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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R2A-DHTKD1 (FusionGDB2 ID:67995)

Fusion Gene Summary for PPP2R2A-DHTKD1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2A-DHTKD1
Fusion gene ID: 67995
HgeneTgene
Gene symbol

PPP2R2A

DHTKD1

Gene ID

5520

55526

Gene nameprotein phosphatase 2 regulatory subunit Balphadehydrogenase E1 and transketolase domain containing 1
SynonymsB55A|B55ALPHA|PR52A|PR55A|PR55alphaAMOXAD|CMT2Q
Cytomap

8p21.2

10p14

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformprotein phosphatase 2, regulatory subunit B, alphaprobable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialdehydrogenase E1 and transketolase domain-containing protein 1
Modification date2020032720200328
UniProtAcc.

Q96HY7

Ensembl transtripts involved in fusion geneENST00000523473, ENST00000315985, 
ENST00000380737, 		ENST00000263035, 
ENST00000465617, 
Fusion gene scores* DoF score17 X 13 X 9=19898 X 10 X 2=160
# samples 2910
** MAII scorelog2(29/1989*10)=-2.77791847081881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R2A [Title/Abstract] AND DHTKD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R2A(26151256)-DHTKD1(12123471), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R2A

GO:0006470

protein dephosphorylation

1849734


check buttonFusion gene breakpoints across PPP2R2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DHTKD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2288-01APPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
ChimerDB4OVTCGA-24-2288PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+


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Fusion Gene ORF analysis for PPP2R2A-DHTKD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000523473ENST00000263035PPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
3UTR-3CDSENST00000523473ENST00000263035PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+
3UTR-intronENST00000523473ENST00000465617PPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
3UTR-intronENST00000523473ENST00000465617PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+
5CDS-intronENST00000315985ENST00000465617PPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
5CDS-intronENST00000315985ENST00000465617PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+
5CDS-intronENST00000380737ENST00000465617PPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
5CDS-intronENST00000380737ENST00000465617PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+
In-frameENST00000315985ENST00000263035PPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
In-frameENST00000315985ENST00000263035PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+
In-frameENST00000380737ENST00000263035PPP2R2Achr8

26151256

+DHTKD1chr10

12123471

+
In-frameENST00000380737ENST00000263035PPP2R2Achr8

26151256

+DHTKD1chr10

12123470

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380737PPP2R2Achr826151256+ENST00000263035DHTKD1chr1012123471+53544113173016899
ENST00000315985PPP2R2Achr826151256+ENST00000263035DHTKD1chr1012123471+5086143312748905
ENST00000380737PPP2R2Achr826151256+ENST00000263035DHTKD1chr1012123470+53544113173016899
ENST00000315985PPP2R2Achr826151256+ENST00000263035DHTKD1chr1012123470+5086143312748905

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380737ENST00000263035PPP2R2Achr826151256+DHTKD1chr1012123471+0.000390670.9996094
ENST00000315985ENST00000263035PPP2R2Achr826151256+DHTKD1chr1012123471+0.0003359870.99966407
ENST00000380737ENST00000263035PPP2R2Achr826151256+DHTKD1chr1012123470+0.000390670.9996094
ENST00000315985ENST00000263035PPP2R2Achr826151256+DHTKD1chr1012123470+0.0003359870.99966407

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Fusion Genomic Features for PPP2R2A-DHTKD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP2R2Achr826151256+DHTKD1chr1012123470+5.52E-111
PPP2R2Achr826151256+DHTKD1chr1012123470+5.52E-111
PPP2R2Achr826151256+DHTKD1chr1012123470+5.52E-111
PPP2R2Achr826151256+DHTKD1chr1012123470+5.52E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP2R2A-DHTKD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:26151256/chr10:12123471)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DHTKD1

Q96HY7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+210175_21337458.0RepeatNote=WD 3
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+210224_26437458.0RepeatNote=WD 4
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+21026_6537458.0RepeatNote=WD 1
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+210283_32137458.0RepeatNote=WD 5
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+210338_37937458.0RepeatNote=WD 6
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+210414_44637458.0RepeatNote=WD 7
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000315985+21091_13237458.0RepeatNote=WD 2
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+210175_21327448.0RepeatNote=WD 3
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+210224_26427448.0RepeatNote=WD 4
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+21026_6527448.0RepeatNote=WD 1
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+210283_32127448.0RepeatNote=WD 5
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+210338_37927448.0RepeatNote=WD 6
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+210414_44627448.0RepeatNote=WD 7
HgenePPP2R2Achr8:26151256chr10:12123470ENST00000380737+21091_13227448.0RepeatNote=WD 2
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+210175_21337458.0RepeatNote=WD 3
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+210224_26437458.0RepeatNote=WD 4
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+21026_6537458.0RepeatNote=WD 1
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+210283_32137458.0RepeatNote=WD 5
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+210338_37937458.0RepeatNote=WD 6
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+210414_44637458.0RepeatNote=WD 7
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000315985+21091_13237458.0RepeatNote=WD 2
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+210175_21327448.0RepeatNote=WD 3
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+210224_26427448.0RepeatNote=WD 4
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+21026_6527448.0RepeatNote=WD 1
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+210283_32127448.0RepeatNote=WD 5
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+210338_37927448.0RepeatNote=WD 6
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+210414_44627448.0RepeatNote=WD 7
HgenePPP2R2Achr8:26151256chr10:12123471ENST00000380737+21091_13227448.0RepeatNote=WD 2


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Fusion Gene Sequence for PPP2R2A-DHTKD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>67995_67995_1_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000315985_DHTKD1_chr10_12123470_ENST00000263035_length(transcript)=5086nt_BP=143nt
ATATGAATCATTACTCCTTACCCAGGCAGTAATGTTCCCGAAGTTTTCTCTTCGTTCTATGTTTCATGGAGCTGGAGGAGGGAATGATAT
TCAGTGGTGTTTTTCTCAGGTGAAAGGAGCAGTAGATGATGATGTAGCAGAAGTTGATCATGGCCTTGCCAGGTTGGTGACAGTATATTG
TGAGCATGGTCATAAAGCTGCCAAAATCAACCCCCTCTTCACCGGACAAGCCCTGCTGGAGAATGTGCCTGAAATCCAAGCCCTGGTGCA
GACACTGCAGGGACCCTTCCACACGGCAGGATTATTGAACATGGGGAAGGAAGAGGCCTCACTTGAGGAAGTGTTAGTCTATCTCAATCA
AATCTACTGTGGGCAGATTTCTATTGAAACCTCCCAACTTCAGAGCCAGGATGAGAAAGACTGGTTTGCCAAGCGGTTTGAGGAACTGCA
AAAGGAGACGTTTACCACAGAAGAGCGAAAACATCTGTCGAAACTAATGCTGGAATCTCAGGAGTTTGACCACTTTCTGGCCACCAAGTT
CTCGACAGTGAAGCGATATGGAGGCGAAGGGGCTGAAAGCATGATGGGCTTTTTCCACGAGCTGCTGAAAATGTCGGCCTACAGCGGGAT
CACTGATGTCATTATTGGGATGCCCCATAGAGGGAGGCTGAATTTATTGACAGGCCTTCTGCAGTTCCCTCCAGAGCTGATGTTCCGTAA
AATGCGAGGCTTAAGTGAATTTCCAGAGAATTTCTCAGCCACTGGAGACGTCCTGTCTCACCTGACCTCCTCTGTGGACCTGTACTTTGG
GGCGCACCATCCCCTCCATGTGACAATGTTGCCCAATCCCTCGCACCTGGAGGCCGTCAACCCCGTGGCCGTGGGCAAAACTCGCGGCAG
GCAGCAGTCTCGCCAAGACGGCGATTACTCTCCAGACAACTCAGCCCAGCCGGGGGACAGGGTCATTTGCTTACAGGTCCATGGTGATGC
TTCTTTCTGTGGTCAAGGGATTGTTCCTGAAACATTCACGCTGTCCAATCTCCCACATTTCAGAATTGGTGGGAGTGTGCATTTGATTGT
TAATAACCAGCTGGGTTACACCACTCCAGCTGAAAGAGGAAGGTCTTCTTTATACTGCAGTGATATTGGGAAGCTTGTGGGCTGTGCCAT
CATCCATGTCAATGGAGACAGCCCAGAGGAAGTGGTCCGTGCCACACGACTGGCTTTTGAATACCAACGCCAGTTCCGCAAGGATGTGAT
TATTGATCTGTTGTGCTACAGGCAGTGGGGCCACAATGAGCTGGATGAGCCATTCTACACCAACCCCATCATGTACAAAATCATCAGAGC
TCGAAAGAGCATTCCAGACACATATGCAGAGCACCTCATTGCTGGCGGACTCATGACGCAGGAGGAGGTGTCTGAAATAAAATCCTCCTA
CTATGCCAAGTTGAATGATCACTTAAATAACATGGCCCACTACAGGCCCCCTGCCCTGAACCTGCAGGCCCACTGGCAGGGCCTGGCTCA
GCCAGAAGCGCAAATCACCACCTGGAGTACAGGTGTGCCCCTCGACCTCCTGCGGTTTGTTGGCATGAAGTCTGTAGAGGTGCCAAGAGA
GCTGCAGATGCACAGTCACCTGCTGAAGACACATGTTCAGTCCAGAATGGAGAAGATGATGGACGGAATCAAGCTAGACTGGGCCACCGC
GGAAGCTCTTGCCTTGGGTTCTTTACTTGCTCAAGGTTTTAATGTTCGTCTAAGTGGCCAAGATGTTGGTCGTGGAACTTTCAGTCAGAG
GCATGCAATCGTGGTTTGCCAGGAGACGGATGACACCTACATCCCCCTGAACCATATGGACCCAAATCAGAAGGGGTTTCTAGAGGTCAG
CAACAGCCCACTGTCAGAAGAGGCCGTCCTGGGATTTGAATATGGGATGAGCATTGAGAGCCCAAAGTTACTGCCCCTGTGGGAGGCACA
GTTTGGCGATTTCTTCAATGGTGCCCAGATCATCTTTGACACATTCATCTCTGGAGGAGAGGCCAAGTGGCTCCTACAAAGCGGCATCGT
CATCCTCCTTCCACATGGCTACGATGGGGCTGGGCCAGACCACTCATCCTGTCGAATAGAGCGTTTCCTGCAGATGTGTGACAGTGCGGA
AGAGGGGGTGGACGGAGACACTGTGAACATGTTTGTGGTTCACCCAACAACTCCTGCACAGTATTTCCACTTGCTTAGGAGACAGATGGT
CCGGAACTTCAGAAAACCACTCATTGTTGCTTCCCCTAAGATGTTACTCAGGCTCCCGGCAGCCGTGTCAACTCTTCAAGAAATGGCACC
AGGAACAACATTTAACCCGGTCATTGGTGATTCATCTGTGGATCCAAAAAAGGTTAAGACCCTCGTGTTCTGCTCCGGCAAACATTTCTA
CTCCCTGGTGAAACAAAGAGAATCTCTGGGGGCCAAGAAGCATGACTTTGCCATCATCCGAGTAGAGGAACTCTGCCCCTTCCCGTTGGA
TTCTTTACAGCAAGAGATGAGCAAATACAAACATGTTAAAGATCATATTTGGAGTCAGGAGGAACCTCAGAACATGGGTCCGTGGTCGTT
TGTTTCTCCAAGGTTTGAAAAGCAGCTGGCCTGCAAGCTCCGTCTGGTGGGCCGGCCCCCTTTGCCAGTACCCGCTGTAGGAATTGGCAC
AGTTCACTTGCACCAGCATGAAGATATCCTCGCCAAGACCTTCGCTTGATGATGACTTTTGAAGAAACACTATTTCTCTTTAAGAAAATG
GCCATTAAGGCCGGGTGGGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCTGGTGGATCACCTGAGGTCAGGAGTTCGA
GACCAGCCTGGCCAACACGGTGAAACCCCGCCTCTACTAAAAATACAAAAAATAGCCGGGTGTGGTGGTGGGCACCTGTGATCCCAGCTT
CCTGGGAGGCTGAGGCAAGAGAATCGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAGCCAGGATCACACCATTGCTGTCCAGCCTGGGTG
ACAGAGCAAGACTGCGTTTCAAAAAAAAAAAAAAAAAAACCCATTAAAAGAGGCCTCCTTCCTCCACTCTCTCAACCCCTCTGTTGGGTA
ACATGAAAAGACTGTATTCCTCTAAGATGTTGGGATTGATATACGTGATTTAATCTGCAATAGGTGGAATAACCAGGGGAACTGGTTATG
AATATGTGAATGCAACCAGCAAATTTATCCTTGAAGGTGTGATGGTAGAAATAGGAAAACAACAAAAGAAAAACAATAACAAAAAAAGAA
AGTGTGATGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTTAGGCGGCTGGATCACCTGAGGTCAGGAGTTCAA
GACCAGCCTGGTCAACGTGGTGAAACGCCGTTTCTACTAAAAATATGAAAATTAGTTGGGTGTGGTGGCATGCGCTTGTAGTCTCAGCTA
CTCCGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGAAGGCAGAGGTTGCAGTGAGCCGAAATGGCGCCACTGTACTCCAACCTGGGCG
ACAGAGCAAGACTCCATCTCATAAATTAAAAGGAAAGTATGATAGTGTTATGGATTTTAGCTCTGAGTGAGCTGGAAAACTAGGTCATTA
TCTAGATGATTTCAGACTTGACCCTAATTGACCATATATGACCAGGAAACACTTCTGAGTTTACAGCTCCGTGGAGATGACCTCAACACT
GCCTCTTGATTTGTTTGATGCATGTCACTTTCATTAATTTTCCCCCTCCTTTTTGAAAGTCCTGTGGCAGTACTAATATTTTCATTTTAT
GTAATCTCTGGTGCTGCTTTCCAGTCACTGTATGAAGTGTCTCCCCAACACTAGCAAATCTAGGTCCTACTAAATACAAATCTCTGGGTG
GATGATCTTCTAGTACTGTATTTTTAAATTAAGGAGTTTTAGTTATAATGAAATTGATTTGTAGTCTGTTTTGCCGTAAACTTGTTTTTC
TTTAAATTGTTCTTACAGTGATATCTTACTATTTTTAACTGTCTGGGGTTTCTGATATGGGGATTTCAGCCCCTGGTTAATCAGTCTTGT
CCCTACAAGTCCCTGATGCAGTATGTTTATTTGTGATGTTTAAAGAACATTTCTTGGCTGGGCGCTGCGGCTTGCGCCTGTAATCTCAGC
ACTTTGGGAGGCTGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACAAAACATAGTGAAACCCCGTCTCTACTAAAA
ATACAAAAATTAGCTGGGCGTGGTGGTGGGTGTCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGT
GGAGGTTGCAGTGAGCTGAGATCCTGCCACTGCACTCCAGTCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAATAAATAGAAAGA
GAGAGAGAGGAAAAAAAAAGAAAAGAACACTTCTTTATTTGAGGGACTTTCCCAACACCAGGTGCTTGGGGATTTCTTAGAGATCACCAA
CCGACTCCCTCACTGTGAAATTAAACCAAGTACTGGAAACGTAACTAAACAGCGAACCATGTAGCTTCACCTGACTCAGTGCTGGGGGCC
TCTACCATCTACTGTGCTTGTGTCATGATGCTTTTTCTCTGAAGTGGTGTGGGAAGTACCAGGGGACTGGCAGAAGCCCAGGCCCTCTCT
ACTTTTACCAGCAACTGATCATGTCTTTCAGAATCCATGTACATATAGGCTGTTCTAGCCACAGTGGTAGATTTATGATTCACATCCGAA
AGTGTGCCTTAGTTATCAATTTAACATTTCTCTAGTATTCATATCCCTTTTCTTACCATATACCTCAGTGTATCCTTCCTGTGTCAAGCC
TTATAAATCATGTAATTTAGTGCCACTCATGTAAATCAGTAAAATCACAAAGGTCTATTTAATGAAAACGATTTACCAATGTTGTTTTTT

>67995_67995_1_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000315985_DHTKD1_chr10_12123470_ENST00000263035_length(amino acids)=905AA_BP=37
MFPKFSLRSMFHGAGGGNDIQWCFSQVKGAVDDDVAEVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAG
LLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEG
AESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTML
PNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPA
ERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAE
HLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKT
HVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVL
GFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNM
FVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLG
AKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDIL

--------------------------------------------------------------
>67995_67995_2_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000315985_DHTKD1_chr10_12123471_ENST00000263035_length(transcript)=5086nt_BP=143nt
ATATGAATCATTACTCCTTACCCAGGCAGTAATGTTCCCGAAGTTTTCTCTTCGTTCTATGTTTCATGGAGCTGGAGGAGGGAATGATAT
TCAGTGGTGTTTTTCTCAGGTGAAAGGAGCAGTAGATGATGATGTAGCAGAAGTTGATCATGGCCTTGCCAGGTTGGTGACAGTATATTG
TGAGCATGGTCATAAAGCTGCCAAAATCAACCCCCTCTTCACCGGACAAGCCCTGCTGGAGAATGTGCCTGAAATCCAAGCCCTGGTGCA
GACACTGCAGGGACCCTTCCACACGGCAGGATTATTGAACATGGGGAAGGAAGAGGCCTCACTTGAGGAAGTGTTAGTCTATCTCAATCA
AATCTACTGTGGGCAGATTTCTATTGAAACCTCCCAACTTCAGAGCCAGGATGAGAAAGACTGGTTTGCCAAGCGGTTTGAGGAACTGCA
AAAGGAGACGTTTACCACAGAAGAGCGAAAACATCTGTCGAAACTAATGCTGGAATCTCAGGAGTTTGACCACTTTCTGGCCACCAAGTT
CTCGACAGTGAAGCGATATGGAGGCGAAGGGGCTGAAAGCATGATGGGCTTTTTCCACGAGCTGCTGAAAATGTCGGCCTACAGCGGGAT
CACTGATGTCATTATTGGGATGCCCCATAGAGGGAGGCTGAATTTATTGACAGGCCTTCTGCAGTTCCCTCCAGAGCTGATGTTCCGTAA
AATGCGAGGCTTAAGTGAATTTCCAGAGAATTTCTCAGCCACTGGAGACGTCCTGTCTCACCTGACCTCCTCTGTGGACCTGTACTTTGG
GGCGCACCATCCCCTCCATGTGACAATGTTGCCCAATCCCTCGCACCTGGAGGCCGTCAACCCCGTGGCCGTGGGCAAAACTCGCGGCAG
GCAGCAGTCTCGCCAAGACGGCGATTACTCTCCAGACAACTCAGCCCAGCCGGGGGACAGGGTCATTTGCTTACAGGTCCATGGTGATGC
TTCTTTCTGTGGTCAAGGGATTGTTCCTGAAACATTCACGCTGTCCAATCTCCCACATTTCAGAATTGGTGGGAGTGTGCATTTGATTGT
TAATAACCAGCTGGGTTACACCACTCCAGCTGAAAGAGGAAGGTCTTCTTTATACTGCAGTGATATTGGGAAGCTTGTGGGCTGTGCCAT
CATCCATGTCAATGGAGACAGCCCAGAGGAAGTGGTCCGTGCCACACGACTGGCTTTTGAATACCAACGCCAGTTCCGCAAGGATGTGAT
TATTGATCTGTTGTGCTACAGGCAGTGGGGCCACAATGAGCTGGATGAGCCATTCTACACCAACCCCATCATGTACAAAATCATCAGAGC
TCGAAAGAGCATTCCAGACACATATGCAGAGCACCTCATTGCTGGCGGACTCATGACGCAGGAGGAGGTGTCTGAAATAAAATCCTCCTA
CTATGCCAAGTTGAATGATCACTTAAATAACATGGCCCACTACAGGCCCCCTGCCCTGAACCTGCAGGCCCACTGGCAGGGCCTGGCTCA
GCCAGAAGCGCAAATCACCACCTGGAGTACAGGTGTGCCCCTCGACCTCCTGCGGTTTGTTGGCATGAAGTCTGTAGAGGTGCCAAGAGA
GCTGCAGATGCACAGTCACCTGCTGAAGACACATGTTCAGTCCAGAATGGAGAAGATGATGGACGGAATCAAGCTAGACTGGGCCACCGC
GGAAGCTCTTGCCTTGGGTTCTTTACTTGCTCAAGGTTTTAATGTTCGTCTAAGTGGCCAAGATGTTGGTCGTGGAACTTTCAGTCAGAG
GCATGCAATCGTGGTTTGCCAGGAGACGGATGACACCTACATCCCCCTGAACCATATGGACCCAAATCAGAAGGGGTTTCTAGAGGTCAG
CAACAGCCCACTGTCAGAAGAGGCCGTCCTGGGATTTGAATATGGGATGAGCATTGAGAGCCCAAAGTTACTGCCCCTGTGGGAGGCACA
GTTTGGCGATTTCTTCAATGGTGCCCAGATCATCTTTGACACATTCATCTCTGGAGGAGAGGCCAAGTGGCTCCTACAAAGCGGCATCGT
CATCCTCCTTCCACATGGCTACGATGGGGCTGGGCCAGACCACTCATCCTGTCGAATAGAGCGTTTCCTGCAGATGTGTGACAGTGCGGA
AGAGGGGGTGGACGGAGACACTGTGAACATGTTTGTGGTTCACCCAACAACTCCTGCACAGTATTTCCACTTGCTTAGGAGACAGATGGT
CCGGAACTTCAGAAAACCACTCATTGTTGCTTCCCCTAAGATGTTACTCAGGCTCCCGGCAGCCGTGTCAACTCTTCAAGAAATGGCACC
AGGAACAACATTTAACCCGGTCATTGGTGATTCATCTGTGGATCCAAAAAAGGTTAAGACCCTCGTGTTCTGCTCCGGCAAACATTTCTA
CTCCCTGGTGAAACAAAGAGAATCTCTGGGGGCCAAGAAGCATGACTTTGCCATCATCCGAGTAGAGGAACTCTGCCCCTTCCCGTTGGA
TTCTTTACAGCAAGAGATGAGCAAATACAAACATGTTAAAGATCATATTTGGAGTCAGGAGGAACCTCAGAACATGGGTCCGTGGTCGTT
TGTTTCTCCAAGGTTTGAAAAGCAGCTGGCCTGCAAGCTCCGTCTGGTGGGCCGGCCCCCTTTGCCAGTACCCGCTGTAGGAATTGGCAC
AGTTCACTTGCACCAGCATGAAGATATCCTCGCCAAGACCTTCGCTTGATGATGACTTTTGAAGAAACACTATTTCTCTTTAAGAAAATG
GCCATTAAGGCCGGGTGGGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCTGGTGGATCACCTGAGGTCAGGAGTTCGA
GACCAGCCTGGCCAACACGGTGAAACCCCGCCTCTACTAAAAATACAAAAAATAGCCGGGTGTGGTGGTGGGCACCTGTGATCCCAGCTT
CCTGGGAGGCTGAGGCAAGAGAATCGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAGCCAGGATCACACCATTGCTGTCCAGCCTGGGTG
ACAGAGCAAGACTGCGTTTCAAAAAAAAAAAAAAAAAAACCCATTAAAAGAGGCCTCCTTCCTCCACTCTCTCAACCCCTCTGTTGGGTA
ACATGAAAAGACTGTATTCCTCTAAGATGTTGGGATTGATATACGTGATTTAATCTGCAATAGGTGGAATAACCAGGGGAACTGGTTATG
AATATGTGAATGCAACCAGCAAATTTATCCTTGAAGGTGTGATGGTAGAAATAGGAAAACAACAAAAGAAAAACAATAACAAAAAAAGAA
AGTGTGATGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTTAGGCGGCTGGATCACCTGAGGTCAGGAGTTCAA
GACCAGCCTGGTCAACGTGGTGAAACGCCGTTTCTACTAAAAATATGAAAATTAGTTGGGTGTGGTGGCATGCGCTTGTAGTCTCAGCTA
CTCCGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGAAGGCAGAGGTTGCAGTGAGCCGAAATGGCGCCACTGTACTCCAACCTGGGCG
ACAGAGCAAGACTCCATCTCATAAATTAAAAGGAAAGTATGATAGTGTTATGGATTTTAGCTCTGAGTGAGCTGGAAAACTAGGTCATTA
TCTAGATGATTTCAGACTTGACCCTAATTGACCATATATGACCAGGAAACACTTCTGAGTTTACAGCTCCGTGGAGATGACCTCAACACT
GCCTCTTGATTTGTTTGATGCATGTCACTTTCATTAATTTTCCCCCTCCTTTTTGAAAGTCCTGTGGCAGTACTAATATTTTCATTTTAT
GTAATCTCTGGTGCTGCTTTCCAGTCACTGTATGAAGTGTCTCCCCAACACTAGCAAATCTAGGTCCTACTAAATACAAATCTCTGGGTG
GATGATCTTCTAGTACTGTATTTTTAAATTAAGGAGTTTTAGTTATAATGAAATTGATTTGTAGTCTGTTTTGCCGTAAACTTGTTTTTC
TTTAAATTGTTCTTACAGTGATATCTTACTATTTTTAACTGTCTGGGGTTTCTGATATGGGGATTTCAGCCCCTGGTTAATCAGTCTTGT
CCCTACAAGTCCCTGATGCAGTATGTTTATTTGTGATGTTTAAAGAACATTTCTTGGCTGGGCGCTGCGGCTTGCGCCTGTAATCTCAGC
ACTTTGGGAGGCTGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACAAAACATAGTGAAACCCCGTCTCTACTAAAA
ATACAAAAATTAGCTGGGCGTGGTGGTGGGTGTCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGT
GGAGGTTGCAGTGAGCTGAGATCCTGCCACTGCACTCCAGTCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAATAAATAGAAAGA
GAGAGAGAGGAAAAAAAAAGAAAAGAACACTTCTTTATTTGAGGGACTTTCCCAACACCAGGTGCTTGGGGATTTCTTAGAGATCACCAA
CCGACTCCCTCACTGTGAAATTAAACCAAGTACTGGAAACGTAACTAAACAGCGAACCATGTAGCTTCACCTGACTCAGTGCTGGGGGCC
TCTACCATCTACTGTGCTTGTGTCATGATGCTTTTTCTCTGAAGTGGTGTGGGAAGTACCAGGGGACTGGCAGAAGCCCAGGCCCTCTCT
ACTTTTACCAGCAACTGATCATGTCTTTCAGAATCCATGTACATATAGGCTGTTCTAGCCACAGTGGTAGATTTATGATTCACATCCGAA
AGTGTGCCTTAGTTATCAATTTAACATTTCTCTAGTATTCATATCCCTTTTCTTACCATATACCTCAGTGTATCCTTCCTGTGTCAAGCC
TTATAAATCATGTAATTTAGTGCCACTCATGTAAATCAGTAAAATCACAAAGGTCTATTTAATGAAAACGATTTACCAATGTTGTTTTTT

>67995_67995_2_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000315985_DHTKD1_chr10_12123471_ENST00000263035_length(amino acids)=905AA_BP=37
MFPKFSLRSMFHGAGGGNDIQWCFSQVKGAVDDDVAEVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAG
LLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEG
AESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTML
PNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPA
ERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAE
HLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKT
HVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVL
GFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNM
FVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLG
AKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDIL

--------------------------------------------------------------
>67995_67995_3_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000380737_DHTKD1_chr10_12123470_ENST00000263035_length(transcript)=5354nt_BP=411nt
AGGTGACGTCACTGGCCAGGCCAGCCGGCGCCATTTTGAAAGTGGAGTCGCCTGCCCCTGCCGCTGCCGCCGCCGCCGTCGCTGTCGTAG
TCGCCGCCGCCGCTGCCGGAGAAAGAGCACGAGCGGGGAAGCCCCAGAGTGAAATCTAGCATCCTGCCGGCTGGTCTGCCCGCCCCTCCT
TCCTTTTCCCCCCGGCCCCCGTCCCCTCCCCCCGCAGGTGCCATCCGCCGCCATCCGCCCTCTCTACCCCCCCATCCCCAGGTGAGGGGG
GTGAGTTCAGGAAGCGGAGACCCCGAGGAACCCAGCAGGGTCACCATTTGCAGCGCAACATGGCAGGAGCTGGAGGAGGGAATGATATTC
AGTGGTGTTTTTCTCAGGTGAAAGGAGCAGTAGATGATGATGTAGCAGAAGTTGATCATGGCCTTGCCAGGTTGGTGACAGTATATTGTG
AGCATGGTCATAAAGCTGCCAAAATCAACCCCCTCTTCACCGGACAAGCCCTGCTGGAGAATGTGCCTGAAATCCAAGCCCTGGTGCAGA
CACTGCAGGGACCCTTCCACACGGCAGGATTATTGAACATGGGGAAGGAAGAGGCCTCACTTGAGGAAGTGTTAGTCTATCTCAATCAAA
TCTACTGTGGGCAGATTTCTATTGAAACCTCCCAACTTCAGAGCCAGGATGAGAAAGACTGGTTTGCCAAGCGGTTTGAGGAACTGCAAA
AGGAGACGTTTACCACAGAAGAGCGAAAACATCTGTCGAAACTAATGCTGGAATCTCAGGAGTTTGACCACTTTCTGGCCACCAAGTTCT
CGACAGTGAAGCGATATGGAGGCGAAGGGGCTGAAAGCATGATGGGCTTTTTCCACGAGCTGCTGAAAATGTCGGCCTACAGCGGGATCA
CTGATGTCATTATTGGGATGCCCCATAGAGGGAGGCTGAATTTATTGACAGGCCTTCTGCAGTTCCCTCCAGAGCTGATGTTCCGTAAAA
TGCGAGGCTTAAGTGAATTTCCAGAGAATTTCTCAGCCACTGGAGACGTCCTGTCTCACCTGACCTCCTCTGTGGACCTGTACTTTGGGG
CGCACCATCCCCTCCATGTGACAATGTTGCCCAATCCCTCGCACCTGGAGGCCGTCAACCCCGTGGCCGTGGGCAAAACTCGCGGCAGGC
AGCAGTCTCGCCAAGACGGCGATTACTCTCCAGACAACTCAGCCCAGCCGGGGGACAGGGTCATTTGCTTACAGGTCCATGGTGATGCTT
CTTTCTGTGGTCAAGGGATTGTTCCTGAAACATTCACGCTGTCCAATCTCCCACATTTCAGAATTGGTGGGAGTGTGCATTTGATTGTTA
ATAACCAGCTGGGTTACACCACTCCAGCTGAAAGAGGAAGGTCTTCTTTATACTGCAGTGATATTGGGAAGCTTGTGGGCTGTGCCATCA
TCCATGTCAATGGAGACAGCCCAGAGGAAGTGGTCCGTGCCACACGACTGGCTTTTGAATACCAACGCCAGTTCCGCAAGGATGTGATTA
TTGATCTGTTGTGCTACAGGCAGTGGGGCCACAATGAGCTGGATGAGCCATTCTACACCAACCCCATCATGTACAAAATCATCAGAGCTC
GAAAGAGCATTCCAGACACATATGCAGAGCACCTCATTGCTGGCGGACTCATGACGCAGGAGGAGGTGTCTGAAATAAAATCCTCCTACT
ATGCCAAGTTGAATGATCACTTAAATAACATGGCCCACTACAGGCCCCCTGCCCTGAACCTGCAGGCCCACTGGCAGGGCCTGGCTCAGC
CAGAAGCGCAAATCACCACCTGGAGTACAGGTGTGCCCCTCGACCTCCTGCGGTTTGTTGGCATGAAGTCTGTAGAGGTGCCAAGAGAGC
TGCAGATGCACAGTCACCTGCTGAAGACACATGTTCAGTCCAGAATGGAGAAGATGATGGACGGAATCAAGCTAGACTGGGCCACCGCGG
AAGCTCTTGCCTTGGGTTCTTTACTTGCTCAAGGTTTTAATGTTCGTCTAAGTGGCCAAGATGTTGGTCGTGGAACTTTCAGTCAGAGGC
ATGCAATCGTGGTTTGCCAGGAGACGGATGACACCTACATCCCCCTGAACCATATGGACCCAAATCAGAAGGGGTTTCTAGAGGTCAGCA
ACAGCCCACTGTCAGAAGAGGCCGTCCTGGGATTTGAATATGGGATGAGCATTGAGAGCCCAAAGTTACTGCCCCTGTGGGAGGCACAGT
TTGGCGATTTCTTCAATGGTGCCCAGATCATCTTTGACACATTCATCTCTGGAGGAGAGGCCAAGTGGCTCCTACAAAGCGGCATCGTCA
TCCTCCTTCCACATGGCTACGATGGGGCTGGGCCAGACCACTCATCCTGTCGAATAGAGCGTTTCCTGCAGATGTGTGACAGTGCGGAAG
AGGGGGTGGACGGAGACACTGTGAACATGTTTGTGGTTCACCCAACAACTCCTGCACAGTATTTCCACTTGCTTAGGAGACAGATGGTCC
GGAACTTCAGAAAACCACTCATTGTTGCTTCCCCTAAGATGTTACTCAGGCTCCCGGCAGCCGTGTCAACTCTTCAAGAAATGGCACCAG
GAACAACATTTAACCCGGTCATTGGTGATTCATCTGTGGATCCAAAAAAGGTTAAGACCCTCGTGTTCTGCTCCGGCAAACATTTCTACT
CCCTGGTGAAACAAAGAGAATCTCTGGGGGCCAAGAAGCATGACTTTGCCATCATCCGAGTAGAGGAACTCTGCCCCTTCCCGTTGGATT
CTTTACAGCAAGAGATGAGCAAATACAAACATGTTAAAGATCATATTTGGAGTCAGGAGGAACCTCAGAACATGGGTCCGTGGTCGTTTG
TTTCTCCAAGGTTTGAAAAGCAGCTGGCCTGCAAGCTCCGTCTGGTGGGCCGGCCCCCTTTGCCAGTACCCGCTGTAGGAATTGGCACAG
TTCACTTGCACCAGCATGAAGATATCCTCGCCAAGACCTTCGCTTGATGATGACTTTTGAAGAAACACTATTTCTCTTTAAGAAAATGGC
CATTAAGGCCGGGTGGGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCTGGTGGATCACCTGAGGTCAGGAGTTCGAGA
CCAGCCTGGCCAACACGGTGAAACCCCGCCTCTACTAAAAATACAAAAAATAGCCGGGTGTGGTGGTGGGCACCTGTGATCCCAGCTTCC
TGGGAGGCTGAGGCAAGAGAATCGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAGCCAGGATCACACCATTGCTGTCCAGCCTGGGTGAC
AGAGCAAGACTGCGTTTCAAAAAAAAAAAAAAAAAAACCCATTAAAAGAGGCCTCCTTCCTCCACTCTCTCAACCCCTCTGTTGGGTAAC
ATGAAAAGACTGTATTCCTCTAAGATGTTGGGATTGATATACGTGATTTAATCTGCAATAGGTGGAATAACCAGGGGAACTGGTTATGAA
TATGTGAATGCAACCAGCAAATTTATCCTTGAAGGTGTGATGGTAGAAATAGGAAAACAACAAAAGAAAAACAATAACAAAAAAAGAAAG
TGTGATGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTTAGGCGGCTGGATCACCTGAGGTCAGGAGTTCAAGA
CCAGCCTGGTCAACGTGGTGAAACGCCGTTTCTACTAAAAATATGAAAATTAGTTGGGTGTGGTGGCATGCGCTTGTAGTCTCAGCTACT
CCGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGAAGGCAGAGGTTGCAGTGAGCCGAAATGGCGCCACTGTACTCCAACCTGGGCGAC
AGAGCAAGACTCCATCTCATAAATTAAAAGGAAAGTATGATAGTGTTATGGATTTTAGCTCTGAGTGAGCTGGAAAACTAGGTCATTATC
TAGATGATTTCAGACTTGACCCTAATTGACCATATATGACCAGGAAACACTTCTGAGTTTACAGCTCCGTGGAGATGACCTCAACACTGC
CTCTTGATTTGTTTGATGCATGTCACTTTCATTAATTTTCCCCCTCCTTTTTGAAAGTCCTGTGGCAGTACTAATATTTTCATTTTATGT
AATCTCTGGTGCTGCTTTCCAGTCACTGTATGAAGTGTCTCCCCAACACTAGCAAATCTAGGTCCTACTAAATACAAATCTCTGGGTGGA
TGATCTTCTAGTACTGTATTTTTAAATTAAGGAGTTTTAGTTATAATGAAATTGATTTGTAGTCTGTTTTGCCGTAAACTTGTTTTTCTT
TAAATTGTTCTTACAGTGATATCTTACTATTTTTAACTGTCTGGGGTTTCTGATATGGGGATTTCAGCCCCTGGTTAATCAGTCTTGTCC
CTACAAGTCCCTGATGCAGTATGTTTATTTGTGATGTTTAAAGAACATTTCTTGGCTGGGCGCTGCGGCTTGCGCCTGTAATCTCAGCAC
TTTGGGAGGCTGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACAAAACATAGTGAAACCCCGTCTCTACTAAAAAT
ACAAAAATTAGCTGGGCGTGGTGGTGGGTGTCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGG
AGGTTGCAGTGAGCTGAGATCCTGCCACTGCACTCCAGTCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAATAAATAGAAAGAGA
GAGAGAGGAAAAAAAAAGAAAAGAACACTTCTTTATTTGAGGGACTTTCCCAACACCAGGTGCTTGGGGATTTCTTAGAGATCACCAACC
GACTCCCTCACTGTGAAATTAAACCAAGTACTGGAAACGTAACTAAACAGCGAACCATGTAGCTTCACCTGACTCAGTGCTGGGGGCCTC
TACCATCTACTGTGCTTGTGTCATGATGCTTTTTCTCTGAAGTGGTGTGGGAAGTACCAGGGGACTGGCAGAAGCCCAGGCCCTCTCTAC
TTTTACCAGCAACTGATCATGTCTTTCAGAATCCATGTACATATAGGCTGTTCTAGCCACAGTGGTAGATTTATGATTCACATCCGAAAG
TGTGCCTTAGTTATCAATTTAACATTTCTCTAGTATTCATATCCCTTTTCTTACCATATACCTCAGTGTATCCTTCCTGTGTCAAGCCTT
ATAAATCATGTAATTTAGTGCCACTCATGTAAATCAGTAAAATCACAAAGGTCTATTTAATGAAAACGATTTACCAATGTTGTTTTTTTT

>67995_67995_3_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000380737_DHTKD1_chr10_12123470_ENST00000263035_length(amino acids)=899AA_BP=31
MQRNMAGAGGGNDIQWCFSQVKGAVDDDVAEVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGK
EEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMG
FFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHL
EAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSS
LYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGG
LMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRM
EKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGM
SIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPT
TPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDF

--------------------------------------------------------------
>67995_67995_4_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000380737_DHTKD1_chr10_12123471_ENST00000263035_length(transcript)=5354nt_BP=411nt
AGGTGACGTCACTGGCCAGGCCAGCCGGCGCCATTTTGAAAGTGGAGTCGCCTGCCCCTGCCGCTGCCGCCGCCGCCGTCGCTGTCGTAG
TCGCCGCCGCCGCTGCCGGAGAAAGAGCACGAGCGGGGAAGCCCCAGAGTGAAATCTAGCATCCTGCCGGCTGGTCTGCCCGCCCCTCCT
TCCTTTTCCCCCCGGCCCCCGTCCCCTCCCCCCGCAGGTGCCATCCGCCGCCATCCGCCCTCTCTACCCCCCCATCCCCAGGTGAGGGGG
GTGAGTTCAGGAAGCGGAGACCCCGAGGAACCCAGCAGGGTCACCATTTGCAGCGCAACATGGCAGGAGCTGGAGGAGGGAATGATATTC
AGTGGTGTTTTTCTCAGGTGAAAGGAGCAGTAGATGATGATGTAGCAGAAGTTGATCATGGCCTTGCCAGGTTGGTGACAGTATATTGTG
AGCATGGTCATAAAGCTGCCAAAATCAACCCCCTCTTCACCGGACAAGCCCTGCTGGAGAATGTGCCTGAAATCCAAGCCCTGGTGCAGA
CACTGCAGGGACCCTTCCACACGGCAGGATTATTGAACATGGGGAAGGAAGAGGCCTCACTTGAGGAAGTGTTAGTCTATCTCAATCAAA
TCTACTGTGGGCAGATTTCTATTGAAACCTCCCAACTTCAGAGCCAGGATGAGAAAGACTGGTTTGCCAAGCGGTTTGAGGAACTGCAAA
AGGAGACGTTTACCACAGAAGAGCGAAAACATCTGTCGAAACTAATGCTGGAATCTCAGGAGTTTGACCACTTTCTGGCCACCAAGTTCT
CGACAGTGAAGCGATATGGAGGCGAAGGGGCTGAAAGCATGATGGGCTTTTTCCACGAGCTGCTGAAAATGTCGGCCTACAGCGGGATCA
CTGATGTCATTATTGGGATGCCCCATAGAGGGAGGCTGAATTTATTGACAGGCCTTCTGCAGTTCCCTCCAGAGCTGATGTTCCGTAAAA
TGCGAGGCTTAAGTGAATTTCCAGAGAATTTCTCAGCCACTGGAGACGTCCTGTCTCACCTGACCTCCTCTGTGGACCTGTACTTTGGGG
CGCACCATCCCCTCCATGTGACAATGTTGCCCAATCCCTCGCACCTGGAGGCCGTCAACCCCGTGGCCGTGGGCAAAACTCGCGGCAGGC
AGCAGTCTCGCCAAGACGGCGATTACTCTCCAGACAACTCAGCCCAGCCGGGGGACAGGGTCATTTGCTTACAGGTCCATGGTGATGCTT
CTTTCTGTGGTCAAGGGATTGTTCCTGAAACATTCACGCTGTCCAATCTCCCACATTTCAGAATTGGTGGGAGTGTGCATTTGATTGTTA
ATAACCAGCTGGGTTACACCACTCCAGCTGAAAGAGGAAGGTCTTCTTTATACTGCAGTGATATTGGGAAGCTTGTGGGCTGTGCCATCA
TCCATGTCAATGGAGACAGCCCAGAGGAAGTGGTCCGTGCCACACGACTGGCTTTTGAATACCAACGCCAGTTCCGCAAGGATGTGATTA
TTGATCTGTTGTGCTACAGGCAGTGGGGCCACAATGAGCTGGATGAGCCATTCTACACCAACCCCATCATGTACAAAATCATCAGAGCTC
GAAAGAGCATTCCAGACACATATGCAGAGCACCTCATTGCTGGCGGACTCATGACGCAGGAGGAGGTGTCTGAAATAAAATCCTCCTACT
ATGCCAAGTTGAATGATCACTTAAATAACATGGCCCACTACAGGCCCCCTGCCCTGAACCTGCAGGCCCACTGGCAGGGCCTGGCTCAGC
CAGAAGCGCAAATCACCACCTGGAGTACAGGTGTGCCCCTCGACCTCCTGCGGTTTGTTGGCATGAAGTCTGTAGAGGTGCCAAGAGAGC
TGCAGATGCACAGTCACCTGCTGAAGACACATGTTCAGTCCAGAATGGAGAAGATGATGGACGGAATCAAGCTAGACTGGGCCACCGCGG
AAGCTCTTGCCTTGGGTTCTTTACTTGCTCAAGGTTTTAATGTTCGTCTAAGTGGCCAAGATGTTGGTCGTGGAACTTTCAGTCAGAGGC
ATGCAATCGTGGTTTGCCAGGAGACGGATGACACCTACATCCCCCTGAACCATATGGACCCAAATCAGAAGGGGTTTCTAGAGGTCAGCA
ACAGCCCACTGTCAGAAGAGGCCGTCCTGGGATTTGAATATGGGATGAGCATTGAGAGCCCAAAGTTACTGCCCCTGTGGGAGGCACAGT
TTGGCGATTTCTTCAATGGTGCCCAGATCATCTTTGACACATTCATCTCTGGAGGAGAGGCCAAGTGGCTCCTACAAAGCGGCATCGTCA
TCCTCCTTCCACATGGCTACGATGGGGCTGGGCCAGACCACTCATCCTGTCGAATAGAGCGTTTCCTGCAGATGTGTGACAGTGCGGAAG
AGGGGGTGGACGGAGACACTGTGAACATGTTTGTGGTTCACCCAACAACTCCTGCACAGTATTTCCACTTGCTTAGGAGACAGATGGTCC
GGAACTTCAGAAAACCACTCATTGTTGCTTCCCCTAAGATGTTACTCAGGCTCCCGGCAGCCGTGTCAACTCTTCAAGAAATGGCACCAG
GAACAACATTTAACCCGGTCATTGGTGATTCATCTGTGGATCCAAAAAAGGTTAAGACCCTCGTGTTCTGCTCCGGCAAACATTTCTACT
CCCTGGTGAAACAAAGAGAATCTCTGGGGGCCAAGAAGCATGACTTTGCCATCATCCGAGTAGAGGAACTCTGCCCCTTCCCGTTGGATT
CTTTACAGCAAGAGATGAGCAAATACAAACATGTTAAAGATCATATTTGGAGTCAGGAGGAACCTCAGAACATGGGTCCGTGGTCGTTTG
TTTCTCCAAGGTTTGAAAAGCAGCTGGCCTGCAAGCTCCGTCTGGTGGGCCGGCCCCCTTTGCCAGTACCCGCTGTAGGAATTGGCACAG
TTCACTTGCACCAGCATGAAGATATCCTCGCCAAGACCTTCGCTTGATGATGACTTTTGAAGAAACACTATTTCTCTTTAAGAAAATGGC
CATTAAGGCCGGGTGGGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCTGGTGGATCACCTGAGGTCAGGAGTTCGAGA
CCAGCCTGGCCAACACGGTGAAACCCCGCCTCTACTAAAAATACAAAAAATAGCCGGGTGTGGTGGTGGGCACCTGTGATCCCAGCTTCC
TGGGAGGCTGAGGCAAGAGAATCGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAGCCAGGATCACACCATTGCTGTCCAGCCTGGGTGAC
AGAGCAAGACTGCGTTTCAAAAAAAAAAAAAAAAAAACCCATTAAAAGAGGCCTCCTTCCTCCACTCTCTCAACCCCTCTGTTGGGTAAC
ATGAAAAGACTGTATTCCTCTAAGATGTTGGGATTGATATACGTGATTTAATCTGCAATAGGTGGAATAACCAGGGGAACTGGTTATGAA
TATGTGAATGCAACCAGCAAATTTATCCTTGAAGGTGTGATGGTAGAAATAGGAAAACAACAAAAGAAAAACAATAACAAAAAAAGAAAG
TGTGATGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTTAGGCGGCTGGATCACCTGAGGTCAGGAGTTCAAGA
CCAGCCTGGTCAACGTGGTGAAACGCCGTTTCTACTAAAAATATGAAAATTAGTTGGGTGTGGTGGCATGCGCTTGTAGTCTCAGCTACT
CCGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGAAGGCAGAGGTTGCAGTGAGCCGAAATGGCGCCACTGTACTCCAACCTGGGCGAC
AGAGCAAGACTCCATCTCATAAATTAAAAGGAAAGTATGATAGTGTTATGGATTTTAGCTCTGAGTGAGCTGGAAAACTAGGTCATTATC
TAGATGATTTCAGACTTGACCCTAATTGACCATATATGACCAGGAAACACTTCTGAGTTTACAGCTCCGTGGAGATGACCTCAACACTGC
CTCTTGATTTGTTTGATGCATGTCACTTTCATTAATTTTCCCCCTCCTTTTTGAAAGTCCTGTGGCAGTACTAATATTTTCATTTTATGT
AATCTCTGGTGCTGCTTTCCAGTCACTGTATGAAGTGTCTCCCCAACACTAGCAAATCTAGGTCCTACTAAATACAAATCTCTGGGTGGA
TGATCTTCTAGTACTGTATTTTTAAATTAAGGAGTTTTAGTTATAATGAAATTGATTTGTAGTCTGTTTTGCCGTAAACTTGTTTTTCTT
TAAATTGTTCTTACAGTGATATCTTACTATTTTTAACTGTCTGGGGTTTCTGATATGGGGATTTCAGCCCCTGGTTAATCAGTCTTGTCC
CTACAAGTCCCTGATGCAGTATGTTTATTTGTGATGTTTAAAGAACATTTCTTGGCTGGGCGCTGCGGCTTGCGCCTGTAATCTCAGCAC
TTTGGGAGGCTGAGATGGGTGGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGACAAAACATAGTGAAACCCCGTCTCTACTAAAAAT
ACAAAAATTAGCTGGGCGTGGTGGTGGGTGTCTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGG
AGGTTGCAGTGAGCTGAGATCCTGCCACTGCACTCCAGTCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAATAAATAGAAAGAGA
GAGAGAGGAAAAAAAAAGAAAAGAACACTTCTTTATTTGAGGGACTTTCCCAACACCAGGTGCTTGGGGATTTCTTAGAGATCACCAACC
GACTCCCTCACTGTGAAATTAAACCAAGTACTGGAAACGTAACTAAACAGCGAACCATGTAGCTTCACCTGACTCAGTGCTGGGGGCCTC
TACCATCTACTGTGCTTGTGTCATGATGCTTTTTCTCTGAAGTGGTGTGGGAAGTACCAGGGGACTGGCAGAAGCCCAGGCCCTCTCTAC
TTTTACCAGCAACTGATCATGTCTTTCAGAATCCATGTACATATAGGCTGTTCTAGCCACAGTGGTAGATTTATGATTCACATCCGAAAG
TGTGCCTTAGTTATCAATTTAACATTTCTCTAGTATTCATATCCCTTTTCTTACCATATACCTCAGTGTATCCTTCCTGTGTCAAGCCTT
ATAAATCATGTAATTTAGTGCCACTCATGTAAATCAGTAAAATCACAAAGGTCTATTTAATGAAAACGATTTACCAATGTTGTTTTTTTT

>67995_67995_4_PPP2R2A-DHTKD1_PPP2R2A_chr8_26151256_ENST00000380737_DHTKD1_chr10_12123471_ENST00000263035_length(amino acids)=899AA_BP=31
MQRNMAGAGGGNDIQWCFSQVKGAVDDDVAEVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGK
EEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMG
FFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHL
EAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSS
LYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGG
LMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRM
EKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGM
SIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPT
TPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDF

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Fusion Gene PPI Analysis for PPP2R2A-DHTKD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R2A-DHTKD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R2A-DHTKD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource