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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R2B-FBXO15 (FusionGDB2 ID:68015)

Fusion Gene Summary for PPP2R2B-FBXO15

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2B-FBXO15
Fusion gene ID: 68015
HgeneTgene
Gene symbol

PPP2R2B

FBXO15

Gene ID

5521

201456

Gene nameprotein phosphatase 2 regulatory subunit BbetaF-box protein 15
SynonymsB55BETA|PP2AB55BETA|PP2ABBETA|PP2APR55B|PP2APR55BETA|PR2AB55BETA|PR2ABBETA|PR2APR55BETA|PR52B|PR55-BETA|PR55BETA|SCA12FBX15
Cytomap

5q32

18q22.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformPP2A subunit B isoform B55-betaPP2A subunit B isoform PR55-betaPP2A subunit B isoform R2-betaPP2A, subunit B, B-beta isoformprotein phosphatase 2 (formerly 2A), regulatorF-box only protein 15
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356826, ENST00000394409, 
ENST00000394411, ENST00000394413, 
ENST00000394414, ENST00000453001, 
ENST00000530902, ENST00000336640, 
ENST00000394410, ENST00000504198, 
ENST00000508545, 		ENST00000580806, 
ENST00000269500, ENST00000419743, 
Fusion gene scores* DoF score9 X 7 X 5=3155 X 4 X 4=80
# samples 115
** MAII scorelog2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R2B [Title/Abstract] AND FBXO15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R2B(146257565)-FBXO15(71740965), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP2R2B-FBXO15 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP2R2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXO15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-1829-01APPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-


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Fusion Gene ORF analysis for PPP2R2B-FBXO15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000356826ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5CDS-5UTRENST00000394409ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5CDS-5UTRENST00000394411ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5CDS-5UTRENST00000394413ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5CDS-5UTRENST00000394414ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5CDS-5UTRENST00000453001ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5UTR-3CDSENST00000530902ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5UTR-3CDSENST00000530902ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
5UTR-5UTRENST00000530902ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000356826ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000394409ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000394411ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000394411ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000394413ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000394414ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
Frame-shiftENST00000453001ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
In-frameENST00000356826ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
In-frameENST00000394409ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
In-frameENST00000394413ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
In-frameENST00000394414ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
In-frameENST00000453001ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000336640ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000336640ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000394410ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000394410ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000504198ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000504198ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000508545ENST00000269500PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-3CDSENST00000508545ENST00000419743PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-5UTRENST00000336640ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-5UTRENST00000394410ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-5UTRENST00000504198ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-
intron-5UTRENST00000508545ENST00000580806PPP2R2Bchr5

146257565

-FBXO15chr18

71740965

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394413PPP2R2Bchr5146257565-ENST00000269500FBXO15chr1871740965-10196413691123
ENST00000394414PPP2R2Bchr5146257565-ENST00000419743FBXO15chr1871740965-922557500826108
ENST00000453001PPP2R2Bchr5146257565-ENST00000269500FBXO15chr1871740965-766388331657108
ENST00000356826PPP2R2Bchr5146257565-ENST00000269500FBXO15chr1871740965-1045667610936108
ENST00000394409PPP2R2Bchr5146257565-ENST00000419743FBXO15chr1871740965-609244187513108

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394413ENST00000269500PPP2R2Bchr5146257565-FBXO15chr1871740965-0.097553880.90244615
ENST00000394414ENST00000419743PPP2R2Bchr5146257565-FBXO15chr1871740965-0.73529060.26470947
ENST00000453001ENST00000269500PPP2R2Bchr5146257565-FBXO15chr1871740965-0.069794910.9302051
ENST00000356826ENST00000269500PPP2R2Bchr5146257565-FBXO15chr1871740965-0.686152040.31384793
ENST00000394409ENST00000419743PPP2R2Bchr5146257565-FBXO15chr1871740965-0.130771120.8692289

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Fusion Genomic Features for PPP2R2B-FBXO15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP2R2B-FBXO15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:146257565/chr18:71740965)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-21022_6181502.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-21022_6189510.0RepeatNote=WD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-19171_2090447.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-19220_2600447.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-1922_610447.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-19279_3170447.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-19334_3750447.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-19410_4420447.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000336640-1987_1280447.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-210171_20923444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-210220_26023444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-21022_6123444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-210279_31723444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-210334_37523444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-210410_44223444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000356826-21087_12823444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-210171_20981502.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-210220_26081502.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-210279_31781502.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-210334_37581502.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-210410_44281502.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394409-21087_12881502.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-111171_2090433.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-111220_2600433.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-11122_610433.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-111279_3170433.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-111334_3750433.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-111410_4420433.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394410-11187_1280433.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-210171_20923444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-210220_26023444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-21022_6123444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-210279_31723444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-210334_37523444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-210410_44223444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394411-21087_12823444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-19171_20923444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-19220_26023444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-1922_6123444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-19279_31723444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-19334_37523444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-19410_44223444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394413-1987_12823444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-210171_20989510.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-210220_26089510.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-210279_31789510.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-210334_37589510.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-210410_44289510.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000394414-21087_12889510.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-210171_20923444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-210220_26023444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-21022_6123444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-210279_31723444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-210334_37523444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-210410_44223444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000453001-21087_12823444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-110171_2090450.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-110220_2600450.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-11022_610450.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-110279_3170450.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-110334_3750450.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-110410_4420450.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000504198-11087_1280450.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-110171_2090433.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-110220_2600433.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-11022_610433.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-110279_3170433.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-110334_3750433.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-110410_4420433.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146257565chr18:71740965ENST00000508545-11087_1280433.0RepeatNote=WD 2
TgeneFBXO15chr5:146257565chr18:71740965ENST0000026950081077_117345435.0DomainF-box
TgeneFBXO15chr5:146257565chr18:71740965ENST0000041974381077_117421511.0DomainF-box


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Fusion Gene Sequence for PPP2R2B-FBXO15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68015_68015_1_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000356826_FBXO15_chr18_71740965_ENST00000269500_length(transcript)=1045nt_BP=667nt
ATATCCTGCTGGATTTCTCTTGCGAAAAGAGAAACTCACCACACGGGAAAAGGTAGAGGTTTCAGGCAGAGCATTTCAGCGTGTGTTTAC
AGGCAGGACTGACTTACTCAGCAAATCCTGTTCAGAGGAGCTTCAGCCAATGAAGAGGCTATATCCCGGCTTGCTTGGGGGCTTCTGAGT
TTGAGCTGCATGCAGAAATGTAAGGCAGTGCTTCCTGGCGCTGATGGCAAAATGGGACCCATCTCCAGTTATTCCTCGGGCACCCCAGCT
TTGCAAATCTGGGAAAGAACCTACATAAACATATTGGTGATGTAGCCAGCTTAAAAGGCCGAGAGAATCCTTATGGATTCAGGAGACTGT
TTTTTTATTTAGATTTTTATTTTTTATTTGGAAGATGAAATGCTTCTCTCGTTACCTGCCTTACATCTTCAGACCTCCGAACACCATCCT
TTCTTCCAGCTGCCACACAGAAGGCTCGGACCATGGTGCAGTCCCACTGGCTCCCCTGCCCCCCTCTCCTGTGAGACTGGCTGCGGGGAG
GGATCATGGATACTTGTCTGCCGGCTTCTGGTTCCCACGCAAGTAAGCCTGCTGTCAATGGAGGAGGACATTGATACCCGCAAAATCAAC
AACAGTTTCCTGCGCGACCACAGCTATGCGACCGAAGAGTTGTTCCATGATGGACGTAACTCTTTTGGATGAACATGGGAAACCCTTTTG
GTGTTTCAGTTCCCCGGTGTGCCTGAGATCGCCTGCCACACCCTCTGACAGCTCTAGCTTCTTGGGACAGACATACAACGTGGACTACGT
TGATGCGGAAGGAAGAGTGCACGTGGAGCTGGTGTGGATCAGAGAGACCGAAGAATACCTTATTGTCAACCTGGTCCTTTATCTTAGTAT
CGCAAAAATCAACCATTGGTTTGGGACTGAATATTAGCAGTAGGTGGCAAATTATTGTTGTTATTTAGTTGTTTATTTTTGACTGGCTTT

>68015_68015_1_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000356826_FBXO15_chr18_71740965_ENST00000269500_length(amino acids)=108AA_BP=19
MIPAKSTTVSCATTAMRPKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVN

--------------------------------------------------------------
>68015_68015_2_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000394409_FBXO15_chr18_71740965_ENST00000419743_length(transcript)=609nt_BP=244nt
ATGGTGCTTCAGCCAAGTGAAAGGCACTATCGAGATTGGAACCACAGAAGGCTCGGACCATGGTGCAGTCCCACTGGCTCCCCTGCCCCC
CTCTCCTGTGAGACTGGCTGCGGGGAGGGATCATGGATACTTGTCTGCCGGCTTCTGGTTCCCACGCAAGTAAGCCTGCTGTCAATGGAG
GAGGACATTGATACCCGCAAAATCAACAACAGTTTCCTGCGCGACCACAGCTATGCGACCGAAGAGTTGTTCCATGATGGACGTAACTCT
TTTGGATGAACATGGGAAACCCTTTTGGTGTTTCAGTTCCCCGGTGTGCCTGAGATCGCCTGCCACACCCTCTGACAGCTCTAGCTTCTT
GGGACAGACATACAACGTGGACTACGTTGATGCGGAAGGAAGAGTGCACGTGGAGCTGGTGTGGATCAGAGAGACCGAAGAATACCTTAT
TGTCAACCTGGTCCTTTATCTTAGTATCGCAAAAATCAACCATTGGTTTGGGACTGAATATTAGCAGTAGGTGGCAAATTATTGTTGTTA

>68015_68015_2_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000394409_FBXO15_chr18_71740965_ENST00000419743_length(amino acids)=108AA_BP=19
MIPAKSTTVSCATTAMRPKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVN

--------------------------------------------------------------
>68015_68015_3_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000394413_FBXO15_chr18_71740965_ENST00000269500_length(transcript)=1019nt_BP=641nt
CCCGCCTGCCGGAGCCGCCCTCCCGTGGGACCAGCACCCTCATTCCGGCCAGGCAAGCCTGAATCCTGTCCCTGCCATCTCGCCACTGCA
GCTCGGGTCCAGAAAGGCACCATTTTGTCGCGGCTGCCCGCTCTCCCAGGGGGAGGAGGGATCTTTTTTGCATTTTGGAGCGGCTGCCAA
GGAGGGGAACCTGTTGGGCATCTCCCCAGACCCGCTTGTGAGCGCCTCCGGGGCGGGCGGGCGGGACCAGACCCCTCGGGGCACGGCGTA
TCTTGGCACCCGGAGGCAGCGGAGGCAGGCGCAGCATCCTCGCTGGGAACTGGAGCTGGAGTGAGCGCACCGCGCGGGAGGAGCCGCCGC
AGCCTCGCAGAACCCGAGTGGAGGAGGTGACAGCTCCATTGCCGGGTTTTTATTTTTTTTCTCTCCGCCTCCCCGTCTCCTCCTCAGGCT
CGGACCATGGTGCAGTCCCACTGGCTCCCCTGCCCCCCTCTCCTGTGAGACTGGCTGCGGGGAGGGATCATGGATACTTGTCTGCCGGCT
TCTGGTTCCCACGCAAGTAAGCCTGCTGTCAATGGAGGAGGACATTGATACCCGCAAAATCAACAACAGTTTCCTGCGCGACCACAGCTA
TGCGACCGAAGAGTTGTTCCATGATGGACGTAACTCTTTTGGATGAACATGGGAAACCCTTTTGGTGTTTCAGTTCCCCGGTGTGCCTGA
GATCGCCTGCCACACCCTCTGACAGCTCTAGCTTCTTGGGACAGACATACAACGTGGACTACGTTGATGCGGAAGGAAGAGTGCACGTGG
AGCTGGTGTGGATCAGAGAGACCGAAGAATACCTTATTGTCAACCTGGTCCTTTATCTTAGTATCGCAAAAATCAACCATTGGTTTGGGA
CTGAATATTAGCAGTAGGTGGCAAATTATTGTTGTTATTTAGTTGTTTATTTTTGACTGGCTTTGTTCTTGGTGTTGAAAATTAAAATAA

>68015_68015_3_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000394413_FBXO15_chr18_71740965_ENST00000269500_length(amino acids)=123AA_BP=
MRGCGGSSRAVRSLQLQFPARMLRLPPLPPGAKIRRAPRGLVPPARPGGAHKRVWGDAQQVPLLGSRSKMQKRSLLPLGERAAATKWCLS

--------------------------------------------------------------
>68015_68015_4_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000394414_FBXO15_chr18_71740965_ENST00000419743_length(transcript)=922nt_BP=557nt
GCAAATCCTGTTCAGAGGAGCTTCAGCCAATGAAGAGGCTATATCCCGGCTTGCTTGGGGGCTTCTGAGTTTGAGCTGCATGCAGAAATG
TAAGGCAGTGCTTCCTGGCGCTGATGGCAAAATGGGACCCATCTCCAGTTATTCCTCGGGCACCCCAGCTTTGCAAATCTGGGAAAGAAC
CTACATAAACATATTGGTGATGTAGCCAGCTTAAAAGGCCGAGAGAATCCTTATGGATTCAGGAGACTGTTTTTTTATTTAGATTTTTAT
TTTTTATTTGGAAGATGAAATGCTTCTCTCGTTACCTGCCTTACATCTTCAGACCTCCGAACACCATCCTTTCTTCCAGCTGCCACACAG
AAGGCTCGGACCATGGTGCAGTCCCACTGGCTCCCCTGCCCCCCTCTCCTGTGAGACTGGCTGCGGGGAGGGATCATGGATACTTGTCTG
CCGGCTTCTGGTTCCCACGCAAGTAAGCCTGCTGTCAATGGAGGAGGACATTGATACCCGCAAAATCAACAACAGTTTCCTGCGCGACCA
CAGCTATGCGACCGAAGAGTTGTTCCATGATGGACGTAACTCTTTTGGATGAACATGGGAAACCCTTTTGGTGTTTCAGTTCCCCGGTGT
GCCTGAGATCGCCTGCCACACCCTCTGACAGCTCTAGCTTCTTGGGACAGACATACAACGTGGACTACGTTGATGCGGAAGGAAGAGTGC
ACGTGGAGCTGGTGTGGATCAGAGAGACCGAAGAATACCTTATTGTCAACCTGGTCCTTTATCTTAGTATCGCAAAAATCAACCATTGGT
TTGGGACTGAATATTAGCAGTAGGTGGCAAATTATTGTTGTTATTTAGTTGTTTATTTTTGACTGGCTTTGTTCTTGGTGTTGAAAATTA

>68015_68015_4_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000394414_FBXO15_chr18_71740965_ENST00000419743_length(amino acids)=108AA_BP=19
MIPAKSTTVSCATTAMRPKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVN

--------------------------------------------------------------
>68015_68015_5_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000453001_FBXO15_chr18_71740965_ENST00000269500_length(transcript)=766nt_BP=388nt
GCATGCGCCCCACTGCAGCAAAGAGCAGCCGCAGCCTCTGCCTCGGCCACCACTGCTGCTGGGAAAGAGTCGTGGGGCTGCTGACGCGGT
TGGGAGGAGCCTCGCCTTTAATGCACCAGCCGCCTCCAGCCTCCTGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCTGCGAGTGCGCGC
GTGTGGGTGTGAGGGCTCGGACCATGGTGCAGTCCCACTGGCTCCCCTGCCCCCCTCTCCTGTGAGACTGGCTGCGGGGAGGGATCATGG
ATACTTGTCTGCCGGCTTCTGGTTCCCACGCAAGTAAGCCTGCTGTCAATGGAGGAGGACATTGATACCCGCAAAATCAACAACAGTTTC
CTGCGCGACCACAGCTATGCGACCGAAGAGTTGTTCCATGATGGACGTAACTCTTTTGGATGAACATGGGAAACCCTTTTGGTGTTTCAG
TTCCCCGGTGTGCCTGAGATCGCCTGCCACACCCTCTGACAGCTCTAGCTTCTTGGGACAGACATACAACGTGGACTACGTTGATGCGGA
AGGAAGAGTGCACGTGGAGCTGGTGTGGATCAGAGAGACCGAAGAATACCTTATTGTCAACCTGGTCCTTTATCTTAGTATCGCAAAAAT
CAACCATTGGTTTGGGACTGAATATTAGCAGTAGGTGGCAAATTATTGTTGTTATTTAGTTGTTTATTTTTGACTGGCTTTGTTCTTGGT

>68015_68015_5_PPP2R2B-FBXO15_PPP2R2B_chr5_146257565_ENST00000453001_FBXO15_chr18_71740965_ENST00000269500_length(amino acids)=108AA_BP=19
MIPAKSTTVSCATTAMRPKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP2R2B-FBXO15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R2B-FBXO15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R2B-FBXO15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource