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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R5A-CD55 (FusionGDB2 ID:68060)

Fusion Gene Summary for PPP2R5A-CD55

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R5A-CD55
Fusion gene ID: 68060
HgeneTgene
Gene symbol

PPP2R5A

CD55

Gene ID

5525

1604

Gene nameprotein phosphatase 2 regulatory subunit B'alphaCD55 molecule (Cromer blood group)
SynonymsB56A|B56alpha|PR61ACHAPLE|CR|CROM|DAF|TC
Cytomap

1q32.3

1q32.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B sucomplement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen
Modification date2020031320200313
UniProtAcc.

P08174

Ensembl transtripts involved in fusion geneENST00000498129, ENST00000261461, 
ENST00000537030, 		ENST00000367064, 
ENST00000314754, ENST00000367062, 
ENST00000367065, ENST00000367067, 
ENST00000391920, ENST00000465534, 
ENST00000367063, ENST00000391921, 
Fusion gene scores* DoF score6 X 5 X 4=12010 X 8 X 4=320
# samples 610
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R5A [Title/Abstract] AND CD55 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R5A(212506940)-CD55(207532890), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R5A

GO:0006470

protein dephosphorylation

24157919

TgeneCD55

GO:0007204

positive regulation of cytosolic calcium ion concentration

8223854

TgeneCD55

GO:0030449

regulation of complement activation

25284781

TgeneCD55

GO:0031664

regulation of lipopolysaccharide-mediated signaling pathway

12731067

TgeneCD55

GO:0035743

CD4-positive, alpha-beta T cell cytokine production

16818763

TgeneCD55

GO:0045916

negative regulation of complement activation

6211481

TgeneCD55

GO:1903659

regulation of complement-dependent cytotoxicity

25284781

TgeneCD55

GO:2000516

positive regulation of CD4-positive, alpha-beta T cell activation

16818763

TgeneCD55

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

16818763


check buttonFusion gene breakpoints across PPP2R5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD55 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080PPP2R5Achr1

212506940

+CD55chr1

207532890

+


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Fusion Gene ORF analysis for PPP2R5A-CD55

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000498129ENST00000367064PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-3UTRENST00000498129ENST00000314754PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-3UTRENST00000498129ENST00000367062PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-3UTRENST00000498129ENST00000367065PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-3UTRENST00000498129ENST00000367067PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-3UTRENST00000498129ENST00000391920PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-3UTRENST00000498129ENST00000465534PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-intronENST00000498129ENST00000367063PPP2R5Achr1

212506940

+CD55chr1

207532890

+
3UTR-intronENST00000498129ENST00000391921PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000261461ENST00000314754PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000261461ENST00000367062PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000261461ENST00000367065PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000261461ENST00000367067PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000261461ENST00000391920PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000261461ENST00000465534PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000537030ENST00000314754PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000537030ENST00000367062PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000537030ENST00000367065PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000537030ENST00000367067PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000537030ENST00000391920PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-3UTRENST00000537030ENST00000465534PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-intronENST00000261461ENST00000367063PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-intronENST00000261461ENST00000391921PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-intronENST00000537030ENST00000367063PPP2R5Achr1

212506940

+CD55chr1

207532890

+
5CDS-intronENST00000537030ENST00000391921PPP2R5Achr1

212506940

+CD55chr1

207532890

+
In-frameENST00000261461ENST00000367064PPP2R5Achr1

212506940

+CD55chr1

207532890

+
In-frameENST00000537030ENST00000367064PPP2R5Achr1

212506940

+CD55chr1

207532890

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261461PPP2R5Achr1212506940+ENST00000367064CD55chr1207532890+2475105475215245
ENST00000537030PPP2R5Achr1212506940+ENST00000367064CD55chr1207532890+2007586277606109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261461ENST00000367064PPP2R5Achr1212506940+CD55chr1207532890+0.0042128230.9957872
ENST00000537030ENST00000367064PPP2R5Achr1212506940+CD55chr1207532890+0.0109141550.98908585

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Fusion Genomic Features for PPP2R5A-CD55


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP2R5Achr1212506940+CD55chr1207532890+6.57E-070.9999993
PPP2R5Achr1212506940+CD55chr1207532890+6.57E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP2R5A-CD55


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:212506940/chr1:207532890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CD55

P08174

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R5Achr1:212506940chr1:207532890ENST00000261461+3132_5160487.0Compositional biasNote=Poly-Ser
HgenePPP2R5Achr1:212506940chr1:207532890ENST00000537030+3132_5103430.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD55chr1:212506940chr1:207532890ENST00000314754911287_356399441.0Compositional biasNote=Ser/Thr-rich
TgeneCD55chr1:212506940chr1:207532890ENST00000367062911287_356388436.0Compositional biasNote=Ser/Thr-rich
TgeneCD55chr1:212506940chr1:207532890ENST00000367064810287_356360382.0Compositional biasNote=Ser/Thr-rich
TgeneCD55chr1:212506940chr1:207532890ENST00000367065911287_356398440.0Compositional biasNote=Ser/Thr-rich
TgeneCD55chr1:212506940chr1:207532890ENST00000391920911287_356391456.0Compositional biasNote=Ser/Thr-rich
TgeneCD55chr1:212506940chr1:207532890ENST00000314754911161_222399441.0DomainSushi 3
TgeneCD55chr1:212506940chr1:207532890ENST00000314754911223_285399441.0DomainSushi 4
TgeneCD55chr1:212506940chr1:207532890ENST0000031475491135_96399441.0DomainSushi 1
TgeneCD55chr1:212506940chr1:207532890ENST0000031475491196_160399441.0DomainSushi 2
TgeneCD55chr1:212506940chr1:207532890ENST00000367062911161_222388436.0DomainSushi 3
TgeneCD55chr1:212506940chr1:207532890ENST00000367062911223_285388436.0DomainSushi 4
TgeneCD55chr1:212506940chr1:207532890ENST0000036706291135_96388436.0DomainSushi 1
TgeneCD55chr1:212506940chr1:207532890ENST0000036706291196_160388436.0DomainSushi 2
TgeneCD55chr1:212506940chr1:207532890ENST00000367064810161_222360382.0DomainSushi 3
TgeneCD55chr1:212506940chr1:207532890ENST00000367064810223_285360382.0DomainSushi 4
TgeneCD55chr1:212506940chr1:207532890ENST0000036706481035_96360382.0DomainSushi 1
TgeneCD55chr1:212506940chr1:207532890ENST0000036706481096_160360382.0DomainSushi 2
TgeneCD55chr1:212506940chr1:207532890ENST00000367065911161_222398440.0DomainSushi 3
TgeneCD55chr1:212506940chr1:207532890ENST00000367065911223_285398440.0DomainSushi 4
TgeneCD55chr1:212506940chr1:207532890ENST0000036706591135_96398440.0DomainSushi 1
TgeneCD55chr1:212506940chr1:207532890ENST0000036706591196_160398440.0DomainSushi 2
TgeneCD55chr1:212506940chr1:207532890ENST00000391920911161_222391456.0DomainSushi 3
TgeneCD55chr1:212506940chr1:207532890ENST00000391920911223_285391456.0DomainSushi 4
TgeneCD55chr1:212506940chr1:207532890ENST0000039192091135_96391456.0DomainSushi 1
TgeneCD55chr1:212506940chr1:207532890ENST0000039192091196_160391456.0DomainSushi 2


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Fusion Gene Sequence for PPP2R5A-CD55


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68060_68060_1_PPP2R5A-CD55_PPP2R5A_chr1_212506940_ENST00000261461_CD55_chr1_207532890_ENST00000367064_length(transcript)=2475nt_BP=1054nt
CGCAGAGGGCCGGGGCTACGGGGCAGCGCCCCGGGCGATGAGGGGCCGGCGTTGACCGGGAAGAGCGGGCACCGCGGCAGTGGCTCCGAG
GGGACCCGCGATGGCAGCGCCCTGAGAGGAGGCTCCAGGCAGGGCGGGCTGCGCTGGCAGCGGCCGCTGAGGTGCTGGCCGGCCGGCTGG
CTGGCGACGGGGGCAGAAGCGACGAGAGGCGCGCTCGGCACCCGCACCCCCGTGCCCCCGCCTCAGTTGTCTAAACTTCGGGCTCTCTTC
CACCCGCTCTGCGCGCCCAGAGTCAACAACTTCTTCACCCCCCTCCGCCCCCGCCCTTCCCTCCGTCAGCCCCGGGAGCTCGCCGCGCGC
CGGGGACCAGGAACCTCCAGCGCTGAGATGTGGCCGTGAGGCGTTGGCGGGCGGCGAGGAGAAGCTCGGCGGCGTCCCGGGGCCGGAGGG
CCGTGGGGCCGGGGCGCAGGGGCGCGAGCACCCCGCGCCTCTCCCCCGCCTCCTCCTGCCGTCTCCGCCGCTGCCCGTGCCTTGCAAGCA
GCAGCCGGAGCTGCCAAGCGTCAGGGCCGCGGAGATGTCGTCGTCGTCGCCGCCGGCGGGGGCTGCCAGCGCCGCCATCTCGGCCTCGGA
GAAAGTGGACGGCTTCACCCGGAAATCGGTCCGCAAGGCGCAGAGGCAGAAGCGCTCCCAGGGCTCGTCGCAGTTTCGCAGCCAGGGCAG
CCAGGCAGAGCTGCACCCGCTGCCCCAGCTCAAAGATGCCACTTCAAATGAACAACAAGAGCTTTTCTGTCAGAAGTTGCAGCAGTGTTG
TATACTGTTTGATTTCATGGACTCTGTTTCAGACTTGAAGAGCAAAGAAATTAAAAGAGCAACACTGAATGAACTGGTTGAGTATGTTTC
AACTAATCGTGGTGTAATTGTTGAATCAGCGTATTCTGATATAGTAAAAATGATCAGTGCTAACATCTTCCGTACACTTCCTCCAAGTGA
TAATCCAGATTTTGATCCAGAAGAGGATGAACCCACGCTTGAGGCCTCTTGGCCTCACATACAGGGCACACGTGTTTCACGTTGACAGGT
TTGCTTGGGACGCTAGTAACCATGGGCTTGCTGACTTAGCCAAAGAAGAGTTAAGAAGAAAATACACACAAGTATACAGACTGTTCCTAG
TTTCTTAGACTTATCTGCATATTGGATAAAATAAATGCAATTGTGCTCTTCATTTAGGATGCTTTCATTGTCTTTAAGATGTGTTAGGAA
TGTCAACAGAGCAAGGAGAAAAAAGGCAGTCCTGGAATCACATTCTTAGCACACCTACACCTCTTGAAAATAGAACAACTTGCAGAATTG
AGAGTGATTCCTTTCCTAAAAGTGTAAGAAAGCATAGAGATTTGTTCGTATTTAGAATGGGATCACGAGGAAAAGAGAAGGAAAGTGATT
TTTTTCCACAAGATCTGTAATGTTATTTCCACTTATAAAGGAAATAAAAAATGAAAAACATTATTTGGATATCAAAAGCAAATAAAAACC
CAATTCAGTCTCTTCTAAGCAAAATTGCTAAAGAGAGATGAACCACATTATAAAGTAATCTTTGGCTGTAAGGCATTTTCATCTTTCCTT
CGGGTTGGCAAAATATTTTAAAGGTAAAACATGCTGGTGAACCAGGGGTGTTGATGGTGATAAGGGAGGAATATAGAATGAAAGACTGAA
TCTTCCTTTGTTGCACAAATAGAGTTTGGAAAAAGCCTGTGAAAGGTGTCTTCTTTGACTTAATGTCTTTAAAAGTATCCAGAGATACTA
CAATATTAACATAAGAAAAGATTATATATTATTTCTGAATCGAGATGTCCATAGTCAAATTTGTAAATCTTATTCTTTTGTAATATTTAT
TTATATTTATTTATGACAGTGAACATTCTGATTTTACATGTAAAACAAGAAAAGTTGAAGAAGATATGTGAAGAAAAATGTATTTTTCCT
AAATAGAAATAAATGATCCCATTTTTTGGTATCATGTAGTATGTGAAATTTATTCTTAAACGTGACTACTTTATTTCTAAATAAGAAATT
CCCTACCTGCTTCCTACAAGCAGTTCAGAATGCCATGCCTTGGTTGTCCTAGTGTGAATAATTTTCAGCTACTTTAAAATTATATTGTAC
TTTCTCAAGCATGTCATATCCTTTCCTATTAGAGTATCTATATTACTTGTTACTGATTTACCTGAAGGCAATCTGATTAATTTCTAGGTT
TTTACCATATTCTTGTCATCTTGCCAATTACATTTTAAGTGTTAGACTAGACTAAGATGTACTAGTTGTATAGAATATAACTAGATTTAT
TATGGCAATGTTTATTTTGTCATTTTGCTTCATCTGTTTTGTTGTTGAAGTACTTTAAATTTCATACGTTCATGGCATTTCACTGTAAAG

>68060_68060_1_PPP2R5A-CD55_PPP2R5A_chr1_212506940_ENST00000261461_CD55_chr1_207532890_ENST00000367064_length(amino acids)=245AA_BP=
MSWGSGCSSAWLPWLRNCDEPWERFCLCALRTDFRVKPSTFSEAEMAALAAPAGGDDDDISAALTLGSSGCCLQGTGSGGDGRRRRGRGA
GCSRPCAPAPRPSGPGTPPSFSSPPANASRPHLSAGGSWSPARGELPGLTEGRAGAEGGEEVVDSGRAERVEESPKFRQLRRGHGGAGAE

--------------------------------------------------------------
>68060_68060_2_PPP2R5A-CD55_PPP2R5A_chr1_212506940_ENST00000537030_CD55_chr1_207532890_ENST00000367064_length(transcript)=2007nt_BP=586nt
ATGATACAGTGCTTGTTCTATAATTTGTAGCATGAATCCTATATGAGATCTTACTTTAGATTTCAAGTATGTTAGCAGCAGTAATTAGGG
ATGTTTTCCTCTAAGGAAAATTATAGTTATAAAATTATTATTTGTTAGAAATGATTCCTGCTACTTCAAATTATTTATCCTTAAATGTAG
AGGATTAACAATGAACAACTTGAAATAACTTGGTTATCACCTCAGAAGTTTAGTTTATCACTGATTTAATGAAGAAGGGCAAGAAGAGGA
AGGCTTTATGATAATGAATGCCACTTCAAATGAACAACAAGAGCTTTTCTGTCAGAAGTTGCAGCAGTGTTGTATACTGTTTGATTTCAT
GGACTCTGTTTCAGACTTGAAGAGCAAAGAAATTAAAAGAGCAACACTGAATGAACTGGTTGAGTATGTTTCAACTAATCGTGGTGTAAT
TGTTGAATCAGCGTATTCTGATATAGTAAAAATGATCAGTGCTAACATCTTCCGTACACTTCCTCCAAGTGATAATCCAGATTTTGATCC
AGAAGAGGATGAACCCACGCTTGAGGCCTCTTGGCCTCACATACAGGGCACACGTGTTTCACGTTGACAGGTTTGCTTGGGACGCTAGTA
ACCATGGGCTTGCTGACTTAGCCAAAGAAGAGTTAAGAAGAAAATACACACAAGTATACAGACTGTTCCTAGTTTCTTAGACTTATCTGC
ATATTGGATAAAATAAATGCAATTGTGCTCTTCATTTAGGATGCTTTCATTGTCTTTAAGATGTGTTAGGAATGTCAACAGAGCAAGGAG
AAAAAAGGCAGTCCTGGAATCACATTCTTAGCACACCTACACCTCTTGAAAATAGAACAACTTGCAGAATTGAGAGTGATTCCTTTCCTA
AAAGTGTAAGAAAGCATAGAGATTTGTTCGTATTTAGAATGGGATCACGAGGAAAAGAGAAGGAAAGTGATTTTTTTCCACAAGATCTGT
AATGTTATTTCCACTTATAAAGGAAATAAAAAATGAAAAACATTATTTGGATATCAAAAGCAAATAAAAACCCAATTCAGTCTCTTCTAA
GCAAAATTGCTAAAGAGAGATGAACCACATTATAAAGTAATCTTTGGCTGTAAGGCATTTTCATCTTTCCTTCGGGTTGGCAAAATATTT
TAAAGGTAAAACATGCTGGTGAACCAGGGGTGTTGATGGTGATAAGGGAGGAATATAGAATGAAAGACTGAATCTTCCTTTGTTGCACAA
ATAGAGTTTGGAAAAAGCCTGTGAAAGGTGTCTTCTTTGACTTAATGTCTTTAAAAGTATCCAGAGATACTACAATATTAACATAAGAAA
AGATTATATATTATTTCTGAATCGAGATGTCCATAGTCAAATTTGTAAATCTTATTCTTTTGTAATATTTATTTATATTTATTTATGACA
GTGAACATTCTGATTTTACATGTAAAACAAGAAAAGTTGAAGAAGATATGTGAAGAAAAATGTATTTTTCCTAAATAGAAATAAATGATC
CCATTTTTTGGTATCATGTAGTATGTGAAATTTATTCTTAAACGTGACTACTTTATTTCTAAATAAGAAATTCCCTACCTGCTTCCTACA
AGCAGTTCAGAATGCCATGCCTTGGTTGTCCTAGTGTGAATAATTTTCAGCTACTTTAAAATTATATTGTACTTTCTCAAGCATGTCATA
TCCTTTCCTATTAGAGTATCTATATTACTTGTTACTGATTTACCTGAAGGCAATCTGATTAATTTCTAGGTTTTTACCATATTCTTGTCA
TCTTGCCAATTACATTTTAAGTGTTAGACTAGACTAAGATGTACTAGTTGTATAGAATATAACTAGATTTATTATGGCAATGTTTATTTT
GTCATTTTGCTTCATCTGTTTTGTTGTTGAAGTACTTTAAATTTCATACGTTCATGGCATTTCACTGTAAAGACTTTAATGTGTATTTCT

>68060_68060_2_PPP2R5A-CD55_PPP2R5A_chr1_212506940_ENST00000537030_CD55_chr1_207532890_ENST00000367064_length(amino acids)=109AA_BP=
MIMNATSNEQQELFCQKLQQCCILFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEE

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Fusion Gene PPI Analysis for PPP2R5A-CD55


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R5A-CD55


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R5A-CD55


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource