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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R2C-CTBP1 (FusionGDB2 ID:68020)

Fusion Gene Summary for PPP2R2C-CTBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2C-CTBP1
Fusion gene ID: 68020
HgeneTgene
Gene symbol

PPP2R2C

CTBP1

Gene ID

5522

1487

Gene nameprotein phosphatase 2 regulatory subunit BgammaC-terminal binding protein 1
SynonymsB55-GAMMA|B55gamma|IMYPNO|IMYPNO1|PR52|PR55GBARS|HADDTS
Cytomap

4p16.1

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 2, regulatory subunit B, gammaPP2A, subunit B, B-gamma isoformPP2A, subunit B, B55-gamma isoformPP2A, subunit B, PR55-gamma isoformPP2A, subunit B, R2-gamma isoformgamma isoform of regulatory subunit B55, protein phosphatase 2phoC-terminal-binding protein 1brefeldin A-ribosylated substrate
Modification date2020031320200328
UniProtAcc.

Q13363

Ensembl transtripts involved in fusion geneENST00000335585, ENST00000382599, 
ENST00000506140, ENST00000507294, 
ENST00000515571, ENST00000314348, 
ENST00000510568, ENST00000515690, 
ENST00000290921, ENST00000382952, 
Fusion gene scores* DoF score5 X 5 X 3=7520 X 11 X 10=2200
# samples 525
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2200*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R2C [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R2C(6349573)-CTBP1(1207393), # samples:2
Anticipated loss of major functional domain due to fusion event.PPP2R2C-CTBP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PPP2R2C-CTBP1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PPP2R2C-CTBP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP2R2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DH-A669-01APPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-


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Fusion Gene ORF analysis for PPP2R2C-CTBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000335585ENST00000510568PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000335585ENST00000515690PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000382599ENST00000510568PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000382599ENST00000515690PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000506140ENST00000510568PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000506140ENST00000515690PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000507294ENST00000510568PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000507294ENST00000515690PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000515571ENST00000510568PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
5CDS-intronENST00000515571ENST00000515690PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
Frame-shiftENST00000335585ENST00000290921PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
Frame-shiftENST00000335585ENST00000382952PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
Frame-shiftENST00000382599ENST00000290921PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
Frame-shiftENST00000382599ENST00000382952PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
Frame-shiftENST00000506140ENST00000290921PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
Frame-shiftENST00000506140ENST00000382952PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
In-frameENST00000507294ENST00000290921PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
In-frameENST00000507294ENST00000382952PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
In-frameENST00000515571ENST00000290921PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
In-frameENST00000515571ENST00000382952PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
intron-3CDSENST00000314348ENST00000290921PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
intron-3CDSENST00000314348ENST00000382952PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
intron-intronENST00000314348ENST00000510568PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-
intron-intronENST00000314348ENST00000515690PPP2R2Cchr4

6349573

-CTBP1chr4

1207393

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000515571PPP2R2Cchr46349573-ENST00000382952CTBP1chr41207393-224410222621041259
ENST00000515571PPP2R2Cchr46349573-ENST00000290921CTBP1chr41207393-224410222621041259
ENST00000507294PPP2R2Cchr46349573-ENST00000382952CTBP1chr41207393-2194972203991262
ENST00000507294PPP2R2Cchr46349573-ENST00000290921CTBP1chr41207393-2194972203991262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000515571ENST00000382952PPP2R2Cchr46349573-CTBP1chr41207393-0.0052096970.9947903
ENST00000515571ENST00000290921PPP2R2Cchr46349573-CTBP1chr41207393-0.0052096970.9947903
ENST00000507294ENST00000382952PPP2R2Cchr46349573-CTBP1chr41207393-0.0060936740.9939063
ENST00000507294ENST00000290921PPP2R2Cchr46349573-CTBP1chr41207393-0.0060936740.9939063

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Fusion Genomic Features for PPP2R2C-CTBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP2R2C-CTBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:6349573/chr4:1207393)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTBP1

Q13363

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-69171_209263448.0RepeatNote=WD 3
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-69220_260263448.0RepeatNote=WD 4
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-6922_61263448.0RepeatNote=WD 1
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-6987_128263448.0RepeatNote=WD 2
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-69171_209263448.0RepeatNote=WD 3
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-69220_260263448.0RepeatNote=WD 4
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-6922_61263448.0RepeatNote=WD 1
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-6987_128263448.0RepeatNote=WD 2
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-710171_209256441.0RepeatNote=WD 3
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-71022_61256441.0RepeatNote=WD 1
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-71087_128256441.0RepeatNote=WD 2
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-710171_209256441.0RepeatNote=WD 3
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-71022_61256441.0RepeatNote=WD 1
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-71087_128256441.0RepeatNote=WD 2
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-710171_209246431.0RepeatNote=WD 3
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-71022_61246431.0RepeatNote=WD 1
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-71087_128246431.0RepeatNote=WD 2
TgeneCTBP1chr4:6349573chr4:1207393ENST0000029092159315_318297441.0Nucleotide bindingNAD
TgeneCTBP1chr4:6349573chr4:1207393ENST00000382952610315_318286430.0Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-69279_317263448.0RepeatNote=WD 5
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-69334_375263448.0RepeatNote=WD 6
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000335585-69410_446263448.0RepeatNote=WD 7
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-69279_317263448.0RepeatNote=WD 5
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-69334_375263448.0RepeatNote=WD 6
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000382599-69410_446263448.0RepeatNote=WD 7
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-710220_260256441.0RepeatNote=WD 4
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-710279_317256441.0RepeatNote=WD 5
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-710334_375256441.0RepeatNote=WD 6
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000506140-710410_446256441.0RepeatNote=WD 7
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-710220_260256441.0RepeatNote=WD 4
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-710279_317256441.0RepeatNote=WD 5
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-710334_375256441.0RepeatNote=WD 6
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000507294-710410_446256441.0RepeatNote=WD 7
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-710220_260246431.0RepeatNote=WD 4
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-710279_317246431.0RepeatNote=WD 5
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-710334_375246431.0RepeatNote=WD 6
HgenePPP2R2Cchr4:6349573chr4:1207393ENST00000515571-710410_446246431.0RepeatNote=WD 7
TgeneCTBP1chr4:6349573chr4:1207393ENST0000029092159180_185297441.0Nucleotide bindingNAD
TgeneCTBP1chr4:6349573chr4:1207393ENST0000029092159237_243297441.0Nucleotide bindingNAD
TgeneCTBP1chr4:6349573chr4:1207393ENST0000029092159264_266297441.0Nucleotide bindingNAD
TgeneCTBP1chr4:6349573chr4:1207393ENST00000382952610180_185286430.0Nucleotide bindingNAD
TgeneCTBP1chr4:6349573chr4:1207393ENST00000382952610237_243286430.0Nucleotide bindingNAD
TgeneCTBP1chr4:6349573chr4:1207393ENST00000382952610264_266286430.0Nucleotide bindingNAD


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Fusion Gene Sequence for PPP2R2C-CTBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68020_68020_1_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000507294_CTBP1_chr4_1207393_ENST00000290921_length(transcript)=2194nt_BP=972nt
ATCATTCAAAGGATTCCTGCGGTGGTGCAGAGCTGCGGCAAAGGGCCCTCGCCCGTGGGGTTCACTCTCATCACCCAGAAGCAGGGAGAA
GGGCCTGCGGCTGCAGGCCTGGCTGCCACACCGGCCTCCAGACAACACACAGCAGAAGTAAAATAGAAAGAAGACCTTTTTTGAAATGAC
CTGTGTTAGTCACCTCTCTCAGGATGCGTGAGGCGGACACGTTGAGGCCACCTCAGCTGATGGAAGTTTCCGCTGACATCATCTCTACCG
TTGAGTTCAACCACACGGGAGAGCTGCTGGCCACAGGTGACAAGGGCGGCCGGGTCGTCATCTTCCAGCGGGAACCAGAGAGTAAAAATG
CGCCCCACAGCCAGGGCGAATACGACGTGTACAGCACTTTCCAGAGCCACGAGCCGGAGTTTGACTATCTCAAGAGCCTGGAGATAGAGG
AGAAGATCAACAAGATCAAGTGGCTCCCACAGCAGAACGCCGCCCACTCACTCCTGTCCACCAACGATAAAACTATCAAATTATGGAAGA
TTACCGAACGAGATAAAAGGCCCGAAGGATACAACCTGAAGGATGAAGAGGGGAAACTTAAGGACCTGTCCACGGTGACGTCACTGCAGG
TGCCAGTGCTGAAGCCCATGGATCTGATGGTGGAGGTGAGCCCTCGGAGGATCTTTGCCAATGGCCACACCTACCACATCAACTCCATCT
CCGTCAACAGTGACTGCGAGACCTACATGTCGGCGGATGACCTGCGCATCAACCTCTGGCACCTGGCCATCACCGACAGGAGCTTCAACA
TCGTGGACATCAAGCCGGCCAACATGGAGGACCTTACGGAGGTGATCACAGCATCTGAGTTCCATCCGCACCACTGCAACCTCTTCGTCT
ACAGCAGCAGCAAGGGCTCCCTGCGGCTCTGCGACATGCGGGCAGCTGCCCTGTGTGACAAGCATTCCAAGCCTTTAGCCAGGGCCCTCT
GAAGGATGCACCCAACCTCATCTGCACCCCCCATGCTGCATGGTACAGCGAGCAGGCATCCATCGAGATGCGAGAGGAGGCGGCACGGGA
GATCCGCAGAGCCATCACAGGCCGGATCCCAGACAGCCTGAAGAACTGTGTCAACAAGGACCATCTGACAGCCGCCACCCACTGGGCCAG
CATGGACCCCGCCGTCGTGCACCCTGAGCTCAATGGGGCTGCCTATAGGTACCCTCCGGGCGTGGTGGGCGTGGCCCCCACTGGCATCCC
AGCTGCTGTGGAAGGTATCGTCCCCAGCGCCATGTCCCTGTCCCACGGCCTGCCCCCTGTGGCCCACCCGCCCCACGCCCCTTCTCCTGG
CCAAACCGTCAAGCCCGAGGCGGATAGAGACCACGCCAGTGACCAGTTGTAGCCCGGGAGGAGCTCTCCAGCCTCGGCGCCTGGGCAGAG
GGCCCGGAAACCCTCGGACCAGAGTGTGTGGAGGAGGCATCTGTGTGGTGGCCCTGGCACTGCAGAGACTGGTCCGGGCTGTCAGGAGGC
GGGAGGGGGCAGCGCTGGGCCTCGTGTCGCTTGTCGTCGTCCGTCCTGTGGGCGCTCTGCCCTGTGTCCTTCGCGTTCCTCGTTAAGCAG
AAGAAGTCAGTAGTTATTCTCCCATGAACGTTCTTGTCTGTGTACAGTTTTTAGAACATTACAAAGGATCTGTTTGCTTAGCTGTCAACA
AAAAGAAAACCTGAAGGAGCATTTGGAAGTCAATTTGAGGTTTTTTTTTTTGTTTTTTTTTTTTTTGTATGTTGGAACGTGCCCCAGAAT
GAGGCAGTTGGCAAACTTCTCAGGACAATGAATCCTTCCCGTTTTTCTTTTTATGCCACACAGTGCATTGTTTTTTCTACCTGCTTGTCT
TATTTTTAGAATAATTTAGAAAAACAAAACAAAGGCTGTTTTTCCTAATTTTGGCATGAACCCCCCCTTGTTCCAAATGAAGACGGCATC
ACGAAGCAGCTCCAAAAGGAAAAGCTTGGGCGGTGCCCAGCGTGCCCGCTGCCCATCGACGTCTGTCCTGGGGACGTGGAGGGTGGCAGC
GTCCCCGCCTGCACCAGTGCCGTCCTGCTGATGTGGTAGGCTAGCAATATTTTGGTTAAAATCATGTTTGTGACTGTAACCATTTGTATG

>68020_68020_1_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000507294_CTBP1_chr4_1207393_ENST00000290921_length(amino acids)=262AA_BP=
MREADTLRPPQLMEVSADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKW
LPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCET

--------------------------------------------------------------
>68020_68020_2_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000507294_CTBP1_chr4_1207393_ENST00000382952_length(transcript)=2194nt_BP=972nt
ATCATTCAAAGGATTCCTGCGGTGGTGCAGAGCTGCGGCAAAGGGCCCTCGCCCGTGGGGTTCACTCTCATCACCCAGAAGCAGGGAGAA
GGGCCTGCGGCTGCAGGCCTGGCTGCCACACCGGCCTCCAGACAACACACAGCAGAAGTAAAATAGAAAGAAGACCTTTTTTGAAATGAC
CTGTGTTAGTCACCTCTCTCAGGATGCGTGAGGCGGACACGTTGAGGCCACCTCAGCTGATGGAAGTTTCCGCTGACATCATCTCTACCG
TTGAGTTCAACCACACGGGAGAGCTGCTGGCCACAGGTGACAAGGGCGGCCGGGTCGTCATCTTCCAGCGGGAACCAGAGAGTAAAAATG
CGCCCCACAGCCAGGGCGAATACGACGTGTACAGCACTTTCCAGAGCCACGAGCCGGAGTTTGACTATCTCAAGAGCCTGGAGATAGAGG
AGAAGATCAACAAGATCAAGTGGCTCCCACAGCAGAACGCCGCCCACTCACTCCTGTCCACCAACGATAAAACTATCAAATTATGGAAGA
TTACCGAACGAGATAAAAGGCCCGAAGGATACAACCTGAAGGATGAAGAGGGGAAACTTAAGGACCTGTCCACGGTGACGTCACTGCAGG
TGCCAGTGCTGAAGCCCATGGATCTGATGGTGGAGGTGAGCCCTCGGAGGATCTTTGCCAATGGCCACACCTACCACATCAACTCCATCT
CCGTCAACAGTGACTGCGAGACCTACATGTCGGCGGATGACCTGCGCATCAACCTCTGGCACCTGGCCATCACCGACAGGAGCTTCAACA
TCGTGGACATCAAGCCGGCCAACATGGAGGACCTTACGGAGGTGATCACAGCATCTGAGTTCCATCCGCACCACTGCAACCTCTTCGTCT
ACAGCAGCAGCAAGGGCTCCCTGCGGCTCTGCGACATGCGGGCAGCTGCCCTGTGTGACAAGCATTCCAAGCCTTTAGCCAGGGCCCTCT
GAAGGATGCACCCAACCTCATCTGCACCCCCCATGCTGCATGGTACAGCGAGCAGGCATCCATCGAGATGCGAGAGGAGGCGGCACGGGA
GATCCGCAGAGCCATCACAGGCCGGATCCCAGACAGCCTGAAGAACTGTGTCAACAAGGACCATCTGACAGCCGCCACCCACTGGGCCAG
CATGGACCCCGCCGTCGTGCACCCTGAGCTCAATGGGGCTGCCTATAGGTACCCTCCGGGCGTGGTGGGCGTGGCCCCCACTGGCATCCC
AGCTGCTGTGGAAGGTATCGTCCCCAGCGCCATGTCCCTGTCCCACGGCCTGCCCCCTGTGGCCCACCCGCCCCACGCCCCTTCTCCTGG
CCAAACCGTCAAGCCCGAGGCGGATAGAGACCACGCCAGTGACCAGTTGTAGCCCGGGAGGAGCTCTCCAGCCTCGGCGCCTGGGCAGAG
GGCCCGGAAACCCTCGGACCAGAGTGTGTGGAGGAGGCATCTGTGTGGTGGCCCTGGCACTGCAGAGACTGGTCCGGGCTGTCAGGAGGC
GGGAGGGGGCAGCGCTGGGCCTCGTGTCGCTTGTCGTCGTCCGTCCTGTGGGCGCTCTGCCCTGTGTCCTTCGCGTTCCTCGTTAAGCAG
AAGAAGTCAGTAGTTATTCTCCCATGAACGTTCTTGTCTGTGTACAGTTTTTAGAACATTACAAAGGATCTGTTTGCTTAGCTGTCAACA
AAAAGAAAACCTGAAGGAGCATTTGGAAGTCAATTTGAGGTTTTTTTTTTTGTTTTTTTTTTTTTTGTATGTTGGAACGTGCCCCAGAAT
GAGGCAGTTGGCAAACTTCTCAGGACAATGAATCCTTCCCGTTTTTCTTTTTATGCCACACAGTGCATTGTTTTTTCTACCTGCTTGTCT
TATTTTTAGAATAATTTAGAAAAACAAAACAAAGGCTGTTTTTCCTAATTTTGGCATGAACCCCCCCTTGTTCCAAATGAAGACGGCATC
ACGAAGCAGCTCCAAAAGGAAAAGCTTGGGCGGTGCCCAGCGTGCCCGCTGCCCATCGACGTCTGTCCTGGGGACGTGGAGGGTGGCAGC
GTCCCCGCCTGCACCAGTGCCGTCCTGCTGATGTGGTAGGCTAGCAATATTTTGGTTAAAATCATGTTTGTGACTGTAACCATTTGTATG

>68020_68020_2_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000507294_CTBP1_chr4_1207393_ENST00000382952_length(amino acids)=262AA_BP=
MREADTLRPPQLMEVSADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKW
LPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCET

--------------------------------------------------------------
>68020_68020_3_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000515571_CTBP1_chr4_1207393_ENST00000290921_length(transcript)=2244nt_BP=1022nt
ATGTGTTTTGGGGGAAACAGAGAGAAAGGTGTGGCCTCTCCACTTCTGTGGACACCCCAAATAGGAAGAAGGGTGCACACAAAGCACCGC
TTCCTCCACGAAGCCCTCCTCAGGCACATCGAGGAGAACCAGCTGCCCAAGCTCTTGGCTGCTGCCCTTCTGAGGCCTGCCTGATTTGGG
CCACATAGATCTGGTTTTGGCCATTGACTGGCAACATGGCAGTAGCCAACTGCAGAGCCACCAGGGAGCAGCCTCATTCTGATTGAGTAT
AACGAAGACGCTGATGGGAAAGAGAGACACGGCTGACATCATCTCTACCGTTGAGTTCAACCACACGGGAGAGCTGCTGGCCACAGGTGA
CAAGGGCGGCCGGGTCGTCATCTTCCAGCGGGAACCAGAGAGTAAAAATGCGCCCCACAGCCAGGGCGAATACGACGTGTACAGCACTTT
CCAGAGCCACGAGCCGGAGTTTGACTATCTCAAGAGCCTGGAGATAGAGGAGAAGATCAACAAGATCAAGTGGCTCCCACAGCAGAACGC
CGCCCACTCACTCCTGTCCACCAACGATAAAACTATCAAATTATGGAAGATTACCGAACGAGATAAAAGGCCCGAAGGATACAACCTGAA
GGATGAAGAGGGGAAACTTAAGGACCTGTCCACGGTGACGTCACTGCAGGTGCCAGTGCTGAAGCCCATGGATCTGATGGTGGAGGTGAG
CCCTCGGAGGATCTTTGCCAATGGCCACACCTACCACATCAACTCCATCTCCGTCAACAGTGACTGCGAGACCTACATGTCGGCGGATGA
CCTGCGCATCAACCTCTGGCACCTGGCCATCACCGACAGGAGCTTCAACATCGTGGACATCAAGCCGGCCAACATGGAGGACCTTACGGA
GGTGATCACAGCATCTGAGTTCCATCCGCACCACTGCAACCTCTTCGTCTACAGCAGCAGCAAGGGCTCCCTGCGGCTCTGCGACATGCG
GGCAGCTGCCCTGTGTGACAAGCATTCCAAGCCTTTAGCCAGGGCCCTCTGAAGGATGCACCCAACCTCATCTGCACCCCCCATGCTGCA
TGGTACAGCGAGCAGGCATCCATCGAGATGCGAGAGGAGGCGGCACGGGAGATCCGCAGAGCCATCACAGGCCGGATCCCAGACAGCCTG
AAGAACTGTGTCAACAAGGACCATCTGACAGCCGCCACCCACTGGGCCAGCATGGACCCCGCCGTCGTGCACCCTGAGCTCAATGGGGCT
GCCTATAGGTACCCTCCGGGCGTGGTGGGCGTGGCCCCCACTGGCATCCCAGCTGCTGTGGAAGGTATCGTCCCCAGCGCCATGTCCCTG
TCCCACGGCCTGCCCCCTGTGGCCCACCCGCCCCACGCCCCTTCTCCTGGCCAAACCGTCAAGCCCGAGGCGGATAGAGACCACGCCAGT
GACCAGTTGTAGCCCGGGAGGAGCTCTCCAGCCTCGGCGCCTGGGCAGAGGGCCCGGAAACCCTCGGACCAGAGTGTGTGGAGGAGGCAT
CTGTGTGGTGGCCCTGGCACTGCAGAGACTGGTCCGGGCTGTCAGGAGGCGGGAGGGGGCAGCGCTGGGCCTCGTGTCGCTTGTCGTCGT
CCGTCCTGTGGGCGCTCTGCCCTGTGTCCTTCGCGTTCCTCGTTAAGCAGAAGAAGTCAGTAGTTATTCTCCCATGAACGTTCTTGTCTG
TGTACAGTTTTTAGAACATTACAAAGGATCTGTTTGCTTAGCTGTCAACAAAAAGAAAACCTGAAGGAGCATTTGGAAGTCAATTTGAGG
TTTTTTTTTTTGTTTTTTTTTTTTTTGTATGTTGGAACGTGCCCCAGAATGAGGCAGTTGGCAAACTTCTCAGGACAATGAATCCTTCCC
GTTTTTCTTTTTATGCCACACAGTGCATTGTTTTTTCTACCTGCTTGTCTTATTTTTAGAATAATTTAGAAAAACAAAACAAAGGCTGTT
TTTCCTAATTTTGGCATGAACCCCCCCTTGTTCCAAATGAAGACGGCATCACGAAGCAGCTCCAAAAGGAAAAGCTTGGGCGGTGCCCAG
CGTGCCCGCTGCCCATCGACGTCTGTCCTGGGGACGTGGAGGGTGGCAGCGTCCCCGCCTGCACCAGTGCCGTCCTGCTGATGTGGTAGG

>68020_68020_3_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000515571_CTBP1_chr4_1207393_ENST00000290921_length(amino acids)=259AA_BP=
MSITKTLMGKRDTADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQ
QNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMS

--------------------------------------------------------------
>68020_68020_4_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000515571_CTBP1_chr4_1207393_ENST00000382952_length(transcript)=2244nt_BP=1022nt
ATGTGTTTTGGGGGAAACAGAGAGAAAGGTGTGGCCTCTCCACTTCTGTGGACACCCCAAATAGGAAGAAGGGTGCACACAAAGCACCGC
TTCCTCCACGAAGCCCTCCTCAGGCACATCGAGGAGAACCAGCTGCCCAAGCTCTTGGCTGCTGCCCTTCTGAGGCCTGCCTGATTTGGG
CCACATAGATCTGGTTTTGGCCATTGACTGGCAACATGGCAGTAGCCAACTGCAGAGCCACCAGGGAGCAGCCTCATTCTGATTGAGTAT
AACGAAGACGCTGATGGGAAAGAGAGACACGGCTGACATCATCTCTACCGTTGAGTTCAACCACACGGGAGAGCTGCTGGCCACAGGTGA
CAAGGGCGGCCGGGTCGTCATCTTCCAGCGGGAACCAGAGAGTAAAAATGCGCCCCACAGCCAGGGCGAATACGACGTGTACAGCACTTT
CCAGAGCCACGAGCCGGAGTTTGACTATCTCAAGAGCCTGGAGATAGAGGAGAAGATCAACAAGATCAAGTGGCTCCCACAGCAGAACGC
CGCCCACTCACTCCTGTCCACCAACGATAAAACTATCAAATTATGGAAGATTACCGAACGAGATAAAAGGCCCGAAGGATACAACCTGAA
GGATGAAGAGGGGAAACTTAAGGACCTGTCCACGGTGACGTCACTGCAGGTGCCAGTGCTGAAGCCCATGGATCTGATGGTGGAGGTGAG
CCCTCGGAGGATCTTTGCCAATGGCCACACCTACCACATCAACTCCATCTCCGTCAACAGTGACTGCGAGACCTACATGTCGGCGGATGA
CCTGCGCATCAACCTCTGGCACCTGGCCATCACCGACAGGAGCTTCAACATCGTGGACATCAAGCCGGCCAACATGGAGGACCTTACGGA
GGTGATCACAGCATCTGAGTTCCATCCGCACCACTGCAACCTCTTCGTCTACAGCAGCAGCAAGGGCTCCCTGCGGCTCTGCGACATGCG
GGCAGCTGCCCTGTGTGACAAGCATTCCAAGCCTTTAGCCAGGGCCCTCTGAAGGATGCACCCAACCTCATCTGCACCCCCCATGCTGCA
TGGTACAGCGAGCAGGCATCCATCGAGATGCGAGAGGAGGCGGCACGGGAGATCCGCAGAGCCATCACAGGCCGGATCCCAGACAGCCTG
AAGAACTGTGTCAACAAGGACCATCTGACAGCCGCCACCCACTGGGCCAGCATGGACCCCGCCGTCGTGCACCCTGAGCTCAATGGGGCT
GCCTATAGGTACCCTCCGGGCGTGGTGGGCGTGGCCCCCACTGGCATCCCAGCTGCTGTGGAAGGTATCGTCCCCAGCGCCATGTCCCTG
TCCCACGGCCTGCCCCCTGTGGCCCACCCGCCCCACGCCCCTTCTCCTGGCCAAACCGTCAAGCCCGAGGCGGATAGAGACCACGCCAGT
GACCAGTTGTAGCCCGGGAGGAGCTCTCCAGCCTCGGCGCCTGGGCAGAGGGCCCGGAAACCCTCGGACCAGAGTGTGTGGAGGAGGCAT
CTGTGTGGTGGCCCTGGCACTGCAGAGACTGGTCCGGGCTGTCAGGAGGCGGGAGGGGGCAGCGCTGGGCCTCGTGTCGCTTGTCGTCGT
CCGTCCTGTGGGCGCTCTGCCCTGTGTCCTTCGCGTTCCTCGTTAAGCAGAAGAAGTCAGTAGTTATTCTCCCATGAACGTTCTTGTCTG
TGTACAGTTTTTAGAACATTACAAAGGATCTGTTTGCTTAGCTGTCAACAAAAAGAAAACCTGAAGGAGCATTTGGAAGTCAATTTGAGG
TTTTTTTTTTTGTTTTTTTTTTTTTTGTATGTTGGAACGTGCCCCAGAATGAGGCAGTTGGCAAACTTCTCAGGACAATGAATCCTTCCC
GTTTTTCTTTTTATGCCACACAGTGCATTGTTTTTTCTACCTGCTTGTCTTATTTTTAGAATAATTTAGAAAAACAAAACAAAGGCTGTT
TTTCCTAATTTTGGCATGAACCCCCCCTTGTTCCAAATGAAGACGGCATCACGAAGCAGCTCCAAAAGGAAAAGCTTGGGCGGTGCCCAG
CGTGCCCGCTGCCCATCGACGTCTGTCCTGGGGACGTGGAGGGTGGCAGCGTCCCCGCCTGCACCAGTGCCGTCCTGCTGATGTGGTAGG

>68020_68020_4_PPP2R2C-CTBP1_PPP2R2C_chr4_6349573_ENST00000515571_CTBP1_chr4_1207393_ENST00000382952_length(amino acids)=259AA_BP=
MSITKTLMGKRDTADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQ
QNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP2R2C-CTBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCTBP1chr4:6349573chr4:1207393ENST00000382952610288_360286.6666666666667430.0GLIS2 2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCTBP1chr4:6349573chr4:1207393ENST00000290921591_70297.6666666666667441.0GLIS2 1
TgeneCTBP1chr4:6349573chr4:1207393ENST000003829526101_70286.6666666666667430.0GLIS2 1
TgeneCTBP1chr4:6349573chr4:1207393ENST0000029092159288_360297.6666666666667441.0GLIS2 2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R2C-CTBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R2C-CTBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource