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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R1A-PPP2R1A (FusionGDB2 ID:67976)

Fusion Gene Summary for PPP2R1A-PPP2R1A

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R1A-PPP2R1A
Fusion gene ID: 67976
HgeneTgene
Gene symbol

PPP2R1A

PPP2R1A

Gene ID

5518

5518

Gene nameprotein phosphatase 2 scaffold subunit Aalphaprotein phosphatase 2 scaffold subunit Aalpha
SynonymsMRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65AMRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65A
Cytomap

19q13.41

19q13.41

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (Pserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (P
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000322088, ENST00000444322, 
ENST00000462990, ENST00000473455, 
ENST00000477989, 		ENST00000462990, 
ENST00000473455, ENST00000477989, 
ENST00000322088, ENST00000444322, 
Fusion gene scores* DoF score10 X 8 X 7=56010 X 12 X 4=480
# samples 1112
** MAII scorelog2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R1A [Title/Abstract] AND PPP2R1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R1A(52716252)-PPP2R1A(52719071), # samples:1
PPP2R1A(52724323)-PPP2R1A(52716038), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP2R1A-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PPP2R1A-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PPP2R1A-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP2R1A-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PPP2R1A-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PPP2R1A-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R1A

GO:0007059

chromosome segregation

16580887

TgenePPP2R1A

GO:0007059

chromosome segregation

16580887


check buttonFusion gene breakpoints across PPP2R1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW473090PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
ChiTaRS5.0N/ACN418097PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+


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Fusion Gene ORF analysis for PPP2R1A-PPP2R1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000322088ENST00000462990PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000322088ENST00000462990PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000322088ENST00000473455PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000322088ENST00000473455PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000322088ENST00000477989PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000322088ENST00000477989PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000444322ENST00000462990PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000444322ENST00000462990PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000444322ENST00000473455PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000444322ENST00000473455PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000444322ENST00000477989PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000444322ENST00000477989PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000462990ENST00000462990PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000462990ENST00000462990PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000462990ENST00000473455PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000462990ENST00000473455PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
5CDS-intronENST00000462990ENST00000477989PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
5CDS-intronENST00000462990ENST00000477989PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
Frame-shiftENST00000322088ENST00000322088PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
Frame-shiftENST00000322088ENST00000444322PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
Frame-shiftENST00000444322ENST00000322088PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
Frame-shiftENST00000444322ENST00000444322PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
Frame-shiftENST00000462990ENST00000322088PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
Frame-shiftENST00000462990ENST00000444322PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
In-frameENST00000322088ENST00000322088PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
In-frameENST00000322088ENST00000444322PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
In-frameENST00000444322ENST00000322088PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
In-frameENST00000444322ENST00000444322PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
In-frameENST00000462990ENST00000322088PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
In-frameENST00000462990ENST00000444322PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-3CDSENST00000473455ENST00000322088PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-3CDSENST00000473455ENST00000322088PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-3CDSENST00000473455ENST00000444322PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-3CDSENST00000473455ENST00000444322PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-3CDSENST00000477989ENST00000322088PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-3CDSENST00000477989ENST00000322088PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-3CDSENST00000477989ENST00000444322PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-3CDSENST00000477989ENST00000444322PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-intronENST00000473455ENST00000462990PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-intronENST00000473455ENST00000462990PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-intronENST00000473455ENST00000473455PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-intronENST00000473455ENST00000473455PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-intronENST00000473455ENST00000477989PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-intronENST00000473455ENST00000477989PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-intronENST00000477989ENST00000462990PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-intronENST00000477989ENST00000462990PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-intronENST00000477989ENST00000473455PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-intronENST00000477989ENST00000473455PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+
intron-intronENST00000477989ENST00000477989PPP2R1Achr19

52716252

-PPP2R1Achr19

52719071

+
intron-intronENST00000477989ENST00000477989PPP2R1Achr19

52724323

+PPP2R1Achr19

52716038

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP2R1A-PPP2R1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP2R1A-PPP2R1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52716252/chr19:52719071)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015400_5890590.0RegionNote=PP2A subunit C binding
TgenePPP2R1Achr19:52716252chr19:52719071ENST0000032208801547_3210590.0RegionNote=Polyoma small and medium T antigens Binding
TgenePPP2R1Achr19:52716252chr19:52719071ENST0000032208801585_2390590.0RegionNote=SV40 small T antigen binding
TgenePPP2R1Achr19:52716252chr19:52719071ENST000003220880158_3990590.0RegionNote=PP2A subunit B binding
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015124_1610590.0RepeatNote=HEAT 4
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015162_2000590.0RepeatNote=HEAT 5
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015201_2390590.0RepeatNote=HEAT 6
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015240_2780590.0RepeatNote=HEAT 7
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015279_3210590.0RepeatNote=HEAT 8
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015322_3600590.0RepeatNote=HEAT 9
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015361_3990590.0RepeatNote=HEAT 10
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015400_4380590.0RepeatNote=HEAT 11
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015439_4770590.0RepeatNote=HEAT 12
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015478_5160590.0RepeatNote=HEAT 13
TgenePPP2R1Achr19:52716252chr19:52719071ENST0000032208801547_840590.0RepeatNote=HEAT 2
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015517_5550590.0RepeatNote=HEAT 14
TgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088015556_5890590.0RepeatNote=HEAT 15
TgenePPP2R1Achr19:52716252chr19:52719071ENST0000032208801585_1230590.0RepeatNote=HEAT 3
TgenePPP2R1Achr19:52716252chr19:52719071ENST000003220880158_460590.0RepeatNote=HEAT 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115400_5890590.0RegionNote=PP2A subunit C binding
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-11547_3210590.0RegionNote=Polyoma small and medium T antigens Binding
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-11585_2390590.0RegionNote=SV40 small T antigen binding
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-1158_3990590.0RegionNote=PP2A subunit B binding
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115124_1610590.0RepeatNote=HEAT 4
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115162_2000590.0RepeatNote=HEAT 5
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115201_2390590.0RepeatNote=HEAT 6
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115240_2780590.0RepeatNote=HEAT 7
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115279_3210590.0RepeatNote=HEAT 8
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115322_3600590.0RepeatNote=HEAT 9
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115361_3990590.0RepeatNote=HEAT 10
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115400_4380590.0RepeatNote=HEAT 11
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115439_4770590.0RepeatNote=HEAT 12
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115478_5160590.0RepeatNote=HEAT 13
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-11547_840590.0RepeatNote=HEAT 2
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115517_5550590.0RepeatNote=HEAT 14
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-115556_5890590.0RepeatNote=HEAT 15
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-11585_1230590.0RepeatNote=HEAT 3
HgenePPP2R1Achr19:52716252chr19:52719071ENST00000322088-1158_460590.0RepeatNote=HEAT 1


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Fusion Gene Sequence for PPP2R1A-PPP2R1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP2R1A-PPP2R1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R1A-PPP2R1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R1A-PPP2R1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource