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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R4-AGTPBP1 (FusionGDB2 ID:68049)

Fusion Gene Summary for PPP2R4-AGTPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R4-AGTPBP1
Fusion gene ID: 68049
HgeneTgene
Gene symbol

PPP2R4

AGTPBP1

Gene ID

5524

23287

Gene nameprotein phosphatase 2 phosphatase activatorATP/GTP binding protein 1
SynonymsPP2A|PPP2R4|PR53CCP1|CONDCA|NNA1
Cytomap

9q34.11

9q21.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosphcytosolic carboxypeptidase 1carboxypeptidase-tubulinnervous system nuclear protein induced by axotomy protein 1 homologsoluble carboxypeptidasetubulinyl-Tyr carboxypeptidasetyrosine carboxypeptidase
Modification date2020032920200313
UniProtAcc.

Q9UPW5

Ensembl transtripts involved in fusion geneENST00000337738, ENST00000347048, 
ENST00000348141, ENST00000355007, 
ENST00000357197, ENST00000358994, 
ENST00000393370, ENST00000452489, 
ENST00000414510, ENST00000419582, 
ENST00000423100, ENST00000432124, 
ENST00000432651, ENST00000434095, 
ENST00000435132, ENST00000435305, 
ENST00000436883, ENST00000524946, 
ENST00000337006, ENST00000357081, 
ENST00000376083, ENST00000376109, 
ENST00000432218, ENST00000376080, 
ENST00000376081, ENST00000491784, 
Fusion gene scores* DoF score10 X 9 X 8=72013 X 9 X 7=819
# samples 1213
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/819*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R4 [Title/Abstract] AND AGTPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R4(131873910)-AGTPBP1(88257858), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R4

GO:0032515

negative regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0032516

positive regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0035307

positive regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0035308

negative regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0043065

positive regulation of apoptotic process

17333320

HgenePPP2R4

GO:0043666

regulation of phosphoprotein phosphatase activity

16916641


check buttonFusion gene breakpoints across PPP2R4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AGTPBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-V9-A7HT-01APPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-


Top

Fusion Gene ORF analysis for PPP2R4-AGTPBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337738ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000337738ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000337738ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000337738ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000337738ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000347048ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000347048ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000347048ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000347048ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000347048ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000348141ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000348141ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000348141ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000348141ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000348141ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000355007ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000355007ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000355007ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000355007ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000355007ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000357197ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000357197ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000357197ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000357197ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000357197ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000358994ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000358994ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000358994ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000358994ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000358994ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000393370ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000393370ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000393370ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000393370ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000393370ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000452489ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000452489ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000452489ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000452489ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-3UTRENST00000452489ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000337738ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000337738ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000337738ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000347048ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000347048ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000347048ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000348141ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000348141ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000348141ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000355007ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000355007ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000355007ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000357197ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000357197ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000357197ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000358994ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000358994ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000358994ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000393370ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000393370ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000393370ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000452489ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000452489ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
5CDS-intronENST00000452489ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000414510ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000414510ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000414510ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000414510ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000414510ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000419582ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000419582ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000419582ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000419582ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000419582ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000423100ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000423100ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000423100ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000423100ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000423100ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432124ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432124ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432124ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432124ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432124ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432651ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432651ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432651ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432651ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000432651ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000434095ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000434095ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000434095ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000434095ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000434095ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435132ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435132ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435132ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435132ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435132ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435305ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435305ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435305ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435305ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000435305ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000436883ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000436883ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000436883ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000436883ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000436883ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000524946ENST00000337006PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000524946ENST00000357081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000524946ENST00000376083PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000524946ENST00000376109PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-3UTRENST00000524946ENST00000432218PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000414510ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000414510ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000414510ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000419582ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000419582ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000419582ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000423100ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000423100ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000423100ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000432124ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000432124ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000432124ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000432651ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000432651ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000432651ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000434095ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000434095ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000434095ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000435132ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000435132ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000435132ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000435305ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000435305ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000435305ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000436883ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000436883ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000436883ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000524946ENST00000376080PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000524946ENST00000376081PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-
intron-intronENST00000524946ENST00000491784PPP2R4chr9

131873910

-AGTPBP1chr9

88257858

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PPP2R4-AGTPBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP2R4-AGTPBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131873910/:88257858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AGTPBP1

Q9UPW5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins (PubMed:30420557). Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q641K1, ECO:0000269|PubMed:30420557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PPP2R4-AGTPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP2R4-AGTPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R4-AGTPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R4-AGTPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource