FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARPC3-APAF1 (FusionGDB2 ID:6805)

Fusion Gene Summary for ARPC3-APAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARPC3-APAF1
Fusion gene ID: 6805
HgeneTgene
Gene symbol

ARPC3

APAF1

Gene ID

10094

317

Gene nameactin related protein 2/3 complex subunit 3apoptotic peptidase activating factor 1
SynonymsARC21|p21-ArcAPAF-1|CED4
Cytomap

12q24.11

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2/3 complex subunit 3ARP2/3 protein complex subunit p21actin related protein 2/3 complex, subunit 3, 21kDaarp2/3 complex 21 kDa subunitapoptotic protease-activating factor 1
Modification date2020031320200315
UniProtAcc

O15145

O14727

Ensembl transtripts involved in fusion geneENST00000228825, ENST00000471641, 
ENST00000547666, ENST00000547743, 
ENST00000333991, ENST00000339433, 
ENST00000357310, ENST00000359972, 
ENST00000547045, ENST00000549007, 
ENST00000550527, ENST00000551964, 
ENST00000552268, 
Fusion gene scores* DoF score6 X 6 X 3=1081 X 1 X 1=1
# samples 61
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ARPC3 [Title/Abstract] AND APAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARPC3(110883257)-APAF1(99126198), # samples:2
Anticipated loss of major functional domain due to fusion event.ARPC3-APAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARPC3-APAF1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARPC3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539

TgeneAPAF1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

21827945

TgeneAPAF1

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

9267021


check buttonFusion gene breakpoints across ARPC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1022-01AARPC3chr12

110883257

-APAF1chr12

99126198

+


Top

Fusion Gene ORF analysis for ARPC3-APAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000228825ENST00000547666ARPC3chr12

110883257

-APAF1chr12

99126198

+
5CDS-intronENST00000228825ENST00000547743ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000333991ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000339433ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000357310ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000359972ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000547045ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000549007ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000550527ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000551964ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-3CDSENST00000471641ENST00000552268ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-intronENST00000471641ENST00000547666ARPC3chr12

110883257

-APAF1chr12

99126198

+
5UTR-intronENST00000471641ENST00000547743ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000339433ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000357310ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000359972ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000547045ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000549007ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000550527ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000551964ARPC3chr12

110883257

-APAF1chr12

99126198

+
Frame-shiftENST00000228825ENST00000552268ARPC3chr12

110883257

-APAF1chr12

99126198

+
In-frameENST00000228825ENST00000333991ARPC3chr12

110883257

-APAF1chr12

99126198

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000228825ARPC3chr12110883257-ENST00000333991APAF1chr1299126198+326025310399129

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000228825ENST00000333991ARPC3chr12110883257-APAF1chr1299126198+0.93405380.065946266

Top

Fusion Genomic Features for ARPC3-APAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARPC3chr12110883256-APAF1chr1299126197+3.33E-091
ARPC3chr12110883256-APAF1chr1299126197+3.33E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARPC3-APAF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110883257/chr12:99126198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARPC3

O15145

APAF1

O14727

FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168910_921318339.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857910_921318339.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681001_1040318339.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681042_1080318339.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681083_1122318339.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681125_1164318339.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681175_1212318339.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681213_1248318339.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168613_652318339.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168655_694318339.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168697_738318339.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168741_780318339.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168796_836318339.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168838_877318339.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168880_910318339.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168922_958318339.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168959_998318339.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261175_121211571206.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261213_124811571206.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261175_121211461195.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261213_124811461195.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251175_121211571206.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251213_124811571206.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261213_124811891238.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271213_124812001249.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571001_1040318339.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571042_1080318339.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571083_1122318339.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571125_1164318339.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571175_1212318339.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571213_1248318339.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857613_652318339.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857655_694318339.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857697_738318339.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857741_780318339.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857796_836318339.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857838_877318339.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857880_910318339.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857922_958318339.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857959_998318339.0RepeatNote=WD 2-2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPAF1chr12:110883257chr12:99126198ENST000003339916895_98318339.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000357310242695_9811571206.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000359972242695_9811461195.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000547045232595_9811571206.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000550527242695_9811891238.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000551964252795_9812001249.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST000005522685795_98318339.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168104_415318339.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681_90318339.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426104_41511571206.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261_9011571206.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426104_41511461195.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261_9011461195.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325104_41511571206.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251_9011571206.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426104_41511891238.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261_9011891238.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527104_41512001249.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271_9012001249.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857104_415318339.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571_90318339.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168154_161318339.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426154_16111571206.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426154_16111461195.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325154_16111571206.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426154_16111891238.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527154_16112001249.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857154_161318339.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426910_92111571206.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426910_92111461195.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325910_92111571206.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426910_92111891238.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527910_92112001249.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261001_104011571206.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261042_108011571206.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261083_112211571206.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261125_116411571206.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426613_65211571206.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426655_69411571206.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426697_73811571206.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426741_78011571206.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426796_83611571206.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426838_87711571206.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426880_91011571206.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426922_95811571206.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426959_99811571206.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261001_104011461195.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261042_108011461195.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261083_112211461195.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261125_116411461195.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426613_65211461195.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426655_69411461195.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426697_73811461195.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426741_78011461195.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426796_83611461195.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426838_87711461195.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426880_91011461195.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426922_95811461195.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426959_99811461195.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251001_104011571206.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251042_108011571206.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251083_112211571206.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251125_116411571206.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325613_65211571206.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325655_69411571206.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325697_73811571206.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325741_78011571206.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325796_83611571206.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325838_87711571206.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325880_91011571206.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325922_95811571206.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325959_99811571206.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261001_104011891238.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261042_108011891238.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261083_112211891238.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261125_116411891238.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261175_121211891238.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426613_65211891238.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426655_69411891238.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426697_73811891238.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426741_78011891238.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426796_83611891238.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426838_87711891238.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426880_91011891238.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426922_95811891238.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426959_99811891238.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271001_104012001249.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271042_108012001249.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271083_112212001249.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271125_116412001249.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271175_121212001249.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527613_65212001249.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527655_69412001249.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527697_73812001249.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527741_78012001249.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527796_83612001249.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527838_87712001249.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527880_91012001249.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527922_95812001249.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527959_99812001249.0RepeatNote=WD 2-2


Top

Fusion Gene Sequence for ARPC3-APAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6805_6805_1_ARPC3-APAF1_ARPC3_chr12_110883257_ENST00000228825_APAF1_chr12_99126198_ENST00000333991_length(transcript)=3260nt_BP=253nt
AGAAGCGGAACTGCAAGGCCGGAAGCTCCACGTCCGCACCCGCCCCTTCCGTTTCGCTTCCGCCTACCTCGCCCAGGCTGCCAGACCGGA
AGCGCTCCGCTGTACCTGGATCCTGCTCCTCTGGGTTGAAACCCGGGCGCCGCCAAGATGCCGGCTTACCACTCTTCTCTCATGGATCCT
GATACCAAACTCATCGGAAACATGGCACTGTTGCCTATCAGAAGTCAATTCAAAGGACCTGCCCCCAGAGAGATGGTGGAACGTTGTCAC
TGGGGAATCCTCACAGACCTTCTACACAAATGGAACCAATCTTAAGAAAATACACGTGTCCCCTGACTTCAAAACATATGTGACTGTGGA
TAATCTTGGTATTTTATATATTTTACAGACTTTAGAATAAAATAGTTAAGCATTAATGTAGTTGAACTTTTTAAATTTTTGAATTGGAAA
AAAATTCTAATGAAACCCTGATATCAACTTTTTATAAAGCTCTTAATTGTTGTGCAGTATTGCATTCATTACAAAAGTGTTTGTGGTTGG
ATGAATAATATTAATGTAGCTTTTTCCCAAATGAACATACCTTTAATCTTGTTTTTCATGATCATCATTAACAGTTTGTCCTTAGGATGC
AAATGAAAATGTGAATACATACCTTGTTGTACTGTTGGTAAAATTCTGTCTTGATGCATTCAAAATGGTTGACATAATTAATGAGAAGAA
TTTGGAAGAAATTGGTATTTTAATACTGTCTGTATTTATTACTGTTATGCAGGCTGTGCCTCAGGGTAGCAGTGGCCTGCTTTTTGAACC
ACACTTACCCCAAGGGGGTTTTGTTCTCCTAAATACAATCTTAGAGGTTTTTTGCACTCTTTAAATTTGCTTTAAAAATATTGTGTCTGT
GTGCATAGTCTGCAGCATTTCCTTTAATTGACTCAATAAGTGAGTCTTGGATTTAGCAGGCCCCCCCACCTTTTTTTTTTGTTTTTGGAG
ACAGAGTCTTGCTTTGTTGCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACCACAATCGCTGCCTCCTGGGTTCAAGCAATTCTCCT
GCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGTGCGCACATGCCAGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGT
TGGCCGGGATGGTCTCGATCTCTTGACCTCATGATCTACCCGCCTTGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGTGCCT
GGCCAGGCCCCTTCTCTTTTAATGGAGACAGGGTCTTGCACTATCACCCAGGCTGGAGTGCAGTGGCATAATCATACCTCATTGCAGCCT
CAGACTCCTGGGTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGAGACTACAGGCACGAGCCACCACACCCAGCTAATTTTTAA
GTTTTCTTGTAGAGACAGGGTCTCACTATGTTGTCTAGGCTGGTCTTGAACTCTTGGCCTCAAGTAATCCTCCTGCCTCAGCCTCCCAAA
GTGTTGGGATTGCAGATATGAGCCACTGGCCTGGCCTTCAGCAGTTCTTTTTGTGAAGTAAAACTTGTATGTTGGAAAGAGTAGATTTTA
TTGGTCTACCCTTTTCTCACTGTAGCTGCTGGCAGCCCTGTGCCATATCTGGACTCTAGTTGTCAGTATCTGAGTTGGACACTATTCCTG
CTCCCTCTTGTTTCTTACATATCAGACTTCTTACTTGAATGAAACCTGATCTTTCCTAATCCTCACTTTTTTCTTTTTTAAAAAGCAGTT
TCTCCACTGCTAAATGTTAGTCATTGAGGTGGGGCCAATTTTAATCATAAGCCTTAATAAGATTTTTCTAAGAAATGTGAAATAGAACAA
TTTTCATCTAATTCCATTTACTTTTAGATGAATGGCATTGTGAATGCCATTCTTTTAATGAATTTCAAGAGAATTCTCTGGTTTTCTGTG
TAATTCCAGATGAGTCACTGTAACTCTAGAAGATTAACCTTCCAGCCAACCTATTTTCCTTTCCCTTGTCTCTCTCATCCTCTTTTCCTT
CCTTCTTTCCTTTCTCTTCTTTTATCTCCAAGGTTAATCAGGAAAAATAGCTTTTGACAGGGGAAAAAACTCAATAACTAGCTATTTTTG
ACCTCCTGATCAGGAACTTTAGTTGAAGCGTAAATCTAAAGAAACATTTTCTCTGAAATATATTATTAAGGGCAATGGAGATAAATTAAT
AGTAGATGTGGTTCCCAGAAAATATAATCAAAATTCAAAGATTTTTTTTGTTTCTGTAACTGGAACTAAATCAAATGATTACTAGTGTTA
ATAGTAGATAACTTGTTTTTATTGTTGGTGCATATTAGTATAACTGTGGGGTAGGTCGGGGAGAGGGTAAGGGAATAGATCACTCAGATG
TATTTTAGATAAGCTATTTAGCCTTTGATGGAATCATAAATACAGTGAATACAATCCTTTGCATTGTTAAGGAGGTTTTTTGTTTTTAAA
TGGTGGGTCAAGGAGCTAGTTTACAGGCTTACTGTGATTTAAGCAAATGTGAAAAGTGAAACCTTAATTTTATCAAAAGAAATTTCTGTA
AATGGTATGTCTCCTTAGAATACCCAAATCATAATTTTATTTGTACACACTGTTAGGGGCTCATCTCATGTAGGCAGAGTATAAAGTATT
ACCTTTTGGAATTAAAAGCCACTGACTGTTATAAAGTATAACAACACACATCAGGTTTTAAAAAGCCTTGAATGGCCCTTGTCTTAAAAA
GAAATTAGGAGCCAGGTGCGGTGGCACGTGCCTGTAATCCCAGCTCCTTGGGAGGCTAAGACAGGAGGATTCCTTGAGCCCTGGAGTTTG
AGTCCAGCCTGGGTGACATAGCAAGACCCTGTCTTAAAAGAAAAATGGGAAGAAAGACAAGGTAACATGAAGAAAGAAGAGATACCTAGT
ATGATGGAGCTGCAAATTTCATGGCAGTTCATGCAGTCGGTCAAGAGGAGGATTTTGTTTTGTAGTTTGCAGATGAGCATTTCTAAAGCA
TTTTCCCTTGCTGTATTTTTTTGTATTATAAATTACATTGGACTTCATATATATAATTTTTTTTTACATTATATGTCTCTTGTATGTTTT
GAAACTCTTGTATTTATGATATAGCTTATATGATTTTTTTGCCTTGGTATACATTTTAAAATATGAATTTAAAAAATTTTTGTAAAAATA

>6805_6805_1_ARPC3-APAF1_ARPC3_chr12_110883257_ENST00000228825_APAF1_chr12_99126198_ENST00000333991_length(amino acids)=129AA_BP=72
MQGRKLHVRTRPFRFASAYLAQAARPEALRCTWILLLWVETRAPPRCRLTTLLSWILIPNSSETWHCCLSEVNSKDLPPERWWNVVTGES

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARPC3-APAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARPC3-APAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARPC3-APAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource