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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R2B-WWOX (FusionGDB2 ID:68017)

Fusion Gene Summary for PPP2R2B-WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2B-WWOX
Fusion gene ID: 68017
HgeneTgene
Gene symbol

PPP2R2B

WWOX

Gene ID

5521

51741

Gene nameprotein phosphatase 2 regulatory subunit BbetaWW domain containing oxidoreductase
SynonymsB55BETA|PP2AB55BETA|PP2ABBETA|PP2APR55B|PP2APR55BETA|PR2AB55BETA|PR2ABBETA|PR2APR55BETA|PR52B|PR55-BETA|PR55BETA|SCA12D16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

5q32

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoformPP2A subunit B isoform B55-betaPP2A subunit B isoform PR55-betaPP2A subunit B isoform R2-betaPP2A, subunit B, B-beta isoformprotein phosphatase 2 (formerly 2A), regulatorWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000394409, ENST00000504198, 
ENST00000394410, ENST00000336640, 
ENST00000356826, ENST00000394411, 
ENST00000394413, ENST00000394414, 
ENST00000453001, ENST00000508545, 
ENST00000530902, 
ENST00000355860, 
ENST00000402655, ENST00000406884, 
ENST00000408984, ENST00000539474, 
ENST00000565791, ENST00000569818, 
ENST00000566780, 
Fusion gene scores* DoF score9 X 7 X 5=31530 X 23 X 10=6900
# samples 1136
** MAII scorelog2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R2B [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R2B(146460621)-WWOX(78420756), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP2R2B-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP2R2B-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PPP2R2B-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across PPP2R2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7620PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+


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Fusion Gene ORF analysis for PPP2R2B-WWOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394409ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000394409ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000394409ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000394409ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000394409ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000394409ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000394409ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5CDS-intronENST00000504198ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-3CDSENST00000394410ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
5UTR-intronENST00000394410ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
Frame-shiftENST00000504198ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
In-frameENST00000394409ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000336640ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000356826ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000394411ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000394413ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000394414ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000453001ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000508545ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-3CDSENST00000530902ENST00000566780PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000336640ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000356826ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394411ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394413ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000394414ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000453001ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000508545ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000355860PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000402655PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000406884PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000408984PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000539474PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000565791PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+
intron-intronENST00000530902ENST00000569818PPP2R2Bchr5

146460621

-WWOXchr16

78420756

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000394409PPP2R2Bchr5146460621-ENST00000566780WWOXchr1678420756+16505035778247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394409ENST00000566780PPP2R2Bchr5146460621-WWOXchr1678420756+0.059441610.9405584

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Fusion Genomic Features for PPP2R2B-WWOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP2R2Bchr5146460621-WWOXchr1678420756+1.39E-050.99998605
PPP2R2Bchr5146460621-WWOXchr1678420756+1.39E-050.99998605

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP2R2B-WWOX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:146460621/chr16:78420756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWOXchr5:146460621chr16:78420756ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr5:146460621chr16:78420756ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr5:146460621chr16:78420756ENST000004026550516_490312.0DomainWW 1
TgeneWWOXchr5:146460621chr16:78420756ENST000004026550557_900312.0DomainWW 2
TgeneWWOXchr5:146460621chr16:78420756ENST000004068840616_490235.0DomainWW 1
TgeneWWOXchr5:146460621chr16:78420756ENST000004068840657_900235.0DomainWW 2
TgeneWWOXchr5:146460621chr16:78420756ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr5:146460621chr16:78420756ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr5:146460621chr16:78420756ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr5:146460621chr16:78420756ENST000004026550550_550312.0MotifNuclear localization signal
TgeneWWOXchr5:146460621chr16:78420756ENST000004068840650_550235.0MotifNuclear localization signal
TgeneWWOXchr5:146460621chr16:78420756ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr5:146460621chr16:78420756ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr5:146460621chr16:78420756ENST0000040265505131_1370312.0Nucleotide bindingNADP
TgeneWWOXchr5:146460621chr16:78420756ENST0000040688406131_1370235.0Nucleotide bindingNADP
TgeneWWOXchr5:146460621chr16:78420756ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr5:146460621chr16:78420756ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr5:146460621chr16:78420756ENST0000040265505209_2730312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr5:146460621chr16:78420756ENST0000040688406209_2730235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr5:146460621chr16:78420756ENST00000408984410209_273172311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr5:146460621chr16:78420756ENST0000056678049209_273172415.0RegionMediates targeting to the mitochondria
TgeneWWOXchr5:146460621chr16:78420756ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-19171_2090447.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-19220_2600447.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-1922_610447.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-19279_3170447.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-19334_3750447.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-19410_4420447.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000336640-1987_1280447.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-110171_2090444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-110220_2600444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-11022_610444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-110279_3170444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-110334_3750444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-110410_4420444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000356826-11087_1280444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-110171_20916502.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-110220_26016502.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-11022_6116502.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-110279_31716502.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-110334_37516502.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-110410_44216502.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394409-11087_12816502.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-211171_2090433.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-211220_2600433.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-21122_610433.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-211279_3170433.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-211334_3750433.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-211410_4420433.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394410-21187_1280433.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-110171_2090444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-110220_2600444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-11022_610444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-110279_3170444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-110334_3750444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-110410_4420444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394411-11087_1280444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-19171_2090444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-19220_2600444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-1922_610444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-19279_3170444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-19334_3750444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-19410_4420444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394413-1987_1280444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-110171_2090510.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-110220_2600510.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-11022_610510.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-110279_3170510.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-110334_3750510.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-110410_4420510.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000394414-11087_1280510.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-110171_2090444.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-110220_2600444.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-11022_610444.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-110279_3170444.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-110334_3750444.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-110410_4420444.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000453001-11087_1280444.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-210171_20929450.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-210220_26029450.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-21022_6129450.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-210279_31729450.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-210334_37529450.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-210410_44229450.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000504198-21087_12829450.0RepeatNote=WD 2
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-110171_2090433.0RepeatNote=WD 3
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-110220_2600433.0RepeatNote=WD 4
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-11022_610433.0RepeatNote=WD 1
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-110279_3170433.0RepeatNote=WD 5
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-110334_3750433.0RepeatNote=WD 6
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-110410_4420433.0RepeatNote=WD 7
HgenePPP2R2Bchr5:146460621chr16:78420756ENST00000508545-11087_1280433.0RepeatNote=WD 2
TgeneWWOXchr5:146460621chr16:78420756ENST0000040898441016_49172311.6666666666667DomainWW 1
TgeneWWOXchr5:146460621chr16:78420756ENST0000040898441057_90172311.6666666666667DomainWW 2
TgeneWWOXchr5:146460621chr16:78420756ENST000005667804916_49172415.0DomainWW 1
TgeneWWOXchr5:146460621chr16:78420756ENST000005667804957_90172415.0DomainWW 2
TgeneWWOXchr5:146460621chr16:78420756ENST0000040898441050_55172311.6666666666667MotifNuclear localization signal
TgeneWWOXchr5:146460621chr16:78420756ENST000005667804950_55172415.0MotifNuclear localization signal
TgeneWWOXchr5:146460621chr16:78420756ENST00000408984410131_137172311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr5:146460621chr16:78420756ENST0000056678049131_137172415.0Nucleotide bindingNADP


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Fusion Gene Sequence for PPP2R2B-WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68017_68017_1_PPP2R2B-WWOX_PPP2R2B_chr5_146460621_ENST00000394409_WWOX_chr16_78420756_ENST00000566780_length(transcript)=1650nt_BP=50nt
ATGGTGCTTCAGCCAAGTGAAAGGCACTATCGAGATTGGAACCACAGAAGCATAAAGCCAAGGTAGAAGCAATGACCCTGGACCTCGCTC
TGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTGTGCAACGCAGCAACTTTTGCTC
TACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTCCAGCTCCTCCAGGATG
TTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGATTTACAGATATTAACGACTCCTTGGGAAAACTGG
ACTTCAGTCGCCTCTCTCCAACAAAAAACGACTATTGGGCGATGCTGGCTTATAACAGGTCCAAGCTCTGCAACATCCTCTTCTCCAACG
AGCTGCACCGTCGCCTCTCCCCACGCGGGGTCACGTCGAACGCAGTGCATCCTGGAAATATGATGTACTCCAACATTCATCGCAGCTGGT
GGGTGTACACACTGCTGTTTACCTTGGCGAGGCCTTTCACCAAGTCCATGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCC
CAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGA
CCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACC
CGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAA
GAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAG
GCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCA
GCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCT
GGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCA
AGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAG
AATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTT
TTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAA
ACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTA

>68017_68017_1_PPP2R2B-WWOX_PPP2R2B_chr5_146460621_ENST00000394409_WWOX_chr16_78420756_ENST00000566780_length(amino acids)=247AA_BP=5
MEPQKHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIV
VSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARP

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Fusion Gene PPI Analysis for PPP2R2B-WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr5:146460621chr16:78420756ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr5:146460621chr16:78420756ENST0000040265505125_4140312.0MAPT
TgeneWWOXchr5:146460621chr16:78420756ENST0000040688406125_4140235.0MAPT
TgeneWWOXchr5:146460621chr16:78420756ENST0000056981801125_414037.0MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr5:146460621chr16:78420756ENST00000408984410125_414172.0311.6666666666667MAPT
TgeneWWOXchr5:146460621chr16:78420756ENST0000056678049125_414172.0415.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R2B-WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R2B-WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource