGGGAGAA
CCTCAGAAGCCCAAGGTACTGCTCAGTTCTGAGGCCTGAGACCCAAGCTGGGTGCACCTGGGCTGGAACAGTCACATCCCCAGCCCATGA
CTAGGGTTACGTATTTTAAAGGACACCCCAATTTCTCAGAAGCAGCACCTGACAAGACCATGGGTGTAAAGACAGGAAGGATGTTCCAGG
CAGCTCCCGGGGAGGGTCTGACTACCTGGGTCAACCACAAGCTAGCTCCATGGGAACCAATGGCAGTGACCAGCGGGCACCAGCTCCTGA
CACAGAAATGCTCTTCTTCCCCCTCAGTACCCCGGAGGCCAAGACTGGGCAAGAGGCCCCAGGGACACACCTGTCCCTTGTGCCACAAGT
GTGCCCTCTAGCAGCCTTGGAGAATGAGGCTCAGGTGGCCTTCTGGCTGCAGGGGGGCAGCCCTTGCCTGGAAGGCCGTTCTCCAGGACA
CTGACCCGCTGGGGGTTACCGGGGGACCAGCAGCCTCCAAGGGTGCTGGGGATCGGGGTGGAGAAGCCAAGGCCGCACACTGTGTTTCAA
ATGGGAGGTCGAGAGGAGCATCAGGGTTTAGGCCGGGAAGCTGTGGCAGCTCTCTCCACAGTTCCAAATTCCCAAAGGGACAAAGCTCTG
CAGCGACAGGAAGGCAGATCCAACTTGAGACATTTTCCTTTATGACAGGGCAGAAACAGTAGTGCAGAGCTGGAGAAGCCTTTATTTTAG
GGGGTGTAAGAAGTTTAAATGTGGTCAATCTATCTGTGAGCTGCAAATTAGTCTAGGGATCTAAATTTAGTCTCAGGTCTACCAGGTATC
TCAAGACGCCAAGATGACTCATGATAAATCCCAGCCTTAGTTTGTCCCTAGGCCTCTAGAGCACCACAGTTACTGGAACTTCACAGGTGC
GGCCACTGCGCACACCTTCCTGGAAGCAGGCCCAGCCCCACACGCCATGTTCTCGGAGGAGAAGCCTTCTCTGAGATCCTCTCCTTTTGT
TGAGAAAGGCCTGGCTAGAGTGCTTTGTGCAGGATGGTTCCAGTGCCTACACCCTAGGTCTGAGAAGCCACATGGCTCAGTGCCTTCAGG
ACATGCCCTCCCCTCCCCTCCTAGTGTCGTTTCTGCTGAGCAGCTGGTCGTAAGGACCCGGGCCTTCAGCTTTCCCCGCATGCTGGCTTT
CCAATTTGACATCACTGACCAGGCACTAAGAGATTCCCAGGTGCTAGACGAGGTGAGTAACATGTCTGTCCTTCAGCGGCCTTTCACAGC
CCACCTAAGGGCACCCTGCATCCAAGCACATTTCCATTGCCCAGCTGCATCCTTGGTCGGGGGGCTGCTGAACAGTGGTATCTTCGTGGG
TTTTCTCTCATCGAACACCACCAGCTTAATCCAGTTAAGGAATTCCTCATAACTTAGCCCTGTAGGTATTTCCTTAGGGGATAACAGGAG
TTTTCAACTAAATAGAACAACCTTTTTTCTACTTCAGTTAGCCCTATAATGTTCCTCAGTATTTCATATTGGAAAGTAAACAATTCTGTG
CCTGCCAGGGAACAGGAATCCTGGGAACTGTTTAGTTCAAAAGCACCGGGAAAGTGAGTGGCTGGCAGCCAGCAACCAAGGTCATCTTGA
CCCAGGAACACATGTTAGAAGAATGTGGAACATTCCGCAAATACTGGGTGCAGGGTTTAGCACCCCTGAAGATCGGTGATGGAGATGCTG
TCTAACGACTATGAGATTATCAGTTTCATCCCGAATTCCCAGAAACAGAGGGGACTGGACAAAACTAGTGACATTAGGGAGAGGGGCGGC
ACATAGGCTGGTTATTCAGAAGAGGAAGCAGAATGAATGCGCGCCTCACAGGCTTTCAAATGACTGTGGTGGTAAAAAGGCAGGTGCGCC
ATGCTGCCACTGTGGGAGACCGAGGAACAAGGGCCACAGGTACCCACACATCTCAGGGGCTGGCTTTCTTTGAGGGAATGCAATGGGCAG
CTCACTGTCCACATTGTTTCTGAGCTCTTGGGAGTATTTTCTTAGAAAACAGTAACTTTCAATGTACTAACAATCCTTTTAAGTTATTCT
CCATAAATCTGTCTTTTGACTGAATTACAAGCTTCTAGAGGGCGAGAGTTAGTAAGCCCCATGATGTCACATAGGCCAAGGAAGTTATGT
CACTCCGCCATGGAGTCTCTAAATATGGGGAAACCAACTATCCTATTAACAATTCACCAACTGTCCATAAAACCCCGTTAGACCCAGGCT
GCATGCCTTGCAGTGGGGGCCTCACCTGGCATCCTGCAGACAGGGAGACAGTGCAATCATGATGGAGCAGTCCTTGGCAGTCATGGCGAC
GCGGTACTGCTGCACCTGCAGGGGCGGGAAAGATCAGCTCCAGGTCACACAGGAAGCCTCTGCCCCCCCACACAACCTTCCTTCCCAGTA
GCCAAGTGTGGGAACTGCTTCCTGCCTCAGAACCTGAGGGTGGGATTAGGAGCGAGGGCCACGGTGAGCACGGGCGTCAGGAGGTCGCCC
TGTGAGAGCACCTGGGCCAGCCCTCAGTGCCACGGGGCTGCTCAGAGGCCAGCACCGCCCCCTGACCTCTCACGGCAAGCAGTGTGGGAC
CCCGACTCCAGACCCTGAGACGGATGATCTGTCTTCAGCAAGGTCACCACAGTCGGCCTTTGGAAGGAAAAGCAGTAAGCCACCTGAGCC
CCGCATGTTGGCCACACTCAGAGTATCAAGTGAGTATCACTCGACACCTGCAAGGAGAGCGCAGGGGGTGTTCAGCAAGGCATCGCTTAG
AACGACATTCCCTCCGGAACATCATACAGCCACCAGAGACAACGGCAGACGGCCACCCTTCTACAGGCTGTGCATGTGTTAACTTGCTCC
ACCCTCACAGCAGCCCAACAGGGCAGCACGGCCGGCGTCCCACTTTACAGACAAGCAACAGACACAGACATCACTTGTCTGTCATGCCCT
GCTTGTCAATGGCAAGGCAGGGACTCAAACCCGGTACGCTGGCTCTGACATTTACACTCTTCAACACATGCTCCAAGCTATGTGGGTCTG
TCCATACTGACCAGGGACAGCTCAACACACACCACACTGTCAGAGTCGACATACGTAAAGCTGTACATGTGCACATGTGTGTGACGCGGG
CAGGGAGAAAGGTGAAGGACAGGCACCACAATGCTCACAACTGTCTCCTCTACAGAGCAGAATGTGAGGCACTCTCTCCTCTTCCTTCTT

>67973_67973_2_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000322088_CENPP_chr9_95373596_ENST00000375587_length(amino acids)=215AA_BP=
MRRMICLQQGHHSRPLEGKAVSHLSPACWPHSEYQVSITRHLQGERRGCSARHRLERHSLRNIIQPPETTADGHPSTGCACVNLLHPHSS
PTGQHGRRPTLQTSNRHRHHLSVMPCLSMARQGLKPGTLALTFTLFNTCSKLCGSVHTDQGQLNTHHTVRVDIRKAVHVHMCVTRAGRKV

--------------------------------------------------------------
>67973_67973_3_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000477989_CENPP_chr9_95373596_ENST00000375579_length(transcript)=2402nt_BP=84nt
GCCAAGATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGAACTCCGCAATGAGGACGTTCAGGAAAAG
TACCCAGATGCCGTGTACCTCTCGGAGGGGCCCTCCTCCTGCTCCATGGGGATCCGCAGCGCCAGCCGGCCAGGGTTTGAATTAGTCATT
GTTTGGAGGATACAAATAGATGAAGATGGGAAGGTTTTTCCAAAGCTGGATCTTCTCACCAAAGTCCCACAGCGAGCCCTGGAGCTGGAC
AAGAACAGAGCCATAGAAACTGCTCCTCTCAGCTTCCGAACCCTGGTAGGACTGCTTGGAATCGAAGCTGCTCTGGAAAGCCTGATAAAA
TCGCTTTGTGCAGAGGAGAACAACTAGTTCCAAAACAGTGAACGTGGAGGATGAAGATGCTGCGTGGAGGAACATGCAATTTTATTCAAT
ATAAACATTTGCTATTTTCTGCTTAGAAACCACACCCTGAAGACGTGCTGTCTATGCAGTTATGGCACATTATATGGAAACTCTCATGAC
ATGAAAAATAAATACAACTAGTTAAGTATAAAATGCCAAATAAAAGTGACACGTACAATGTGGTTTATAAAAATAAGCTTAACATCTGAG
AAAATGTACCAAGTGGTTGTGTGTCCTCAGATGTGTGGGGAGGATCCATCCCCCACCCACTGCAGCCTCACACCGAGTCCACCTTGGACA
TGGTGGCCACATTACTCAGCTGGGAGAAGCCACCCTTATCCTGGTTCCTGCCTCCTGGGGGCTCTGGAGACGGATGCCTATGGCGCCTCA
TCTTTAAACTGTCCTTAGTAGCCCAGGGGAGCCACACCCTCACTCCCTGCCTCCCCCCGGTCCGCATGGTGGCACCGTGAGGCAGTCTCA
GCAAGTCCTCATGCTGTTCTTGGTCTTCCACAAGAAAGTGAAGCTGTCAGCTTAATAACAAGAATGGCCTAAGACAGCAAAGACAGCACT
GTTCCTGGGCTGGGACGCAAGGAATGAGGTCCTTTATGAAAGAAAGACCCCCCTGCATAGCCTAAGTGCTATATCGATCGTCCCGGATGT
GCCTTAAGAACCGTGACCTCATCAGTCGCCCATTTAGCATTGTTAAGATCTGTGAACGCGTGTTGTCTCAAACCAGTCAGGGCCGTCATG
ACTACGCAGCAGCAGCAGTTTCCAAGACGGGCCAGAAACGCATCCACAGCAGTGGCACCCGCGGCTCAGGGGCTCCTCACAGCCCGGGCT
GGTGGGAGCCAAGACCAGACAGAGTGGGGGTCTCCATCTGTTTTCTCTTCTCCCTCAAATACAGGCTGTTTTCATCGTGTCTAGTCCAGC
CCTGTCTGGGCCCTGTGCTAGGCAATAACTCTTGCAGCCCTGAAGGACCTAGGGAGCCCAGCCCACCTTCCCACGGACTGGGGTTCCCTC
ACATGTGCACTTGAACCCAGGACCCAGCATCCTCCACACACCGTGACAATGGGCAAAATCATCCCAAACCAGGCTGCCCCAGCCCCAGCC
CAGCAACAGTGAACTCCCTTGGGTCAAGACAGTACTCAACGGCCACTACCTCCACGCTTCCCAGAGCCTGCGGCTTGTCCGTGAGCTCCG
TGCACTTCACCAAAGCCCCCATCCCAGCACACAGGACCCGTGTGTATGAGACGGTGTCATTGGAAGTGAGAAGAAAACAGTAAAAGTGTC
CAGTTAGATAAGTATCTTTTTGCACCTCTGAGAGTAGAATTAGAAGTAAATATGACAGAATTGAACAATAAATTCTAGAAGAGTTGCCTT
GATTCAAACAAGTATAATTCTCAAGTTATCACAAAATTTCCCACAAAAATTTACAATCAGCAAAATAGTTTCCTTATTTCTCATGTATCA
TTTTCATATAATTCCATGGTTTCACTAATATTATATGTTACAATAAGCCTCCATTAGTCCCTCAAAACGATGATATAAATAAGTCTGTAC
AACCTAGCATAGAATAAAAAACTGAAACCAAGATTCCCAACGTTTTTCATAGCAGCCGGGCACACTTTGGTGACCCCAACGAGAACCCTC
TCGGCAGCAGCCAGGAGCTGTTCACCTTCCAGAAGCAGGGCCTGTGGCAGCCTAACAGGGAGAGGCCACGGGGCCCAAAAACGCAACACG
TCTCAAGGCAAACCCGAGGGAGGAACTTGGTCTGGGAGGAAGAGAGAACTCGCTCCTCAACCACCCCAGACACTGGAGTGTCAGGAAAGC
ACTGAGCTGTTGGGGCACACTGCCCAGCCCGGCCACAGCAGCTCAGCCAGTCACAGCTCCACCTCCAACTTCTACAGCAGCAATTTTTAG

>67973_67973_3_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000477989_CENPP_chr9_95373596_ENST00000375579_length(amino acids)=126AA_BP=16
MAAADGDDSLYPIAVLIDELRNEDVQEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLTKVPQRALELDKN

--------------------------------------------------------------
>67973_67973_4_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000477989_CENPP_chr9_95373596_ENST00000375587_length(transcript)=7771nt_BP=84nt
GCCAAGATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGAACTCCGCAATGAGGACGTTCAGGAAAAG
TACCCAGATGCCGTGTACCTCTCGGAGGGGCCCTCCTCCTGCTCCATGGGGATCCGCAGCGCCAGCCGGCCAGGGTTTGAATTAGTCATT
GTTTGGAGGATACAAATAGATGAAGATGGGAAGGTTTTTCCAAAGCTGGATCTTCTCACCAAAGTCCCACAGCGAGCCCTGGAGCTGGAC
AAGAACAGAGCCATAGAAACTGCTCCTCTCAGCTTCCGAACCCTGGTAGGACTGCTTGGAATCGAAGCTGCTCTGGAAAGCCTGATAAAA
TCGCTTTGTGCAGAGGAGAACAACTAGTTCCAAAACAGTGAACGTGGAGGATGAAGATGCTGCGTGGAGGAACATGCAATTTTATTCAAT
ATAAACATTTGCTATTTTCTGCTTAGAAACCACACCCTGAAGACGTGCTGTCTATGCAGTTATGGCACATTATATGGAAACTCTCATGAC
ATGAAAAATAAATACAACTAGTTAAGTATAAAATGCCAAATAAAAGTGACACGTACAATGTGGTTTATAAAAATAAGCTTAACATCTGAG
AAAATGTACCAAGTGGTTGTGTGTCCTCAGATGTGTGGGGAGGATCCATCCCCCACCCACTGCAGCCTCACACCGAGTCCACCTTGGACA
TGGTGGCCACATTACTCAGCTGGGAGAAGCCACCCTTATCCTGGTTCCTGCCTCCTGGGGGCTCTGGAGACGGATGCCTATGGCGCCTCA
TCTTTAAACTGTCCTTAGTAGCCCAGGGGAGCCACACCCTCACTCCCTGCCTCCCCCCGGTCCGCATGGTGGCACCGTGAGGCAGTCTCA
GCAAGTCCTCATGCTGTTCTTGGTCTTCCACAAGAAAGTGAAGCTGTCAGCTTAATAACAAGAATGGCCTAAGACAGCAAAGACAGCACT
GTTCCTGGGCTGGGACGCAAGGAATGAGGTCCTTTATGAAAGAAAGACCCCCCTGCATAGCCTAAGTGCTATATCGATCGTCCCGGATGT
GCCTTAAGAACCGTGACCTCATCAGTCGCCCATTTAGCATTGTTAAGATCTGTGAACGCGTGTTGTCTCAAACCAGTCAGGGCCGTCATG
ACTACGCAGCAGCAGCAGTTTCCAAGACGGGCCAGAAACGCATCCACAGCAGTGGCACCCGCGGCTCAGGGGCTCCTCACAGCCCGGGCT
GGTGGGAGCCAAGACCAGACAGAGTGGGGGTCTCCATCTGTTTTCTCTTCTCCCTCAAATACAGGCTGTTTTCATCGTGTCTAGTCCAGC
CCTGTCTGGGCCCTGTGCTAGGCAATAACTCTTGCAGCCCTGAAGGACCTAGGGAGCCCAGCCCACCTTCCCACGGACTGGGGTTCCCTC
ACATGTGCACTTGAACCCAGGACCCAGCATCCTCCACACACCGTGACAATGGGCAAAATCATCCCAAACCAGGCTGCCCCAGCCCCAGCC
CAGCAACAGTGAACTCCCTTGGGTCAAGACAGTACTCAACGGCCACTACCTCCACGCTTCCCAGAGCCTGCGGCTTGTCCGTGAGCTCCG
TGCACTTCACCAAAGCCCCCATCCCAGCACACAGGACCCGTGTGTATGAGACGGTGTCATTGGAAGTGAGAAGAAAACAGTAAAAGTGTC
CAGTTAGATAAGTATCTTTTTGCACCTCTGAGAGTAGAATTAGAAGTAAATATGACAGAATTGAACAATAAATTCTAGAAGAGTTGCCTT
GATTCAAACAAGTATAATTCTCAAGTTATCACAAAATTTCCCACAAAAATTTACAATCAGCAAAATAGTTTCCTTATTTCTCATGTATCA
TTTTCATATAATTCCATGGTTTCACTAATATTATATGTTACAATAAGCCTCCATTAGTCCCTCAAAACGATGATATAAATAAGTCTGTAC
AACCTAGCATAGAATAAAAAACTGAAACCAAGATTCCCAACGTTTTTCATAGCAGCCGGGCACACTTTGGTGACCCCAACGAGAACCCTC
TCGGCAGCAGCCAGGAGCTGTTCACCTTCCAGAAGCAGGGCCTGTGGCAGCCTAACAGGGAGAGGCCACGGGGCCCAAAAACGCAACACG
TCTCAAGGCAAACCCGAGGGAGGAACTTGGTCTGGGAGGAAGAGAGAACTCGCTCCTCAACCACCCCAGACACTGGAGTGTCAGGAAAGC
ACTGAGCTGTTGGGGCACACTGCCCAGCCCGGCCACAGCAGCTCAGCCAGTCACAGCTCCACCTCCAACTTCTACAGCAGCAATTTTTAG
TGGGAAAGAACAGCTCATCTCCCCCTCATGTGAAAGATTAAATTGTAAAGCAAAAAAAAAAAGGTCAATGCTCGCATGAGTGGTGTCCAT
CCTGACCTGAGCCTTGCGCTCCCTGCTGCCCTGTGTGGAACTGTGGGCTTCAGCACCTCCACAGGGACCCTGAGTCTACACTGCTCAGAA
TCGGCATCTGCGCGACCACGAGGTCACGCTGTGCAGCAGGGAACCACCTAAAAACCTGTGTTGATATGTGGCTTGCACTGAAAAAGTGAC
CATGTAACTCAGCTGGGGGAAGTTCCAGTAGTATCCATGTTTTCTTAAAAGTCCAAACTGTAAAATGTATGTGACAATTCAAGTTTTCTA
TGTTAGGAGTCTGGTGGTAGCAGATCCAAACCTTGGGTCTTAGAATAAGGCTTTTCGCATTAGAGAATCAGACATGAGCCCTGGTTGGGA
AAGAAGAACTATCCAGAACGTCTTCCCAGGGCTTAACGGACACTTCCATTTTAAGAGTGTGAGCAGCTTCCTGGGACACAGCACTCACTT
CCTACATTCCTTGTCCAGGAAGTTGTTTCTAGTGCTCTTCAATTCCATGTCTCCAAGAGGCAATCCCACCTCAAAAGGGGTTAAAAGCAA
AAACATTCACAACCAAAGGTCACCCAACACAACAGAAAATATCTCTATCATTCAGCCTTCACATTATGTTCAAGTTTCAAAGACACTGCA
GGGAAAGAGTTAGACCTTGTGGAGAACTAATGTGCAATCTTCGCTTTCCTTGAACCGAGTCGACATCACGGCGTTGTCTTTGGCACGTAC
AGTCTTTGAATAATAGTTGACGATCTTGCCGTCCAGTTTATACTGATGGGGAATGCTCTCGTAGGGCTTGAGGTCAAGGTCCAGCACAGA
CACGGAAAAGGCAAACCTGGACCTCGATGAAGGGACGACAGGCCTTTGATCAGAGCTGCAAGTAAAAAGTACCATTTCAGGATACACAAG
CCCCCCATTCATTTCCCTCCCTCCCGTTCTCTCTCCCTTTCTTCTTTCAACTAGTATGTTTTTATGTTTTTTCTTTGACTTCTGCAAAGT
TAGATAAATCAATCTCTTTTAAAAGAGAAGTGAATGGCCTCACACCCCAGCTCACAAAGAGCACTCGTTCTGTGCACCTGTGATCTGTGC
GTGTGACAGCTGTCTGTGCCGGCTGTGTGCACCAGCGTGCAAAGCTTCCTCAGGCCAGTGCACCCCACCATACCAGGCGAGAGAGGGTTA
AAGGACTGAAAGATGGAAAAGTAATTATGTGGAACATGTGAGCGATGTTCCCCCAGCCCAGTGGTATAAACGAACGCTGAAAAATCACTT
TATCATGAGCCAAGTATTACAAAACCCAACAAAAAGTAAAAAGTAGATCTGGCCATTCCAGCGCCAAATGGATGGAATGTCGACAAGCCT
TCTTCTTTGCCTCTCCTGTCTGCTGAGAAACGCAAGCTCCTTTGGTTCACATTTGAAGAGATCTGGTTTCTCATTTTATTCTCAAATTTT
ATCTTCAGTCCTTTGTATTTTGCTTCTCAGGGCTTAGTTTTGTGGTTTTAACCTCAGAAGTCGTGTGCTTATAACAAGATGTGATTAATT
ATTTGCCCTGAAAAACACATTTAGGATTACTCCGAGTCCTGAGCTCTGACTGCTGTGTGTCCCGCTTTTCGTCTCCGGGCACTCAGCGCA
CAGCACTCAAGACACTGGCTAAACAAGTGACCTAAGCTCAGTTCAGTCCAAGAGAAGTATCCTGGGTTCTGGTGTCCCAATGTTTACTAC
GCTTTGAGATTTAGAAATCAACAAGCCAAACCCCAACTTCAAAAGCTCCTGCCGAGGAGAGGAAATACTGATCAGCACGTCCCTGCTCTG
ACGCTGCTCACCATGGCCTTGGCGCTCACTGCTGCCCTGCCCCAGAATCCTGTTTGTAGAAAAAACAAATCCCTGACTAAGCTGCTGGGG
TAAGTAACTATTCTCATCTGAAGAGTAAACAGCAAATAACTCATTTACAAATTAAGGTCATGAGTCTCGCTCCAGAAGCTGGAGTGTGCC
TGCAGCTCATCCCAAGGGGCCACATTTTATTGGGAGAACCTCAGAAGCCCAAGGTACTGCTCAGTTCTGAGGCCTGAGACCCAAGCTGGG
TGCACCTGGGCTGGAACAGTCACATCCCCAGCCCATGACTAGGGTTACGTATTTTAAAGGACACCCCAATTTCTCAGAAGCAGCACCTGA
CAAGACCATGGGTGTAAAGACAGGAAGGATGTTCCAGGCAGCTCCCGGGGAGGGTCTGACTACCTGGGTCAACCACAAGCTAGCTCCATG
GGAACCAATGGCAGTGACCAGCGGGCACCAGCTCCTGACACAGAAATGCTCTTCTTCCCCCTCAGTACCCCGGAGGCCAAGACTGGGCAA
GAGGCCCCAGGGACACACCTGTCCCTTGTGCCACAAGTGTGCCCTCTAGCAGCCTTGGAGAATGAGGCTCAGGTGGCCTTCTGGCTGCAG
GGGGGCAGCCCTTGCCTGGAAGGCCGTTCTCCAGGACACTGACCCGCTGGGGGTTACCGGGGGACCAGCAGCCTCCAAGGGTGCTGGGGA
TCGGGGTGGAGAAGCCAAGGCCGCACACTGTGTTTCAAATGGGAGGTCGAGAGGAGCATCAGGGTTTAGGCCGGGAAGCTGTGGCAGCTC
TCTCCACAGTTCCAAATTCCCAAAGGGACAAAGCTCTGCAGCGACAGGAAGGCAGATCCAACTTGAGACATTTTCCTTTATGACAGGGCA
GAAACAGTAGTGCAGAGCTGGAGAAGCCTTTATTTTAGGGGGTGTAAGAAGTTTAAATGTGGTCAATCTATCTGTGAGCTGCAAATTAGT
CTAGGGATCTAAATTTAGTCTCAGGTCTACCAGGTATCTCAAGACGCCAAGATGACTCATGATAAATCCCAGCCTTAGTTTGTCCCTAGG
CCTCTAGAGCACCACAGTTACTGGAACTTCACAGGTGCGGCCACTGCGCACACCTTCCTGGAAGCAGGCCCAGCCCCACACGCCATGTTC
TCGGAGGAGAAGCCTTCTCTGAGATCCTCTCCTTTTGTTGAGAAAGGCCTGGCTAGAGTGCTTTGTGCAGGATGGTTCCAGTGCCTACAC
CCTAGGTCTGAGAAGCCACATGGCTCAGTGCCTTCAGGACATGCCCTCCCCTCCCCTCCTAGTGTCGTTTCTGCTGAGCAGCTGGTCGTA
AGGACCCGGGCCTTCAGCTTTCCCCGCATGCTGGCTTTCCAATTTGACATCACTGACCAGGCACTAAGAGATTCCCAGGTGCTAGACGAG
GTGAGTAACATGTCTGTCCTTCAGCGGCCTTTCACAGCCCACCTAAGGGCACCCTGCATCCAAGCACATTTCCATTGCCCAGCTGCATCC
TTGGTCGGGGGGCTGCTGAACAGTGGTATCTTCGTGGGTTTTCTCTCATCGAACACCACCAGCTTAATCCAGTTAAGGAATTCCTCATAA
CTTAGCCCTGTAGGTATTTCCTTAGGGGATAACAGGAGTTTTCAACTAAATAGAACAACCTTTTTTCTACTTCAGTTAGCCCTATAATGT
TCCTCAGTATTTCATATTGGAAAGTAAACAATTCTGTGCCTGCCAGGGAACAGGAATCCTGGGAACTGTTTAGTTCAAAAGCACCGGGAA
AGTGAGTGGCTGGCAGCCAGCAACCAAGGTCATCTTGACCCAGGAACACATGTTAGAAGAATGTGGAACATTCCGCAAATACTGGGTGCA
GGGTTTAGCACCCCTGAAGATCGGTGATGGAGATGCTGTCTAACGACTATGAGATTATCAGTTTCATCCCGAATTCCCAGAAACAGAGGG
GACTGGACAAAACTAGTGACATTAGGGAGAGGGGCGGCACATAGGCTGGTTATTCAGAAGAGGAAGCAGAATGAATGCGCGCCTCACAGG
CTTTCAAATGACTGTGGTGGTAAAAAGGCAGGTGCGCCATGCTGCCACTGTGGGAGACCGAGGAACAAGGGCCACAGGTACCCACACATC
TCAGGGGCTGGCTTTCTTTGAGGGAATGCAATGGGCAGCTCACTGTCCACATTGTTTCTGAGCTCTTGGGAGTATTTTCTTAGAAAACAG
TAACTTTCAATGTACTAACAATCCTTTTAAGTTATTCTCCATAAATCTGTCTTTTGACTGAATTACAAGCTTCTAGAGGGCGAGAGTTAG
TAAGCCCCATGATGTCACATAGGCCAAGGAAGTTATGTCACTCCGCCATGGAGTCTCTAAATATGGGGAAACCAACTATCCTATTAACAA
TTCACCAACTGTCCATAAAACCCCGTTAGACCCAGGCTGCATGCCTTGCAGTGGGGGCCTCACCTGGCATCCTGCAGACAGGGAGACAGT
GCAATCATGATGGAGCAGTCCTTGGCAGTCATGGCGACGCGGTACTGCTGCACCTGCAGGGGCGGGAAAGATCAGCTCCAGGTCACACAG
GAAGCCTCTGCCCCCCCACACAACCTTCCTTCCCAGTAGCCAAGTGTGGGAACTGCTTCCTGCCTCAGAACCTGAGGGTGGGATTAGGAG
CGAGGGCCACGGTGAGCACGGGCGTCAGGAGGTCGCCCTGTGAGAGCACCTGGGCCAGCCCTCAGTGCCACGGGGCTGCTCAGAGGCCAG
CACCGCCCCCTGACCTCTCACGGCAAGCAGTGTGGGACCCCGACTCCAGACCCTGAGACGGATGATCTGTCTTCAGCAAGGTCACCACAG
TCGGCCTTTGGAAGGAAAAGCAGTAAGCCACCTGAGCCCCGCATGTTGGCCACACTCAGAGTATCAAGTGAGTATCACTCGACACCTGCA
AGGAGAGCGCAGGGGGTGTTCAGCAAGGCATCGCTTAGAACGACATTCCCTCCGGAACATCATACAGCCACCAGAGACAACGGCAGACGG
CCACCCTTCTACAGGCTGTGCATGTGTTAACTTGCTCCACCCTCACAGCAGCCCAACAGGGCAGCACGGCCGGCGTCCCACTTTACAGAC
AAGCAACAGACACAGACATCACTTGTCTGTCATGCCCTGCTTGTCAATGGCAAGGCAGGGACTCAAACCCGGTACGCTGGCTCTGACATT
TACACTCTTCAACACATGCTCCAAGCTATGTGGGTCTGTCCATACTGACCAGGGACAGCTCAACACACACCACACTGTCAGAGTCGACAT
ACGTAAAGCTGTACATGTGCACATGTGTGTGACGCGGGCAGGGAGAAAGGTGAAGGACAGGCACCACAATGCTCACAACTGTCTCCTCTA
CAGAGCAGAATGTGAGGCACTCTCTCCTCTTCCTTCTTTGGACTTTCATATATGGTTTGCATTGTTTTAGATGGCATAGCTCTCGCTTTC

>67973_67973_4_PPP2R1A-CENPP_PPP2R1A_chr19_52693427_ENST00000477989_CENPP_chr9_95373596_ENST00000375587_length(amino acids)=215AA_BP=
MRRMICLQQGHHSRPLEGKAVSHLSPACWPHSEYQVSITRHLQGERRGCSARHRLERHSLRNIIQPPETTADGHPSTGCACVNLLHPHSS
PTGQHGRRPTLQTSNRHRHHLSVMPCLSMARQGLKPGTLALTFTLFNTCSKLCGSVHTDQGQLNTHHTVRVDIRKAVHVHMCVTRAGRKV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP2R1A-CENPP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R1A-CENPP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R1A-CENPP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource