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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PPP2R5C-ABCG1 (FusionGDB2 ID:68068)

Fusion Gene Summary for PPP2R5C-ABCG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R5C-ABCG1
Fusion gene ID: 68068
HgeneTgene
Gene symbol

PPP2R5C

ABCG1

Gene ID

5527

9619

Gene nameprotein phosphatase 2 regulatory subunit B'gammaATP binding cassette subfamily G member 1
SynonymsB56G|B56gamma|PR61GABC8|WHITE1
Cytomap

14q32.31

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphatATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2020031320200329
UniProtAcc.

P45844

Ensembl transtripts involved in fusion geneENST00000556068, ENST00000328724, 
ENST00000554442, ENST00000334743, 
ENST00000350249, ENST00000422945, 
ENST00000445439, ENST00000556260, 
ENST00000556946, ENST00000557095, 
ENST00000557714, 		ENST00000398457, 
ENST00000340588, ENST00000343687, 
ENST00000347800, ENST00000361802, 
ENST00000398437, ENST00000398449, 
ENST00000462050, 
Fusion gene scores* DoF score18 X 11 X 8=15849 X 5 X 8=360
# samples 1910
** MAII scorelog2(19/1584*10)=-3.05950101174866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R5C [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP2R5C(102252520)-ABCG1(43691180), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R5C

GO:0008285

negative regulation of cell proliferation

17245430

TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612

TgeneABCG1

GO:0050714

positive regulation of protein secretion

17293612

TgeneABCG1

GO:1902004

positive regulation of amyloid-beta formation

17293612


check buttonFusion gene breakpoints across PPP2R5C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315353PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+


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Fusion Gene ORF analysis for PPP2R5C-ABCG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000556068ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
3UTR-3UTRENST00000556068ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000328724ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
5CDS-3UTRENST00000554442ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
In-frameENST00000328724ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
In-frameENST00000554442ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000334743ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000350249ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000422945ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000445439ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000556260ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000556946ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000557095ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3CDSENST00000557714ENST00000398457PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000334743ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000350249ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000422945ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000445439ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556260ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000556946ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557095ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000340588PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000343687PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000347800PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000361802PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000398437PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000398449PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+
intron-3UTRENST00000557714ENST00000462050PPP2R5Cchr14

102252520

+ABCG1chr21

43691180

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000554442PPP2R5Cchr14102252520+ENST00000398457ABCG1chr2143691180+2858291322005657
ENST00000328724PPP2R5Cchr14102252520+ENST00000398457ABCG1chr2143691180+283526891982657

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000554442ENST00000398457PPP2R5Cchr14102252520+ABCG1chr2143691180+0.0017193670.99828064
ENST00000328724ENST00000398457PPP2R5Cchr14102252520+ABCG1chr2143691180+0.00162510.9983748

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Fusion Genomic Features for PPP2R5C-ABCG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PPP2R5Cchr14102252520+ABCG1chr2143691179+3.90E-050.999961
PPP2R5Cchr14102252520+ABCG1chr2143691179+3.90E-050.999961

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PPP2R5C-ABCG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102252520/chr21:43691180)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCG1

P45844

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115415_673106678.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115415_67392664.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115415_67395679.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115415_67395667.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216415_67397669.0DomainNote=ABC transmembrane type-2
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115118_125106678.0Nucleotide bindingATP
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115118_12592664.0Nucleotide bindingATP
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115118_12595679.0Nucleotide bindingATP
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115118_12595667.0Nucleotide bindingATP
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216118_12597669.0Nucleotide bindingATP
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115446_456106678.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115478_506106678.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115526_533106678.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115556_567106678.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115587_649106678.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115670_678106678.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115446_45692664.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115478_50692664.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115526_53392664.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115556_56792664.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115587_64992664.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115670_67892664.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115446_45695679.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115478_50695679.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115526_53395679.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115556_56795679.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115587_64995679.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115670_67895679.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115446_45695667.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115478_50695667.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115526_53395667.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115556_56795667.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115587_64995667.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115670_67895667.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216446_45697669.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216478_50697669.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216526_53397669.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216556_56797669.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216587_64997669.0Topological domainExtracellular
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216670_67897669.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115427_445106678.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115457_477106678.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115507_525106678.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115534_555106678.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115568_586106678.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000343687115650_669106678.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115427_44592664.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115457_47792664.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115507_52592664.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115534_55592664.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115568_58692664.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000347800115650_66992664.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115427_44595679.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115457_47795679.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115507_52595679.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115534_55595679.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115568_58695679.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000361802115650_66995679.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115427_44595667.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115457_47795667.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115507_52595667.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115534_55595667.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115568_58695667.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398449115650_66995667.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216427_44597669.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216457_47797669.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216507_52597669.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216534_55597669.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216568_58697669.0TransmembraneHelical
TgeneABCG1chr14:102252520chr21:43691180ENST00000398457216650_66997669.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R5Cchr14:102252520chr21:43691180ENST00000328724+315416_42286541.0MotifNuclear localization signal
HgenePPP2R5Cchr14:102252520chr21:43691180ENST00000334743+114416_4220525.0MotifNuclear localization signal
HgenePPP2R5Cchr14:102252520chr21:43691180ENST00000350249+113416_4220486.0MotifNuclear localization signal
HgenePPP2R5Cchr14:102252520chr21:43691180ENST00000422945+116416_4220556.0MotifNuclear localization signal
HgenePPP2R5Cchr14:102252520chr21:43691180ENST00000445439+112416_4220450.0MotifNuclear localization signal
TgeneABCG1chr14:102252520chr21:43691180ENST0000034368711577_317106678.0DomainABC transporter
TgeneABCG1chr14:102252520chr21:43691180ENST0000034780011577_31792664.0DomainABC transporter
TgeneABCG1chr14:102252520chr21:43691180ENST0000036180211577_31795679.0DomainABC transporter
TgeneABCG1chr14:102252520chr21:43691180ENST0000039844911577_31795667.0DomainABC transporter
TgeneABCG1chr14:102252520chr21:43691180ENST0000039845721677_31797669.0DomainABC transporter
TgeneABCG1chr14:102252520chr21:43691180ENST000003436871151_426106678.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST000003478001151_42692664.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST000003618021151_42695679.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST000003984491151_42695667.0Topological domainCytoplasmic
TgeneABCG1chr14:102252520chr21:43691180ENST000003984572161_42697669.0Topological domainCytoplasmic


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Fusion Gene Sequence for PPP2R5C-ABCG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>68068_68068_1_PPP2R5C-ABCG1_PPP2R5C_chr14_102252520_ENST00000328724_ABCG1_chr21_43691180_ENST00000398457_length(transcript)=2835nt_BP=268nt
GCTCCAGCCATGCCGAATAAAAACAAGAAGGAGAAAGAATCACCAAAAGCAGGGAAGAGTGGAAAAAGTTCAAAAGAAGGACAAGACACA
GTAGAATCAGAGCAAATTTCCGTCAGGAAAAACAGCCTTGTTGCTGTCCCGTCTACAGTATCTGCTAAAATAAAAGTACCAGTCTCTCAG
CCCATAGTGAAGAAAGACAAACGGCAAAATTCTTCAAGGTTTAGCGCAAGCAATAATAGAGAACTTCAAAAACTACCATCCTTAAAAGGA
TACAAGACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAGTCCACG
CTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGG
AAGGTGTCCTGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTGAAGCTT
CAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGC
CTGTCAGGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACCAGCGGC
CTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCC
AGCGCCAAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTTGTGCCA
TATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAG
AACAGTCGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAACCCTTTT
CTTTGGCACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAGTTCTGCATCCTC
TTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGC
CTGCTGTACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTCCTCATGTTCGCG
GCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTAC
TACCTGGCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATGACGTCGCAGCCG
TCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCC
TCCACGTCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTCAGCTTCGACACC
ATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGG
GAAGATCTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAAAATGCCAAGCTG
TACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGG
TAAAACACCTGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAGGAGGCAAGCCTGTGCCCGACCGA
CGACACAGAGACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGCCACTCTGCCCAGCTGGGTTGGAT
CTTCTCTCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTTTAACATACAGAATTTTAAATACC
ACAACTGGGGCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTCCTTAGCACCAGGCACCGTGGGTC
CTGGATGGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAGTCCGAGCATGGAGCGATTCCATT
TTATGACTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTTTTGCAAGCCAAAAGTCGATCAAT
CGCATTCATTTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATACTTTGTTTAGAGAGGCGAGGGGT
TTAACCGAGTCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAGGTGGAGGGAAGACGTGGACACCA
TCTCCACTGAGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACTCTTTCAAAGTCTTTCTTTTTCCA

>68068_68068_1_PPP2R5C-ABCG1_PPP2R5C_chr14_102252520_ENST00000328724_ABCG1_chr21_43691180_ENST00000398457_length(amino acids)=657AA_BP=86
MPNKNKKEKESPKAGKSGKSSKEGQDTVESEQISVRKNSLVAVPSTVSAKIKVPVSQPIVKKDKRQNSSRFSASNNRELQKLPSLKGYKT
LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK
DEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAK
LFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWH
RPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALM
PTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTS
LQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLD

--------------------------------------------------------------
>68068_68068_2_PPP2R5C-ABCG1_PPP2R5C_chr14_102252520_ENST00000554442_ABCG1_chr21_43691180_ENST00000398457_length(transcript)=2858nt_BP=291nt
GGCGGCGGCGGCGGCGGCGGCCCGCTCCAGCCATGCCGAATAAAAACAAGAAGGAGAAAGAATCACCAAAAGCAGGGAAGAGTGGAAAAA
GTTCAAAAGAAGGACAAGACACAGTAGAATCAGAGCAAATTTCCGTCAGGAAAAACAGCCTTGTTGCTGTCCCGTCTACAGTATCTGCTA
AAATAAAAGTACCAGTCTCTCAGCCCATAGTGAAGAAAGACAAACGGCAAAATTCTTCAAGGTTTAGCGCAAGCAATAATAGAGAACTTC
AAAAACTACCATCCTTAAAAGGATACAAGACCCTCCTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTC
CTTCCGGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTCATCAACGGCCTGC
CCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGA
TGGTGTCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTGGGCTTGCTGTCTT
GCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGT
TCTTCGATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAAGGGGGTCGCTCCA
TCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGG
GAAAAGTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTTGTCATGGAGGTTG
CATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGG
GTGATGCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCT
GCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACACCTGCGCATCACCTCGCACA
TTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCT
CCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTTCTTCGGGAACACCTGAACT
ACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCG
TGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACCTCCCTGGTGGCACAGTCCC
TGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGG
GGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTATGGGTTCGAAGGGGTCATCC
TCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGC
TGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTCATTGCCTATTTTGTCCTCA
GGTACAAAATCCGGGCAGAGAGGTAAAACACCTGAATGCCAGGAAACAGGAAGATTAGACACTGTGGCCGAGGGCACGTCTAGAATCGAG
GAGGCAAGCCTGTGCCCGACCGACGACACAGAGACTCTTCTGATCCAACCCCTAGAACCGCGTTGGGTTTGTGGGTGTCTCGTGCTCAGC
CACTCTGCCCAGCTGGGTTGGATCTTCTCTCCATTCCCCTTTCTAGCTTTAACTAGGAAGATGTAGGCAGATTGGTGGTTTTTTTTTTTT
TAACATACAGAATTTTAAATACCACAACTGGGGCAGAATTTAAAGCTGCAACACAGCTGGTGATGAGAGGCTTCCTCAGTCCAGTCGCTC
CTTAGCACCAGGCACCGTGGGTCCTGGATGGGGAACTGCAAGCAGCCTCTCAGCTGATGGCTGCACAGTCAGATGTCTGGTGGCAGAGAG
TCCGAGCATGGAGCGATTCCATTTTATGACTGTTGTTTTTCACATTTTCATCTTTCTAAGGTGTGTCTCTTTTCCAATGAGAAGTCATTT
TTGCAAGCCAAAAGTCGATCAATCGCATTCATTTTAAGAAATTATACCTTTTTAGTACTTGCTGAAGAATGATTCAGGGTAAATCACATA
CTTTGTTTAGAGAGGCGAGGGGTTTAACCGAGTCACCCAGCTGGTCTCATACATAGACAGCACTTGTGAAGGATTGAATGCAGGTTCCAG
GTGGAGGGAAGACGTGGACACCATCTCCACTGAGCCATGCAGACATTTTTAAAAGCTATACAAAAAATTGTGAGAAGACATTGGCCAACT

>68068_68068_2_PPP2R5C-ABCG1_PPP2R5C_chr14_102252520_ENST00000554442_ABCG1_chr21_43691180_ENST00000398457_length(amino acids)=657AA_BP=86
MPNKNKKEKESPKAGKSGKSSKEGQDTVESEQISVRKNSLVAVPSTVSAKIKVPVSQPIVKKDKRQNSSRFSASNNRELQKLPSLKGYKT
LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK
DEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAK
LFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWH
RPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALM
PTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTS
LQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PPP2R5C-ABCG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PPP2R5C-ABCG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PPP2R5C-ABCG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource