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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PPP2R4-FAM73B (FusionGDB2 ID:68051)

Fusion Gene Summary for PPP2R4-FAM73B

Fusion gene summary

Fusion gene information	Fusion gene name: PPP2R4-FAM73B
	Fusion gene ID: 68051
		Hgene	Tgene
	Gene symbol	PPP2R4	FAM73B
	Gene ID	5524	84895
	Gene name	protein phosphatase 2 phosphatase activator	mitoguardin 2
	Synonyms	PP2A\|PPP2R4\|PR53	C9orf54\|FAM73B
	Cytomap	9q34.11	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosph	mitoguardin 2family with sequence similarity 73, member Bprotein FAM73B
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000423100, ENST00000524946, ENST00000337738, ENST00000347048, ENST00000348141, ENST00000355007, ENST00000357197, ENST00000358994, ENST00000393370, ENST00000414510, ENST00000419582, ENST00000432124, ENST00000432651, ENST00000434095, ENST00000435132, ENST00000435305, ENST00000436883, ENST00000452489,	ENST00000277475, ENST00000406926, ENST00000358369, ENST00000474534,
Fusion gene scores	* DoF score	10 X 9 X 8=720	1 X 2 X 1=2
	# samples	12	1
	** MAII score	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/2*10)=2.32192809488736
Context	PubMed: PPP2R4 [Title/Abstract] AND FAM73B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PPP2R4(131901928)-FAM73B(131831355), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP2R4	GO:0032515	negative regulation of phosphoprotein phosphatase activity	16916641
Hgene	PPP2R4	GO:0032516	positive regulation of phosphoprotein phosphatase activity	16916641
Hgene	PPP2R4	GO:0035307	positive regulation of protein dephosphorylation	16916641
Hgene	PPP2R4	GO:0035308	negative regulation of protein dephosphorylation	16916641
Hgene	PPP2R4	GO:0043065	positive regulation of apoptotic process	17333320
Hgene	PPP2R4	GO:0043666	regulation of phosphoprotein phosphatase activity	16916641
Tgene	FAM73B	GO:0008053	mitochondrial fusion	26711011

Fusion gene breakpoints across PPP2R4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM73B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A5D6-01A	PPP2R4	chr9	131901928	-	FAM73B	chr9	131831355	+
ChimerDB4	BRCA	TCGA-OL-A5D6-01A	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
ChimerDB4	BRCA	TCGA-OL-A5D6-01A	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+

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Fusion Gene ORF analysis for PPP2R4-FAM73B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3UTR	ENST00000423100	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-3UTR	ENST00000423100	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-3UTR	ENST00000524946	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-3UTR	ENST00000524946	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-intron	ENST00000423100	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-intron	ENST00000423100	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-intron	ENST00000524946	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
5UTR-intron	ENST00000524946	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000337738	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000337738	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000347048	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000347048	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000348141	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000348141	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000355007	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000355007	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000357197	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000357197	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000358994	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000358994	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000393370	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000393370	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000414510	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000414510	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000419582	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000419582	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000432124	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000432124	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000432651	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000432651	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000434095	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000434095	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000435132	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000435132	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000435305	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000435305	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000436883	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000436883	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000452489	ENST00000277475	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-3UTR	ENST00000452489	ENST00000406926	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000337738	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000337738	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000337738	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000337738	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000337738	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000337738	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000347048	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000347048	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000347048	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000347048	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000347048	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000347048	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000348141	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000348141	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000348141	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000348141	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000348141	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000348141	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000355007	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000355007	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000355007	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000355007	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000355007	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000355007	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000357197	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000357197	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000357197	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000357197	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000357197	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000357197	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000358994	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000358994	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000358994	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000358994	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000358994	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000358994	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000393370	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000393370	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000393370	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000393370	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000393370	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000393370	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000414510	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000414510	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000414510	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000414510	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000414510	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000414510	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000419582	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000419582	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000419582	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000419582	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000419582	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000419582	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000423100	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000423100	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000423100	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000423100	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432124	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432124	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000432124	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432124	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432124	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000432124	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432651	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432651	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000432651	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432651	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000432651	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000432651	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000434095	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000434095	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000434095	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000434095	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000434095	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000434095	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435132	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435132	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000435132	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435132	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435132	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000435132	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435305	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435305	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000435305	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435305	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000435305	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000435305	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000436883	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000436883	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000436883	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000436883	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000436883	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000436883	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000452489	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000452489	ENST00000358369	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000452489	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000452489	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000452489	ENST00000474534	PPP2R4	chr9	131901928	+	FAM73B	chr9	131831355	+
intron-intron	ENST00000452489	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000524946	ENST00000277475	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000524946	ENST00000358369	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000524946	ENST00000406926	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+
intron-intron	ENST00000524946	ENST00000474534	PPP2R4	chr9	131902623	+	FAM73B	chr9	131830766	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PPP2R4-FAM73B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PPP2R4	chr9	131901928	+	FAM73B	chr9	131831354	+	0.73784083	0.26215923
PPP2R4	chr9	131901928	+	FAM73B	chr9	131831354	+	0.73784083	0.26215923

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PPP2R4-FAM73B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131901928/:131831355)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PPP2R4-FAM73B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PPP2R4-FAM73B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PPP2R4-FAM73B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PPP2R4-FAM73B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source