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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R4-PRRX2 (FusionGDB2 ID:68058)

Fusion Gene Summary for PPP2R4-PRRX2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R4-PRRX2
Fusion gene ID: 68058
HgeneTgene
Gene symbol

PPP2R4

PRRX2

Gene ID

5524

51450

Gene nameprotein phosphatase 2 phosphatase activatorpaired related homeobox 2
SynonymsPP2A|PPP2R4|PR53PMX2|PRX2
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosphpaired mesoderm homeobox protein 2PRX-2paired-like homeodomain protein PRX2paired-related homeobox protein 2testicular tissue protein Li 148testicular tissue protein Li 160
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337738, ENST00000348141, 
ENST00000355007, ENST00000357197, 
ENST00000358994, ENST00000393370, 
ENST00000452489, ENST00000347048, 
ENST00000414510, ENST00000419582, 
ENST00000423100, ENST00000432124, 
ENST00000432651, ENST00000434095, 
ENST00000435132, ENST00000435305, 
ENST00000436883, ENST00000524946, 
ENST00000372469, 
Fusion gene scores* DoF score10 X 9 X 8=7205 X 4 X 6=120
# samples 127
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R4 [Title/Abstract] AND PRRX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R4(131898874)-PRRX2(132481509), # samples:1
PRRX2(132428405)-PPP2R4(131882791), # samples:1
PRRX2(132428405)-PPP2R4(131882792), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R4

GO:0032515

negative regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0032516

positive regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0035307

positive regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0035308

negative regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0043065

positive regulation of apoptotic process

17333320

HgenePPP2R4

GO:0043666

regulation of phosphoprotein phosphatase activity

16916641


check buttonFusion gene breakpoints across PPP2R4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRRX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GRPPP2R4chr9

131898874

+PRRX2chr9

132481509

+


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Fusion Gene ORF analysis for PPP2R4-PRRX2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000337738ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
In-frameENST00000348141ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
In-frameENST00000355007ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
In-frameENST00000357197ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
In-frameENST00000358994ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
In-frameENST00000393370ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
In-frameENST00000452489ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000347048ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000414510ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000419582ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000423100ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000432124ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000432651ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000434095ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000435132ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000435305ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000436883ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+
intron-3CDSENST00000524946ENST00000372469PPP2R4chr9

131898874

+PRRX2chr9

132481509

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358994PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+164489781399463
ENST00000393370PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+17159681691470433
ENST00000337738PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+180410571531559468
ENST00000348141PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+17159681511470439
ENST00000452489PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+17501003991505468
ENST00000357197PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+1537790781292404
ENST00000355007PPP2R4chr9131898874+ENST00000372469PRRX2chr9132481509+1493746731248391

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358994ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.0169122740.9830877
ENST00000393370ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.0133338020.98666614
ENST00000337738ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.0086334980.99136645
ENST00000348141ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.0138391270.9861609
ENST00000452489ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.0094824930.99051756
ENST00000357197ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.021925860.9780741
ENST00000355007ENST00000372469PPP2R4chr9131898874+PRRX2chr9132481509+0.0178049580.9821951

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Fusion Genomic Features for PPP2R4-PRRX2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP2R4chr9131898874+PRRX2chr9132481509+2.25E-060.99999774
PPP2R4chr9131898874+PRRX2chr9132481509+2.25E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP2R4-PRRX2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131898874/chr9:132481509)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R4chr9:131898874chr9:132481509ENST00000337738+811183_189263359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000337738+811240_242263359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000355007+69183_189186282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000357197+69183_189199295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000358994+811183_189228324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000393370+710183_189228324.0Nucleotide bindingNote=ATP
TgenePRRX2chr9:131898874chr9:132481509ENST0000037246904104_16386254.0DNA bindingHomeobox
TgenePRRX2chr9:131898874chr9:132481509ENST0000037246904230_24386254.0MotifOAR

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R4chr9:131898874chr9:132481509ENST00000337738+811342_343263359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000355007+69240_242186282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000355007+69342_343186282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000357197+69240_242199295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000357197+69342_343199295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000358994+811240_242228324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000358994+811342_343228324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000393370+710240_242228324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131898874chr9:132481509ENST00000393370+710342_343228324.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for PPP2R4-PRRX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68058_68058_1_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000337738_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1804nt_BP=1057nt
CCGCACTGACATGGCCGTCGCCCGGTTCCGCGCGTCCGCCGCGCGCCGGCCGTTAATAGGCTTGCTCCCTGAGCGCCCCGCACCGACATG
GCGGCCGTCTTCGCTGTGGTGACTTTAACTCTCGGTTTTCGGTTATAGCCGGCCGGCGCTCACTTGTCTTCAGGAAGCTCGGAGCCTTTG
GTGGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTGCAAGCATCCGGGTCGGCTCCTGGCCGGAGCAAGATG
GCTGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCCACTCAGAACTTCATCATTCCAAAAAAGGAGATCCAC
ACAGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGCATACGCTGACTACATCGGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGG
AAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGATGTGGAATGAGGTTCATGAGGAAAAGGAGCAGGCTGCAAAGCAGAGTGTGTCCTGC
GATGAATGCATACCATTACCCCGCGCCGGGCACTGTGCACCTTCGGAGGCCATTGAGAAACTAGTCGCTCTTCTCAACACGCTGGACAGG
TGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACAGGACCTGGTATGCCAAACTTGATGAGGAAGCA
GAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTCC
ACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGAC
CAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGCAGC
CAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGCAGCTGATAGGTGAGTGTCCCAGCCCGGGGCGC
GGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCGCACCACGTTCAACAGCAGCCAACTGCAGGCGCTGGAGCGCGTGTTCGAG
CGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGCCCGGCGCGTCAACCTCAGCGAGGCGCGCGTTCAGGTCTGGTTTCAGAAC
CGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGCCAGCCGCTCTGCCTCGCTGCTCAAGTCCTACAGCCAGGAGGCCGCCATC
GAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGATTATCTCTCCTGGACAGCCTCGTCCCCCTACAGCACAGTGCCACCCTAC
AGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACATGGCCAACAGCATCGCCAGCCTCCGTCTCAAGGCCAAGGAGTTCAGCCTG
CACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCCACCAGGACCCAGACGCCTCCCTGGGTGGACAGCAATAGAAAAGGGGGCA
GACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGGCCCGTCTGTCCAGCCTGGACTCCCGAGCCCACGAGGCTGTTGAGGCCCC
TGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGACTGCAGCCCACAACCCTTGGAGGGGTTGGGCCGGAAGGTGGAAGAGCCTG

>68058_68058_1_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000337738_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=468AA_BP=1
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI
LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRT
WYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQK
TYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSE
ARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASL

--------------------------------------------------------------
>68058_68058_2_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000348141_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1715nt_BP=968nt
GCACTGACATGGCCGTCGCCCGGTTCCGCGCGTCCGCCGCGCGCCGGCCGTTAATAGGCTTGCTCCCTGAGCGCCCCGCACCGACATGGC
GGCCGTCTTCGCTGTGGTGACTTTAACTCTCGGTTTTCGGTTATAGCCGGCCGGCGCTCACTTGTCTTCAGGAAGCTCGGAGCCTTTGGT
GGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTGCAAGCATCCGGGTCGGCTCCTGGCCGGAGCAAGATGGC
TGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCCACTCAGAACTTCATCATTCCAAAAAAGGAGATCCACAC
AGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGTACCATTTGGAACTGTGGCATACGCTGACTACATCGGATTCATCCTTACCCTCAA
CGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGCCATTGAGAAACTAGTCGCTCTTCTCAACACGCTGGACAG
GTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACAGGACCTGGTATGCCAAACTTGATGAGGAAGC
AGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTC
CACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGA
CCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGCAG
CCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGCAGCTGATAGGTGAGTGTCCCAGCCCGGGGCG
CGGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCGCACCACGTTCAACAGCAGCCAACTGCAGGCGCTGGAGCGCGTGTTCGA
GCGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGCCCGGCGCGTCAACCTCAGCGAGGCGCGCGTTCAGGTCTGGTTTCAGAA
CCGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGCCAGCCGCTCTGCCTCGCTGCTCAAGTCCTACAGCCAGGAGGCCGCCAT
CGAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGATTATCTCTCCTGGACAGCCTCGTCCCCCTACAGCACAGTGCCACCCTA
CAGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACATGGCCAACAGCATCGCCAGCCTCCGTCTCAAGGCCAAGGAGTTCAGCCT
GCACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCCACCAGGACCCAGACGCCTCCCTGGGTGGACAGCAATAGAAAAGGGGGC
AGACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGGCCCGTCTGTCCAGCCTGGACTCCCGAGCCCACGAGGCTGTTGAGGCCC
CTGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGACTGCAGCCCACAACCCTTGGAGGGGTTGGGCCGGAAGGTGGAAGAGCCT

>68058_68058_2_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000348141_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=439AA_BP=1
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQVPFGTVAYA
DYIGFILTLNEGVKGKKLTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVA
VYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQ
LIGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASL

--------------------------------------------------------------
>68058_68058_3_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000355007_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1493nt_BP=746nt
CACCGACATGGCGGCCGTCTTCGCTGTGGTGACTTTAACTCTCGGTTTTCGGTTATAGCCGGCCGGCGCTCACTTGTCTTCAGGAAGCTC
GGAGCCTTTGGTGGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTGCAAGCATCCGGGTCGGCTCCTGGCCG
GAGCAAGATGGCTGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCCACTCAGAACTTCATCATTCCAAAAAA
GGAGATCCACACAGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGCATACGCTGACTACATCGGATTCATCCTTACCCTCAACGAAGG
TGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGC
TGCTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGC
TGCTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGA
GGTTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTT
CATCTGGGGCAGTTCGCAGCTGATAGGTGAGTGTCCCAGCCCGGGGCGCGGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCG
CACCACGTTCAACAGCAGCCAACTGCAGGCGCTGGAGCGCGTGTTCGAGCGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGC
CCGGCGCGTCAACCTCAGCGAGGCGCGCGTTCAGGTCTGGTTTCAGAACCGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGC
CAGCCGCTCTGCCTCGCTGCTCAAGTCCTACAGCCAGGAGGCCGCCATCGAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGA
TTATCTCTCCTGGACAGCCTCGTCCCCCTACAGCACAGTGCCACCCTACAGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACAT
GGCCAACAGCATCGCCAGCCTCCGTCTCAAGGCCAAGGAGTTCAGCCTGCACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCC
ACCAGGACCCAGACGCCTCCCTGGGTGGACAGCAATAGAAAAGGGGGCAGACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGG
CCCGTCTGTCCAGCCTGGACTCCCGAGCCCACGAGGCTGTTGAGGCCCCTGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGAC

>68058_68058_3_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000355007_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=391AA_BP=1
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI
LTLNEGVKGKKLTFEYRVSEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKV
FNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAF
VREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPA

--------------------------------------------------------------
>68058_68058_4_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000357197_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1537nt_BP=790nt
CCCCGCACCGACATGGCGGCCGTCTTCGCTGTGGTGACTTTAACTCTCGGTTTTCGGTTATAGCCGGCCGGCGCTCACTTGTCTTCAGGA
AGCTCGGAGCCTTTGGTGGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTGCAAGCATCCGGGTCGGCTCCT
GGCCGGAGCAAGATGGCTGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCCACTCAGAACTTCATCATTCCA
AAAAAGGAGATCCACACAGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGCCATTGAGAAACTAGTCGCTCTTCTCAACACGCTGGAC
AGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACAGGACCTGGTATGCCAAACTTGATGAGGAA
GCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAAC
TCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGAT
GACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGC
AGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGCAGCTGATAGGTGAGTGTCCCAGCCCGGGG
CGCGGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCGCACCACGTTCAACAGCAGCCAACTGCAGGCGCTGGAGCGCGTGTTC
GAGCGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGCCCGGCGCGTCAACCTCAGCGAGGCGCGCGTTCAGGTCTGGTTTCAG
AACCGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGCCAGCCGCTCTGCCTCGCTGCTCAAGTCCTACAGCCAGGAGGCCGCC
ATCGAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGATTATCTCTCCTGGACAGCCTCGTCCCCCTACAGCACAGTGCCACCC
TACAGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACATGGCCAACAGCATCGCCAGCCTCCGTCTCAAGGCCAAGGAGTTCAGC
CTGCACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCCACCAGGACCCAGACGCCTCCCTGGGTGGACAGCAATAGAAAAGGGG
GCAGACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGGCCCGTCTGTCCAGCCTGGACTCCCGAGCCCACGAGGCTGTTGAGGC
CCCTGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGACTGCAGCCCACAACCCTTGGAGGGGTTGGGCCGGAAGGTGGAAGAGC

>68058_68058_4_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000357197_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=404AA_BP=1
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAIEKLVALL
NTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGV
LRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQAL
ERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYS

--------------------------------------------------------------
>68058_68058_5_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000358994_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1644nt_BP=897nt
ATTGAGACCTGTGGAGGAGGAAGGAGGAGGTCACCGTCCAGCTGTCTCTCCCCTGTCCCCACATGTCTTCTAAGCTGTTGGAGCCGGCCG
GCGCTCACTTGTCTTCAGGAAGCTCGGAGCCTTTGGTGGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTGC
AAGCATCCGGGTCGGCTCCTGGCCGGAGCAAGATGGCTGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCCA
CTCAGAACTTCATCATTCCAAAAAAGGAGATCCACACAGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGCATACGCTGACTACATCG
GATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGCCATTGAGAAACTAGTCGCTC
TTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACAGGACCTGGTATG
CCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGGCTGTTTACCTAA
AGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTCTCTGCAAGATTG
GGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCCAGAAAACATACA
GGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGCAGCTGATAGGTG
AGTGTCCCAGCCCGGGGCGCGGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCGCACCACGTTCAACAGCAGCCAACTGCAGG
CGCTGGAGCGCGTGTTCGAGCGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGCCCGGCGCGTCAACCTCAGCGAGGCGCGCG
TTCAGGTCTGGTTTCAGAACCGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGCCAGCCGCTCTGCCTCGCTGCTCAAGTCCT
ACAGCCAGGAGGCCGCCATCGAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGATTATCTCTCCTGGACAGCCTCGTCCCCCT
ACAGCACAGTGCCACCCTACAGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACATGGCCAACAGCATCGCCAGCCTCCGTCTCA
AGGCCAAGGAGTTCAGCCTGCACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCCACCAGGACCCAGACGCCTCCCTGGGTGGA
CAGCAATAGAAAAGGGGGCAGACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGGCCCGTCTGTCCAGCCTGGACTCCCGAGCC
CACGAGGCTGTTGAGGCCCCTGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGACTGCAGCCCACAACCCTTGGAGGGGTTGGG

>68058_68058_5_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000358994_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=463AA_BP=1
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL
DEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRME
PAGSQGVWGLDDFQFLPFIWGSSQLIGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQV
WFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAK

--------------------------------------------------------------
>68058_68058_6_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000393370_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1715nt_BP=968nt
ATGCGCCCCGCGCGCCCCGCACTGACATGGCCGTCGCCCGGTTCCGCGCGTCCGCCGCGCGCCGGCCGTTAATAGGCTTGCTCCCTGAGC
GCCCCGCACCGACATGGCGGCCGTCTTCGCTGTGGTGACTTTAACTCTCGGTTTTCGGTTATAGCCGGCCGGCGCTCACTTGTCTTCAGG
AAGCTCGGAGCCTTTGGTGGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTGCAAGCATCCGGGTCGGCTCC
TGGCCGGAGCAAGATGGCTGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCCACTCAGAACTTCATCATTCC
AAAAAAGGAGATCCACACAGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGCATACGCTGACTACATCGGATTCATCCTTACCCTCAA
CGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGCCATTGAGAAACTAGTCGCTCTTCTCAACACGCTGGACAG
GTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACAGGACCTGGTATGCCAAACTTGATGAGGAAGC
AGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTC
CACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGA
CCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGCAG
CCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGCAGCTGATAGGTGAGTGTCCCAGCCCGGGGCG
CGGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCGCACCACGTTCAACAGCAGCCAACTGCAGGCGCTGGAGCGCGTGTTCGA
GCGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGCCCGGCGCGTCAACCTCAGCGAGGCGCGCGTTCAGGTCTGGTTTCAGAA
CCGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGCCAGCCGCTCTGCCTCGCTGCTCAAGTCCTACAGCCAGGAGGCCGCCAT
CGAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGATTATCTCTCCTGGACAGCCTCGTCCCCCTACAGCACAGTGCCACCCTA
CAGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACATGGCCAACAGCATCGCCAGCCTCCGTCTCAAGGCCAAGGAGTTCAGCCT
GCACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCCACCAGGACCCAGACGCCTCCCTGGGTGGACAGCAATAGAAAAGGGGGC
AGACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGGCCCGTCTGTCCAGCCTGGACTCCCGAGCCCACGAGGCTGTTGAGGCCC
CTGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGACTGCAGCCCACAACCCTTGGAGGGGTTGGGCCGGAAGGTGGAAGAGCCT

>68058_68058_6_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000393370_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=433AA_BP=1
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI
LTLNEGVKGKKLTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKES
VGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIGECP
SPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQ

--------------------------------------------------------------
>68058_68058_7_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000452489_PRRX2_chr9_132481509_ENST00000372469_length(transcript)=1750nt_BP=1003nt
AATAGGCTTGCTCCCTGAGCGCCCCGCACCGACATGGCGGCCGTCTTCGCTGTGGTGACTTTAACTCTCGGTTTTCGGTTATAGCCGGCC
GGCGCTCACTTGTCTTCAGGAAGCTCGGAGCCTTTGGTGGAGCCGGGGAGAGGAAGGGTGGGTGCAAGAGTGAAAGGCGAGAGGGGACTG
CAAGCATCCGGGTCGGCTCCTGGCCGGAGCAAGATGGCTGAGGGCGAGCGGCAGCCGCCGCCAGATTCTTCAGAGGAGGCCCCTCCAGCC
ACTCAGAACTTCATCATTCCAAAAAAGGAGATCCACACAGTTCCAGACATGGGCAAATGGAAGCGTTCTCAGGCATACGCTGACTACATC
GGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGATGTGGAATGAGGTTCATGAG
GAAAAGGAGCAGGCTGCAAAGCAGAGTGTGTCCTGCGATGAATGCATACCATTACCCCGCGCCGGGCACTGTGCACCTTCGGAGGCCATT
GAGAAACTAGTCGCTCTTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCA
TACAGGACCTGGTATGCCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAG
GTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGC
TGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAA
CTCCAGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGT
TCGCAGCTGATAGGTGAGTGTCCCAGCCCGGGGCGCGGTAGCGCCGCCAAGCGGAAGAAGAAGCAGCGGCGGAACCGCACCACGTTCAAC
AGCAGCCAACTGCAGGCGCTGGAGCGCGTGTTCGAGCGCACGCACTACCCCGACGCCTTTGTGCGCGAGGAGCTTGCCCGGCGCGTCAAC
CTCAGCGAGGCGCGCGTTCAGGTCTGGTTTCAGAACCGCCGCGCCAAGTTCCGCAGGAATGAAAGGGCCATGCTGGCCAGCCGCTCTGCC
TCGCTGCTCAAGTCCTACAGCCAGGAGGCCGCCATCGAGCAGCCCGTGGCTCCCCGGCCCACCGCCCTGAGTCCAGATTATCTCTCCTGG
ACAGCCTCGTCCCCCTACAGCACAGTGCCACCCTACAGCCCTGGGAGCTCAGGCCCCGCAACCCCAGGGGTCAACATGGCCAACAGCATC
GCCAGCCTCCGTCTCAAGGCCAAGGAGTTCAGCCTGCACCACAGCCAGGTGCCTACGGTGAACTGAAGTCCAGTCCCACCAGGACCCAGA
CGCCTCCCTGGGTGGACAGCAATAGAAAAGGGGGCAGACGCCCAGGAAGTGACCTTCTCCTGGATGAGCTCTCCTGGCCCGTCTGTCCAG
CCTGGACTCCCGAGCCCACGAGGCTGTTGAGGCCCCTGCAGCCGGGCCCAGCTCTTCTGTCCTTGGCCACCAGAGACTGCAGCCCACAAC

>68058_68058_7_PPP2R4-PRRX2_PPP2R4_chr9_131898874_ENST00000452489_PRRX2_chr9_132481509_ENST00000372469_length(amino acids)=468AA_BP=1
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI
LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRT
WYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQK
TYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSE
ARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP2R4-PRRX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R4-PRRX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R4-PRRX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource